The network for 'regulation of intrinsic apoptotic signaling pathway' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of intrinsic apoptotic signaling pathway

Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway.

Mus musculus
Name Description Probability Func Analog Organism
Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.999
Pten phosphatase and tensin homolog 0.983
Trp53 transformation related protein 53 0.967
Tnf tumor necrosis factor 0.954
Lyz2 lysozyme 2 0.926
Map3k7 mitogen-activated protein kinase kinase kinase 7 0.914
Lepr leptin receptor 0.902
Ncoa3 nuclear receptor coactivator 3 0.900
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.818
Hdac2 histone deacetylase 2 0.728
Nfe2l2 nuclear factor, erythroid derived 2, like 2 0.709
Igh immunoglobulin heavy chain complex 0.672
Tgfb1 transforming growth factor, beta 1 0.631
Mmp9 matrix metallopeptidase 9 0.583
Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) 0.554
Bax BCL2-associated X protein 0.547
Atp5a1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1 0.533
Mdm4 transformed mouse 3T3 cell double minute 4 0.529
Atp5b ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit 0.488
Ndufa9 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9 0.475
Ikbkb inhibitor of kappaB kinase beta 0.471
Stat3 signal transducer and activator of transcription 3 0.469
Tnfaip3 tumor necrosis factor, alpha-induced protein 3 0.458
Bcl2 B-cell leukemia/lymphoma 2 0.456
Col1a1 collagen, type I, alpha 1 0.455
Ren1 renin 1 structural 0.435
S100a9 S100 calcium binding protein A9 (calgranulin B) 0.430
S100a8 S100 calcium binding protein A8 (calgranulin A) 0.411
Ikbkg inhibitor of kappaB kinase gamma 0.404
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.404
Bak1 BCL2-antagonist/killer 1 0.400
Crim1 cysteine rich transmembrane BMP regulator 1 (chordin like) 0.393
Agtr1a angiotensin II receptor, type 1a 0.379
Cul3 cullin 3 0.339
Fas Fas (TNF receptor superfamily member 6) 0.325
Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha 0.321
Vhl von Hippel-Lindau tumor suppressor 0.319
Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 0.316
Sin3a transcriptional regulator, SIN3A (yeast) 0.311
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.307
Sufu suppressor of fused homolog (Drosophila) 0.285
Rpgrip1l Rpgrip1-like 0.270
Pparg peroxisome proliferator activated receptor gamma 0.263
Timm17a translocase of inner mitochondrial membrane 17a 0.254
Rxra retinoid X receptor alpha 0.251
Ppp2ca protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform 0.241
Ppp1cc protein phosphatase 1, catalytic subunit, gamma isoform 0.240
Ikzf1 IKAROS family zinc finger 1 0.237
Hdac1 histone deacetylase 1 0.235
Eif2c1 eukaryotic translation initiation factor 2C, 1 0.234
Sfn stratifin 0.229
Ncstn nicastrin 0.228
Wt1 Wilms tumor 1 homolog 0.224
Lep leptin 0.220
Kdm2b lysine (K)-specific demethylase 2B 0.215
Suz12 suppressor of zeste 12 homolog (Drosophila) 0.206
Pik3cd phosphatidylinositol 3-kinase catalytic delta polypeptide 0.198
Nlrp3 NLR family, pyrin domain containing 3 0.195
Skil SKI-like 0.194
Casp8 caspase 8 0.193
Mapk8 mitogen-activated protein kinase 8 0.190
Cd79a CD79A antigen (immunoglobulin-associated alpha) 0.189
Zfp362 zinc finger protein 362 0.188
