The network for 'negative regulation of cyclin dependent protein serine threonine kinase activity' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of cyclin dependent protein serine threonine kinase activity

Any process that stops, prevents, or reduces the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity.

Mus musculus
Name Description Probability Func Analog Organism
Trp53 transformation related protein 53 1.000
Ctnnb1 catenin (cadherin associated protein), beta 1 1.000
Rb1 retinoblastoma 1 0.999
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.996
Pten phosphatase and tensin homolog 0.995
Apc adenomatosis polyposis coli 0.994
Casp1 caspase 1 0.949
Cdkn2c cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) 0.919
Braf Braf transforming gene 0.899
Casp4 caspase 4, apoptosis-related cysteine peptidase 0.891
Nf1 neurofibromatosis 1 0.883
Mdm2 transformed mouse 3T3 cell double minute 2 0.820
Esr1 estrogen receptor 1 (alpha) 0.817
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.812
E2f1 E2F transcription factor 1 0.737
Hif1a hypoxia inducible factor 1, alpha subunit 0.706
Kit kit oncogene 0.647
Lepr leptin receptor 0.647
Gbp5 guanylate binding protein 5 0.614
Ptch1 patched homolog 1 0.589
Smad3 MAD homolog 3 (Drosophila) 0.472
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.433
Pycard PYD and CARD domain containing 0.422
Meox2 mesenchyme homeobox 2 0.389
Tlr4 toll-like receptor 4 0.357
Thbs1 thrombospondin 1 0.337
Ghr growth hormone receptor 0.318
Smad4 MAD homolog 4 (Drosophila) 0.284
Lyz2 lysozyme 2 0.280
Kitl kit ligand 0.245
Ahr aryl-hydrocarbon receptor 0.245
Il18 interleukin 18 0.223
Psen1 presenilin 1 0.220
Aim2 absent in melanoma 2 0.211
Foxo3 forkhead box O3 0.159
Nf2 neurofibromatosis 2 0.146
Vhl von Hippel-Lindau tumor suppressor 0.141
Smad2 MAD homolog 2 (Drosophila) 0.127
Il1b interleukin 1 beta 0.126
Col1a1 collagen, type I, alpha 1 0.124
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.121
Bmpr1a bone morphogenetic protein receptor, type 1A 0.121
Men1 multiple endocrine neoplasia 1 0.114
Notch1 Notch gene homolog 1 (Drosophila) 0.114
Cdkn2a cyclin-dependent kinase inhibitor 2A 0.112
Tgfb1 transforming growth factor, beta 1 0.107
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.102
Notch2 Notch gene homolog 2 (Drosophila) 0.100
Csrp2bp cysteine and glycine-rich protein 2 binding protein 0.099
Fas Fas (TNF receptor superfamily member 6) 0.099
Hes1 hairy and enhancer of split 1 (Drosophila) 0.094
Rbpj recombination signal binding protein for immunoglobulin kappa J region 0.091
Tsc1 tuberous sclerosis 1 0.090
Zeb1 zinc finger E-box binding homeobox 1 0.090
Ccnd1 cyclin D1 0.087
Traf6 TNF receptor-associated factor 6 0.084
Ar androgen receptor 0.082
Runx1 runt related transcription factor 1 0.080
Cdkn2d cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) 0.078
Mdm4 transformed mouse 3T3 cell double minute 4 0.073
Brca1 breast cancer 1 0.069
Ptgs2 prostaglandin-endoperoxide synthase 2 0.069
Bmp4 bone morphogenetic protein 4 0.065
Nr2f1 nuclear receptor subfamily 2, group F, member 1 0.064
Fgfr2 fibroblast growth factor receptor 2 0.062
Apaf1 apoptotic peptidase activating factor 1 0.060
Yap1 yes-associated protein 1 0.056
Brca2 breast cancer 2 0.053
Amhr2 anti-Mullerian hormone type 2 receptor 0.052
Fadd Fas (TNFRSF6)-associated via death domain 0.052
Pparg peroxisome proliferator activated receptor gamma 0.051
Ripk1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.051
Map3k7 mitogen-activated protein kinase kinase kinase 7 0.050
Tmpo thymopoietin 0.048
Nfya nuclear transcription factor-Y alpha 0.044
Stk11 serine/threonine kinase 11 0.042
Twsg1 twisted gastrulation homolog 1 (Drosophila) 0.042
Clock circadian locomotor output cycles kaput 0.041
Atf3 activating transcription factor 3 0.041
Il6st interleukin 6 signal transducer 0.041
Nr3c1 nuclear receptor subfamily 3, group C, member 1 0.040
Nlrp3 NLR family, pyrin domain containing 3 0.040
Fgfr1 fibroblast growth factor receptor 1 0.039
Csf1 colony stimulating factor 1 (macrophage) 0.037
Sav1 salvador homolog 1 (Drosophila) 0.035
Mr1 major histocompatibility complex, class I-related 0.035
Rxra retinoid X receptor alpha 0.034
Trp63 transformation related protein 63 0.034
Cdk9 cyclin-dependent kinase 9 (CDC2-related kinase) 0.032
Mobkl1b MOB1, Mps One Binder kinase activator-like 1B (yeast) 0.032
Traf2 TNF receptor-associated factor 2 0.031
Vav2 vav 2 oncogene 0.031
Arntl aryl hydrocarbon receptor nuclear translocator-like 0.031
Nfe2l2 nuclear factor, erythroid derived 2, like 2 0.030
Kiss1 KiSS-1 metastasis-suppressor 0.029
Usp21 ubiquitin specific peptidase 21 0.029
Elavl1 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R) 0.029
Nos3 nitric oxide synthase 3, endothelial cell 0.029
Wls wntless homolog (Drosophila) 0.028
Birc3 baculoviral IAP repeat-containing 3 0.028
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
hpo hippo 0.121
Mlf Myelodysplasia/myeloid leukemia factor 0.102
Myb Myb oncogene-like 0.100
dm diminutive 0.078
ex expanded 0.052
cutlet CG33122 gene product from transcript CG33122-RA 0.042
pie pineapple eye 0.037
cnn centrosomin 0.037
pim pimples 0.029
Tsc1 CG6147 gene product from transcript CG6147-RA 0.026
Rbf Retinoblastoma-family protein 0.026
Su(H) Suppressor of Hairless 0.026
cmet CENP-meta 0.024
CycE Cyclin E 0.024
Vang Van Gogh 0.023
Gug Grunge 0.023
CycA Cyclin A 0.022
Slip1 CG1783 gene product from transcript CG1783-RA 0.020
sno strawberry notch 0.019
rin rasputin 0.019
CG10631 CG10631 gene product from transcript CG10631-RA 0.018
Pi3K92E CG4141 gene product from transcript CG4141-RB 0.018
Axn Axin 0.018
wisp wispy 0.018
gig gigas 0.017
rl rolled 0.016
Gap1 GTPase-activating protein 1 0.016
cnk connector enhancer of ksr 0.016
sbb scribbler 0.016
pho pleiohomeotic 0.016
dsh dishevelled 0.015
gek genghis khan 0.015
Med Medea 0.014
sina seven in absentia 0.013
pygo pygopus 0.013
tefu telomere fusion 0.013
Abl Abl tyrosine kinase 0.012
Vap-33-1 CG5014 gene product from transcript CG5014-RB 0.012
cno canoe 0.012
PTP-ER Protein tyrosine phosphatase-ERK/Enhancer of Ras1 0.011
mxc multi sex combs 0.011
pUf68 poly U binding factor 68kD 0.011
Klp3A Kinesin-like protein at 3A 0.011
wee CG4488 gene product from transcript CG4488-RA 0.011
Hcf Host cell factor 0.011
Akt1 CG4006 gene product from transcript CG4006-RA 0.011
Cdc27 CG8610 gene product from transcript CG8610-RA 0.011
bif bifocal 0.011
Rheb CG1081 gene product from transcript CG1081-RA 0.010
Ras64B Ras oncogene at 64B 0.010
brat brain tumor 0.010
exu exuperantia 0.010
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Homo sapiens
Name Description Probability Func Analog Organism
SRF serum response factor (c-fos serum response element-binding transcription factor) 0.669
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.456
CCND3 cyclin D3 0.096
BTRC beta-transducin repeat containing 0.090
RARA retinoic acid receptor, alpha 0.078
CDK6 cyclin-dependent kinase 6 0.067
RB1 retinoblastoma 1 0.063
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.062
SPOP speckle-type POZ protein 0.062
CCND1 cyclin D1 0.058
UHRF2 ubiquitin-like with PHD and ring finger domains 2 0.058
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 0.058
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 0.057
MED25 mediator complex subunit 25 0.048
CDK2 cyclin-dependent kinase 2 0.042
SKP1 S-phase kinase-associated protein 1 0.041
CDKN2A cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) 0.039
NCOA1 nuclear receptor coactivator 1 0.037
FBXW11 F-box and WD repeat domain containing 11 0.030
MOBKL1B MOB1, Mps One Binder kinase activator-like 1B (yeast) 0.026
SNAI1 snail homolog 1 (Drosophila) 0.026
JUB jub, ajuba homolog (Xenopus laevis) 0.021
NR0B2 nuclear receptor subfamily 0, group B, member 2 0.020
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.020
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.019
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 0.019
YAP1 Yes-associated protein 1 0.019
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.016
MDM4 Mdm4 p53 binding protein homolog (mouse) 0.015
SFN stratifin 0.015
LATS2 LATS, large tumor suppressor, homolog 2 (Drosophila) 0.015
PINK1 PTEN induced putative kinase 1 0.014
PROX1 prospero homeobox 1 0.014
FAM46A family with sequence similarity 46, member A 0.013
TNIP1 TNFAIP3 interacting protein 1 0.013
BRCA2 breast cancer 2, early onset 0.012
SMAD1 SMAD family member 1 0.011
MLL myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) 0.011
CHEK2 CHK2 checkpoint homolog (S. pombe) 0.011
STK38L serine/threonine kinase 38 like 0.011
PRNP prion protein 0.011
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism