IMP

Process View

Homo sapiens

31 genes annotated in human

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regulation of chemokine production

GO:0032642

Any process that modulates the frequency, rate, or extent of chemokine production.

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "regulation of chemokine production"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "regulation of chemokine production" (in gray)

Name	Description	Probability	Func Analog Organism
MYD88	myeloid differentiation primary response gene (88)	0.997	Mouse
IL1R1	interleukin 1 receptor, type I	0.997
C1QA	complement component 1, q subcomponent, A chain	0.973	Human
TIRAP	toll-interleukin 1 receptor (TIR) domain containing adaptor protein	0.957	Mouse
TLR4	toll-like receptor 4	0.904
ABI2	abl-interactor 2	0.617
VEGFA	vascular endothelial growth factor A	0.609
HDAC2	histone deacetylase 2	0.587
LATS2	LATS, large tumor suppressor, homolog 2 (Drosophila)	0.569
CASP1	caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)	0.527
IL6ST	interleukin 6 signal transducer (gp130, oncostatin M receptor)	0.396
C1QC	complement component 1, q subcomponent, C chain	0.395	Human
NRP1	neuropilin 1	0.356
TNFAIP3	tumor necrosis factor, alpha-induced protein 3	0.309
STAT6	signal transducer and activator of transcription 6, interleukin-4 induced	0.302
TICAM2	toll-like receptor adaptor molecule 2	0.277
IL4R	interleukin 4 receptor	0.260	Mouse
TNFRSF1B	tumor necrosis factor receptor superfamily, member 1B	0.236
ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	0.233
GATA1	GATA binding protein 1 (globin transcription factor 1)	0.230
TMEM173	transmembrane protein 173	0.228
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.222	Human
KDR	kinase insert domain receptor (a type III receptor tyrosine kinase)	0.222	Human
IL8	interleukin 8	0.220
BIRC3	baculoviral IAP repeat containing 3	0.212
PDGFB	platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)	0.209
MAD2L2	MAD2 mitotic arrest deficient-like 2 (yeast)	0.191
CXCL1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	0.177
GAB1	GRB2-associated binding protein 1	0.175
PDGFRB	platelet-derived growth factor receptor, beta polypeptide	0.173	Human
IL6	interleukin 6 (interferon, beta 2)	0.173
KLF6	Kruppel-like factor 6	0.170	Human
COTL1	coactosin-like 1 (Dictyostelium)	0.166
IL4	interleukin 4	0.161	Mouse
SNX9	sorting nexin 9	0.154
APOE	apolipoprotein E	0.150
IL1RAP	interleukin 1 receptor accessory protein	0.136
C1QB	complement component 1, q subcomponent, B chain	0.127	Human
RBBP4	retinoblastoma binding protein 4	0.121
PTPRB	protein tyrosine phosphatase, receptor type, B	0.121
NLRC4	NLR family, CARD domain containing 4	0.113
MEFV	Mediterranean fever	0.113
CXCL2	chemokine (C-X-C motif) ligand 2	0.112
GATA2	GATA binding protein 2	0.110
TCF3	transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)	0.103
FZD1	frizzled homolog 1 (Drosophila)	0.100
PGF	placental growth factor	0.096
DLG1	discs, large homolog 1 (Drosophila)	0.084
LDLR	low density lipoprotein receptor	0.084
LAT	linker for activation of T cells	0.083
TGM2	transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)	0.078
KLF4	Kruppel-like factor 4 (gut)	0.073
MAP3K2	mitogen-activated protein kinase kinase kinase 2	0.072
CTBP1	C-terminal binding protein 1	0.069
CFH	complement factor H	0.068
TAL1	T-cell acute lymphocytic leukemia 1	0.065	Human
IGFBP3	insulin-like growth factor binding protein 3	0.063
SH3D19	SH3 domain containing 19	0.055
DUSP1	dual specificity phosphatase 1	0.054
IL1R2	interleukin 1 receptor, type II	0.053
IRAK4	interleukin-1 receptor-associated kinase 4	0.052
CXCL3	chemokine (C-X-C motif) ligand 3	0.051
FCGR2B	Fc fragment of IgG, low affinity IIb, receptor (CD32)	0.050
CDH5	cadherin 5, type 2 (vascular endothelium)	0.049
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.048
CXCL6	chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)	0.048
JUN	jun proto-oncogene	0.048
ASRGL1	asparaginase like 1	0.047
PDGFA	platelet-derived growth factor alpha polypeptide	0.046
TLR2	toll-like receptor 2	0.046
EHMT2	euchromatic histone-lysine N-methyltransferase 2	0.043
IRAK2	interleukin-1 receptor-associated kinase 2	0.042
PDIA3	protein disulfide isomerase family A, member 3	0.042
TICAM1	toll-like receptor adaptor molecule 1	0.042	Mouse
IL6R	interleukin 6 receptor	0.041
HLA-DQA1	major histocompatibility complex, class II, DQ alpha 1	0.041
SOS1	son of sevenless homolog 1 (Drosophila)	0.041
KITLG	KIT ligand	0.039
CFI	complement factor I	0.039
STAB1	stabilin 1	0.038
FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	0.038	Human
PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	0.037
SERPINB2	serpin peptidase inhibitor, clade B (ovalbumin), member 2	0.037
IRF8	interferon regulatory factor 8	0.035
LY96	lymphocyte antigen 96	0.035
PIAS2	protein inhibitor of activated STAT, 2	0.035
IL2RG	interleukin 2 receptor, gamma	0.034
SNX33	sorting nexin 33	0.034
NLRP3	NLR family, pyrin domain containing 3	0.034
TXN	thioredoxin	0.033
PYCARD	PYD and CARD domain containing	0.033
NFKBIA	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.033
MAFA	v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)	0.033
SMURF1	SMAD specific E3 ubiquitin protein ligase 1	0.032
VSIG4	V-set and immunoglobulin domain containing 4	0.032
MPO	myeloperoxidase	0.032
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.030
PACSIN3	protein kinase C and casein kinase substrate in neurons 3	0.030
CCL20	chemokine (C-C motif) ligand 20	0.030
MTA1	metastasis associated 1	0.029
JAK1	Janus kinase 1	0.029
MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	0.028
ALOX12B	arachidonate 12-lipoxygenase, 12R type	0.028	Human
ASAP1	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	0.028
MAP2K4	mitogen-activated protein kinase kinase 4	0.028
CSF3	colony stimulating factor 3 (granulocyte)	0.027
CSF2RA	colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)	0.027
MTA2	metastasis associated 1 family, member 2	0.027
TGIF1	TGFB-induced factor homeobox 1	0.027
LMO2	LIM domain only 2 (rhombotin-like 1)	0.027
SERPINA1	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1	0.026
RCOR1	REST corepressor 1	0.026
CTSG	cathepsin G	0.026
SH3KBP1	SH3-domain kinase binding protein 1	0.025
JAG1	jagged 1	0.025
ALOXE3	arachidonate lipoxygenase 3	0.025	Human
NOD1	nucleotide-binding oligomerization domain containing 1	0.025
TRAF2	TNF receptor-associated factor 2	0.025
MPEG1	macrophage expressed 1	0.025
TLR1	toll-like receptor 1	0.024	Human
MSR1	macrophage scavenger receptor 1	0.024
MAP3K3	mitogen-activated protein kinase kinase kinase 3	0.023
CD40	CD40 molecule, TNF receptor superfamily member 5	0.023
IKBKE	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon	0.022
MAPK7	mitogen-activated protein kinase 7	0.022
HBQ1	hemoglobin, theta 1	0.022
TRADD	TNFRSF1A-associated via death domain	0.021
SIGLEC1	sialic acid binding Ig-like lectin 1, sialoadhesin	0.021
IRF5	interferon regulatory factor 5	0.021
AZU1	azurocidin 1	0.021
DICER1	dicer 1, ribonuclease type III	0.021
ZFP36	zinc finger protein 36, C3H type, homolog (mouse)	0.021
SAMHD1	SAM domain and HD domain 1	0.020
PI3	peptidase inhibitor 3, skin-derived	0.020
STC2	stanniocalcin 2	0.020
LY86	lymphocyte antigen 86	0.019
EGFR	epidermal growth factor receptor	0.019
SHC2	SHC (Src homology 2 domain containing) transforming protein 2	0.019
CTBP2	C-terminal binding protein 2	0.018
HIC1	hypermethylated in cancer 1	0.018
EMP1	epithelial membrane protein 1	0.018
RUNX1	runt-related transcription factor 1	0.018
LIF	leukemia inhibitory factor (cholinergic differentiation factor)	0.018
CHD4	chromodomain helicase DNA binding protein 4	0.018
PTPRJ	protein tyrosine phosphatase, receptor type, J	0.018
PPP1R15A	protein phosphatase 1, regulatory (inhibitor) subunit 15A	0.018
HLA-DMB	major histocompatibility complex, class II, DM beta	0.018
PRTN3	proteinase 3	0.018	Human
FOXC2	forkhead box C2 (MFH-1, mesenchyme forkhead 1)	0.018
MOV10	Mov10, Moloney leukemia virus 10, homolog (mouse)	0.018
ITGA2B	integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)	0.017
TRAF1	TNF receptor-associated factor 1	0.017
CCL8	chemokine (C-C motif) ligand 8	0.017
CH25H	cholesterol 25-hydroxylase	0.017
SLA	Src-like-adaptor	0.017
CSF1	colony stimulating factor 1 (macrophage)	0.017
XPNPEP1	X-prolyl aminopeptidase (aminopeptidase P) 1, soluble	0.017
FGFR1	fibroblast growth factor receptor 1	0.017
ZFPM1	zinc finger protein, multitype 1	0.017	Mouse
SPRR2A	small proline-rich protein 2A	0.017
ID1	inhibitor of DNA binding 1, dominant negative helix-loop-helix protein	0.017
ELK1	ELK1, member of ETS oncogene family	0.017
XPO7	exportin 7	0.017
MAPK1	mitogen-activated protein kinase 1	0.017
NOD2	nucleotide-binding oligomerization domain containing 2	0.016
SOX18	SRY (sex determining region Y)-box 18	0.016
TRAF7	TNF receptor-associated factor 7	0.016
CLEC5A	C-type lectin domain family 5, member A	0.016
ENO2	enolase 2 (gamma, neuronal)	0.016
C1S	complement component 1, s subcomponent	0.016
ALAS2	aminolevulinate, delta-, synthase 2	0.016
SH3RF3	SH3 domain containing ring finger 3	0.016
HEMGN	hemogen	0.015
MTA3	metastasis associated 1 family, member 3	0.015
CNR2	cannabinoid receptor 2 (macrophage)	0.015
IKZF1	IKAROS family zinc finger 1 (Ikaros)	0.015
KIT	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	0.015	Human
CD180	CD180 molecule	0.015	Human
CAMP	cathelicidin antimicrobial peptide	0.015
EPB42	erythrocyte membrane protein band 4.2	0.015
CCL11	chemokine (C-C motif) ligand 11	0.015
HIPK2	homeodomain interacting protein kinase 2	0.014
SAMD3	sterile alpha motif domain containing 3	0.014
DNM2	dynamin 2	0.014
TRPM2	transient receptor potential cation channel, subfamily M, member 2	0.014
CMIP	c-Maf-inducing protein	0.014
TLR3	toll-like receptor 3	0.014
RUNX2	runt-related transcription factor 2	0.014
C4B	complement component 4B (Chido blood group)	0.014
SH3PXD2A	SH3 and PX domains 2A	0.014
CFB	complement factor B	0.014
DCN	decorin	0.014
PTPN6	protein tyrosine phosphatase, non-receptor type 6	0.014
SERPINF1	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1	0.014
MS4A3	membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)	0.014
NRP2	neuropilin 2	0.013
TNFRSF1A	tumor necrosis factor receptor superfamily, member 1A	0.013
ELANE	elastase, neutrophil expressed	0.013
P2RY13	purinergic receptor P2Y, G-protein coupled, 13	0.013
DRD4	dopamine receptor D4	0.013
SLPI	secretory leukocyte peptidase inhibitor	0.013
GP1BA	glycoprotein Ib (platelet), alpha polypeptide	0.013
C1R	complement component 1, r subcomponent	0.013
FLT3	fms-related tyrosine kinase 3	0.013	Human
ROBO4	roundabout homolog 4, magic roundabout (Drosophila)	0.013
PIAS4	protein inhibitor of activated STAT, 4	0.013
RIPK1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.013
SLAMF8	SLAM family member 8	0.013
CCL7	chemokine (C-C motif) ligand 7	0.013
AVPR2	arginine vasopressin receptor 2	0.013
SOS2	son of sevenless homolog 2 (Drosophila)	0.013
LTF	lactotransferrin	0.013
TNFAIP6	tumor necrosis factor, alpha-induced protein 6	0.013
CIITA	class II, major histocompatibility complex, transactivator	0.013
FLT4	fms-related tyrosine kinase 4	0.013	Human
CYBB	cytochrome b-245, beta polypeptide	0.013
ALOX5AP	arachidonate 5-lipoxygenase-activating protein	0.013
CLEC7A	C-type lectin domain family 7, member A	0.013
NFE2	nuclear factor (erythroid-derived 2), 45kDa	0.013
CD14	CD14 molecule	0.013
IKBKG	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma	0.013
CCR2	chemokine (C-C motif) receptor 2	0.013
LEP	leptin	0.013
DHRS9	dehydrogenase/reductase (SDR family) member 9	0.013
WNT6	wingless-type MMTV integration site family, member 6	0.012
GNA15	guanine nucleotide binding protein (G protein), alpha 15 (Gq class)	0.012
HCK	hemopoietic cell kinase	0.012
CBFA2T3	core-binding factor, runt domain, alpha subunit 2; translocated to, 3	0.012
TLR5	toll-like receptor 5	0.012	Human
PF4	platelet factor 4	0.012
CFD	complement factor D (adipsin)	0.012
FTL	ferritin, light polypeptide	0.012
FPR1	formyl peptide receptor 1	0.012
CAV1	caveolin 1, caveolae protein, 22kDa	0.012
SMAD3	SMAD family member 3	0.012
IGSF6	immunoglobulin superfamily, member 6	0.012
DEFA4	defensin, alpha 4, corticostatin	0.012
THBS2	thrombospondin 2	0.012
PRKCQ	protein kinase C, theta	0.012
HOXD13	homeobox D13	0.012
ITCH	itchy E3 ubiquitin protein ligase homolog (mouse)	0.012
RHOB	ras homolog gene family, member B	0.012
SPOP	speckle-type POZ protein	0.012
C3	complement component 3	0.012	Human
FOSL2	FOS-like antigen 2	0.012
LCAT	lecithin-cholesterol acyltransferase	0.012
WISP1	WNT1 inducible signaling pathway protein 1	0.012
TLR7	toll-like receptor 7	0.012
CHI3L1	chitinase 3-like 1 (cartilage glycoprotein-39)	0.012	Human
RNASE3	ribonuclease, RNase A family, 3	0.012
RUNX1T1	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	0.012
EGR1	early growth response 1	0.012
CRHBP	corticotropin releasing hormone binding protein	0.012
VNN1	vanin 1	0.012
ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.012
LYL1	lymphoblastic leukemia derived sequence 1	0.012	Human
BST1	bone marrow stromal cell antigen 1	0.012
FGF3	fibroblast growth factor 3	0.011
FSTL3	follistatin-like 3 (secreted glycoprotein)	0.011
SIGLEC5	sialic acid binding Ig-like lectin 5	0.011
GGT5	gamma-glutamyltransferase 5	0.011
FPR3	formyl peptide receptor 3	0.011
C3AR1	complement component 3a receptor 1	0.011
CYP7B1	cytochrome P450, family 7, subfamily B, polypeptide 1	0.011
MMP12	matrix metallopeptidase 12 (macrophage elastase)	0.011
DHX58	DEXH (Asp-Glu-X-His) box polypeptide 58	0.011
DDX58	DEAD (Asp-Glu-Ala-Asp) box polypeptide 58	0.011
S1PR1	sphingosine-1-phosphate receptor 1	0.011
IRF4	interferon regulatory factor 4	0.011
ADCYAP1	adenylate cyclase activating polypeptide 1 (pituitary)	0.011
IL13	interleukin 13	0.011
ZBTB16	zinc finger and BTB domain containing 16	0.011
PLA2G7	phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)	0.011
UBE4A	ubiquitination factor E4A (UFD2 homolog, yeast)	0.011
ALOX15B	arachidonate 15-lipoxygenase, type B	0.011
IL7R	interleukin 7 receptor	0.011
CXCL5	chemokine (C-X-C motif) ligand 5	0.011	Mouse
SERPINA3	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3	0.011
WNT10B	wingless-type MMTV integration site family, member 10B	0.011
FOXE3	forkhead box E3	0.011
ZBTB25	zinc finger and BTB domain containing 25	0.011
GP6	glycoprotein VI (platelet)	0.011
SEPT8	septin 8	0.011
PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	0.011
ITGB3	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	0.011
THBD	thrombomodulin	0.011
KCNC1	potassium voltage-gated channel, Shaw-related subfamily, member 1	0.011
SOD2	superoxide dismutase 2, mitochondrial	0.011
RHAG	Rh-associated glycoprotein	0.011
ADORA3	adenosine A3 receptor	0.011
HRH1	histamine receptor H1	0.011
PROCR	protein C receptor, endothelial	0.011
IL3	interleukin 3 (colony-stimulating factor, multiple)	0.011
ADAP2	ArfGAP with dual PH domains 2	0.011
C5AR1	complement component 5a receptor 1	0.010
FTH1	ferritin, heavy polypeptide 1	0.010
OLFML2B	olfactomedin-like 2B	0.010
INHBA	inhibin, beta A	0.010
ARG1	arginase, liver	0.010
CD300C	CD300c molecule	0.010
ID3	inhibitor of DNA binding 3, dominant negative helix-loop-helix protein	0.010
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.010
CRKL	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.010
MARCH5	membrane-associated ring finger (C3HC4) 5	0.010
RARRES1	retinoic acid receptor responder (tazarotene induced) 1	0.010
F13A1	coagulation factor XIII, A1 polypeptide	0.010
EDN1	endothelin 1	0.010
TRAF3	TNF receptor-associated factor 3	0.010
S100A12	S100 calcium binding protein A12	0.010
LTC4S	leukotriene C4 synthase	0.010
MMP19	matrix metallopeptidase 19	0.010
IL9	interleukin 9	0.010
GATA4	GATA binding protein 4	0.010