The network for 'negative regulation of t cell activation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of t cell activation

Any process that stops, prevents, or reduces the frequency, rate or extent of T cell activation.

Mus musculus
Name Description Probability Func Analog Organism
Stat3 signal transducer and activator of transcription 3 1.000
Foxp3 forkhead box P3 0.998
Gli2 GLI-Kruppel family member GLI2 0.961
Socs1 suppressor of cytokine signaling 1 0.921
Il6st interleukin 6 signal transducer 0.807
Cd40 CD40 antigen 0.782
Bcl3 B-cell leukemia/lymphoma 3 0.766
H2-Ab1 histocompatibility 2, class II antigen A, beta 1 0.749
Stat6 signal transducer and activator of transcription 6 0.727
Ifng interferon gamma 0.721
Jak2 Janus kinase 2 0.718
Csf2rb2 colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage) 0.717
Casp4 caspase 4, apoptosis-related cysteine peptidase 0.716
Tnfrsf4 tumor necrosis factor receptor superfamily, member 4 0.707
Batf basic leucine zipper transcription factor, ATF-like 0.680
Nf1 neurofibromatosis 1 0.680
Lyn Yamaguchi sarcoma viral (v-yes-1) oncogene homolog 0.677
Cd80 CD80 antigen 0.663
Lta lymphotoxin A 0.626
Tnf tumor necrosis factor 0.621
Myd88 myeloid differentiation primary response gene 88 0.609
Erbb3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.591
H2-Aa histocompatibility 2, class II antigen A, alpha 0.567
Icos inducible T-cell co-stimulator 0.550
Lyz2 lysozyme 2 0.545
Tlr4 toll-like receptor 4 0.535
Ticam1 toll-like receptor adaptor molecule 1 0.525
Csf2rb colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 0.516
Zeb1 zinc finger E-box binding homeobox 1 0.514
Stat1 signal transducer and activator of transcription 1 0.503
Pik3cd phosphatidylinositol 3-kinase catalytic delta polypeptide 0.496
Stat2 signal transducer and activator of transcription 2 0.487
Ccr7 chemokine (C-C motif) receptor 7 0.466
Pdcd1 programmed cell death 1 0.439
Fas Fas (TNF receptor superfamily member 6) 0.437
Ren1 renin 1 structural 0.413
H2-DMa histocompatibility 2, class II, locus DMa 0.411
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.410
Fcgr2b Fc receptor, IgG, low affinity IIb 0.410
Il1b interleukin 1 beta 0.406
Clec4d C-type lectin domain family 4, member d 0.394
Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) 0.382
Rb1 retinoblastoma 1 0.370
Ikzf1 IKAROS family zinc finger 1 0.367
Irf1 interferon regulatory factor 1 0.366
Il27ra interleukin 27 receptor, alpha 0.331
Irf4 interferon regulatory factor 4 0.330
Tnfaip3 tumor necrosis factor, alpha-induced protein 3 0.330
Itgb2 integrin beta 2 0.315
Erbb2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.314
Neurog3 neurogenin 3 0.313
Cd28 CD28 antigen 0.308
Stat5a signal transducer and activator of transcription 5A 0.308
Cd5 CD5 antigen 0.306
Tcrd T-cell receptor delta chain 0.298
Prf1 perforin 1 (pore forming protein) 0.293
Il2rb interleukin 2 receptor, beta chain 0.291
Birc3 baculoviral IAP repeat-containing 3 0.285
Cd4 CD4 antigen 0.282
Tgfb1 transforming growth factor, beta 1 0.282
Ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 0.275
Dlg4 discs, large homolog 4 (Drosophila) 0.267
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.267
Jak1 Janus kinase 1 0.265
Clec4e C-type lectin domain family 4, member e 0.261
Hif1a hypoxia inducible factor 1, alpha subunit 0.259
Tbx21 T-box 21 0.256
Ptch1 patched homolog 1 0.252
Ciita class II transactivator 0.245
Ifnar1 interferon (alpha and beta) receptor 1 0.238
Prkcd protein kinase C, delta 0.229
Ccl24 chemokine (C-C motif) ligand 24 0.226
Ifnar2 interferon (alpha and beta) receptor 2 0.223
Il10ra interleukin 10 receptor, alpha 0.220
Foxp1 forkhead box P1 0.219
H2-Eb1 histocompatibility 2, class II antigen E beta 0.216
Ripk1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.215
Ifnb1 interferon beta 1, fibroblast 0.215
Foxc1 forkhead box C1 0.214
Hhex hematopoietically expressed homeobox 0.214
Nlrp3 NLR family, pyrin domain containing 3 0.212
Ptprc protein tyrosine phosphatase, receptor type, C 0.209
Batf3 basic leucine zipper transcription factor, ATF-like 3 0.203
Pthlh parathyroid hormone-like peptide 0.199
Twist2 twist homolog 2 (Drosophila) 0.193
Cd209b CD209b antigen 0.193
Il2 interleukin 2 0.192
Aire autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy) 0.190
Cd14 CD14 antigen 0.186
Bdkrb2 bradykinin receptor, beta 2 0.185
Wfikkn2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 0.185
Sufu suppressor of fused homolog (Drosophila) 0.184
Pstpip2 proline-serine-threonine phosphatase-interacting protein 2 0.175
Lag3 lymphocyte-activation gene 3 0.175
Nfatc1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 0.175
Egfr epidermal growth factor receptor 0.174
Rag1 recombination activating gene 1 0.172
Map3k14 mitogen-activated protein kinase kinase kinase 14 0.167
Il6 interleukin 6 0.166
Socs5 suppressor of cytokine signaling 5 0.160
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
HLA-B major histocompatibility complex, class I, B 0.908
B2M beta-2-microglobulin 0.879
CD80 CD80 molecule 0.548
HLA-DRA major histocompatibility complex, class II, DR alpha 0.505
HLA-DMA major histocompatibility complex, class II, DM alpha 0.494
PTPN6 protein tyrosine phosphatase, non-receptor type 6 0.353
HLA-F major histocompatibility complex, class I, F 0.338
HLA-DMB major histocompatibility complex, class II, DM beta 0.263
HLA-G major histocompatibility complex, class I, G 0.249
PILRA paired immunoglobin-like type 2 receptor alpha 0.165
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 0.157
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 0.136
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 0.121
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 1 0.114
HLA-E major histocompatibility complex, class I, E 0.109
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1 0.100
BMPR1A bone morphogenetic protein receptor, type IA 0.100
CCL4 chemokine (C-C motif) ligand 4 0.085
HLA-DRB5 major histocompatibility complex, class II, DR beta 5 0.079
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.078
ITCH itchy E3 ubiquitin protein ligase homolog (mouse) 0.077
IL4R interleukin 4 receptor 0.075
CCR5 chemokine (C-C motif) receptor 5 0.068
HLA-DRB4 major histocompatibility complex, class II, DR beta 4 0.065
IL2RG interleukin 2 receptor, gamma 0.064
CASP9 caspase 9, apoptosis-related cysteine peptidase 0.064
CXCL9 chemokine (C-X-C motif) ligand 9 0.063
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa 0.062
ICAM1 intercellular adhesion molecule 1 0.060
HLA-DPB1 major histocompatibility complex, class II, DP beta 1 0.059
FSTL1 follistatin-like 1 0.053
CD86 CD86 molecule 0.052
HLA-C major histocompatibility complex, class I, C 0.045
XIAP X-linked inhibitor of apoptosis 0.043
HK3 hexokinase 3 (white cell) 0.041
HLA-A major histocompatibility complex, class I, A 0.040
LAT linker for activation of T cells 0.038
CD247 CD247 molecule 0.038
RNF11 ring finger protein 11 0.037
ADAM17 ADAM metallopeptidase domain 17 0.036
SIGLEC7 sialic acid binding Ig-like lectin 7 0.036
CXCL10 chemokine (C-X-C motif) ligand 10 0.035
TRAF1 TNF receptor-associated factor 1 0.035
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced 0.035
CCR7 chemokine (C-C motif) receptor 7 0.034
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 0.033
CD40 CD40 molecule, TNF receptor superfamily member 5 0.032
CCL8 chemokine (C-C motif) ligand 8 0.032
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 0.030
CCL13 chemokine (C-C motif) ligand 13 0.030
IL10 interleukin 10 0.029
CCL5 chemokine (C-C motif) ligand 5 0.029
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin 0.027
EGFR epidermal growth factor receptor 0.027
BTN3A1 butyrophilin, subfamily 3, member A1 0.027
APAF1 apoptotic peptidase activating factor 1 0.026
LILRA1 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1 0.026
CCR1 chemokine (C-C motif) receptor 1 0.025
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2 0.025
DPP4 dipeptidyl-peptidase 4 0.024
TFF1 trefoil factor 1 0.024
BIRC3 baculoviral IAP repeat containing 3 0.024
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 0.023
IFNG interferon, gamma 0.022
TAPBP TAP binding protein (tapasin) 0.022
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain 0.022
IL4 interleukin 4 0.022
GRAP2 GRB2-related adaptor protein 2 0.021
IDE insulin-degrading enzyme 0.021
LAIR1 leukocyte-associated immunoglobulin-like receptor 1 0.021
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.020
MICA MHC class I polypeptide-related sequence A 0.020
VAV1 vav 1 guanine nucleotide exchange factor 0.020
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 0.019
NCOR2 nuclear receptor corepressor 2 0.019
CD300C CD300c molecule 0.018
CCR4 chemokine (C-C motif) receptor 4 0.018
DRD2 dopamine receptor D2 0.018
CCL2 chemokine (C-C motif) ligand 2 0.017
CXCL11 chemokine (C-X-C motif) ligand 11 0.017
NAMPT nicotinamide phosphoribosyltransferase 0.017
CMKLR1 chemokine-like receptor 1 0.016
CFLAR CASP8 and FADD-like apoptosis regulator 0.016
CD163 CD163 molecule 0.016
BTN2A2 butyrophilin, subfamily 2, member A2 0.016
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 0.015
UBE2D3 ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast) 0.015
CD2 CD2 molecule 0.015
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 0.015
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14 0.015
APP amyloid beta (A4) precursor protein 0.015
C1QB complement component 1, q subcomponent, B chain 0.014
IL2RA interleukin 2 receptor, alpha 0.014
CCL7 chemokine (C-C motif) ligand 7 0.013
BTN3A3 butyrophilin, subfamily 3, member A3 0.013
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) 0.013
HDAC9 histone deacetylase 9 0.013
INSR insulin receptor 0.013
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 0.013
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.013
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Rattus norvegicus
Name Description Probability Func Analog Organism
Cd74 Cd74 molecule, major histocompatibility complex, class II invariant chain 0.985
RT1-Db1 RT1 class II, locus Db1 0.969
RT1-DMb RT1 class II, locus DMb 0.809
RT1-Da RT1 class II, locus Da 0.512
RT1-Ba RT1 class II, locus Ba 0.318
RT1-Bb RT1 class II, locus Bb 0.202
Cd37 CD37 molecule 0.075
Cd2 Cd2 molecule 0.013
Spn sialophorin 0.012
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism