The network for 'regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

Any process that modulates the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata.

Mus musculus
Name Description Probability Func Analog Organism
Igh immunoglobulin heavy chain complex 1.000
Tnf tumor necrosis factor 0.999
Cd40 CD40 antigen 0.998
Cd19 CD19 antigen 0.996
Lta lymphotoxin A 0.993
Stat3 signal transducer and activator of transcription 3 0.991
Il4 interleukin 4 0.989
Lyz2 lysozyme 2 0.988
Fas Fas (TNF receptor superfamily member 6) 0.984
Lyn Yamaguchi sarcoma viral (v-yes-1) oncogene homolog 0.984
Ifng interferon gamma 0.977
Ccr1 chemokine (C-C motif) receptor 1 0.969
Ccl2 chemokine (C-C motif) ligand 2 0.955
Cd79a CD79A antigen (immunoglobulin-associated alpha) 0.936
Icos inducible T-cell co-stimulator 0.927
Tnfrsf4 tumor necrosis factor receptor superfamily, member 4 0.909
B2m beta-2 microglobulin 0.903
Ikzf1 IKAROS family zinc finger 1 0.897
Traf6 TNF receptor-associated factor 6 0.891
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.877
Jak2 Janus kinase 2 0.867
Pax5 paired box gene 5 0.859
Cd22 CD22 antigen 0.857
Foxp3 forkhead box P3 0.841
Cd74 CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) 0.825
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.824
H2-Aa histocompatibility 2, class II antigen A, alpha 0.822
Il4ra interleukin 4 receptor, alpha 0.821
Il1b interleukin 1 beta 0.807
H2-Eb1 histocompatibility 2, class II antigen E beta 0.806
Fcer1g Fc receptor, IgE, high affinity I, gamma polypeptide 0.785
Pik3cd phosphatidylinositol 3-kinase catalytic delta polypeptide 0.783
Cd28 CD28 antigen 0.782
Batf basic leucine zipper transcription factor, ATF-like 0.753
H2-Ab1 histocompatibility 2, class II antigen A, beta 1 0.739
Ccr7 chemokine (C-C motif) receptor 7 0.701
Socs1 suppressor of cytokine signaling 1 0.692
Csf2rb2 colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage) 0.686
Ccl4 chemokine (C-C motif) ligand 4 0.675
Ccr6 chemokine (C-C motif) receptor 6 0.674
Bcl6 B-cell leukemia/lymphoma 6 0.645
H2-K1 histocompatibility 2, K1, K region 0.645
Ciita class II transactivator 0.610
Tapbp TAP binding protein 0.605
Casp4 caspase 4, apoptosis-related cysteine peptidase 0.603
Casp8 caspase 8 0.597
Ltb lymphotoxin B 0.596
Il10 interleukin 10 0.595
Clec4d C-type lectin domain family 4, member d 0.591
Pdcd1 programmed cell death 1 0.589
Tnfaip3 tumor necrosis factor, alpha-induced protein 3 0.588
Stat6 signal transducer and activator of transcription 6 0.581
Klrd1 killer cell lectin-like receptor, subfamily D, member 1 0.570
Il12rb2 interleukin 12 receptor, beta 2 0.570
Blk B lymphoid kinase 0.569
Cd5 CD5 antigen 0.564
Map3k14 mitogen-activated protein kinase kinase kinase 14 0.564
H2-DMb2 histocompatibility 2, class II, locus Mb2 0.561
Prf1 perforin 1 (pore forming protein) 0.555
Cd40lg CD40 ligand 0.550
Il6 interleukin 6 0.544
Il1rl1 interleukin 1 receptor-like 1 0.544
Traf2 TNF receptor-associated factor 2 0.543
Prdm1 PR domain containing 1, with ZNF domain 0.539
Rc3h1 RING CCCH (C3H) domains 1 0.532
C3 complement component 3 0.531
Itgb2 integrin beta 2 0.530
Gpr132 G protein-coupled receptor 132 0.526
Klrk1 killer cell lectin-like receptor subfamily K, member 1 0.525
Btk Bruton agammaglobulinemia tyrosine kinase 0.509
Ccl8 chemokine (C-C motif) ligand 8 0.507
Lepr leptin receptor 0.505
Cxcl9 chemokine (C-X-C motif) ligand 9 0.491
Gdf3 growth differentiation factor 3 0.491
Hbb-b1 hemoglobin, beta adult major chain 0.491
Cish cytokine inducible SH2-containing protein 0.490
Ccr2 chemokine (C-C motif) receptor 2 0.483
Ifngr1 interferon gamma receptor 1 0.473
Sh2d2a SH2 domain protein 2A 0.459
Il10ra interleukin 10 receptor, alpha 0.452
Fasl Fas ligand (TNF superfamily, member 6) 0.452
Igk immunoglobulin kappa chain complex 0.449
Cxcl13 chemokine (C-X-C motif) ligand 13 0.448
Fcna ficolin A 0.443
Ripk1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.442
H2-D1 histocompatibility 2, D region locus 1 0.436
Pitx1 paired-like homeodomain transcription factor 1 0.408
Myd88 myeloid differentiation primary response gene 88 0.406
Cd4 CD4 antigen 0.394
Stat5a signal transducer and activator of transcription 5A 0.393
Il18rap interleukin 18 receptor accessory protein 0.388
H2-Q7 histocompatibility 2, Q region locus 7 0.386
Stat5b signal transducer and activator of transcription 5B 0.382
Clec4e C-type lectin domain family 4, member e 0.381
Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 0.377
Ggt5 gamma-glutamyltransferase 5 0.375
Pnp2 purine-nucleoside phosphorylase 2 0.364
Nanog Nanog homeobox 0.360
Pdcd1lg2 programmed cell death 1 ligand 2 0.356
Cxcr5 chemokine (C-X-C motif) receptor 5 0.355
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
B2M beta-2-microglobulin 0.989
HLA-G major histocompatibility complex, class I, G 0.965
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.960
HLA-C major histocompatibility complex, class I, C 0.956
PTPN6 protein tyrosine phosphatase, non-receptor type 6 0.932
HLA-A major histocompatibility complex, class I, A 0.913
HLA-B major histocompatibility complex, class I, B 0.904
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 0.880
IL4R interleukin 4 receptor 0.865
SYK spleen tyrosine kinase 0.864
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 0.800
HLA-F major histocompatibility complex, class I, F 0.731
TAPBP TAP binding protein (tapasin) 0.682
TRAF3 TNF receptor-associated factor 3 0.661
LCK lymphocyte-specific protein tyrosine kinase 0.656
IL2RG interleukin 2 receptor, gamma 0.610
BIRC3 baculoviral IAP repeat containing 3 0.602
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 1 0.505
CCR5 chemokine (C-C motif) receptor 5 0.493
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 0.483
LTA lymphotoxin alpha (TNF superfamily, member 1) 0.472
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 0.469
CD40 CD40 molecule, TNF receptor superfamily member 5 0.461
CCL4 chemokine (C-C motif) ligand 4 0.442
HLA-DMB major histocompatibility complex, class II, DM beta 0.438
CXCL9 chemokine (C-X-C motif) ligand 9 0.436
HLA-E major histocompatibility complex, class I, E 0.420
TRAF6 TNF receptor-associated factor 6 0.404
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B 0.360
CCL5 chemokine (C-C motif) ligand 5 0.336
TRAF1 TNF receptor-associated factor 1 0.331
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.299
GRAP2 GRB2-related adaptor protein 2 0.294
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2 0.288
FGR Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog 0.281
CCR1 chemokine (C-C motif) receptor 1 0.273
TGIF1 TGFB-induced factor homeobox 1 0.273
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 0.264
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 0.259
HK3 hexokinase 3 (white cell) 0.233
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.204
AIF1 allograft inflammatory factor 1 0.192
CCR7 chemokine (C-C motif) receptor 7 0.191
LAIR1 leukocyte-associated immunoglobulin-like receptor 1 0.145
HLA-DRB5 major histocompatibility complex, class II, DR beta 5 0.140
LILRA1 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1 0.137
CD2 CD2 molecule 0.136
HDAC9 histone deacetylase 9 0.129
ICAM1 intercellular adhesion molecule 1 0.127
SIGLEC7 sialic acid binding Ig-like lectin 7 0.124
PILRA paired immunoglobin-like type 2 receptor alpha 0.121
CD3E CD3e molecule, epsilon (CD3-TCR complex) 0.112
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.111
CCL22 chemokine (C-C motif) ligand 22 0.108
CD22 CD22 molecule 0.106
CCL19 chemokine (C-C motif) ligand 19 0.104
INPP5D inositol polyphosphate-5-phosphatase, 145kDa 0.100
TNF tumor necrosis factor 0.097
TRAF5 TNF receptor-associated factor 5 0.095
IL12B interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) 0.094
IRF4 interferon regulatory factor 4 0.094
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 0.091
FRA10AC1 fragile site, folic acid type, rare, fra(10)(q23.3) or fra(10)(q24.2) candidate 1 0.091
FCN1 ficolin (collagen/fibrinogen domain containing) 1 0.089
CLEC10A C-type lectin domain family 10, member A 0.088
PTAFR platelet-activating factor receptor 0.087
FPR3 formyl peptide receptor 3 0.086
CD48 CD48 molecule 0.085
TNFRSF14 tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) 0.085
THOC5 THO complex 5 0.084
TRAF2 TNF receptor-associated factor 2 0.078
FASLG Fas ligand (TNF superfamily, member 6) 0.078
IL4 interleukin 4 0.075
CFH complement factor H 0.074
CCL13 chemokine (C-C motif) ligand 13 0.073
ZMYND11 zinc finger, MYND-type containing 11 0.072
IL6 interleukin 6 (interferon, beta 2) 0.068
IL2RB interleukin 2 receptor, beta 0.068
HLA-DRA major histocompatibility complex, class II, DR alpha 0.067
CASP10 caspase 10, apoptosis-related cysteine peptidase 0.067
IFNG interferon, gamma 0.066
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 0.064
SH2D1A SH2 domain containing 1A 0.062
CCL8 chemokine (C-C motif) ligand 8 0.060
TYROBP TYRO protein tyrosine kinase binding protein 0.054
PVRL4 poliovirus receptor-related 4 0.053
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 0.053
CXCL10 chemokine (C-X-C motif) ligand 10 0.053
IL10RA interleukin 10 receptor, alpha 0.052
CXCL13 chemokine (C-X-C motif) ligand 13 0.050
PLEK pleckstrin 0.049
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) 0.049
CD33 CD33 molecule 0.048
SQSTM1 sequestosome 1 0.047
IGSF6 immunoglobulin superfamily, member 6 0.046
CCR4 chemokine (C-C motif) receptor 4 0.046
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.045
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 0.045
ENG endoglin 0.044
TRAF3IP3 TRAF3 interacting protein 3 0.043
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Rattus norvegicus
Name Description Probability Func Analog Organism
RT1-EC2 RT1 class Ib, locus EC2 0.343
Psmb9 proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2) 0.092
Hsp90aa1 heat shock protein 90, alpha (cytosolic), class A member 1 0.074
Cd37 CD37 molecule 0.071
RT1-Da RT1 class II, locus Da 0.070
Hsph1 heat shock 105/110 protein 1 0.065
Hsp90ab1 heat shock protein 90 alpha (cytosolic), class B member 1 0.063
Fgg fibrinogen gamma chain 0.062
RT1-S3 RT1 class Ib, locus S3 0.048
RT1-Ba RT1 class II, locus Ba 0.041
Cd74 Cd74 molecule, major histocompatibility complex, class II invariant chain 0.037
RT1-DMb RT1 class II, locus DMb 0.037
RT1-CE12 RT1 class I, locus CE12 0.036
Casp1 caspase 1 0.027
Slfn2 schlafen 2 0.026
Aif1 allograft inflammatory factor 1 0.024
Oas1a 2'-5' oligoadenylate synthetase 1A 0.022
RT1-Db1 RT1 class II, locus Db1 0.021
Ripk3 receptor-interacting serine-threonine kinase 3 0.020
RT1-N3 RT1 class Ib, locus N3 0.019
Irf7 interferon regulatory factor 7 0.017
Cxcl10 chemokine (C-X-C motif) ligand 10 0.017
Lyn v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.014
Hspb1 heat shock protein 1 0.014
Plaur plasminogen activator, urokinase receptor 0.013
Hck hemopoietic cell kinase 0.013
Apol3 apolipoprotein L, 3 0.013
Cd53 Cd53 molecule 0.013
Icam1 intercellular adhesion molecule 1 0.013
Tnfrsf4 tumor necrosis factor receptor superfamily, member 4 0.012
RT1-Cl RT1 class Ib, locus Cl 0.011
Dnase1l3 deoxyribonuclease 1-like 3 0.011
Tpt1 tumor protein, translationally-controlled 1 0.011
Rsad2 radical S-adenosyl methionine domain containing 2 0.011
Gbp2 guanylate binding protein 2 0.010
Plcg2 phospholipase C, gamma 2 0.010
Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism