The network for 'intrinsic apoptotic signaling pathway' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

intrinsic apoptotic signaling pathway

A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway starts with reception of an intracellular signal (e.g. DNA damage, endoplasmic reticulum stress, oxidative stress etc.), and ends when the execution phase of apoptosis is triggered. The intrinsic apoptotic signaling pathway is crucially regulated by permeabilization of the mitochondrial outer membrane (MOMP).

Mus musculus
Name Description Probability Func Analog Organism
Trp53 transformation related protein 53 1.000
Pten phosphatase and tensin homolog 0.999
Rb1 retinoblastoma 1 0.997
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.992
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.990
Mdm2 transformed mouse 3T3 cell double minute 2 0.989
Apc adenomatosis polyposis coli 0.971
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.970
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.965
Fas Fas (TNF receptor superfamily member 6) 0.965
Atm ataxia telangiectasia mutated homolog (human) 0.958
Tnf tumor necrosis factor 0.958
Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.938
Pik3ca phosphatidylinositol 3-kinase, catalytic, alpha polypeptide 0.931
Skil SKI-like 0.929
Brca2 breast cancer 2 0.913
Brca1 breast cancer 1 0.904
Casp4 caspase 4, apoptosis-related cysteine peptidase 0.872
Ldb3 LIM domain binding 3 0.845
Cdkn2a cyclin-dependent kinase inhibitor 2A 0.836
Traf6 TNF receptor-associated factor 6 0.831
Msh2 mutS homolog 2 (E. coli) 0.817
Smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.798
Lepr leptin receptor 0.796
Prkce protein kinase C, epsilon 0.796
Map3k7 mitogen-activated protein kinase kinase kinase 7 0.784
E2f1 E2F transcription factor 1 0.756
Ikbkb inhibitor of kappaB kinase beta 0.751
Pik3r1 phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha) 0.747
Igh immunoglobulin heavy chain complex 0.744
Tlr4 toll-like receptor 4 0.743
Dab1 disabled homolog 1 (Drosophila) 0.741
Ncoa3 nuclear receptor coactivator 3 0.737
Pnp2 purine-nucleoside phosphorylase 2 0.720
Casp8 caspase 8 0.713
Xiap X-linked inhibitor of apoptosis 0.706
Hcn4 hyperpolarization-activated, cyclic nucleotide-gated K+ 4 0.701
Pik3cd phosphatidylinositol 3-kinase catalytic delta polypeptide 0.700
Rbl1 retinoblastoma-like 1 (p107) 0.673
Nfe2l2 nuclear factor, erythroid derived 2, like 2 0.669
Nbn nibrin 0.659
Mcm4 minichromosome maintenance deficient 4 homolog (S. cerevisiae) 0.654
Cxcl13 chemokine (C-X-C motif) ligand 13 0.621
Tcf3 transcription factor 3 0.615
Cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.603
Cdk4 cyclin-dependent kinase 4 0.603
Sirt1 sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae) 0.603
Map3k14 mitogen-activated protein kinase kinase kinase 14 0.597
Mdh2 malate dehydrogenase 2, NAD (mitochondrial) 0.583
Atf4 activating transcription factor 4 0.565
Mcl1 myeloid cell leukemia sequence 1 0.563
Ccnd1 cyclin D1 0.563
Stat3 signal transducer and activator of transcription 3 0.561
Mdm4 transformed mouse 3T3 cell double minute 4 0.555
Ppp1cc protein phosphatase 1, catalytic subunit, gamma isoform 0.544
Cdkn2d cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) 0.519
Ltb lymphotoxin B 0.516
Ikzf1 IKAROS family zinc finger 1 0.507
Bax BCL2-associated X protein 0.497
Ptgs2 prostaglandin-endoperoxide synthase 2 0.494
Arid1b AT rich interactive domain 1B (SWI-like) 0.485
Hnrnpu heterogeneous nuclear ribonucleoprotein U 0.472
Bcl2l1 BCL2-like 1 0.462
Gbp5 guanylate binding protein 5 0.443
Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) 0.439
Ctnnb1 catenin (cadherin associated protein), beta 1 0.428
Tnfaip3 tumor necrosis factor, alpha-induced protein 3 0.413
Mapk8 mitogen-activated protein kinase 8 0.404
Trib3 tribbles homolog 3 (Drosophila) 0.403
Cd40 CD40 antigen 0.393
Atp5b ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit 0.382
Stk4 serine/threonine kinase 4 0.378
Cdkn2c cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) 0.365
Cftr cystic fibrosis transmembrane conductance regulator homolog 0.364
Csf1 colony stimulating factor 1 (macrophage) 0.361
Tgfbr1 transforming growth factor, beta receptor I 0.347
Cyc1 cytochrome c-1 0.340
Suz12 suppressor of zeste 12 homolog (Drosophila) 0.334
Ezh2 enhancer of zeste homolog 2 (Drosophila) 0.334
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.332
Smarca2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 0.331
Pold3 polymerase (DNA-directed), delta 3, accessory subunit 0.327
Il7 interleukin 7 0.326
Casp1 caspase 1 0.326
Hdac2 histone deacetylase 2 0.322
Terf1 telomeric repeat binding factor 1 0.321
Tmpo thymopoietin 0.317
Kit kit oncogene 0.316
Myd88 myeloid differentiation primary response gene 88 0.313
Tfdp2 transcription factor Dp 2 0.313
Sin3a transcriptional regulator, SIN3A (yeast) 0.311
Cul4a cullin 4A 0.303
Trp63 transformation related protein 63 0.297
Traf2 TNF receptor-associated factor 2 0.293
Rassf5 Ras association (RalGDS/AF-6) domain family member 5 0.292
Relb avian reticuloendotheliosis viral (v-rel) oncogene related B 0.284
Tgfbr2 transforming growth factor, beta receptor II 0.279
Atp5a1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1 0.274
Cxcr4 chemokine (C-X-C motif) receptor 4 0.273
Becn1 beclin 1, autophagy related 0.272
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
aldh1a2 aldehyde dehydrogenase 1 family, member A2 0.460
ptgs2a prostaglandin-endoperoxide synthase 2a 0.249
bcl2l1 bcl2-like 1 0.134
pknox1.1 pbx/knotted 1 homeobox 1.1 0.098
baxa bcl2-associated X protein, a 0.090
efna5a ephrin A5a 0.058
odc1 ornithine decarboxylase 1 0.051
nr3c1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.051
cdkn1a cyclin-dependent kinase inhibitor 1A 0.046
dct dopachrome tautomerase 0.038
bmpr1aa bone morphogenetic protein receptor, type 1aa 0.036
bcl2 B-cell leukemia/lymphoma 2 0.034
cxcr4b chemokine (C-X-C motif), receptor 4b 0.034
rhoab ras homolog gene family, member Ab 0.034
nrp2b neuropilin 2b 0.034
mych myelocytomatosis oncogene homolog 0.034
eve1 even-skipped-like1 0.032
gpia glucose phosphate isomerase a 0.031
dnmt5 DNA (cytosine-5-)-methyltransferase 5 0.030
scn1ba sodium channel, voltage-gated, type I, beta a 0.029
lamc1 laminin, gamma 1 0.029
ncor1 nuclear receptor co-repressor 1 0.029
ptger4a prostaglandin E receptor 4 (subtype EP4) a 0.029
chat choline acetyltransferase 0.028
myod1 myogenic differentiation 1 0.027
tert telomerase reverse transcriptase 0.027
nos2b nitric oxide synthase 2b, inducible 0.026
ncapg non-SMC condensin I complex, subunit G 0.026
ctnnb1 catenin (cadherin-associated protein), beta 1 0.026
stc1l stanniocalcin 1, like 0.025
myf5 myogenic factor 5 0.025
gata5 GATA-binding protein 5 0.025
mmp9 matrix metalloproteinase 9 0.024
LOC100150924 DNA polymerase subunit gamma-1-like 0.024
mcl1a myeloid cell leukemia sequence 1a 0.024
ef1a elongation factor 1-alpha 0.024
pola2 polymerase (DNA directed), alpha 2 0.023
fgfr1a fibroblast growth factor receptor 1a 0.023
s100v2 S100 calcium binding protein V2 0.023
cxcl12b chemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1) 0.023
per2 period homolog 2 (Drosophila) 0.023
trpv4 transient receptor potential cation channel, subfamily V, member 4 0.023
mapk14a mitogen-activated protein kinase 14a 0.022
ssbp3b single stranded DNA binding protein 3b 0.022
mitfa microphthalmia-associated transcription factor a 0.022
bactin1 bactin1 0.022
ywhabl tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide like 0.021
socs1 suppressor of cytokine signaling 1 0.021
ca8 carbonic anhydrase VIII 0.021
rps12 ribosomal protein S12 0.020
hand2 heart and neural crest derivatives expressed transcript 2 0.020
efna2 ephrin A2 0.020
bmp4 bone morphogenetic protein 4 0.020
eno2 enolase 2 0.019
grn2 granulin 2 0.019
wnt11r wingless-type MMTV integration site family, member 11, related 0.019
pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 0.019
mpx myeloid-specific peroxidase 0.018
znf703 zinc finger protein 703 0.018
bnip3lb BCL2/adenovirus E1B interacting protein 3-like b 0.018
gja3 gap junction protein, alpha 3 0.018
mfn2 mitofusin 2 0.018
ssrp1a structure specific recognition protein 1a 0.018
rps26l ribosomal protein S26, like 0.018
rps27a ribosomal protein S27a 0.018
faua Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed a 0.017
bida BH3 interacting domain death agonist 0.017
nrarpa notch-regulated ankyrin repeat protein a 0.017
chuk conserved helix-loop-helix ubiquitous kinase 0.017
ung uracil-DNA glycosylase 0.017
jup junction plakoglobin 0.017
sf1 splicing factor 1 0.016
ahi1 Abelson helper integration site 1 0.016
opn4a opsin 4a (melanopsin) 0.016
sod1 superoxide dismutase 1, soluble 0.016
zgc:165373 zgc:165373 0.016
slc2a10 solute carrier family 2 (facilitated glucose transporter), member 10 0.016
csnk1da casein kinase 1, delta a 0.016
jun jun proto-oncogene 0.016
zgc:55671 zgc:55671 0.016
wdhd1 WD repeat and HMG-box DNA binding protein 1 0.016
zgc:92648 zgc:92648 0.016
pcna proliferating cell nuclear antigen 0.015
nr1h3 nuclear receptor subfamily 1, group H, member 3 0.015
zgc:92775 zgc:92775 0.015
fzd7a frizzled homolog 7a 0.015
eif4a1a eukaryotic translation initiation factor 4A, isoform 1A 0.015
hyou1 hypoxia up-regulated 1 0.015
brd2a bromodomain-containing 2a 0.015
cyp26a1 cytochrome P450, subfamily XXVIA, polypeptide 1 0.015
il1b interleukin 1, beta and interleukin 1, beta 0.015
zgc:113210 zgc:113210 0.015
hnf4a hepatocyte nuclear factor 4, alpha 0.015
zgc:66326 zgc:66326 0.015
nap1l1 nucleosome assembly protein 1, like 1 0.015
esco2 establishment of cohesion 1 homolog 2 0.014
ctbp2l C-terminal binding protein 2, like 0.014
ptger2a prostaglandin E receptor 2a (subtype EP2) 0.014
hells helicase, lymphoid-specific 0.014
egr1 early growth response 1 0.014
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Drosophila melanogaster
Name Description Probability Func Analog Organism
p53 CG33336 gene product from transcript CG33336-RB 0.996
park parkin 0.952
Rbf Retinoblastoma-family protein 0.713
Dcp-1 Death caspase-1 0.603
loqs loquacious 0.579
rpr reaper 0.495
th thread 0.489
p38b CG7393 gene product from transcript CG7393-RA 0.333
W Wrinkled 0.319
cindr CIN85 and CD2AP orthologue 0.314
imd immune deficiency 0.300
spas spastin 0.284
bsk basket 0.271
E2f E2F transcription factor 0.262
Dp DP transcription factor 0.229
yki yorkie 0.227
alph alphabet 0.217
RASSF8 CG5053 gene product from transcript CG5053-RA 0.185
AGO2 Argonaute 2 0.184
porin CG6647 gene product from transcript CG6647-RA 0.169
M6 CG7540 gene product from transcript CG7540-RA 0.149
HtrA2 CG8464 gene product from transcript CG8464-RA 0.143
tefu telomere fusion 0.136
p120ctn Adherens junction protein p120 0.123
MAGE CG10059 gene product from transcript CG10059-RA 0.122
Ric Ras which interacts with Calmodulin 0.119
Dlc90F Dynein light chain 90F 0.115
dup double parked 0.114
Trx-2 thioredoxin-2 0.113
tud tudor 0.099
rl rolled 0.098
Ptp61F Protein tyrosine phosphatase 61F 0.094
brk brinker 0.081
CG8155 CG8155 gene product from transcript CG8155-RA 0.078
brat brain tumor 0.076
Osbp Oxysterol binding protein 0.075
awd abnormal wing discs 0.071
Hsp83 Heat shock protein 83 0.070
mus205 mutagen-sensitive 205 0.065
hipk homeodomain interacting protein kinase 0.063
Ulp1 CG12359 gene product from transcript CG12359-RA 0.060
Dref DNA replication-related element factor 0.060
shi shibire 0.057
gbb glass bottom boat 0.057
Arr1 Arrestin 1 0.057
CG1021 CG1021 gene product from transcript CG1021-RE 0.055
Sod Superoxide dismutase 0.055
pr-set7 CG3307 gene product from transcript CG3307-RC 0.054
Cat Catalase 0.053
Mnn1 Menin 1 0.052
X11L CG5675 gene product from transcript CG5675-RB 0.051
Pink1 PTEN-induced putative kinase 1 0.051
Atx2 Ataxin-2 0.050
bchs blue cheese 0.049
cln3 CG5582 gene product from transcript CG5582-RA 0.047
G-salpha60A G protein salpha 60A 0.046
Letm1 CG4589 gene product from transcript CG4589-RB 0.046
trx trithorax 0.045
AGO1 Argonaute-1 0.044
FBX011 FBX011 ortholog 0.044
Sin3A CG8815 gene product from transcript CG8815-RC 0.043
CG8885 CG8885 gene product from transcript CG8885-RA 0.043
TORC CG6064 gene product from transcript CG6064-RA 0.042
Cbl CG7037 gene product from transcript CG7037-RB 0.042
APP-BP1 beta-Amyloid precursor protein binding protein 1 0.041
sd scalloped 0.040
Deaf1 Deformed epidermal autoregulatory factor-1 0.039
Hsp26 Heat shock protein 26 0.038
spin spinster 0.038
nmo nemo 0.038
sina seven in absentia 0.038
bun bunched 0.037
ex expanded 0.037
Jafrac2 thioredoxin peroxidase 2 0.036
srpk79D serine-arginine protein kinase at 79D 0.036
Prx5 Peroxiredoxin 5 0.036
dj-1beta CG1349 gene product from transcript CG1349-RA 0.035
klu klumpfuss 0.035
CtBP C-terminal Binding Protein 0.034
ninaE neither inactivation nor afterpotential E 0.034
Hsf Heat shock factor 0.032
Caf1-180 CG12109 gene product from transcript CG12109-RB 0.031
debcl death executioner Bcl-2 homologue 0.031
Smg5 CG8954 gene product from transcript CG8954-RA 0.031
Lac Lachesin 0.031
fs(2)ltoPP43 female sterile (2) ltoPP43 0.031
Jafrac1 thioredoxin peroxidase 1 0.031
CG11347 CG11347 gene product from transcript CG11347-RE 0.030
cpo couch potato 0.029
14-3-3epsilon CG31196 gene product from transcript CG31196-RA 0.028
lok loki 0.028
S6k RPS6-p70-protein kinase 0.028
CG1347 CG1347 gene product from transcript CG1347-RB 0.028
CG3847 CG3847 gene product from transcript CG3847-RA 0.028
egg eggless 0.028
mei-P26 CG12218 gene product from transcript CG12218-RA 0.028
Hsp27 Heat shock protein 27 0.028
mus201 mutagen-sensitive 201 0.027
Moe Moesin 0.027
Hsp22 Heat shock protein 22 0.026
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Homo sapiens
Name Description Probability Func Analog Organism
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 1.000
TP53 tumor protein p53 1.000
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 1.000
BCL2 B-cell CLL/lymphoma 2 1.000
HDAC1 histone deacetylase 1 0.999
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.999
BRCA1 breast cancer 1, early onset 0.999
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.998
UBC ubiquitin C 0.996
RB1 retinoblastoma 1 0.995
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 0.994
ESR1 estrogen receptor 1 0.993
MCL1 myeloid cell leukemia sequence 1 (BCL2-related) 0.990
TP53BP2 tumor protein p53 binding protein, 2 0.989
BCL2L1 BCL2-like 1 0.983
MDM4 Mdm4 p53 binding protein homolog (mouse) 0.979
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.976
NBN nibrin 0.973
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 0.970
SIN3A SIN3 homolog A, transcription regulator (yeast) 0.969
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.968
SQSTM1 sequestosome 1 0.968
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 0.957
EGFR epidermal growth factor receptor 0.954
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.953
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.948
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 0.948
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.947
XIAP X-linked inhibitor of apoptosis 0.946
EP300 E1A binding protein p300 0.945
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.937
FAS Fas (TNF receptor superfamily, member 6) 0.937
RBL1 retinoblastoma-like 1 (p107) 0.927
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) 0.918
CHEK2 CHK2 checkpoint homolog (S. pombe) 0.918
ATM ataxia telangiectasia mutated 0.916
CAV1 caveolin 1, caveolae protein, 22kDa 0.913
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 0.905
SFN stratifin 0.904
BTRC beta-transducin repeat containing 0.903
PML promyelocytic leukemia 0.900
H2AFX H2A histone family, member X 0.893
BAX BCL2-associated X protein 0.871
CFLAR CASP8 and FADD-like apoptosis regulator 0.871
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.866
DAXX death-domain associated protein 0.865
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.858
FADD Fas (TNFRSF6)-associated via death domain 0.849
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.841
CDK2 cyclin-dependent kinase 2 0.839
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme 0.835
BCL2L11 BCL2-like 11 (apoptosis facilitator) 0.834
RPS27 ribosomal protein S27 0.833
SFPQ splicing factor proline/glutamine-rich 0.828
BID BH3 interacting domain death agonist 0.821
MYC v-myc myelocytomatosis viral oncogene homolog (avian) 0.816
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) 0.815
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha 0.813
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.801
RYBP RING1 and YY1 binding protein 0.795
RBBP8 retinoblastoma binding protein 8 0.793
CASP10 caspase 10, apoptosis-related cysteine peptidase 0.779
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.772
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide 0.765
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme 0.753
ANXA1 annexin A1 0.743
S100A4 S100 calcium binding protein A4 0.736
FANCD2 Fanconi anemia, complementation group D2 0.726
LATS2 LATS, large tumor suppressor, homolog 2 (Drosophila) 0.720
HNRNPK heterogeneous nuclear ribonucleoprotein K 0.719
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma 0.714
TGIF1 TGFB-induced factor homeobox 1 0.708
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.705
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.704
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.700
E2F3 E2F transcription factor 3 0.698
BIRC2 baculoviral IAP repeat containing 2 0.698
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.697
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae) 0.695
IER3 immediate early response 3 0.674
CHEK1 CHK1 checkpoint homolog (S. pombe) 0.671
TRAF2 TNF receptor-associated factor 2 0.654
TRADD TNFRSF1A-associated via death domain 0.652
RAD50 RAD50 homolog (S. cerevisiae) 0.647
S100A9 S100 calcium binding protein A9 0.626
RELB v-rel reticuloendotheliosis viral oncogene homolog B 0.624
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.617
DHX9 DEAH (Asp-Glu-Ala-His) box polypeptide 9 0.595
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.594
UBE3A ubiquitin protein ligase E3A 0.582
BIRC3 baculoviral IAP repeat containing 3 0.581
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a 0.577
GSK3B glycogen synthase kinase 3 beta 0.571
OPTN optineurin 0.557
ATF4 activating transcription factor 4 (tax-responsive enhancer element B67) 0.550
CREBBP CREB binding protein 0.546
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.536
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.535
SOCS1 suppressor of cytokine signaling 1 0.534
RASSF5 Ras association (RalGDS/AF-6) domain family member 5 0.528
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Rattus norvegicus
Name Description Probability Func Analog Organism
S100a8 S100 calcium binding protein A8 0.090
S100a9 S100 calcium binding protein A9 0.052
Mapk3 mitogen activated protein kinase 3 0.023
Tp53 tumor protein p53 0.014
Ireb2 iron responsive element binding protein 2 0.011
Exoc5 exocyst complex component 5 0.011
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism