The network for 'regulation of leukocyte differentiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of leukocyte differentiation

Any process that modulates the frequency, rate or extent of leukocyte differentiation.

Mus musculus
Name Description Probability Func Analog Organism
Pten phosphatase and tensin homolog 1.000
Stat3 signal transducer and activator of transcription 3 0.999
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.995
Ikzf1 IKAROS family zinc finger 1 0.993
Tnf tumor necrosis factor 0.992
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.991
Fas Fas (TNF receptor superfamily member 6) 0.991
Lepr leptin receptor 0.989
Egfr epidermal growth factor receptor 0.982
Gli3 GLI-Kruppel family member GLI3 0.982
Ar androgen receptor 0.977
Gli2 GLI-Kruppel family member GLI2 0.977
Cbl Casitas B-lineage lymphoma 0.959
Tgfb2 transforming growth factor, beta 2 0.952
Jak2 Janus kinase 2 0.951
Csf1 colony stimulating factor 1 (macrophage) 0.948
Fgfr2 fibroblast growth factor receptor 2 0.941
Gata4 GATA binding protein 4 0.938
Esr1 estrogen receptor 1 (alpha) 0.931
Mdm2 transformed mouse 3T3 cell double minute 2 0.926
Grb2 growth factor receptor bound protein 2 0.926
Nos3 nitric oxide synthase 3, endothelial cell 0.924
Notch1 Notch gene homolog 1 (Drosophila) 0.916
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.913
Lck lymphocyte protein tyrosine kinase 0.906
Fgf10 fibroblast growth factor 10 0.901
Nf1 neurofibromatosis 1 0.900
Robo1 roundabout homolog 1 (Drosophila) 0.891
Adam19 a disintegrin and metallopeptidase domain 19 (meltrin beta) 0.885
Runx1 runt related transcription factor 1 0.876
Runx2 runt related transcription factor 2 0.875
Rnf2 ring finger protein 2 0.872
Foxp3 forkhead box P3 0.872
Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 0.871
Hr hairless 0.869
Kit kit oncogene 0.864
Pax8 paired box gene 8 0.862
Il10 interleukin 10 0.859
Apc adenomatosis polyposis coli 0.857
Csf2 colony stimulating factor 2 (granulocyte-macrophage) 0.855
Stat5a signal transducer and activator of transcription 5A 0.852
Cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.850
Tgfb1 transforming growth factor, beta 1 0.850
Msx2 homeobox, msh-like 2 0.848
Kiss1 KiSS-1 metastasis-suppressor 0.845
Map3k14 mitogen-activated protein kinase kinase kinase 14 0.840
Stat6 signal transducer and activator of transcription 6 0.828
Neurod1 neurogenic differentiation 1 0.826
Vegfa vascular endothelial growth factor A 0.821
Fos FBJ osteosarcoma oncogene 0.811
Cd247 CD247 antigen 0.806
Twist2 twist homolog 2 (Drosophila) 0.805
Plcg2 phospholipase C, gamma 2 0.804
Rybp RING1 and YY1 binding protein 0.785
Cish cytokine inducible SH2-containing protein 0.785
Lyst lysosomal trafficking regulator 0.779
Zeb1 zinc finger E-box binding homeobox 1 0.774
Cd40 CD40 antigen 0.773
Pgr progesterone receptor 0.766
Tnfaip3 tumor necrosis factor, alpha-induced protein 3 0.749
Bdkrb2 bradykinin receptor, beta 2 0.742
Rel reticuloendotheliosis oncogene 0.738
Il2rb interleukin 2 receptor, beta chain 0.737
Pik3ca phosphatidylinositol 3-kinase, catalytic, alpha polypeptide 0.732
Jun Jun oncogene 0.721
Il6st interleukin 6 signal transducer 0.717
Foxc1 forkhead box C1 0.713
Ldb3 LIM domain binding 3 0.712
Ren1 renin 1 structural 0.709
Gnaq guanine nucleotide binding protein, alpha q polypeptide 0.707
Ltb lymphotoxin B 0.699
Ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 0.695
Lep leptin 0.695
Pax6 paired box gene 6 0.693
Trp53 transformation related protein 53 0.693
Zfpm2 zinc finger protein, multitype 2 0.688
Rc3h1 RING CCCH (C3H) domains 1 0.683
Csf2rb2 colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage) 0.672
Egr2 early growth response 2 0.665
Kiss1r KISS1 receptor 0.661
Ctnnb1 catenin (cadherin associated protein), beta 1 0.660
Sykb spleen tyrosine kinase 0.656
Pik3r1 phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha) 0.649
Pthlh parathyroid hormone-like peptide 0.648
Pitx2 paired-like homeodomain transcription factor 2 0.646
Rb1 retinoblastoma 1 0.646
Inpp5d inositol polyphosphate-5-phosphatase D 0.646
Lyn Yamaguchi sarcoma viral (v-yes-1) oncogene homolog 0.646
Rbpj recombination signal binding protein for immunoglobulin kappa J region 0.639
Tnfrsf4 tumor necrosis factor receptor superfamily, member 4 0.636
Cd28 CD28 antigen 0.635
Zfp36 zinc finger protein 36 0.626
Igh immunoglobulin heavy chain complex 0.625
Lhx3 LIM homeobox protein 3 0.621
Cd4 CD4 antigen 0.619
C1qa complement component 1, q subcomponent, alpha polypeptide 0.606
Lef1 lymphoid enhancer binding factor 1 0.606
Batf3 basic leucine zipper transcription factor, ATF-like 3 0.604
Myd88 myeloid differentiation primary response gene 88 0.602
Hcls1 hematopoietic cell specific Lyn substrate 1 0.599
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
ikzf1 IKAROS family zinc finger 1 (Ikaros) 0.925
rag1 recombination activating gene 1 0.740
lcp1 lymphocyte cytosolic plastin 1 0.504
mpx myeloid-specific peroxidase 0.486
kita kit receptor a 0.410
foxd3 forkhead box D3 0.385
csf1ra colony stimulating factor 1 receptor, a 0.356
tal1 T-cell acute lymphocytic leukemia 1 0.320
lfng lunatic fringe homolog 0.302
nf1a neurofibromin 1a 0.285
bmp2b bone morphogenetic protein 2b 0.279
cmyb transcription factor cmyb 0.248
ets1a v-ets erythroblastosis virus E26 oncogene homolog 1a 0.244
gdf6a growth differentiation factor 6a 0.218
ighz immunoglobulin heavy constant zeta 0.217
ighm immunoglobulin heavy constant mu and immunoglobulin heavy constant mu 0.189
spi1 spleen focus forming virus (SFFV) proviral integration oncogene spi1 0.188
cdx4 caudal type homeo box transcription factor 4 0.145
sc:d812 sc:d812 0.115
lyz lysozyme 0.106
id2a inhibitor of DNA binding 2, dominant negative helix-loop-helix protein, a 0.103
fgf8a fibroblast growth factor 8 a 0.095
nkx2.5 NK2 transcription factor related 5 0.085
wnt8a wingless-type MMTV integration site family, member 8a 0.081
krml2.2 Kreisler (mouse) maf-related leucine zipper homolog 2.2 0.068
bcl2 B-cell leukemia/lymphoma 2 0.064
raraa retinoic acid receptor, alpha a 0.061
erbb3b v-erb-b2 erythroblastic leukemia viral oncogene homolog 3b 0.057
il7r interleukin 7 receptor 0.051
lmo4a LIM domain only 4a 0.049
foxi3a forkhead box I3a 0.049
hoxb3a homeo box B3a 0.044
ltk leukocyte tyrosine kinase 0.044
mitfa microphthalmia-associated transcription factor a 0.044
epor erythropoietin receptor 0.041
tfec transcription factor EC 0.040
sox2 SRY-box containing gene 2 0.035
gata3 GATA-binding protein 3 0.032
myca myelocytomatosis oncogene a 0.030
anxa11a annexin A11a 0.029
tfeb transcription factor EB 0.027
kitlga kit ligand a 0.027
dlc deltaC 0.026
tfap2e transcription factor AP-2 epsilon 0.026
pglyrp6 peptidoglycan recognition protein 6 0.024
trim33 tripartite motif-containing 33 0.022
junbl jun B proto-oncogene, like 0.022
si:dkey-236e20.2 si:dkey-236e20.2 0.021
gcm2 glial cells missing homolog 2 (Drosophila) 0.021
lhb luteinizing hormone, beta polypeptide 0.021
cbfb core-binding factor, beta subunit 0.021
polm polymerase (DNA directed), mu 0.021
glula glutamate-ammonia ligase (glutamine synthase) a 0.020
mgp matrix Gla protein 0.020
cdkn1a cyclin-dependent kinase inhibitor 1A 0.019
erbb3a v-erb-b2 erythroblastic leukemia viral oncogene homolog 3a 0.018
runx1 runt-related transcription factor 1 0.018
rarga retinoic acid receptor gamma a 0.017
ca15a carbonic anhydrase XV a 0.017
mmp9 matrix metalloproteinase 9 0.017
vps39 vacuolar protein sorting 39 homolog (S. cerevisiae) 0.017
tlr21 toll-like receptor 21 0.016
coro1a coronin, actin binding protein, 1A 0.015
sox9b SRY-box containing gene 9b 0.015
wu:fb80a07 wu:fb80a07 0.014
pdcd2 programmed cell death 2 0.014
ighz2 immunoglobulin heavy constant zeta2 0.014
dntt deoxynucleotidyltransferase, terminal 0.014
atp6v0ca ATPase, H+ transporting, lysosomal, V0 subunit c, a 0.014
si:ch211-173o4.2 si:ch211-173o4.2 0.014
nkx2.2a NK2 transcription factor related 2a 0.014
trpv6 transient receptor potential cation channel, subfamily V, member 6 0.013
bmp1a bone morphogenetic protein 1a 0.013
zgc:162329 zgc:162329 0.013
gata1a GATA binding protein 1a 0.013
rag2 recombination activating gene 2 0.013
calrl calreticulin like 0.012
hhex hematopoietically expressed homeobox 0.012
baxa bcl2-associated X protein, a 0.012
col8a1a collagen, type VIII, alpha 1a 0.012
gbx2 gastrulation brain homeo box 2 0.011
nod2 nucleotide-binding oligomerization domain containing 2 0.011
egr2b early growth response 2b 0.011
stc1l stanniocalcin 1, like 0.011
pitx2 paired-like homeodomain transcription factor 2 0.011
id1 inhibitor of DNA binding 1 0.011
bglap bone gamma-carboxyglutamate (gla) protein 0.011
ryk receptor-like tyrosine kinase 0.010
trpm7 transient receptor potential cation channel, subfamily M, member 7 0.010
ca2 carbonic anhydrase II 0.010
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.996
BIRC3 baculoviral IAP repeat containing 3 0.988
TRAF1 TNF receptor-associated factor 1 0.980
ZNF43 zinc finger protein 43 0.974
PTPN6 protein tyrosine phosphatase, non-receptor type 6 0.959
B2M beta-2-microglobulin 0.958
C1QA complement component 1, q subcomponent, A chain 0.945
CCR5 chemokine (C-C motif) receptor 5 0.936
IL4R interleukin 4 receptor 0.934
CFLAR CASP8 and FADD-like apoptosis regulator 0.934
HLA-C major histocompatibility complex, class I, C 0.927
ESR1 estrogen receptor 1 0.926
HLA-B major histocompatibility complex, class I, B 0.926
CXCL9 chemokine (C-X-C motif) ligand 9 0.909
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.892
XIAP X-linked inhibitor of apoptosis 0.889
CCL4 chemokine (C-C motif) ligand 4 0.888
FAS Fas (TNF receptor superfamily, member 6) 0.887
RUNX1 runt-related transcription factor 1 0.853
IL2RB interleukin 2 receptor, beta 0.830
HLA-G major histocompatibility complex, class I, G 0.822
CCL5 chemokine (C-C motif) ligand 5 0.821
CD40 CD40 molecule, TNF receptor superfamily member 5 0.821
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 0.749
IFNG interferon, gamma 0.738
ZNF253 zinc finger protein 253 0.723
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 0.681
ZNF273 zinc finger protein 273 0.674
BIRC2 baculoviral IAP repeat containing 2 0.669
ZNF675 zinc finger protein 675 0.644
EPOR erythropoietin receptor 0.633
SOCS3 suppressor of cytokine signaling 3 0.633
IL8 interleukin 8 0.615
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.607
CCL22 chemokine (C-C motif) ligand 22 0.606
CXCL2 chemokine (C-X-C motif) ligand 2 0.604
IL12B interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) 0.591
RIPK2 receptor-interacting serine-threonine kinase 2 0.589
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.589
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.587
TAL1 T-cell acute lymphocytic leukemia 1 0.572
CD247 CD247 molecule 0.561
CXCL10 chemokine (C-X-C motif) ligand 10 0.559
ICAM1 intercellular adhesion molecule 1 0.557
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.554
IRF1 interferon regulatory factor 1 0.554
HLA-F major histocompatibility complex, class I, F 0.548
CASP1 caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) 0.548
HOXB5 homeobox B5 0.544
EGR1 early growth response 1 0.540
CD80 CD80 molecule 0.538
CCR1 chemokine (C-C motif) receptor 1 0.526
PLCG1 phospholipase C, gamma 1 0.518
GAS6 growth arrest-specific 6 0.509
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.506
TNF tumor necrosis factor 0.499
CXCL3 chemokine (C-X-C motif) ligand 3 0.498
HLA-A major histocompatibility complex, class I, A 0.495
IL1B interleukin 1, beta 0.491
SH2D4A SH2 domain containing 4A 0.491
CD86 CD86 molecule 0.491
CCR7 chemokine (C-C motif) receptor 7 0.488
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 0.467
LAT linker for activation of T cells 0.462
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.452
IL2RG interleukin 2 receptor, gamma 0.437
AXL AXL receptor tyrosine kinase 0.422
IL10 interleukin 10 0.420
CCL8 chemokine (C-C motif) ligand 8 0.413
BMPR1A bone morphogenetic protein receptor, type IA 0.412
CDKN2A cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) 0.402
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 0.382
CXCL11 chemokine (C-X-C motif) ligand 11 0.376
PILRA paired immunoglobin-like type 2 receptor alpha 0.371
SMAD4 SMAD family member 4 0.366
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) 0.363
CASP7 caspase 7, apoptosis-related cysteine peptidase 0.356
FSTL1 follistatin-like 1 0.353
IL7R interleukin 7 receptor 0.346
JUN jun proto-oncogene 0.337
GHR growth hormone receptor 0.334
NCOR2 nuclear receptor corepressor 2 0.327
LIN9 lin-9 homolog (C. elegans) 0.326
FOS FBJ murine osteosarcoma viral oncogene homolog 0.323
IL10RA interleukin 10 receptor, alpha 0.321
FGR Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog 0.316
IRF4 interferon regulatory factor 4 0.308
IL6 interleukin 6 (interferon, beta 2) 0.302
CASP10 caspase 10, apoptosis-related cysteine peptidase 0.295
CTBP1 C-terminal binding protein 1 0.291
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 0.285
ZNF85 zinc finger protein 85 0.276
IL4 interleukin 4 0.274
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a 0.273
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.262
HLA-E major histocompatibility complex, class I, E 0.257
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain 0.248
NOTCH1 notch 1 0.248
ZNF430 zinc finger protein 430 0.241
TP53 tumor protein p53 0.236
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Rattus norvegicus
Name Description Probability Func Analog Organism
Il1b interleukin 1 beta 0.701
Cd86 CD86 molecule 0.400
Fcn1 ficolin (collagen/fibrinogen domain containing) 1 0.319
Cd2 Cd2 molecule 0.274
RT1-Db1 RT1 class II, locus Db1 0.241
Fgr Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog 0.222
Ccl3 chemokine (C-C motif) ligand 3 0.216
Hck hemopoietic cell kinase 0.199
RT1-Da RT1 class II, locus Da 0.190
Atf3 activating transcription factor 3 0.172
Cd3g CD3 molecule, gamma 0.121
Spn sialophorin 0.121
Cd247 Cd247 molecule 0.119
Ccl4 chemokine (C-C motif) ligand 4 0.119
Reg3b regenerating islet-derived 3 beta 0.101
Cxcl1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.096
Klf4 Kruppel-like factor 4 (gut) 0.093
Tmem176b transmembrane protein 176B 0.091
Prrx1 paired related homeobox 1 0.090
Foxs1 forkhead box S1 0.081
Cd37 CD37 molecule 0.066
Egr1 early growth response 1 0.065
Tcf12 transcription factor 12 0.064
Ccr2 chemokine (C-C motif) receptor 2 0.063
Il1a interleukin 1 alpha 0.063
Dock8 dedicator of cytokinesis 8 0.062
Il2rb interleukin 2 receptor, beta 0.061
Faslg Fas ligand (TNF superfamily, member 6) 0.053
Itgam integrin, alpha M 0.050
RT1-Bb RT1 class II, locus Bb 0.047
Cfp complement factor properdin 0.044
RT1-Ba RT1 class II, locus Ba 0.044
Tgfbr2 transforming growth factor, beta receptor II 0.043
Tcrb T-cell receptor beta chain 0.042
Pik3ap1 phosphoinositide-3-kinase adaptor protein 1 0.041
Calcrl calcitonin receptor-like 0.041
Ccl5 chemokine (C-C motif) ligand 5 0.039
Sell selectin L 0.039
Tal1 T-cell acute lymphocytic leukemia 1 0.038
Napsa napsin A aspartic peptidase 0.037
Tnf tumor necrosis factor (TNF superfamily, member 2) 0.036
Lcp2 lymphocyte cytosolic protein 2 0.035
Map4k1 mitogen activated protein kinase kinase kinase kinase 1 0.034
Dnase2a deoxyribonuclease II alpha 0.034
Ctss cathepsin S 0.033
Csf1r colony stimulating factor 1 receptor 0.033
C5ar1 complement component 5a receptor 1 0.032
Acacb acetyl-Coenzyme A carboxylase beta 0.032
Tcp11 t-complex protein 11 0.032
Fxyd4 FXYD domain-containing ion transport regulator 4 0.031
Cd83 CD83 molecule 0.030
Casp1 caspase 1 0.030
Folr2 folate receptor 2 (fetal) 0.028
Ccl19 chemokine (C-C motif) ligand 19 0.028
Rac2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) 0.028
Robo1 roundabout homolog 1 (Drosophila) 0.028
Igsf6 immunoglobulin superfamily, member 6 0.027
Guca2a guanylate cyclase activator 2a (guanylin) 0.027
Gper G protein-coupled estrogen receptor 1 0.027
Dusp1 dual specificity phosphatase 1 0.027
Tgfbr3 transforming growth factor, beta receptor III 0.026
Ptger2 prostaglandin E receptor 2 (subtype EP2) 0.026
Cd53 Cd53 molecule 0.026
Plek pleckstrin 0.026
Ccl2 chemokine (C-C motif) ligand 2 0.026
Kcnmb1 potassium large conductance calcium-activated channel, subfamily M, beta member 1 0.025
Emr1 EGF-like module containing, mucin-like, hormone receptor-like 1 0.025
Bcl2a1d B-cell leukemia/lymphoma 2 related protein A1d 0.025
Ccr5 chemokine (C-C motif) receptor 5 0.025
Acpp acid phosphatase, prostate 0.025
Rassf5 Ras association (RalGDS/AF-6) domain family member 5 0.024
Cd3e CD3 molecule, epsilon 0.024
Itgb7 integrin, beta 7 0.024
Stap1 signal transducing adaptor family member 1 0.023
LOC100302372 hypothetical protein LOC100302372 0.022
Laptm5 lysosomal protein transmembrane 5 0.022
Zfp36 zinc finger protein 36 0.022
Il8rb interleukin 8 receptor, beta 0.022
Nrg2 neuregulin 2 0.022
Cd5 Cd5 molecule 0.022
Gucy2d guanylate cyclase 2d 0.021
Tyrobp Tyro protein tyrosine kinase binding protein 0.021
Olr1500 olfactory receptor 1500 0.021
Apol3 apolipoprotein L, 3 0.021
Alox5 arachidonate 5-lipoxygenase 0.021
St8sia4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 0.020
Retnla resistin like alpha 0.020
Klhl6 kelch-like 6 (Drosophila) 0.020
C4b complement component 4B (Chido blood group) 0.019
S100a8 S100 calcium binding protein A8 0.019
Fam26f family with sequence similarity 26, member F 0.019
Lig3 ligase III, DNA, ATP-dependent 0.019
Cd8a CD8a molecule 0.019
Myo1f myosin IF 0.019
Umod uromodulin 0.018
Ctsc cathepsin C 0.018
Klre1 killer cell lectin-like receptor, family E, member 1 0.018
Grm3 glutamate receptor, metabotropic 3 0.017
Bcl2 B-cell CLL/lymphoma 2 0.017
Myo1g myosin IG 0.017
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism