IMP

Process View

Homo sapiens

21 genes annotated in human

osteoclast differentiation

The process in which a relatively unspecialized monocyte acquires the specialized features of an osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "osteoclast differentiation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "osteoclast differentiation" (in gray)

Name	Description	Probability	Func Analog Organism
TRAF1	TNF receptor-associated factor 1	1.000	Human
CCR5	chemokine (C-C motif) receptor 5	0.999	Human
ZNF43	zinc finger protein 43	0.999
PTPN6	protein tyrosine phosphatase, non-receptor type 6	0.994
IL4R	interleukin 4 receptor	0.994
CD40	CD40 molecule, TNF receptor superfamily member 5	0.985	Human
CCL4	chemokine (C-C motif) ligand 4	0.972	Human
ZNF273	zinc finger protein 273	0.971	Human
TRAF5	TNF receptor-associated factor 5	0.963	Human
ZNF253	zinc finger protein 253	0.943
TRAF2	TNF receptor-associated factor 2	0.930	Human
LILRB3	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3	0.926
LILRA6	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6	0.909
CCL5	chemokine (C-C motif) ligand 5	0.876	Human Rat
TRADD	TNFRSF1A-associated via death domain	0.856
TNFRSF9	tumor necrosis factor receptor superfamily, member 9	0.855
TNFRSF1B	tumor necrosis factor receptor superfamily, member 1B	0.812	Human
RIPK1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.787
TRAF3	TNF receptor-associated factor 3	0.765	Human
CCR7	chemokine (C-C motif) receptor 7	0.726	Human
IL12B	interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)	0.716
ZNF675	zinc finger protein 675	0.713
LAIR1	leukocyte-associated immunoglobulin-like receptor 1	0.712	Human
TNF	tumor necrosis factor	0.683
BIRC3	baculoviral IAP repeat containing 3	0.676
IFNG	interferon, gamma	0.675
CXCL9	chemokine (C-X-C motif) ligand 9	0.672
JUN	jun proto-oncogene	0.668
IKBKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	0.617
CCL22	chemokine (C-C motif) ligand 22	0.601	Human
IL2RG	interleukin 2 receptor, gamma	0.582
NFKB2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)	0.579
ZNF91	zinc finger protein 91	0.533
SHC1	SHC (Src homology 2 domain containing) transforming protein 1	0.532
CCR4	chemokine (C-C motif) receptor 4	0.520	Human
CCR1	chemokine (C-C motif) receptor 1	0.513
IL2RB	interleukin 2 receptor, beta	0.497
ZNF254	zinc finger protein 254	0.493	Human
TNFRSF14	tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)	0.487	Human
ANXA1	annexin A1	0.482	Human
TNFRSF1A	tumor necrosis factor receptor superfamily, member 1A	0.472
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.466
ZNF93	zinc finger protein 93	0.448
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.435	Mouse
SLAMF1	signaling lymphocytic activation molecule family member 1	0.390
IL23A	interleukin 23, alpha subunit p19	0.386
DIP2A	DIP2 disco-interacting protein 2 homolog A (Drosophila)	0.380
PILRA	paired immunoglobin-like type 2 receptor alpha	0.367	Mouse
S100A10	S100 calcium binding protein A10	0.361
PTPN11	protein tyrosine phosphatase, non-receptor type 11	0.353
CCL2	chemokine (C-C motif) ligand 2	0.345	Human
ZMYND11	zinc finger, MYND-type containing 11	0.306
RELB	v-rel reticuloendotheliosis viral oncogene homolog B	0.280
ZNF117	zinc finger protein 117	0.278	Human
ZNF430	zinc finger protein 430	0.274	Human
CD14	CD14 molecule	0.269
PECAM1	platelet/endothelial cell adhesion molecule	0.264
APP	amyloid beta (A4) precursor protein	0.249
CAV1	caveolin 1, caveolae protein, 22kDa	0.243
NFKBIA	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.237
ZNF85	zinc finger protein 85	0.221	Human
IL10	interleukin 10	0.218
GRB2	growth factor receptor-bound protein 2	0.207
BCL3	B-cell CLL/lymphoma 3	0.206
LILRB1	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1	0.203
ZNF708	zinc finger protein 708	0.203	Human
CCL7	chemokine (C-C motif) ligand 7	0.197	Human
CSF2RB	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	0.192
IRF4	interferon regulatory factor 4	0.173
ANXA7	annexin A7	0.171	Human
IL4	interleukin 4	0.158	Mouse
CCL8	chemokine (C-C motif) ligand 8	0.157	Human
CASP8	caspase 8, apoptosis-related cysteine peptidase	0.156
CCL3	chemokine (C-C motif) ligand 3	0.155
SLAMF7	SLAM family member 7	0.151
TMSB4X	thymosin beta 4, X-linked	0.148
CXCL13	chemokine (C-X-C motif) ligand 13	0.147
CXCR3	chemokine (C-X-C motif) receptor 3	0.144	Human
CCL18	chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)	0.137	Human Rat
GRAP2	GRB2-related adaptor protein 2	0.137
CD74	CD74 molecule, major histocompatibility complex, class II invariant chain	0.128
CXCL10	chemokine (C-X-C motif) ligand 10	0.119
STAT6	signal transducer and activator of transcription 6, interleukin-4 induced	0.119
CD28	CD28 molecule	0.116
CASP10	caspase 10, apoptosis-related cysteine peptidase	0.113
ICAM1	intercellular adhesion molecule 1	0.111
CD40LG	CD40 ligand	0.108
FCGR2B	Fc fragment of IgG, low affinity IIb, receptor (CD32)	0.106
SMPD1	sphingomyelin phosphodiesterase 1, acid lysosomal	0.106
TNFSF14	tumor necrosis factor (ligand) superfamily, member 14	0.106	Human
TNFSF11	tumor necrosis factor (ligand) superfamily, member 11	0.102
CCL13	chemokine (C-C motif) ligand 13	0.101	Human
TGFB1	transforming growth factor, beta 1	0.101
CCL11	chemokine (C-C motif) ligand 11	0.101	Human
IL1B	interleukin 1, beta	0.092
ATF3	activating transcription factor 3	0.089
RIPK2	receptor-interacting serine-threonine kinase 2	0.088
LILRB2	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2	0.085	Human
IDE	insulin-degrading enzyme	0.080
CXCL1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	0.079
IL16	interleukin 16 (lymphocyte chemoattractant factor)	0.076
CLIP1	CAP-GLY domain containing linker protein 1	0.075
ANXA5	annexin A5	0.075	Human
CCL19	chemokine (C-C motif) ligand 19	0.073	Human
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.073
JUND	jun D proto-oncogene	0.073
DOCK7	dedicator of cytokinesis 7	0.072
NMT2	N-myristoyltransferase 2	0.072
LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	0.071
SIGLEC7	sialic acid binding Ig-like lectin 7	0.071
CD33	CD33 molecule	0.067
DAB2	disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)	0.063
SIRPB1	signal-regulatory protein beta 1	0.062
IL8	interleukin 8	0.062
LTA	lymphotoxin alpha (TNF superfamily, member 1)	0.061
VCAM1	vascular cell adhesion molecule 1	0.059
TNFAIP3	tumor necrosis factor, alpha-induced protein 3	0.059
CXCL11	chemokine (C-X-C motif) ligand 11	0.056
ANXA2	annexin A2	0.056
ZNF680	zinc finger protein 680	0.054	Human
APC	adenomatous polyposis coli	0.053	Mouse
ZNF682	zinc finger protein 682	0.052	Human
EFNA1	ephrin-A1	0.052
LILRA2	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2	0.051
SMAD3	SMAD family member 3	0.051
LILRA1	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1	0.051	Human
TYMP	thymidine phosphorylase	0.050
TIFA	TRAF-interacting protein with forkhead-associated domain	0.049
MYO1G	myosin IG	0.048
BMP2	bone morphogenetic protein 2	0.048
BATF	basic leucine zipper transcription factor, ATF-like	0.047
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.046
HTT	huntingtin	0.045
MAP3K14	mitogen-activated protein kinase kinase kinase 14	0.045
PDPK1	3-phosphoinositide dependent protein kinase-1	0.044
FOSL1	FOS-like antigen 1	0.043
ZFP36	zinc finger protein 36, C3H type, homolog (mouse)	0.043
IL7R	interleukin 7 receptor	0.041
LAG3	lymphocyte-activation gene 3	0.040
VIM	vimentin	0.039
SMURF1	SMAD specific E3 ubiquitin protein ligase 1	0.038
ZNF92	zinc finger protein 92	0.038	Human
LTB	lymphotoxin beta (TNF superfamily, member 3)	0.037
CCR8	chemokine (C-C motif) receptor 8	0.036	Human
CCR2	chemokine (C-C motif) receptor 2	0.036	Human
CD86	CD86 molecule	0.035
RANBP9	RAN binding protein 9	0.034
CD22	CD22 molecule	0.033
DPP4	dipeptidyl-peptidase 4	0.033
PTAFR	platelet-activating factor receptor	0.033
CCR3	chemokine (C-C motif) receptor 3	0.033	Human
IER2	immediate early response 2	0.032
SH3BP4	SH3-domain binding protein 4	0.031
SNAP23	synaptosomal-associated protein, 23kDa	0.031
PDCD6	programmed cell death 6	0.030
HCK	hemopoietic cell kinase	0.029
CD2	CD2 molecule	0.028
ZNF107	zinc finger protein 107	0.028
GAST	gastrin	0.028
EBI3	Epstein-Barr virus induced 3	0.027
FOS	FBJ murine osteosarcoma viral oncogene homolog	0.027	Mouse
HK3	hexokinase 3 (white cell)	0.026
CSK	c-src tyrosine kinase	0.025
CD83	CD83 molecule	0.025
MDFI	MyoD family inhibitor	0.025
CCL1	chemokine (C-C motif) ligand 1	0.025	Human
ITK	IL2-inducible T-cell kinase	0.025
IL1A	interleukin 1, alpha	0.024
IL13	interleukin 13	0.024
NUCB1	nucleobindin 1	0.023
FCER2	Fc fragment of IgE, low affinity II, receptor for (CD23)	0.023
CXCR5	chemokine (C-X-C motif) receptor 5	0.023	Human
SPI1	spleen focus forming virus (SFFV) proviral integration oncogene spi1	0.023
TNFAIP2	tumor necrosis factor, alpha-induced protein 2	0.023
AOAH	acyloxyacyl hydrolase (neutrophil)	0.023
CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	0.022
ZC3H12A	zinc finger CCCH-type containing 12A	0.022
CXCR6	chemokine (C-X-C motif) receptor 6	0.022	Human
S100A11	S100 calcium binding protein A11	0.022
SH3KBP1	SH3-domain kinase binding protein 1	0.022
GPR171	G protein-coupled receptor 171	0.022
IL6	interleukin 6 (interferon, beta 2)	0.021
IL12A	interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)	0.021
ZBTB48	zinc finger and BTB domain containing 48	0.021
ARRB1	arrestin, beta 1	0.020
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.020	Mouse
C1orf93	chromosome 1 open reading frame 93	0.020	Human
NCOA2	nuclear receptor coactivator 2	0.020
AKT2	v-akt murine thymoma viral oncogene homolog 2	0.020
CCR6	chemokine (C-C motif) receptor 6	0.020	Human
NFKBIB	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta	0.020
NDEL1	nudE nuclear distribution gene E homolog (A. nidulans)-like 1	0.020
TANK	TRAF family member-associated NFKB activator	0.019
SMAD2	SMAD family member 2	0.019
ZNF506	zinc finger protein 506	0.019	Human
TNFSF8	tumor necrosis factor (ligand) superfamily, member 8	0.019
FCGR3B	Fc fragment of IgG, low affinity IIIb, receptor (CD16b)	0.019
KIR2DL1	killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1	0.019
HLA-DOA	major histocompatibility complex, class II, DO alpha	0.019
EPOR	erythropoietin receptor	0.018
IL21R	interleukin 21 receptor	0.018
C3AR1	complement component 3a receptor 1	0.018
LILRB4	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4	0.018
ATP6V1A	ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A	0.017
GRINA	glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)	0.017
MAPK3	mitogen-activated protein kinase 3	0.017
CCL20	chemokine (C-C motif) ligand 20	0.017	Human
BTRC	beta-transducin repeat containing	0.017
HLA-DQA1	major histocompatibility complex, class II, DQ alpha 1	0.017
IL2RA	interleukin 2 receptor, alpha	0.017
TREM1	triggering receptor expressed on myeloid cells 1	0.017
LILRA3	leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3	0.017	Human
NLRP3	NLR family, pyrin domain containing 3	0.017
SMAD1	SMAD family member 1	0.016
SH3BP2	SH3-domain binding protein 2	0.016
CCL17	chemokine (C-C motif) ligand 17	0.016	Human
PRKCD	protein kinase C, delta	0.016
BATF2	basic leucine zipper transcription factor, ATF-like 2	0.016
MAP3K7	mitogen-activated protein kinase kinase kinase 7	0.016
TAB2	TGF-beta activated kinase 1/MAP3K7 binding protein 2	0.016
ITGB5	integrin, beta 5	0.016
IRS1	insulin receptor substrate 1	0.016
CBLC	Cas-Br-M (murine) ecotropic retroviral transforming sequence c	0.015
TNFRSF4	tumor necrosis factor receptor superfamily, member 4	0.015
GNAQ	guanine nucleotide binding protein (G protein), q polypeptide	0.015
JUNB	jun B proto-oncogene	0.015	Mouse
C2	complement component 2	0.015
NCOR1	nuclear receptor corepressor 1	0.015
UBE2D1	ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)	0.015
IL1F5	interleukin 1 family, member 5 (delta)	0.015
BIN2	bridging integrator 2	0.015
AXL	AXL receptor tyrosine kinase	0.014
CCR9	chemokine (C-C motif) receptor 9	0.014	Human
BCL2A1	BCL2-related protein A1	0.014
ZNF136	zinc finger protein 136	0.014
CASP1	caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)	0.014
INHBA	inhibin, beta A	0.014
TRAF3IP2	TRAF3 interacting protein 2	0.014
ASAP1	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	0.014
CMIP	c-Maf-inducing protein	0.014
KIT	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	0.014
MAPKAPK2	mitogen-activated protein kinase-activated protein kinase 2	0.014
SIRPA	signal-regulatory protein alpha	0.013
XCL1	chemokine (C motif) ligand 1	0.013	Human
ATP2B2	ATPase, Ca++ transporting, plasma membrane 2	0.013
IL12RB1	interleukin 12 receptor, beta 1	0.013
CFLAR	CASP8 and FADD-like apoptosis regulator	0.013
ZNF320	zinc finger protein 320	0.013
SELE	selectin E	0.013
XCL2	chemokine (C motif) ligand 2	0.013	Human
ZNF431	zinc finger protein 431	0.012	Human
NOTCH2NL	notch 2 N-terminal like	0.012
VCAN	versican	0.012
CXCL5	chemokine (C-X-C motif) ligand 5	0.012
ITGAV	integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)	0.012
CRKL	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.012
ING2	inhibitor of growth family, member 2	0.012
CLEC10A	C-type lectin domain family 10, member A	0.012
LGALS2	lectin, galactoside-binding, soluble, 2	0.012
IL3	interleukin 3 (colony-stimulating factor, multiple)	0.012
CCL21	chemokine (C-C motif) ligand 21	0.012
AQP9	aquaporin 9	0.012
UBD	ubiquitin D	0.012
PTK2B	PTK2B protein tyrosine kinase 2 beta	0.012
SS18	synovial sarcoma translocation, chromosome 18	0.011
ATXN3	ataxin 3	0.011
PTK2	PTK2 protein tyrosine kinase 2	0.011
ICOSLG	inducible T-cell co-stimulator ligand	0.011
CSF2RA	colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)	0.011
CD72	CD72 molecule	0.011
PLA2G7	phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)	0.011
AHNAK	AHNAK nucleoprotein	0.011
ZNF512B	zinc finger protein 512B	0.011
TNFRSF18	tumor necrosis factor receptor superfamily, member 18	0.011
CCL3L3	chemokine (C-C motif) ligand 3-like 3	0.011
MET	met proto-oncogene (hepatocyte growth factor receptor)	0.011
SIGLEC1	sialic acid binding Ig-like lectin 1, sialoadhesin	0.011
CD6	CD6 molecule	0.011
NFKBIE	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon	0.011
ATF2	activating transcription factor 2	0.011
CXCL2	chemokine (C-X-C motif) ligand 2	0.011
POU2F2	POU class 2 homeobox 2	0.011
FASLG	Fas ligand (TNF superfamily, member 6)	0.010	Human
SGK1	serum/glucocorticoid regulated kinase 1	0.010
MSC	musculin	0.010