Tcra T-cell receptor alpha chain 0.180
Cxcr4 chemokine (C-X-C motif) receptor 4 0.175
Ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 0.174
Apoe apolipoprotein E 0.167
Casp4 caspase 4, apoptosis-related cysteine peptidase 0.164
Plagl2 pleiomorphic adenoma gene-like 2 0.163
Uqcrfs1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 0.161
Zeb1 zinc finger E-box binding homeobox 1 0.159
Usp9x ubiquitin specific peptidase 9, X chromosome 0.159
Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.154
Cyld cylindromatosis (turban tumor syndrome) 0.154
Nos3 nitric oxide synthase 3, endothelial cell 0.154
Ccr1 chemokine (C-C motif) receptor 1 0.149
Ndufs2 NADH dehydrogenase (ubiquinone) Fe-S protein 2 0.147
Tlr2 toll-like receptor 2 0.147
Trp73 transformation related protein 73 0.147
Suclg1 succinate-CoA ligase, GDP-forming, alpha subunit 0.147
H2-Eb1 histocompatibility 2, class II antigen E beta 0.144
Agtrap angiotensin II, type I receptor-associated protein 0.143
Rnf19a ring finger protein 19A 0.137
Mta2 metastasis-associated gene family, member 2 0.136
Agt angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 0.135
Setdb1 SET domain, bifurcated 1 0.129
Bcl2l1 BCL2-like 1 0.127
Traf6 TNF receptor-associated factor 6 0.127
Sqstm1 sequestosome 1 0.126
Ptprc protein tyrosine phosphatase, receptor type, C 0.125
Hnrnpa1 heterogeneous nuclear ribonucleoprotein A1 0.125
Lrrk2 leucine-rich repeat kinase 2 0.123
Lif leukemia inhibitory factor 0.122
Egr2 early growth response 2 0.120
Traf2 TNF receptor-associated factor 2 0.115
Mdh2 malate dehydrogenase 2, NAD (mitochondrial) 0.111
Rbl1 retinoblastoma-like 1 (p107) 0.110
Cftr cystic fibrosis transmembrane conductance regulator homolog 0.107
Park7 Parkinson disease (autosomal recessive, early onset) 7 0.106
Timm23 translocase of inner mitochondrial membrane 23 homolog (yeast) 0.103
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
C14B1.8 Protein C14B1.8 0.024
acly-2 Protein ACLY-2 0.021
eak-7 Protein EAK-7 0.017
mrpl-34 Protein MRPL-34 0.017
apc-11 Protein APC-11 0.017
C05C10.2 Protein C05C10.2 0.017
lsm-3 Protein LSM-3 0.017
gfl-1 Protein GFL-1 0.016
M01A10.1 Protein M01A10.1 0.016
spe-39 Protein SPE-39 0.016
F56D1.2 Protein F56D1.2 0.016
mrpl-23 Protein MRPL-23 0.015
ZK1127.12 Protein ZK1127.12 0.015
R06C7.2 Protein R06C7.2 0.015
F40F11.3 Protein F40F11.3 0.015
col-13 Protein COL-13 0.015
F26H9.4 Protein F26H9.4 0.015
F22G12.5 Protein F22G12.5 0.014
spo-11 Protein SPO-11 0.014
ZK930.1 Protein ZK930.1 0.014
Y48G1C.9 Protein Y48G1C.9 0.014
rpb-10 Protein RPB-10 0.014
K11H3.4 Protein K11H3.4 0.013
pqn-55 Protein PQN-55 0.013
gut-2 Protein GUT-2 0.013
C16C8.11 Protein C16C8.11 0.013
unc-27 Protein UNC-27 0.013
C24F3.2 Protein C24F3.2 0.013
CELE_F25B4.5 Protein F25B4.5 0.013
nlp-17 Protein NLP-17 0.013
C14H10.2 Protein C14H10.2 0.013
W06D11.3 Protein W06D11.3 0.013
hda-6 Protein HDA-6 0.013
CELE_T04B2.5 Protein T04B2.5 0.013
T27F7.1 Protein T27F7.1 0.013
hpd-1 Protein HPD-1 0.013
CELE_F02H6.4 Protein F02H6.4 0.013
F58A6.1 Protein F58A6.1 0.013
T25E12.6 Protein T25E12.6 0.012
gta-1 Protein GTA-1 0.012
CELE_Y47G6A.19 Protein Y47G6A.19 0.012
T01H8.2 Protein T01H8.2 0.012
H14A12.3 Protein H14A12.3 0.012
daf-22 Protein DAF-22 0.012
haf-9 Protein HAF-9 0.012
C14B1.9 Protein C14B1.9 0.012
C06A8.3 Protein C06A8.3 0.012
F48E8.6 Protein F48E8.6 0.012
ttr-18 Protein TTR-18 0.012
R10H10.3 Protein R10H10.3 0.012
C07H6.2 Protein C07H6.2 0.012
CELE_F43G6.7 Protein F43G6.7 0.012
lin-49 Protein LIN-49 0.012
mrpl-51 Protein MRPL-51 0.012
bath-27 Protein BATH-27 0.012
smg-7 Protein SMG-7 0.012
bmy-1 Protein BMY-1 0.012
F42A8.3 Protein F42A8.3 0.012
T01G9.2 Protein T01G9.2 0.012
ZK1058.5 Protein ZK1058.5 0.012
CELE_JC8.5 Protein JC8.5 0.012
K10C3.4 Protein K10C3.4 0.012
pir-1 Protein PIR-1 0.012
ras-2 Protein RAS-2 0.012
CELE_F53F4.13 Protein F53F4.13 0.012
mig-22 Protein MIG-22 0.012
B0491.1 Protein B0491.1 0.012
C33H5.8 Protein C33H5.8 0.012
F40G9.2 Protein F40G9.2 0.012
gst-6 Protein GST-6 0.012
mdt-27 Protein MDT-27 0.012
sod-2 Protein SOD-2 0.012
T27A3.2 Protein T27A3.2 0.011
CELE_F22E5.9 Protein F22E5.9 0.011
gas-1 Protein GAS-1 0.011
F28H6.4 Protein F28H6.4 0.011
C14H10.1 Protein C14H10.1 0.011
CELE_W07A8.2 Protein W07A8.2 0.011
mrpl-28 Protein MRPL-28 0.011
K09G1.1 Protein K09G1.1 0.011
F49E7.2 Protein F49E7.2 0.011
Y97E10AL.3 Protein Y97E10AL.3 0.011
K06A5.1 Protein K06A5.1 0.011
ttr-24 Protein TTR-24 0.011
skr-3 Protein SKR-3 0.011
col-182 Protein COL-182 0.011
F59A2.5 Protein F59A2.5 0.011
F53B3.6 Protein F53B3.6 0.011
ttr-31 Protein TTR-31 0.011
T06D4.1 Protein T06D4.1 0.011
col-133 Protein COL-133 0.011
sqt-2 Protein SQT-2 0.011
pqn-22 Protein PQN-22 0.011
msh-5 Protein MSH-5 0.011
mpz-2 Protein MPZ-2 0.011
C17E7.9 Protein C17E7.9 0.011
C47D12.8 Protein C47D12.8 0.011
emb-1 Protein EMB-1 0.011
K11B4.2 Protein K11B4.2 0.011
rsp-7 Protein RSP-7 0.011
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Danio rerio
Name Description Probability Func Analog Organism
baxa bcl2-associated X protein, a 0.016
bcl2l1 bcl2-like 1 0.014
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
BCL2L1 BCL2-like 1 1.000
BCL2 B-cell CLL/lymphoma 2 0.998
TP53 tumor protein p53 0.998
BCL2L11 BCL2-like 11 (apoptosis facilitator) 0.990
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.987
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) 0.976
UBC ubiquitin C 0.976
BAX BCL2-associated X protein 0.942
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.924
SFPQ splicing factor proline/glutamine-rich 0.878
HDAC1 histone deacetylase 1 0.867
MCL1 myeloid cell leukemia sequence 1 (BCL2-related) 0.866
TP53BP2 tumor protein p53 binding protein, 2 0.845
NFE2L2 nuclear factor (erythroid-derived 2)-like 2 0.793
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) 0.786
PML promyelocytic leukemia 0.777
BID BH3 interacting domain death agonist 0.774
SQSTM1 sequestosome 1 0.754
S100A9 S100 calcium binding protein A9 0.752
DAXX death-domain associated protein 0.748
UBE3A ubiquitin protein ligase E3A 0.722
S100A8 S100 calcium binding protein A8 0.715
GUCY2C guanylate cyclase 2C (heat stable enterotoxin receptor) 0.669
S100A1 S100 calcium binding protein A1 0.643
S100B S100 calcium binding protein B 0.642
MDM4 Mdm4 p53 binding protein homolog (mouse) 0.641
RYBP RING1 and YY1 binding protein 0.631
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.622
BMI1 BMI1 polycomb ring finger oncogene 0.607
S100A6 S100 calcium binding protein A6 0.567
SLC9A3R1 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 0.552
MAFG v-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian) 0.546
S100A4 S100 calcium binding protein A4 0.522
ESR1 estrogen receptor 1 0.517
BAD BCL2-associated agonist of cell death 0.475
DERL1 Der1-like domain family, member 1 0.472
BAK1 BCL2-antagonist/killer 1 0.462
LASS2 LAG1 homolog, ceramide synthase 2 0.445
SPRR2A small proline-rich protein 2A 0.435
BIRC3 baculoviral IAP repeat containing 3 0.414
XIAP X-linked inhibitor of apoptosis 0.411
PTEN phosphatase and tensin homolog 0.406
HCK hemopoietic cell kinase 0.399
UBQLN1 ubiquilin 1 0.390
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.389
ANXA2 annexin A2 0.387
LCK lymphocyte-specific protein tyrosine kinase 0.382
CDKN2A cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) 0.356
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.335
TOP1 topoisomerase (DNA) I 0.332
SYVN1 synovial apoptosis inhibitor 1, synoviolin 0.330
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.310
SIN3A SIN3 homolog A, transcription regulator (yeast) 0.308
MAPK8 mitogen-activated protein kinase 8 0.299
S100A14 S100 calcium binding protein A14 0.293
ZNF746 zinc finger protein 746 0.292
RNF11 ring finger protein 11 0.284
DAZAP2 DAZ associated protein 2 0.281
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.279
ITCH itchy E3 ubiquitin protein ligase homolog (mouse) 0.279
SEPT2 septin 2 0.272
WWOX WW domain containing oxidoreductase 0.271
FKBP4 FK506 binding protein 4, 59kDa 0.269
JUN jun proto-oncogene 0.267
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.253
SYK spleen tyrosine kinase 0.247
SMCR7L Smith-Magenis syndrome chromosome region, candidate 7-like 0.246
BIK BCL2-interacting killer (apoptosis-inducing) 0.244
IL8 interleukin 8 0.235
FAS Fas (TNF receptor superfamily, member 6) 0.230
ANXA1 annexin A1 0.227
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme 0.223
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.217
CASC5 cancer susceptibility candidate 5 0.207
CANX calnexin 0.199
S100A11 S100 calcium binding protein A11 0.194
BECN1 beclin 1, autophagy related 0.187
ABL1 c-abl oncogene 1, non-receptor tyrosine kinase 0.180
GSK3B glycogen synthase kinase 3 beta 0.178
RIPK2 receptor-interacting serine-threonine kinase 2 0.168
UBE2I ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) 0.168
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) 0.166
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.160
ICAM1 intercellular adhesion molecule 1 0.159
RHOA ras homolog gene family, member A 0.151
HTATSF1 HIV-1 Tat specific factor 1 0.149
UBASH3B ubiquitin associated and SH3 domain containing B 0.147
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) 0.147
MAFA v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian) 0.144
CENPE centromere protein E, 312kDa 0.144
GOPC golgi-associated PDZ and coiled-coil motif containing 0.141
SNW1 SNW domain containing 1 0.139
EED embryonic ectoderm development 0.139
NCOR2 nuclear receptor corepressor 2 0.139
DAD1 defender against cell death 1 0.136
MAP2K7 mitogen-activated protein kinase kinase 7 0.134
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.133
MSN moesin 0.129
SP1 Sp1 transcription factor 0.129
MYC v-myc myelocytomatosis viral oncogene homolog (avian) 0.128
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism