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Homo sapiens

35 genes annotated in human

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negative regulation of protein binding

GO:0032091

Any process that stops, prevents, or reduces the frequency, rate or extent of protein binding.

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of protein binding"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of protein binding" (in gray)

Name	Description	Probability	Func Analog Organism
ITGB1	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	0.996
FHL2	four and a half LIM domains 2	0.954
BCL2L1	BCL2-like 1	0.923	Human
C1QA	complement component 1, q subcomponent, A chain	0.792	Human
IFIT1	interferon-induced protein with tetratricopeptide repeats 1	0.698
BCL2	B-cell CLL/lymphoma 2	0.577	Human
ARRB1	arrestin, beta 1	0.522	Human
CAV1	caveolin 1, caveolae protein, 22kDa	0.422
ESR1	estrogen receptor 1	0.350
JUP	junction plakoglobin	0.350
IFIT3	interferon-induced protein with tetratricopeptide repeats 3	0.346	Human
HDAC1	histone deacetylase 1	0.317
GGA2	golgi-associated, gamma adaptin ear containing, ARF binding protein 2	0.315
FN1	fibronectin 1	0.305
IFIT5	interferon-induced protein with tetratricopeptide repeats 5	0.277	Human
CCL4	chemokine (C-C motif) ligand 4	0.262	Human
CCR5	chemokine (C-C motif) receptor 5	0.260
ENG	endoglin	0.259
PXN	paxillin	0.228
IFIT2	interferon-induced protein with tetratricopeptide repeats 2	0.214
AXIN1	axin 1	0.206
ABI2	abl-interactor 2	0.200
AR	androgen receptor	0.193
MPDZ	multiple PDZ domain protein	0.190
ATF2	activating transcription factor 2	0.171
PSEN1	presenilin 1	0.166
PTEN	phosphatase and tensin homolog	0.165
MAP2K4	mitogen-activated protein kinase kinase 4	0.160
BAX	BCL2-associated X protein	0.136
CCL18	chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)	0.129	Human
FLNA	filamin A, alpha	0.128
PDIA3	protein disulfide isomerase family A, member 3	0.126
C1QC	complement component 1, q subcomponent, C chain	0.105	Human
SNTA1	syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component)	0.101
BAK1	BCL2-antagonist/killer 1	0.098	Human
BCL2L11	BCL2-like 11 (apoptosis facilitator)	0.096
CXCL1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	0.096
INCENP	inner centromere protein antigens 135/155kDa	0.094
DLG1	discs, large homolog 1 (Drosophila)	0.094
VCAM1	vascular cell adhesion molecule 1	0.087
SMARCC2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2	0.083
CSNK1E	casein kinase 1, epsilon	0.076
MCL1	myeloid cell leukemia sequence 1 (BCL2-related)	0.073	Human
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.073
SOD1	superoxide dismutase 1, soluble	0.065
BTBD2	BTB (POZ) domain containing 2	0.065
FLNB	filamin B, beta	0.064
PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	0.064
CCL2	chemokine (C-C motif) ligand 2	0.063	Human
CCL8	chemokine (C-C motif) ligand 8	0.061	Human
BID	BH3 interacting domain death agonist	0.061
PSEN2	presenilin 2 (Alzheimer disease 4)	0.058	Mouse
SIGLEC1	sialic acid binding Ig-like lectin 1, sialoadhesin	0.053
C1QB	complement component 1, q subcomponent, B chain	0.052	Human
TP53	tumor protein p53	0.051
SMARCD1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1	0.049
CCR7	chemokine (C-C motif) receptor 7	0.048
FAF1	Fas (TNFRSF6) associated factor 1	0.048
CBX1	chromobox homolog 1	0.047
DVL3	dishevelled, dsh homolog 3 (Drosophila)	0.047	Human
FEZ1	fasciculation and elongation protein zeta 1 (zygin I)	0.043
DPP4	dipeptidyl-peptidase 4	0.042
CXCL9	chemokine (C-X-C motif) ligand 9	0.042
SMARCA4	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	0.041
SLC9A3R1	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1	0.041
NCOR2	nuclear receptor corepressor 2	0.040
ARID1A	AT rich interactive domain 1A (SWI-like)	0.040
DAPK1	death-associated protein kinase 1	0.040
CCL3	chemokine (C-C motif) ligand 3	0.039	Human
CCL13	chemokine (C-C motif) ligand 13	0.038	Human
DNM1	dynamin 1	0.037
MAP2K6	mitogen-activated protein kinase kinase 6	0.037
ICAM1	intercellular adhesion molecule 1	0.036
ITGA3	integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)	0.036	Human
PEX5	peroxisomal biogenesis factor 5	0.036
PTPRC	protein tyrosine phosphatase, receptor type, C	0.036
CDH1	cadherin 1, type 1, E-cadherin (epithelial)	0.035
CCL5	chemokine (C-C motif) ligand 5	0.034	Human
SNX33	sorting nexin 33	0.034
FHL3	four and a half LIM domains 3	0.034
RNR2	l-rRNA	0.033
DVL1	dishevelled, dsh homolog 1 (Drosophila)	0.033
TP53BP2	tumor protein p53 binding protein, 2	0.033
ZNF512B	zinc finger protein 512B	0.031
FKBP8	FK506 binding protein 8, 38kDa	0.031
BAD	BCL2-associated agonist of cell death	0.031
CHD4	chromodomain helicase DNA binding protein 4	0.031
MAPK14	mitogen-activated protein kinase 14	0.031	Human
ITGB2	integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)	0.030
MAPK10	mitogen-activated protein kinase 10	0.030	Human
YY1	YY1 transcription factor	0.029
BECN1	beclin 1, autophagy related	0.029
IDE	insulin-degrading enzyme	0.029
PMAIP1	phorbol-12-myristate-13-acetate-induced protein 1	0.029
ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	0.029
MOV10	Mov10, Moloney leukemia virus 10, homolog (mouse)	0.028
ISG15	ISG15 ubiquitin-like modifier	0.028
SMARCC1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1	0.028
SOCS3	suppressor of cytokine signaling 3	0.028
ARRB2	arrestin, beta 2	0.028
SYNRG	synergin, gamma	0.027
SH3D19	SH3 domain containing 19	0.026
RHOXF2	Rhox homeobox family, member 2	0.025
LRRK2	leucine-rich repeat kinase 2	0.025
HIC1	hypermethylated in cancer 1	0.025
MAGI3	membrane associated guanylate kinase, WW and PDZ domain containing 3	0.025
SMARCB1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1	0.024
IL1B	interleukin 1, beta	0.024
ADAM9	ADAM metallopeptidase domain 9	0.024
ITGB5	integrin, beta 5	0.024
NCOR1	nuclear receptor corepressor 1	0.024
DCTN1	dynactin 1	0.024
TMC8	transmembrane channel-like 8	0.023
APP	amyloid beta (A4) precursor protein	0.023
SORT1	sortilin 1	0.023	Human
CXCL10	chemokine (C-X-C motif) ligand 10	0.022
CAV2	caveolin 2	0.022	Human
CPNE6	copine VI (neuronal)	0.022
PEX13	peroxisomal biogenesis factor 13	0.021
APOE	apolipoprotein E	0.021
ZNF219	zinc finger protein 219	0.021
MAPK8	mitogen-activated protein kinase 8	0.021
NME2	non-metastatic cells 2, protein (NM23B) expressed in	0.021
SPDEF	SAM pointed domain containing ets transcription factor	0.021
F2R	coagulation factor II (thrombin) receptor	0.021
IGFBP3	insulin-like growth factor binding protein 3	0.021
CCL11	chemokine (C-C motif) ligand 11	0.020	Human
SLAMF8	SLAM family member 8	0.020
PTPRF	protein tyrosine phosphatase, receptor type, F	0.020
MAPT	microtubule-associated protein tau	0.020
SSTR3	somatostatin receptor 3	0.020
CCL22	chemokine (C-C motif) ligand 22	0.020	Human
FAM190B	family with sequence similarity 190, member B	0.020
MMP12	matrix metallopeptidase 12 (macrophage elastase)	0.020
IFNG	interferon, gamma	0.019
IL8	interleukin 8	0.019
ITGA2B	integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)	0.019
SKIL	SKI-like oncogene	0.019
C4orf14	chromosome 4 open reading frame 14	0.019
CRIM1	cysteine rich transmembrane BMP regulator 1 (chordin-like)	0.019
MAP2K2	mitogen-activated protein kinase kinase 2	0.019
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.019
CD63	CD63 molecule	0.019
CXCL13	chemokine (C-X-C motif) ligand 13	0.019
MAPK9	mitogen-activated protein kinase 9	0.018	Human
AKT2	v-akt murine thymoma viral oncogene homolog 2	0.018
SORL1	sortilin-related receptor, L(DLR class) A repeats containing	0.018
SH3PXD2A	SH3 and PX domains 2A	0.018
PACSIN3	protein kinase C and casein kinase substrate in neurons 3	0.018
QKI	quaking homolog, KH domain RNA binding (mouse)	0.017
PLEKHA1	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1	0.017
CDKN2A	cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)	0.017
IL6	interleukin 6 (interferon, beta 2)	0.017
MTA1	metastasis associated 1	0.017
ITGA7	integrin, alpha 7	0.017	Human
RUVBL1	RuvB-like 1 (E. coli)	0.017
CBX5	chromobox homolog 5	0.017
OR2AG1	olfactory receptor, family 2, subfamily AG, member 1	0.016
WASL	Wiskott-Aldrich syndrome-like	0.016
FPR3	formyl peptide receptor 3	0.016
MAP3K1	mitogen-activated protein kinase kinase kinase 1	0.016
EPS8	epidermal growth factor receptor pathway substrate 8	0.016
UBE2I	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	0.016
EIF2AK2	eukaryotic translation initiation factor 2-alpha kinase 2	0.016
CCR1	chemokine (C-C motif) receptor 1	0.016
HSF1	heat shock transcription factor 1	0.016
MAPK8IP1	mitogen-activated protein kinase 8 interacting protein 1	0.016
BBC3	BCL2 binding component 3	0.016
MAP3K5	mitogen-activated protein kinase kinase kinase 5	0.016
PPP2R4	protein phosphatase 2A activator, regulatory subunit 4	0.016
PFN1	profilin 1	0.016
NUDT3	nudix (nucleoside diphosphate linked moiety X)-type motif 3	0.016
RNF144B	ring finger protein 144B	0.016
RUNX3	runt-related transcription factor 3	0.016
TMC6	transmembrane channel-like 6	0.016	Human
IL7R	interleukin 7 receptor	0.016
JAG1	jagged 1	0.016
RPL18A	ribosomal protein L18a	0.016
DHRS4	dehydrogenase/reductase (SDR family) member 4	0.015
GNAQ	guanine nucleotide binding protein (G protein), q polypeptide	0.015
CUL7	cullin 7	0.015
VDAC1	voltage-dependent anion channel 1	0.015
GATAD2B	GATA zinc finger domain containing 2B	0.015
THBS1	thrombospondin 1	0.015
CCL19	chemokine (C-C motif) ligand 19	0.015	Human
ID1	inhibitor of DNA binding 1, dominant negative helix-loop-helix protein	0.015
SHARPIN	SHANK-associated RH domain interactor	0.015
ATXN1	ataxin 1	0.015
SPG21	spastic paraplegia 21 (autosomal recessive, Mast syndrome)	0.015
IL10	interleukin 10	0.015
ARID2	AT rich interactive domain 2 (ARID, RFX-like)	0.015
BIK	BCL2-interacting killer (apoptosis-inducing)	0.015
AKT1	v-akt murine thymoma viral oncogene homolog 1	0.015
ARF6	ADP-ribosylation factor 6	0.015
RGS1	regulator of G-protein signaling 1	0.015
CXCL5	chemokine (C-X-C motif) ligand 5	0.015
LAMC1	laminin, gamma 1 (formerly LAMB2)	0.015
SELE	selectin E	0.014
BMP7	bone morphogenetic protein 7	0.014
PEX19	peroxisomal biogenesis factor 19	0.014
CD83	CD83 molecule	0.014
PRKCDBP	protein kinase C, delta binding protein	0.014
DBN1	drebrin 1	0.014
SPRR2A	small proline-rich protein 2A	0.014
FBLN1	fibulin 1	0.014
HSPB1	heat shock 27kDa protein 1	0.014
MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	0.014
MYO6	myosin VI	0.014
PBRM1	polybromo 1	0.014
PKN1	protein kinase N1	0.014
PLA2G7	phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)	0.014
FAS	Fas (TNF receptor superfamily, member 6)	0.014
TAB1	TGF-beta activated kinase 1/MAP3K7 binding protein 1	0.013
IGF2R	insulin-like growth factor 2 receptor	0.013
CEP164	centrosomal protein 164kDa	0.013
CCR3	chemokine (C-C motif) receptor 3	0.013
MAP4K4	mitogen-activated protein kinase kinase kinase kinase 4	0.013
DUSP1	dual specificity phosphatase 1	0.013
GLIS2	GLIS family zinc finger 2	0.013
TLN1	talin 1	0.013
ARRDC3	arrestin domain containing 3	0.013
ATF3	activating transcription factor 3	0.013
MMP1	matrix metallopeptidase 1 (interstitial collagenase)	0.013
ITGA6	integrin, alpha 6	0.013	Human
PI3	peptidase inhibitor 3, skin-derived	0.013
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.013
TRAP1	TNF receptor-associated protein 1	0.013
MAP1LC3B	microtubule-associated protein 1 light chain 3 beta	0.013
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.013
OBSL1	obscurin-like 1	0.012
WT1	Wilms tumor 1	0.012
WISP1	WNT1 inducible signaling pathway protein 1	0.012
CREBBP	CREB binding protein	0.012
PTPN2	protein tyrosine phosphatase, non-receptor type 2	0.012
CDC42	cell division cycle 42 (GTP binding protein, 25kDa)	0.012
CDK5RAP2	CDK5 regulatory subunit associated protein 2	0.012
CXCL3	chemokine (C-X-C motif) ligand 3	0.012
IGSF6	immunoglobulin superfamily, member 6	0.012
PEX16	peroxisomal biogenesis factor 16	0.012
CD80	CD80 molecule	0.012
MAD1L1	MAD1 mitotic arrest deficient-like 1 (yeast)	0.012
NOTCH1	notch 1	0.012
NME3	non-metastatic cells 3, protein expressed in	0.012
SEMA4D	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D	0.012
MSC	musculin	0.012
TCF4	transcription factor 4	0.012
ITGA5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	0.012	Human
WIPF1	WAS/WASL interacting protein family, member 1	0.012
APOC1	apolipoprotein C-I	0.012
TNF	tumor necrosis factor	0.012
PIN1	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	0.012
TNFRSF9	tumor necrosis factor receptor superfamily, member 9	0.012
LRP3	low density lipoprotein receptor-related protein 3	0.012
PRMT6	protein arginine methyltransferase 6	0.012
BMP3	bone morphogenetic protein 3	0.012
YAP1	Yes-associated protein 1	0.012
LRP6	low density lipoprotein receptor-related protein 6	0.011
TXNRD1	thioredoxin reductase 1	0.011
PLA2G2D	phospholipase A2, group IID	0.011
ACP5	acid phosphatase 5, tartrate resistant	0.011
CCBP2	chemokine binding protein 2	0.011
SLCO2B1	solute carrier organic anion transporter family, member 2B1	0.011
MAPK15	mitogen-activated protein kinase 15	0.011
CHD9	chromodomain helicase DNA binding protein 9	0.011
PTPRJ	protein tyrosine phosphatase, receptor type, J	0.011
MAPKAPK3	mitogen-activated protein kinase-activated protein kinase 3	0.011
ITGB1BP1	integrin beta 1 binding protein 1	0.011
SMAD4	SMAD family member 4	0.011
NKG7	natural killer cell group 7 sequence	0.011
ITGB4	integrin, beta 4	0.011
CH25H	cholesterol 25-hydroxylase	0.011
CIB1	calcium and integrin binding 1 (calmyrin)	0.011
ARL15	ADP-ribosylation factor-like 15	0.011
DUSP3	dual specificity phosphatase 3	0.011
CCL7	chemokine (C-C motif) ligand 7	0.011	Human
TNIK	TRAF2 and NCK interacting kinase	0.011
IL12B	interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)	0.011
IL2RB	interleukin 2 receptor, beta	0.011
ITGAL	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)	0.011	Human
PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	0.011
EBI3	Epstein-Barr virus induced 3	0.011
PEX12	peroxisomal biogenesis factor 12	0.011
RABEP1	rabaptin, RAB GTPase binding effector protein 1	0.010
IL1A	interleukin 1, alpha	0.010
NCSTN	nicastrin	0.010
CD9	CD9 molecule	0.010
ACTL6A	actin-like 6A	0.010
PGR	progesterone receptor	0.010
NECAP2	NECAP endocytosis associated 2	0.010
CXCL2	chemokine (C-X-C motif) ligand 2	0.010
SLC1A2	solute carrier family 1 (glial high affinity glutamate transporter), member 2	0.010
ADCYAP1	adenylate cyclase activating polypeptide 1 (pituitary)	0.010
NRP2	neuropilin 2	0.010
PTPRN	protein tyrosine phosphatase, receptor type, N	0.010
NME1	non-metastatic cells 1, protein (NM23A) expressed in	0.010
C5AR1	complement component 5a receptor 1	0.010
IRF8	interferon regulatory factor 8	0.010
GNMT	glycine N-methyltransferase	0.010
IFIT1B	interferon-induced protein with tetratricopeptide repeats 1B	0.010	Human
KIAA1377	KIAA1377	0.010
DHX30	DEAH (Asp-Glu-Ala-His) box polypeptide 30	0.010
HUWE1	HECT, UBA and WWE domain containing 1	0.010
EMD	emerin	0.010
FAM134A	family with sequence similarity 134, member A	0.010
LYAR	Ly1 antibody reactive homolog (mouse)	0.010
TM7SF4	transmembrane 7 superfamily member 4	0.010
NAF1	nuclear assembly factor 1 homolog (S. cerevisiae)	0.010
TUBB2A	tubulin, beta 2A	0.010
UBR1	ubiquitin protein ligase E3 component n-recognin 1	0.010
STC2	stanniocalcin 2	0.010
MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	0.010