IMP

Process View

Homo sapiens

21 genes annotated in human

metaphase anaphase transition of mitotic cell cycle

The cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "metaphase anaphase transition of mitotic cell cycle"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "metaphase anaphase transition of mitotic cell cycle" (in gray)

Name	Description	Probability	Func Analog Organism
CDC20	cell division cycle 20 homolog (S. cerevisiae)	1.000	Yeast Worm Fly
CDC27	cell division cycle 27 homolog (S. cerevisiae)	1.000
BUB1B	budding uninhibited by benzimidazoles 1 homolog beta (yeast)	0.999	Mouse Fly
ANAPC4	anaphase promoting complex subunit 4	0.994
CDK2	cyclin-dependent kinase 2	0.991
CDC16	cell division cycle 16 homolog (S. cerevisiae)	0.984	Fly
ANAPC5	anaphase promoting complex subunit 5	0.962
CCNA2	cyclin A2	0.937
MAD2L1	MAD2 mitotic arrest deficient-like 1 (yeast)	0.931
CCNB1	cyclin B1	0.900
POMP	proteasome maturation protein	0.654
ANAPC7	anaphase promoting complex subunit 7	0.654
CCT8	chaperonin containing TCP1, subunit 8 (theta)	0.634
SMC6	structural maintenance of chromosomes 6	0.570
BUB1	budding uninhibited by benzimidazoles 1 homolog (yeast)	0.534	Fly
CDC26	cell division cycle 26 homolog (S. cerevisiae)	0.420
CBX5	chromobox homolog 5	0.420
ANAPC11	anaphase promoting complex subunit 11	0.401
CDC23	cell division cycle 23 homolog (S. cerevisiae)	0.339
PSMD2	proteasome (prosome, macropain) 26S subunit, non-ATPase, 2	0.330
NSMCE1	non-SMC element 1 homolog (S. cerevisiae)	0.317
PSMC1	proteasome (prosome, macropain) 26S subunit, ATPase, 1	0.301
RBL1	retinoblastoma-like 1 (p107)	0.284	Human
AURKB	aurora kinase B	0.275
SMC3	structural maintenance of chromosomes 3	0.264
CD44	CD44 molecule (Indian blood group)	0.261
MAD2L2	MAD2 mitotic arrest deficient-like 2 (yeast)	0.217
PSMD4	proteasome (prosome, macropain) 26S subunit, non-ATPase, 4	0.216
CDKN1B	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	0.204
PPP1CA	protein phosphatase 1, catalytic subunit, alpha isozyme	0.204
CKS1B	CDC28 protein kinase regulatory subunit 1B	0.177
TFDP1	transcription factor Dp-1	0.159
PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	0.152
RAD21	RAD21 homolog (S. pombe)	0.144
CCNB2	cyclin B2	0.139
PTTG1	pituitary tumor-transforming 1	0.136
ANAPC1	anaphase promoting complex subunit 1	0.133	Worm
RB1	retinoblastoma 1	0.128
STAG1	stromal antigen 1	0.127
PPP2R2A	protein phosphatase 2, regulatory subunit B, alpha	0.125
CDKN3	cyclin-dependent kinase inhibitor 3	0.122
CDT1	chromatin licensing and DNA replication factor 1	0.116
SKP2	S-phase kinase-associated protein 2 (p45)	0.111
PSMC3	proteasome (prosome, macropain) 26S subunit, ATPase, 3	0.104
PSMC2	proteasome (prosome, macropain) 26S subunit, ATPase, 2	0.104
E2F1	E2F transcription factor 1	0.100
CHAF1A	chromatin assembly factor 1, subunit A (p150)	0.094
PSMD7	proteasome (prosome, macropain) 26S subunit, non-ATPase, 7	0.081
PPP2CA	protein phosphatase 2, catalytic subunit, alpha isozyme	0.080
PSMC6	proteasome (prosome, macropain) 26S subunit, ATPase, 6	0.078
PSMD6	proteasome (prosome, macropain) 26S subunit, non-ATPase, 6	0.077
SLC9A3R1	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1	0.077
PPP2R5C	protein phosphatase 2, regulatory subunit B', gamma	0.076
NSMCE4A	non-SMC element 4 homolog A (S. cerevisiae)	0.071
RBBP8	retinoblastoma binding protein 8	0.070
FBXO5	F-box protein 5	0.066
G3BP1	GTPase activating protein (SH3 domain) binding protein 1	0.065
SKA1	spindle and kinetochore associated complex subunit 1	0.065
CKS2	CDC28 protein kinase regulatory subunit 2	0.061
PSMD10	proteasome (prosome, macropain) 26S subunit, non-ATPase, 10	0.061
DOT1L	DOT1-like, histone H3 methyltransferase (S. cerevisiae)	0.059
DSN1	DSN1, MIND kinetochore complex component, homolog (S. cerevisiae)	0.058
ARHGDIA	Rho GDP dissociation inhibitor (GDI) alpha	0.057
CHEK1	CHK1 checkpoint homolog (S. pombe)	0.057
ZWINT	ZW10 interactor	0.055
PSMD13	proteasome (prosome, macropain) 26S subunit, non-ATPase, 13	0.053
UHRF2	ubiquitin-like with PHD and ring finger domains 2	0.053
NDC80	NDC80 homolog, kinetochore complex component (S. cerevisiae)	0.053
SKA3	spindle and kinetochore associated complex subunit 3	0.052
TTK	TTK protein kinase	0.049	Yeast
CASC5	cancer susceptibility candidate 5	0.048
MED1	mediator complex subunit 1	0.045
PSMC4	proteasome (prosome, macropain) 26S subunit, ATPase, 4	0.045
PSMA6	proteasome (prosome, macropain) subunit, alpha type, 6	0.044
PRNP	prion protein	0.044
RBL2	retinoblastoma-like 2 (p130)	0.043	Human
BRCA1	breast cancer 1, early onset	0.043
MYH9	myosin, heavy chain 9, non-muscle	0.042
CCNE1	cyclin E1	0.041	Fly
TP53BP1	tumor protein p53 binding protein 1	0.041
FEN1	flap structure-specific endonuclease 1	0.040
PXN	paxillin	0.040
SMAD2	SMAD family member 2	0.040
TBC1D10A	TBC1 domain family, member 10A	0.039
NEK9	NIMA (never in mitosis gene a)- related kinase 9	0.039
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.039
HERC2	hect domain and RLD 2	0.038
BUB3	budding uninhibited by benzimidazoles 3 homolog (yeast)	0.038	Worm Fly
PSMD11	proteasome (prosome, macropain) 26S subunit, non-ATPase, 11	0.036
MKI67	antigen identified by monoclonal antibody Ki-67	0.035
UHRF1	ubiquitin-like with PHD and ring finger domains 1	0.035
SIRT2	sirtuin 2	0.035
ANKRD52	ankyrin repeat domain 52	0.034
SKA2	spindle and kinetochore associated complex subunit 2	0.034
PPP2R1B	protein phosphatase 2, regulatory subunit A, beta	0.033
TPX2	TPX2, microtubule-associated, homolog (Xenopus laevis)	0.033
NEK2	NIMA (never in mitosis gene a)-related kinase 2	0.033
PPP2R5A	protein phosphatase 2, regulatory subunit B', alpha	0.033
SPC24	SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae)	0.032
INCENP	inner centromere protein antigens 135/155kDa	0.031
KIF18A	kinesin family member 18A	0.030
GSK3B	glycogen synthase kinase 3 beta	0.030	Fly
CDK1	cyclin-dependent kinase 1	0.030
SGOL1	shugoshin-like 1 (S. pombe)	0.030
ZC3HAV1	zinc finger CCCH-type, antiviral 1	0.030
BRCA2	breast cancer 2, early onset	0.029
ASPM	asp (abnormal spindle) homolog, microcephaly associated (Drosophila)	0.029
SMC4	structural maintenance of chromosomes 4	0.028
PTEN	phosphatase and tensin homolog	0.028
PRC1	protein regulator of cytokinesis 1	0.028
FXR2	fragile X mental retardation, autosomal homolog 2	0.027
E2F4	E2F transcription factor 4, p107/p130-binding	0.027
MYBL2	v-myb myeloblastosis viral oncogene homolog (avian)-like 2	0.027
ATRX	alpha thalassemia/mental retardation syndrome X-linked	0.027
UBASH3B	ubiquitin associated and SH3 domain containing B	0.027
CCND1	cyclin D1	0.027
MYST1	MYST histone acetyltransferase 1	0.026
DNMT3A	DNA (cytosine-5-)-methyltransferase 3 alpha	0.026
ATAD2	ATPase family, AAA domain containing 2	0.025
CENPE	centromere protein E, 312kDa	0.025
SGOL2	shugoshin-like 2 (S. pombe)	0.025
CDC42	cell division cycle 42 (GTP binding protein, 25kDa)	0.025
LIN54	lin-54 homolog (C. elegans)	0.025
CDC5L	CDC5 cell division cycle 5-like (S. pombe)	0.025
MAK	male germ cell-associated kinase	0.024
DEAF1	deformed epidermal autoregulatory factor 1 (Drosophila)	0.024
UBE2S	ubiquitin-conjugating enzyme E2S	0.024
CLSPN	claspin	0.024
CDCA8	cell division cycle associated 8	0.024
NASP	nuclear autoantigenic sperm protein (histone-binding)	0.023
SERTAD4	SERTA domain containing 4	0.023
NSMCE2	non-SMC element 2, MMS21 homolog (S. cerevisiae)	0.023
PPME1	protein phosphatase methylesterase 1	0.022
CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	0.022
PSMB7	proteasome (prosome, macropain) subunit, beta type, 7	0.022
FOXM1	forkhead box M1	0.022
PSMB2	proteasome (prosome, macropain) subunit, beta type, 2	0.022
WBP4	WW domain binding protein 4 (formin binding protein 21)	0.022
CCND3	cyclin D3	0.022
IKBKG	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma	0.022
HIST1H4A	histone cluster 1, H4a	0.022
ATMIN	ATM interactor	0.021
STAG2	stromal antigen 2	0.021
C13orf34	chromosome 13 open reading frame 34	0.021
SYVN1	synovial apoptosis inhibitor 1, synoviolin	0.021
CDC25A	cell division cycle 25 homolog A (S. pombe)	0.021
USP49	ubiquitin specific peptidase 49	0.021	Human
KIF11	kinesin family member 11	0.021
KPNA3	karyopherin alpha 3 (importin alpha 4)	0.020
TOP3A	topoisomerase (DNA) III alpha	0.020
BIRC5	baculoviral IAP repeat containing 5	0.020
RIF1	RAP1 interacting factor homolog (yeast)	0.020
TK1	thymidine kinase 1, soluble	0.020
CHAF1B	chromatin assembly factor 1, subunit B (p60)	0.020
PARP3	poly (ADP-ribose) polymerase family, member 3	0.020
CREBBP	CREB binding protein	0.020
PTK2B	PTK2B protein tyrosine kinase 2 beta	0.020
TROAP	trophinin associated protein (tastin)	0.020
E2F5	E2F transcription factor 5, p130-binding	0.020
HIST1H4F	histone cluster 1, H4f	0.020
ANAPC16	anaphase promoting complex subunit 16	0.019
PSMD1	proteasome (prosome, macropain) 26S subunit, non-ATPase, 1	0.019
DEPDC1	DEP domain containing 1	0.019
ZW10	ZW10, kinetochore associated, homolog (Drosophila)	0.019
PLK1	polo-like kinase 1	0.019
C13orf27	chromosome 13 open reading frame 27	0.018
AXIN1	axin 1	0.018
USP44	ubiquitin specific peptidase 44	0.018
IQGAP1	IQ motif containing GTPase activating protein 1	0.018
CDH1	cadherin 1, type 1, E-cadherin (epithelial)	0.018
SMC1A	structural maintenance of chromosomes 1A	0.018
CCDC99	coiled-coil domain containing 99	0.018
LIN9	lin-9 homolog (C. elegans)	0.017
PKMYT1	protein kinase, membrane associated tyrosine/threonine 1	0.017
WAPAL	wings apart-like homolog (Drosophila)	0.017
ANAPC10	anaphase promoting complex subunit 10	0.017	Yeast
AXIN2	axin 2	0.016
CUL2	cullin 2	0.016
OTUB1	OTU domain, ubiquitin aldehyde binding 1	0.016
PTPN12	protein tyrosine phosphatase, non-receptor type 12	0.016
PSMD9	proteasome (prosome, macropain) 26S subunit, non-ATPase, 9	0.016
VHL	von Hippel-Lindau tumor suppressor	0.016
EML2	echinoderm microtubule associated protein like 2	0.016
CDC7	cell division cycle 7 homolog (S. cerevisiae)	0.016
RAC2	ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)	0.016
DCLRE1B	DNA cross-link repair 1B	0.016
HIST1H1E	histone cluster 1, H1e	0.015
TRIP13	thyroid hormone receptor interactor 13	0.015
MAD1L1	MAD1 mitotic arrest deficient-like 1 (yeast)	0.015
RFWD2	ring finger and WD repeat domain 2	0.015
DYNC1I2	dynein, cytoplasmic 1, intermediate chain 2	0.015
ARIH2	ariadne homolog 2 (Drosophila)	0.015
HIST1H1B	histone cluster 1, H1b	0.015
PSMD8	proteasome (prosome, macropain) 26S subunit, non-ATPase, 8	0.015
PPP5C	protein phosphatase 5, catalytic subunit	0.014
SHCBP1	SHC SH2-domain binding protein 1	0.014
MAD2L1BP	MAD2L1 binding protein	0.014
ORC2	origin recognition complex, subunit 2	0.014
PSMA2	proteasome (prosome, macropain) subunit, alpha type, 2	0.014
EPM2A	epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)	0.014
DLGAP5	discs, large (Drosophila) homolog-associated protein 5	0.014
CD97	CD97 molecule	0.014
EML4	echinoderm microtubule associated protein like 4	0.014
LMNA	lamin A/C	0.014
LILRB1	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1	0.013
CENPJ	centromere protein J	0.013
PTK2	PTK2 protein tyrosine kinase 2	0.013
PDS5B	PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)	0.013
NSL1	NSL1, MIND kinetochore complex component, homolog (S. cerevisiae)	0.013
PSMB6	proteasome (prosome, macropain) subunit, beta type, 6	0.013
EHD1	EH-domain containing 1	0.013
ANAPC13	anaphase promoting complex subunit 13	0.012
NDNL2	necdin-like 2	0.012
CEP55	centrosomal protein 55kDa	0.012
MASTL	microtubule associated serine/threonine kinase-like	0.012
EZR	ezrin	0.012	Fly
UBE2R2	ubiquitin-conjugating enzyme E2R 2	0.012
SHFM1	split hand/foot malformation (ectrodactyly) type 1	0.012
HIST1H2BB	histone cluster 1, H2bb	0.012
RHOG	ras homolog gene family, member G (rho G)	0.012
TUBGCP3	tubulin, gamma complex associated protein 3	0.012
HIST1H3F	histone cluster 1, H3f	0.011
PPP4C	protein phosphatase 4, catalytic subunit	0.011
ASF1A	ASF1 anti-silencing function 1 homolog A (S. cerevisiae)	0.011
UCHL5	ubiquitin carboxyl-terminal hydrolase L5	0.011
CCDC101	coiled-coil domain containing 101	0.011
CCNE2	cyclin E2	0.011	Fly
MAPRE1	microtubule-associated protein, RP/EB family, member 1	0.011
CDC45	cell division cycle 45 homolog (S. cerevisiae)	0.011
HIST1H3C	histone cluster 1, H3c	0.011	Yeast
MYO1C	myosin IC	0.011
ADAM17	ADAM metallopeptidase domain 17	0.011
CDCA3	cell division cycle associated 3	0.011
CDC25C	cell division cycle 25 homolog C (S. pombe)	0.011
PPP6R2	protein phosphatase 6, regulatory subunit 2	0.011
PSMA5	proteasome (prosome, macropain) subunit, alpha type, 5	0.011
PSMB1	proteasome (prosome, macropain) subunit, beta type, 1	0.011
MIS18BP1	MIS18 binding protein 1	0.011
MAGI3	membrane associated guanylate kinase, WW and PDZ domain containing 3	0.011
TERF2IP	telomeric repeat binding factor 2, interacting protein	0.011
LIN52	lin-52 homolog (C. elegans)	0.011
PSMB3	proteasome (prosome, macropain) subunit, beta type, 3	0.011
MAPRE3	microtubule-associated protein, RP/EB family, member 3	0.011
KDM5C	lysine (K)-specific demethylase 5C	0.011
HUWE1	HECT, UBA and WWE domain containing 1	0.010
SS18	synovial sarcoma translocation, chromosome 18	0.010
BAG2	BCL2-associated athanogene 2	0.010
PAXIP1	PAX interacting (with transcription-activation domain) protein 1	0.010
HIST1H2AB	histone cluster 1, H2ab	0.010
USP9X	ubiquitin specific peptidase 9, X-linked	0.010
FYN	FYN oncogene related to SRC, FGR, YES	0.010
KIF5B	kinesin family member 5B	0.010
SLC39A7	solute carrier family 39 (zinc transporter), member 7	0.010
DNMT3B	DNA (cytosine-5-)-methyltransferase 3 beta	0.010
KDM4A	lysine (K)-specific demethylase 4A	0.010