The network for 'mapk cascade' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

mapk cascade

An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.

Mus musculus
Name Description Probability Func Analog Organism
Pten phosphatase and tensin homolog 0.999
Ctnnb1 catenin (cadherin associated protein), beta 1 0.999
Grb2 growth factor receptor bound protein 2 0.994
Apc adenomatosis polyposis coli 0.992
Cav1 caveolin 1, caveolae protein 0.989
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.988
Efnb2 ephrin B2 0.987
Cd40 CD40 antigen 0.985
Cd44 CD44 antigen 0.984
Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 0.978
Traf6 TNF receptor-associated factor 6 0.978
Acvr1 activin A receptor, type 1 0.977
Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) 0.973
Tbx3 T-box 3 0.971
Cbl Casitas B-lineage lymphoma 0.971
Inpp5d inositol polyphosphate-5-phosphatase D 0.967
Smad6 MAD homolog 6 (Drosophila) 0.965
Prkce protein kinase C, epsilon 0.953
Pik3r1 phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha) 0.948
Ghr growth hormone receptor 0.944
Mapk14 mitogen-activated protein kinase 14 0.944
Axin1 axin 1 0.943
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.942
Tgfbr2 transforming growth factor, beta receptor II 0.940
Esr1 estrogen receptor 1 (alpha) 0.937
Fgf10 fibroblast growth factor 10 0.930
Tnf tumor necrosis factor 0.925
Mapk8 mitogen-activated protein kinase 8 0.922
Nf1 neurofibromatosis 1 0.921
Vangl2 vang-like 2 (van gogh, Drosophila) 0.917
Dvl2 dishevelled 2, dsh homolog (Drosophila) 0.916
Cdc42 cell division cycle 42 homolog (S. cerevisiae) 0.912
Smad3 MAD homolog 3 (Drosophila) 0.911
Btk Bruton agammaglobulinemia tyrosine kinase 0.905
Egfr epidermal growth factor receptor 0.904
Tnfaip3 tumor necrosis factor, alpha-induced protein 3 0.901
Plcg1 phospholipase C, gamma 1 0.893
Apoe apolipoprotein E 0.890
Bdnf brain derived neurotrophic factor 0.884
Insr insulin receptor 0.883
Shc3 src homology 2 domain-containing transforming protein C3 0.875
Fyn Fyn proto-oncogene 0.874
Ptk7 PTK7 protein tyrosine kinase 7 0.873
Fgr Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog 0.873
Ret ret proto-oncogene 0.870
Dvl1 dishevelled, dsh homolog 1 (Drosophila) 0.863
Zeb1 zinc finger E-box binding homeobox 1 0.852
Tgfb2 transforming growth factor, beta 2 0.851
Grin2b glutamate receptor, ionotropic, NMDA2B (epsilon 2) 0.850
Csf1 colony stimulating factor 1 (macrophage) 0.850
Nos1 nitric oxide synthase 1, neuronal 0.850
Epas1 endothelial PAS domain protein 1 0.844
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.843
Usp8 ubiquitin specific peptidase 8 0.834
Ephb2 Eph receptor B2 0.833
Kitl kit ligand 0.833
Tnfrsf11a tumor necrosis factor receptor superfamily, member 11a 0.831
Grb10 growth factor receptor bound protein 10 0.825
Chrd chordin 0.822
Lepr leptin receptor 0.819
Fgfr1 fibroblast growth factor receptor 1 0.814
Ntf3 neurotrophin 3 0.809
Dok1 docking protein 1 0.807
Nr3c1 nuclear receptor subfamily 3, group C, member 1 0.802
Ccl2 chemokine (C-C motif) ligand 2 0.800
Fgfr2 fibroblast growth factor receptor 2 0.799
Cdon cell adhesion molecule-related/down-regulated by oncogenes 0.787
Map3k3 mitogen-activated protein kinase kinase kinase 3 0.786
Arrb2 arrestin, beta 2 0.786
Ednrb endothelin receptor type B 0.784
Map3k7 mitogen-activated protein kinase kinase kinase 7 0.782
Gli3 GLI-Kruppel family member GLI3 0.780
Mapk8ip3 mitogen-activated protein kinase 8 interacting protein 3 0.779
Zic3 zinc finger protein of the cerebellum 3 0.778
Il1r1 interleukin 1 receptor, type I 0.775
Fjx1 four jointed box 1 (Drosophila) 0.773
Cd22 CD22 antigen 0.767
Gab1 growth factor receptor bound protein 2-associated protein 1 0.766
Cx3cr1 chemokine (C-X3-C) receptor 1 0.765
Il6st interleukin 6 signal transducer 0.760
Adam17 a disintegrin and metallopeptidase domain 17 0.760
Mapk8ip1 mitogen-activated protein kinase 8 interacting protein 1 0.758
Bmpr1a bone morphogenetic protein receptor, type 1A 0.756
Rassf5 Ras association (RalGDS/AF-6) domain family member 5 0.752
Fcer1g Fc receptor, IgE, high affinity I, gamma polypeptide 0.752
Plau plasminogen activator, urokinase 0.752
Sema3f sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F 0.748
Egr1 early growth response 1 0.747
Gsk3b glycogen synthase kinase 3 beta 0.742
Src Rous sarcoma oncogene 0.729
Tenc1 tensin like C1 domain-containing phosphatase 0.729
Fras1 Fraser syndrome 1 homolog (human) 0.728
Smad7 MAD homolog 7 (Drosophila) 0.726
Id1 inhibitor of DNA binding 1 0.724
Atf2 activating transcription factor 2 0.717
Hoxd13 homeobox D13 0.714
Axl AXL receptor tyrosine kinase 0.713
Pdgfb platelet derived growth factor, B polypeptide 0.704
Stat3 signal transducer and activator of transcription 3 0.702
Tek endothelial-specific receptor tyrosine kinase 0.702
Loading network...
Caenorhabditis elegans
Name Description Probability Func Analog Organism
msp-78 Protein MSP-78 0.909
sma-6 Protein SMA-6 0.842
bar-1 Protein BAR-1 0.631
mpk-1 Protein MPK-1 0.556
msp-59 Protein MSP-59 0.544
lin-25 Protein LIN-25 0.539
tps-1 Protein TPS-1 0.492
pdfr-1 Protein PDFR-1 0.474
msp-76 Protein MSP-76 0.472
mec-2 Protein MEC-2 0.437
CELE_Y59E9AR.7 Protein Y59E9AR.7 0.426
cdc-42 Protein CDC-42 0.415
nhr-6 Protein NHR-6 0.381
msp-31 Protein MSP-31 0.370
msp-36 Protein MSP-36 0.349
dpy-22 Protein DPY-22 0.331
egl-18 Protein EGL-18 0.312
msp-77 Protein MSP-77 0.309
msp-45 Protein MSP-45 0.287
msp-40 Protein MSP-40 0.285
inx-4 Protein INX-4 0.276
mig-2 Protein MIG-2 0.267
msp-55 Protein MSP-55 0.262
lat-1 Protein LAT-1 0.262
C06G3.5 Protein C06G3.5 0.244
sek-1 Protein SEK-1 0.229
msp-50 Protein MSP-50 0.206
daf-4 Protein DAF-4 0.206
msp-3 Protein MSP-3 0.205
msp-152 Protein MSP-152 0.202
pry-1 Protein PRY-1 0.180
eps-8 Protein EPS-8 0.177
msp-33 Protein MSP-33 0.177
glp-1 Protein GLP-1 0.171
msp-49 Protein MSP-49 0.164
npp-7 Protein NPP-7 0.163
ncam-1 Protein NCAM-1 0.154
msp-10 Protein MSP-10 0.152
mig-5 Protein MIG-5 0.145
msp-64 Protein MSP-64 0.138
egal-1 Protein EGAL-1 0.137
vab-3 Protein VAB-3 0.126
daf-19 Protein DAF-19 0.120
unc-9 Protein UNC-9 0.119
zag-1 Protein ZAG-1 0.114
pal-1 Protein PAL-1 0.114
pph-4.1 Protein PPH-4.1 0.113
daf-14 Protein DAF-14 0.111
kal-1 Protein KAL-1 0.108
msp-74 Protein MSP-74 0.107
unc-10 Protein UNC-10 0.107
sma-1 Protein SMA-1 0.106
msp-38 Protein MSP-38 0.105
msp-53 Protein MSP-53 0.103
mab-31 Protein MAB-31 0.102
K08E3.5 Protein K08E3.5 0.096
par-3 Protein PAR-3 0.095
R13A5.9 Protein R13A5.9 0.094
dlk-1 Protein DLK-1 0.094
unc-53 Protein UNC-53 0.093
lin-53 Protein LIN-53 0.092
msp-65 Protein MSP-65 0.091
T13C2.6 Protein T13C2.6 0.090
cki-2 Protein CKI-2 0.089
T01C3.9 Protein T01C3.9 0.087
xpo-1 Protein XPO-1 0.086
ceh-20 Protein CEH-20 0.085
R03H10.2 Protein R03H10.2 0.084
rpm-1 Protein RPM-1 0.083
msp-63 Protein MSP-63 0.081
ham-1 Protein HAM-1 0.079
zyg-9 Protein ZYG-9 0.079
ubc-20 Protein UBC-20 0.078
toca-1 Protein TOCA-1 0.076
CELE_Y41D4B.4 Protein Y41D4B.4 0.076
nipi-3 Protein NIPI-3 0.076
sym-4 Protein SYM-4 0.075
eat-4 Protein EAT-4 0.073
sem-5 Protein SEM-5 0.072
gst-7 Protein GST-7 0.071
cap-2 Protein CAP-2 0.070
sad-1 Protein SAD-1 0.070
hrpf-1 Protein HRPF-1 0.069
swsn-2.1 Protein SWSN-2.1 0.069
cst-1 Protein CST-1 0.069
msp-19 Protein MSP-19 0.069
sur-2 Protein SUR-2 0.068
C04G6.4 Protein C04G6.4 0.066
lin-45 Protein LIN-45 0.065
eor-2 Protein EOR-2 0.064
daf-6 Protein DAF-6 0.063
plc-1 Protein PLC-1 0.063
rgs-6 Protein RGS-6 0.063
psf-1 Protein PSF-1 0.063
tag-260 Protein TAG-260 0.062
CELE_C50B6.3 Protein C50B6.3 0.062
elt-6 Protein ELT-6 0.060
T10G3.1 Protein T10G3.1 0.059
F14D12.1 Protein F14D12.1 0.059
hmg-1.2 Protein HMG-1.2 0.059
Loading network...
Danio rerio
Name Description Probability Func Analog Organism
foxd3 forkhead box D3 0.277
spry4 sprouty (Drosophila) homolog 4 0.197
ephb4b eph receptor B4b 0.161
yes1 v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 0.138
dkk1b dickkopf 1b 0.125
crip2 cysteine-rich protein 2 0.124
tagln2 transgelin 2 0.123
fn1 fibronectin 1 0.115
gdf6a growth differentiation factor 6a 0.104
efnb2a ephrin B2a 0.103
hif1ab hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) b 0.103
kdrl kinase insert domain receptor like 0.078
alcama activated leukocyte cell adhesion molecule a 0.073
mstnb myostatin b 0.070
fzd7a frizzled homolog 7a 0.068
med12 mediator of RNA polymerase II transcription, subunit 12 homolog 0.065
wu:fv91b12 wu:fv91b12 0.064
smad9 MAD homolog 9 (Drosophila) 0.063
lmx1b.1 LIM homeobox transcription factor 1, beta 1 0.060
zbtb4 zinc finger and BTB domain containing 4 0.058
sox9b SRY-box containing gene 9b 0.056
igf1 insulin-like growth factor 1 0.055
smad1 MAD homolog 1 (Drosophila) 0.054
ywhae1 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 1 0.054
tnfrsfa tumor necrosis factor receptor superfamily, member a 0.054
mafba v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian) 0.050
brd4 bromodomain containing 4 0.050
igf1rb insulin-like growth factor 1b receptor 0.049
rag1 recombination activating gene 1 0.048
LOC100537975 thyroid receptor-interacting protein 11-like 0.047
fgf3 fibroblast growth factor 3 0.047
her9 hairy-related 9 0.047
odc1 ornithine decarboxylase 1 0.045
shha sonic hedgehog a 0.045
flh floating head 0.044
ptk2.1 protein tyrosine kinase 2a 0.043
jag2 jagged 2 0.041
wnt5a wingless-type MMTV integration site family, member 5a 0.039
nod1 nucleotide-binding oligomerization domain containing 1 0.039
arhgef7b Rho guanine nucleotide exchange factor (GEF) 7b 0.039
junb jun B proto-oncogene 0.038
esr1 estrogen receptor 1 0.038
furina furin (paired basic amino acid cleaving enzyme) a 0.037
rhoab ras homolog gene family, member Ab 0.037
ved ventrally expressed dharma/bozozok antagonist 0.036
vipr2 vasoactive intestinal peptide receptor 2 0.036
nrg2a neuregulin 2a 0.036
brd2a bromodomain-containing 2a 0.036
bmpr1aa bone morphogenetic protein receptor, type 1aa 0.035
jun jun proto-oncogene 0.034
ldb1a LIM-domain binding factor 1a 0.034
oprd1b opioid receptor, delta 1b 0.034
ywhabb tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide b 0.032
tbx1 T-box 1 0.031
tpm4 tropomyosin 4 0.031
csrp1a cysteine and glycine-rich protein 1a 0.031
ptena phosphatase and tensin homolog A 0.031
sulf1 sulfatase 1 0.030
runx3 runt-related transcription factor 3 0.030
mapk6 mitogen-activated protein kinase 6 0.030
nrp2a neuropilin 2a 0.029
jag1b jagged 1b 0.028
bdnf brain-derived neurotrophic factor 0.028
traf4a tnf receptor-associated factor 4a 0.028
adra2b adrenergic, alpha-2B-, receptor 0.028
ywhai tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, iota polypeptide 0.028
cxcl12b chemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1) 0.028
wnt4a wingless-type MMTV integration site family, member 4a 0.027
crestin crestin 0.027
plcb3 phospholipase C, beta 3 (phosphatidylinositol-specific) 0.027
olfm1a olfactomedin 1a 0.027
mapk3 mitogen-activated protein kinase 3 0.026
spry2 sprouty homolog 2 0.026
mbtps1 membrane-bound transcription factor protease, site 1 0.026
csnk1g2a casein kinase 1, gamma 2a 0.026
tp53 tumor protein p53 0.026
wnt3 wingless-type MMTV integration site family, member 3 0.026
ahcyl1 S-adenosylhomocysteine hydrolase-like 1 0.026
bnc2 basonuclin 2 0.026
mpped2 metallophosphoesterase domain containing 2 0.025
frzb frizzled-related protein 0.025
tlr21 toll-like receptor 21 0.025
csnk1da casein kinase 1, delta a 0.025
myca myelocytomatosis oncogene a 0.025
her6 hairy-related 6 0.024
mapk1 mitogen-activated protein kinase 1 0.024
gapdhs glyceraldehyde-3-phosphate dehydrogenase, spermatogenic 0.024
osr1 odd-skipped related 1 (Drosophila) 0.024
gbx2 gastrulation brain homeo box 2 0.024
ntrk2a neurotrophic tyrosine kinase, receptor, type 2a 0.024
fes feline sarcoma oncogene 0.023
sox10 SRY-box containing gene 10 0.023
card9 caspase recruitment domain family, member 9 0.023
th tyrosine hydroxylase 0.023
cdipt CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase) 0.023
plagl2 pleiomorphic adenoma gene-like 2 0.023
mcoln1 mucolipin 1 0.023
twist1a twist1a 0.023
met met proto-oncogene (hepatocyte growth factor receptor) 0.023
cyp26c1 cytochrome P450, family 26, subfamily C, polypeptide 1 0.023
Loading network...
Drosophila melanogaster
Name Description Probability Func Analog Organism
rl rolled 0.985
Akt1 CG4006 gene product from transcript CG4006-RA 0.969
Ras85D Ras oncogene at 85D 0.967
tkv thickveins 0.963
bsk basket 0.911
spi spitz 0.837
hep hemipterous 0.776
rok Rho-kinase 0.742
Jra Jun-related antigen 0.725
kay kayak 0.687
Atg1 Autophagy-specific gene 1 0.686
aop anterior open 0.673
Cdc42 CG12530 gene product from transcript CG12530-RA 0.666
p38b CG7393 gene product from transcript CG7393-RA 0.622
Pi3K92E CG4141 gene product from transcript CG4141-RB 0.591
Src64B Src oncogene at 64B 0.569
eIF-4E Eukaryotic initiation factor 4E 0.491
Egfr Epidermal growth factor receptor 0.459
Src42A Src oncogene at 42A 0.443
Vang Van Gogh 0.432
Mpk2 CG5475 gene product from transcript CG5475-RB 0.429
G-oalpha47A G protein oalpha 47A 0.412
Rab5 Rab-protein 5 0.378
Myb Myb oncogene-like 0.378
sax saxophone 0.373
pnut peanut 0.367
Rac2 CG8556 gene product from transcript CG8556-RA 0.366
wdb widerborst 0.360
mnb minibrain 0.357
gek genghis khan 0.351
ed echinoid 0.351
phl pole hole 0.348
Sra-1 specifically Rac1-associated protein 1 0.344
shi shibire 0.336
mbc myoblast city 0.329
nmo nemo 0.325
rho rhomboid 0.314
Dad Daughters against dpp 0.302
CkIIalpha Casein kinase II alpha subunit 0.302
Mad Mothers against dpp 0.292
Sema-1a CG18405 gene product from transcript CG18405-RD 0.288
Smg1 CG32743 gene product from transcript CG32743-RA 0.273
Pk61C Protein kinase 61C 0.265
Nrx-IV Neurexin IV 0.265
drk downstream of receptor kinase 0.264
Ced-12 CG5336 gene product from transcript CG5336-RA 0.263
sev sevenless 0.262
chico CG5686 gene product from transcript CG5686-RB 0.261
rhea CG6831 gene product from transcript CG6831-RA 0.259
baz bazooka 0.255
puc puckered 0.255
wg wingless 0.253
robo roundabout 0.253
Stat92E Signal-transducer and activator of transcription protein at 92E 0.250
Shc SHC-adaptor protein 0.243
lqf liquid facets 0.243
sd scalloped 0.238
ush u-shaped 0.238
Sdc Syndecan 0.235
babo baboon 0.230
NetB Netrin-B 0.229
gig gigas 0.225
dco discs overgrown 0.225
Pak PAK-kinase 0.223
Pink1 PTEN-induced putative kinase 1 0.217
DptB Diptericin B 0.212
kis kismet 0.207
Ras64B Ras oncogene at 64B 0.205
CG4168 CG4168 gene product from transcript CG4168-RA 0.201
D Dichaete 0.200
pnt pointed 0.200
Eb1 CG3265 gene product from transcript CG3265-RF 0.199
Smox Smad on X 0.197
srp serpent 0.195
Pka-C1 cAMP-dependent protein kinase 1 0.195
Socs36E Suppressor of cytokine signaling at 36E 0.193
Mef2 Myocyte enhancer factor 2 0.192
p120ctn Adherens junction protein p120 0.189
AttA Attacin-A 0.188
S6k RPS6-p70-protein kinase 0.187
Plc21C Phospholipase C at 21C 0.186
Bin1 Bicoid interacting protein 1 0.183
sr stripe 0.182
Pkn Protein kinase related to protein kinase N 0.181
sbb scribbler 0.179
cert ceramide transfer protein 0.178
stck steamer duck 0.175
key kenny 0.172
ex expanded 0.170
S6kII RPS6-protein kinase-II 0.170
ecd ecdysoneless 0.168
raps rapsynoid 0.167
mtt mangetout 0.166
Lis-1 Lissencephaly-1 0.162
Galpha49B G protein alpha49B 0.159
Rel Relish 0.159
stumps CG31317 gene product from transcript CG31317-RC 0.156
alph alphabet 0.154
Ssl1 CG11115 gene product from transcript CG11115-RA 0.153
hipk homeodomain interacting protein kinase 0.152
Loading network...
Homo sapiens
Name Description Probability Func Analog Organism
EGFR epidermal growth factor receptor 1.000
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 1.000
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 1.000
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 1.000
SMAD2 SMAD family member 2 1.000
SMN1 survival of motor neuron 1, telomeric 1.000
MAPK1 mitogen-activated protein kinase 1 0.999
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.999
CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.999
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.999
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.999
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide 0.998
SH3KBP1 SH3-domain kinase binding protein 1 0.998
BCAR1 breast cancer anti-estrogen resistance 1 0.997
CRK v-crk sarcoma virus CT10 oncogene homolog (avian) 0.996
MAPK14 mitogen-activated protein kinase 14 0.996
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 0.994
ILK integrin-linked kinase 0.992
IRAK1 interleukin-1 receptor-associated kinase 1 0.990
MAP2K1 mitogen-activated protein kinase kinase 1 0.990
SMAD3 SMAD family member 3 0.988
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 0.988
GRB2 growth factor receptor-bound protein 2 0.988
CDC42 cell division cycle 42 (GTP binding protein, 25kDa) 0.988
FYN FYN oncogene related to SRC, FGR, YES 0.988
FGFR2 fibroblast growth factor receptor 2 0.987
ABL1 c-abl oncogene 1, non-receptor tyrosine kinase 0.987
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.985
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.985
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.984
RAF1 v-raf-1 murine leukemia viral oncogene homolog 1 0.984
CSNK1E casein kinase 1, epsilon 0.983
FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.981
ESR1 estrogen receptor 1 0.981
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.979
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.979
IRAK2 interleukin-1 receptor-associated kinase 2 0.974
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) 0.972
SFN stratifin 0.972
JUN jun proto-oncogene 0.970
DUSP1 dual specificity phosphatase 1 0.963
FLNA filamin A, alpha 0.959
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 0.959
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 0.957
NCOA3 nuclear receptor coactivator 3 0.957
SMAD7 SMAD family member 7 0.956
GSK3B glycogen synthase kinase 3 beta 0.954
TRAF6 TNF receptor-associated factor 6 0.949
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein 0.946
HRAS v-Ha-ras Harvey rat sarcoma viral oncogene homolog 0.943
BIRC3 baculoviral IAP repeat containing 3 0.939
FN1 fibronectin 1 0.938
TRAF3 TNF receptor-associated factor 3 0.937
FGFR1 fibroblast growth factor receptor 1 0.937
GAB1 GRB2-associated binding protein 1 0.935
ENG endoglin 0.933
MAPK8 mitogen-activated protein kinase 8 0.932
LAT linker for activation of T cells 0.931
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 0.924
C1QA complement component 1, q subcomponent, A chain 0.920
KDR kinase insert domain receptor (a type III receptor tyrosine kinase) 0.919
MAP3K7 mitogen-activated protein kinase kinase kinase 7 0.918
CCR5 chemokine (C-C motif) receptor 5 0.916
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 0.908
MET met proto-oncogene (hepatocyte growth factor receptor) 0.906
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.904
LRRK2 leucine-rich repeat kinase 2 0.904
TGFB1 transforming growth factor, beta 1 0.901
VEGFA vascular endothelial growth factor A 0.898
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) 0.896
XIAP X-linked inhibitor of apoptosis 0.893
SRPK2 SRSF protein kinase 2 0.886
MAP2K4 mitogen-activated protein kinase kinase 4 0.884
ZNF43 zinc finger protein 43 0.882
IL6 interleukin 6 (interferon, beta 2) 0.876
SOCS3 suppressor of cytokine signaling 3 0.870
TEK TEK tyrosine kinase, endothelial 0.868
MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1 0.868
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.866
MAP3K3 mitogen-activated protein kinase kinase kinase 3 0.864
GHR growth hormone receptor 0.861
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.856
IGF1R insulin-like growth factor 1 receptor 0.851
PTEN phosphatase and tensin homolog 0.848
FHL2 four and a half LIM domains 2 0.848
PTK2 PTK2 protein tyrosine kinase 2 0.845
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.842
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.841
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.840
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.833
PRKCA protein kinase C, alpha 0.832
BCR breakpoint cluster region 0.825
IQGAP1 IQ motif containing GTPase activating protein 1 0.819
LCK lymphocyte-specific protein tyrosine kinase 0.819
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.816
MMP2 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) 0.814
SIRT1 sirtuin 1 0.810
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) 0.806
PKM2 pyruvate kinase, muscle 0.802
BRAF v-raf murine sarcoma viral oncogene homolog B1 0.792
Loading network...
Rattus norvegicus
Name Description Probability Func Analog Organism
Dbp D site of albumin promoter (albumin D-box) binding protein 0.758
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.710
Slc18a2 solute carrier family 18 (vesicular monoamine), member 2 0.687
Fgr Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog 0.685
Grin2b glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.668
Sirpa signal-regulatory protein alpha 0.629
Bcan brevican 0.621
Calcrl calcitonin receptor-like 0.612
Gabrg1 gamma-aminobutyric acid (GABA) A receptor, gamma 1 0.608
Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.584
Ncan neurocan 0.583
Ptafr platelet-activating factor receptor 0.570
Egr1 early growth response 1 0.558
Ar androgen receptor 0.557
Fgfr2 fibroblast growth factor receptor 2 0.555
Trhr thyrotropin releasing hormone receptor 0.555
Fgf2 fibroblast growth factor 2 0.545
Alb albumin 0.531
Met met proto-oncogene 0.515
Klf6 Kruppel-like factor 6 0.500
Ccl4 chemokine (C-C motif) ligand 4 0.498
Ppara peroxisome proliferator activated receptor alpha 0.493
Ntrk1 neurotrophic tyrosine kinase, receptor, type 1 0.464
Smad3 SMAD family member 3 0.455
Rgs14 regulator of G-protein signaling 14 0.451
Phkg1 phosphorylase kinase, gamma 1 0.443
Nr5a2 nuclear receptor subfamily 5, group A, member 2 0.431
Junb jun B proto-oncogene 0.431
Adora2a adenosine A2a receptor 0.431
Grm7 glutamate receptor, metabotropic 7 0.416
Slc18a3 solute carrier family 18 (vesicular acetylcholine), member 3 0.411
Ctsj cathepsin J 0.410
Ptgfr prostaglandin F receptor 0.404
Gzmk granzyme K 0.397
Mapk1 mitogen activated protein kinase 1 0.395
Fos FBJ osteosarcoma oncogene 0.388
Vom2r27 vomeronasal 2 receptor, 27 0.387
Oprm1 opioid receptor, mu 1 0.385
Pcdhb12 protocadherin beta 12 0.378
Notch3 Notch homolog 3 (Drosophila) 0.378
Gria1 glutamate receptor, ionotropic, AMPA 1 0.374
Mpp2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) 0.368
Htr7 5-hydroxytryptamine (serotonin) receptor 7 0.348
Cacnb1 calcium channel, voltage-dependent, beta 1 subunit 0.346
Klf4 Kruppel-like factor 4 (gut) 0.341
Agtr1a angiotensin II receptor, type 1a 0.336
Nrg1 neuregulin 1 0.330
Mapk9 mitogen-activated protein kinase 9 0.325
Hpcal4 hippocalcin-like 4 0.317
Efnb1 ephrin B1 0.317
Inpp5d inositol polyphosphate-5-phosphatase D 0.317
Cx3cr1 chemokine (C-X3-C motif) receptor 1 0.316
Cyp21a1 cytochrome P450, family 21, subfamily a, polypeptide 1 0.310
Ncr1 natural cytotoxicity triggering receptor 1 0.309
Cd38 CD38 molecule 0.305
Shox2 short stature homeobox 2 0.304
Jtb jumping translocation breakpoint 0.303
Pfkfb2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 0.302
Il9r interleukin 9 receptor 0.297
Folh1 folate hydrolase 1 0.297
Dock8 dedicator of cytokinesis 8 0.295
Cxcl2 chemokine (C-X-C motif) ligand 2 0.294
Wdr26 WD repeat domain 26 0.294
Reg1a regenerating islet-derived 1 alpha 0.294
RT1-Da RT1 class II, locus Da 0.288
Htr2c 5-hydroxytryptamine (serotonin) receptor 2C 0.288
Slco2a1 solute carrier organic anion transporter family, member 2a1 0.287
Jak1 Janus kinase 1 0.278
Psen1 presenilin 1 0.275
Jak2 Janus kinase 2 0.274
Slc1a3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 0.273
Olr287 olfactory receptor 287 0.271
S1pr2 sphingosine-1-phosphate receptor 2 0.268
Jun Jun oncogene 0.266
Kcnj16 potassium inwardly-rectifying channel, subfamily J, member 16 0.266
Itpkb inositol 1,4,5-trisphosphate 3-kinase B 0.265
Ccl3 chemokine (C-C motif) ligand 3 0.264
Csf2rb colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 0.264
Tgfbr2 transforming growth factor, beta receptor II 0.262
Prok2 prokineticin 2 0.257
Ccr2 chemokine (C-C motif) receptor 2 0.256
Nras neuroblastoma ras oncogene 0.253
Gipr gastric inhibitory polypeptide receptor 0.252
Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 0.251
Socs3 suppressor of cytokine signaling 3 0.250
Dag1 dystroglycan 1 (dystrophin-associated glycoprotein 1) 0.248
Musk muscle, skeletal, receptor tyrosine kinase 0.248
Gfra2 GDNF family receptor alpha 2 0.247
Scn4a sodium channel, voltage-gated, type IV, alpha subunit 0.247
Ptger4 prostaglandin E receptor 4 (subtype EP4) 0.247
Hck hemopoietic cell kinase 0.247
Ndst1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 0.245
Il2ra interleukin 2 receptor, alpha 0.244
Svs1 seminal vesicle secretory protein 1 0.241
Cxcr3 chemokine (C-X-C motif) receptor 3 0.239
Itgam integrin, alpha M 0.239
Itpr2 inositol 1,4,5-triphosphate receptor, type 2 0.238
Pnlip pancreatic lipase 0.238
Crip2 cysteine-rich protein 2 0.236
Bdkrb2 bradykinin receptor B2 0.235
Loading network...
Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
PBS2 Pbs2p 0.999
NBP2 Nbp2p 0.993
SSK2 Ssk2p 0.983
SLT2 Slt2p 0.982
BCK1 Bck1p 0.979
STE7 Ste7p 0.947
CLA4 Cla4p 0.890
KSS1 Kss1p 0.826
STE20 Ste20p 0.822
MSG5 Msg5p 0.810
SSK1 Ssk1p 0.774
SNT1 Snt1p 0.674
SHO1 Sho1p 0.595
STE11 Ste11p 0.589
ZDS1 Zds1p 0.565
FUS3 Fus3p 0.540
BCK2 Bck2p 0.511
RLM1 Rlm1p 0.499
KDX1 Kdx1p 0.448
SSK22 Ssk22p 0.442
HOG1 Hog1p 0.418
STE5 Ste5p 0.405
SOK1 Sok1p 0.387
CPR1 Cpr1p 0.286
HOS4 Hos4p 0.271
PIL1 Pil1p 0.236
BMH1 Bmh1p 0.213
VPS64 Vps64p 0.197
RGD1 Rgd1p 0.178
PPH21 Pph21p 0.169
SIF2 Sif2p 0.138
VMA13 Vma13p 0.116
TED1 Ted1p 0.111
CRZ1 Crz1p 0.110
CAK1 Cak1p 0.101
UFO1 Ufo1p 0.099
GAL7 Gal7p 0.094
KOG1 Kog1p 0.093
TAT1 Tat1p 0.091
AHP1 Ahp1p 0.088
ALD6 Ald6p 0.088
YTA6 Yta6p 0.081
STE4 Ste4p 0.078
EBS1 Ebs1p 0.076
SSN8 Ssn8p 0.076
CRG1 Crg1p 0.074
MRM1 Mrm1p 0.073
PCI8 Pci8p 0.073
ARF2 Arf2p 0.073
LHS1 Lhs1p 0.072
BOI2 Boi2p 0.067
CDC34 Cdc34p 0.065
KIC1 Kic1p 0.065
PAM1 Pam1p 0.065
HST1 Hst1p 0.064
PTP2 Ptp2p 0.064
YHB1 Yhb1p 0.063
HSP60 Hsp60p 0.062
YPL088W hypothetical protein 0.059
IRA1 Ira1p 0.059
ESF1 Esf1p 0.053
HKR1 Hkr1p 0.052
YPL150W hypothetical protein 0.052
CDC24 Cdc24p 0.052
MNN2 Mnn2p 0.050
TRX2 Trx2p 0.048
NAB6 Nab6p 0.048
VPS5 Vps5p 0.048
SMP1 Smp1p 0.047
CDC37 Cdc37p 0.047
HOR7 Hor7p 0.046
PPH3 Pph3p 0.045
RHO1 Rho1p 0.045
FAB1 Fab1p 0.045
ALO1 Alo1p 0.044
HSM3 Hsm3p 0.043
TEC1 Tec1p 0.043
RAS2 Ras2p 0.041
YJR084W hypothetical protein 0.040
FUS2 Fus2p 0.040
HOS2 Hos2p 0.040
OYE2 Oye2p 0.040
MDS3 Mds3p 0.039
TPS1 Tps1p 0.039
NRP1 Nrp1p 0.039
PTC1 Ptc1p 0.039
ASK10 Ask10p 0.038
SET1 Set1p 0.037
KEL3 Kel3p 0.036
BCY1 Bcy1p 0.036
AKL1 Akl1p 0.036
NUP157 Nup157p 0.035
GPX2 Gpx2p 0.034
OPY2 Opy2p 0.034
SMY2 Smy2p 0.034
DBF2 Dbf2p 0.034
YJL193W hypothetical protein 0.033
PUS9 Pus9p 0.031
SKO1 Sko1p 0.031
MOB2 Mob2p 0.030