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Homo sapiens

32 genes annotated in human

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negative regulation of neuron death

GO:1901215

Any process that stops, prevents or reduces the frequency, rate or extent of neuron death.

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of neuron death"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of neuron death" (in gray)

Name	Description	Probability	Func Analog Organism
BCL2	B-cell CLL/lymphoma 2	0.884
VEGFA	vascular endothelial growth factor A	0.833	Human Mouse Rat
SRC	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	0.802
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.535
EGFR	epidermal growth factor receptor	0.515
EP300	E1A binding protein p300	0.466
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.425
ESR1	estrogen receptor 1	0.407	Rat
PDGFRB	platelet-derived growth factor receptor, beta polypeptide	0.302
SMN1	survival of motor neuron 1, telomeric	0.249
FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	0.229
RPL18A	ribosomal protein L18a	0.219
BCL2L11	BCL2-like 11 (apoptosis facilitator)	0.200
INSR	insulin receptor	0.175
CAV1	caveolin 1, caveolae protein, 22kDa	0.172
IL8	interleukin 8	0.170
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.163
BCL2L1	BCL2-like 1	0.160	Human Mouse
NBN	nibrin	0.159
STAT5A	signal transducer and activator of transcription 5A	0.157
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.151
NRP1	neuropilin 1	0.144	Mouse
MAPT	microtubule-associated protein tau	0.140
LAT	linker for activation of T cells	0.139
CRKL	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.126
CCR5	chemokine (C-C motif) receptor 5	0.110
XRCC6	X-ray repair complementing defective repair in Chinese hamster cells 6	0.104
TRIB3	tribbles homolog 3 (Drosophila)	0.097
SOCS3	suppressor of cytokine signaling 3	0.094
RAF1	v-raf-1 murine leukemia viral oncogene homolog 1	0.094
SOS1	son of sevenless homolog 1 (Drosophila)	0.085
NCOR2	nuclear receptor corepressor 2	0.084
APP	amyloid beta (A4) precursor protein	0.083	Fly
HSP90AA1	heat shock protein 90kDa alpha (cytosolic), class A member 1	0.080
NTRK1	neurotrophic tyrosine kinase, receptor, type 1	0.079	Mouse Rat
PTPN23	protein tyrosine phosphatase, non-receptor type 23	0.078
APLF	aprataxin and PNKP like factor	0.075
VHL	von Hippel-Lindau tumor suppressor	0.075
NONO	non-POU domain containing, octamer-binding	0.074
STUB1	STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase	0.074
AGAP5	ArfGAP with GTPase domain, ankyrin repeat and PH domain 5	0.073	Human
HSPA8	heat shock 70kDa protein 8	0.072
ASNS	asparagine synthetase (glutamine-hydrolyzing)	0.071
RUNX1	runt-related transcription factor 1	0.069
CREBBP	CREB binding protein	0.068
FYN	FYN oncogene related to SRC, FGR, YES	0.067	Rat
NR4A1	nuclear receptor subfamily 4, group A, member 1	0.067
GH1	growth hormone 1	0.065	Rat
YWHAQ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide	0.064
CSH1	chorionic somatomammotropin hormone 1 (placental lactogen)	0.062	Rat
HSPA1B	heat shock 70kDa protein 1B	0.061
SMARCA2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	0.060
NOXA1	NADPH oxidase activator 1	0.060
AGAP7	ArfGAP with GTPase domain, ankyrin repeat and PH domain 7	0.059	Human
MAP2K1	mitogen-activated protein kinase kinase 1	0.058
GGA2	golgi-associated, gamma adaptin ear containing, ARF binding protein 2	0.054
GAS6	growth arrest-specific 6	0.054
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.053
PDCD6IP	programmed cell death 6 interacting protein	0.051
ARHGEF7	Rho guanine nucleotide exchange factor (GEF) 7	0.050
PRKCZ	protein kinase C, zeta	0.049	Human
JUN	jun proto-oncogene	0.048	Mouse
SUMO2	SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae)	0.047
PDZD11	PDZ domain containing 11	0.046
CCL18	chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)	0.046	Human
PPARG	peroxisome proliferator-activated receptor gamma	0.046
PPP5C	protein phosphatase 5, catalytic subunit	0.045	Rat
HSP90AB1	heat shock protein 90kDa alpha (cytosolic), class B member 1	0.044
IL6ST	interleukin 6 signal transducer (gp130, oncostatin M receptor)	0.044
BCOR	BCL6 corepressor	0.043
CCL8	chemokine (C-C motif) ligand 8	0.043	Human
NAMPT	nicotinamide phosphoribosyltransferase	0.042
DAB2	disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)	0.041
SFPQ	splicing factor proline/glutamine-rich	0.039	Human
HIPK2	homeodomain interacting protein kinase 2	0.039	Mouse
RPS6	ribosomal protein S6	0.039
APOC1	apolipoprotein C-I	0.038
NCF1	neutrophil cytosolic factor 1	0.037
HDAC4	histone deacetylase 4	0.037
PDGFB	platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)	0.036	Human
CCL4	chemokine (C-C motif) ligand 4	0.036	Human
SH3KBP1	SH3-domain kinase binding protein 1	0.036
A2M	alpha-2-macroglobulin	0.035
TSG101	tumor susceptibility gene 101	0.035
CSH2	chorionic somatomammotropin hormone 2	0.034	Rat
FOS	FBJ murine osteosarcoma viral oncogene homolog	0.034
SH3RF1	SH3 domain containing ring finger 1	0.034
GNL3	guanine nucleotide binding protein-like 3 (nucleolar)	0.033
PPID	peptidylprolyl isomerase D	0.032
PINK1	PTEN induced putative kinase 1	0.032
HIF1A	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	0.031
HNF4A	hepatocyte nuclear factor 4, alpha	0.031
CCL5	chemokine (C-C motif) ligand 5	0.031	Human Rat
ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.031
CXCL9	chemokine (C-X-C motif) ligand 9	0.029
EIF4A1	eukaryotic translation initiation factor 4A1	0.029
ATF3	activating transcription factor 3	0.029
CCL13	chemokine (C-C motif) ligand 13	0.029	Human
HP	haptoglobin	0.029
KDR	kinase insert domain receptor (a type III receptor tyrosine kinase)	0.028
NPM1	nucleophosmin (nucleolar phosphoprotein B23, numatrin)	0.028
BAD	BCL2-associated agonist of cell death	0.028
TGFB1	transforming growth factor, beta 1	0.028
SP1	Sp1 transcription factor	0.028
RHEB	Ras homolog enriched in brain	0.028
SQSTM1	sequestosome 1	0.027
SOD1	superoxide dismutase 1, soluble	0.027
NFKBIZ	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta	0.027
PLCG1	phospholipase C, gamma 1	0.027
DDIT3	DNA-damage-inducible transcript 3	0.026
TCEAL5	transcription elongation factor A (SII)-like 5	0.026
PTPRB	protein tyrosine phosphatase, receptor type, B	0.026
FBXO7	F-box protein 7	0.026
APLP1	amyloid beta (A4) precursor-like protein 1	0.026
SHC1	SHC (Src homology 2 domain containing) transforming protein 1	0.025
CEBPD	CCAAT/enhancer binding protein (C/EBP), delta	0.025
GIT2	G protein-coupled receptor kinase interacting ArfGAP 2	0.025	Human
SOCS2	suppressor of cytokine signaling 2	0.024
CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	0.024
PARK2	parkinson protein 2, E3 ubiquitin protein ligase (parkin)	0.024
PRKDC	protein kinase, DNA-activated, catalytic polypeptide	0.024
PAK1	p21 protein (Cdc42/Rac)-activated kinase 1	0.024
HDAC1	histone deacetylase 1	0.024	Rat
UBE2V1	ubiquitin-conjugating enzyme E2 variant 1	0.024
LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	0.024
PRDX1	peroxiredoxin 1	0.023
ESRRG	estrogen-related receptor gamma	0.023
PKM2	pyruvate kinase, muscle	0.023
MATK	megakaryocyte-associated tyrosine kinase	0.023
DCAF7	DDB1 and CUL4 associated factor 7	0.023
EPAS1	endothelial PAS domain protein 1	0.023	Human
JUNB	jun B proto-oncogene	0.023
PDCD6	programmed cell death 6	0.023
CCL2	chemokine (C-C motif) ligand 2	0.023
HIPK3	homeodomain interacting protein kinase 3	0.023
NR4A2	nuclear receptor subfamily 4, group A, member 2	0.023	Mouse
GABARAPL1	GABA(A) receptor-associated protein like 1	0.022
CSHL1	chorionic somatomammotropin hormone-like 1	0.022	Rat
CASP3	caspase 3, apoptosis-related cysteine peptidase	0.022
CDC37	cell division cycle 37 homolog (S. cerevisiae)	0.022
CRH	corticotropin releasing hormone	0.022
GH2	growth hormone 2	0.022	Rat
RPS3A	ribosomal protein S3A	0.021
MYLK2	myosin light chain kinase 2	0.021
ETS2	v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)	0.021
LPL	lipoprotein lipase	0.021
AKT1	v-akt murine thymoma viral oncogene homolog 1	0.021	Human
PDE4DIP	phosphodiesterase 4D interacting protein	0.021
RPLP2	ribosomal protein, large, P2	0.020
GRB2	growth factor receptor-bound protein 2	0.020
EGLN1	egl nine homolog 1 (C. elegans)	0.020
PEBP1	phosphatidylethanolamine binding protein 1	0.020
IDE	insulin-degrading enzyme	0.020
PARD6B	par-6 partitioning defective 6 homolog beta (C. elegans)	0.020
NGF	nerve growth factor (beta polypeptide)	0.019	Mouse
BAG3	BCL2-associated athanogene 3	0.019
RNR2	l-rRNA	0.019
RPS20	ribosomal protein S20	0.019
ATF4	activating transcription factor 4 (tax-responsive enhancer element B67)	0.019
INCENP	inner centromere protein antigens 135/155kDa	0.019
HSPE1	heat shock 10kDa protein 1 (chaperonin 10)	0.019
RPL5	ribosomal protein L5	0.019
ST13	suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)	0.019
HSPH1	heat shock 105kDa/110kDa protein 1	0.019
GAB1	GRB2-associated binding protein 1	0.019
XPO1	exportin 1 (CRM1 homolog, yeast)	0.019
DPP4	dipeptidyl-peptidase 4	0.018
PARD6A	par-6 partitioning defective 6 homolog alpha (C. elegans)	0.018
SH3GL2	SH3-domain GRB2-like 2	0.018
CRK	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.018
LRIF1	ligand dependent nuclear receptor interacting factor 1	0.017
IPO5	importin 5	0.017
CHD9	chromodomain helicase DNA binding protein 9	0.017
ITGB3	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	0.017
SKP1	S-phase kinase-associated protein 1	0.017
KPNB1	karyopherin (importin) beta 1	0.017
RPS2	ribosomal protein S2	0.017
NR4A3	nuclear receptor subfamily 4, group A, member 3	0.016	Mouse
WWOX	WW domain containing oxidoreductase	0.016
RPL36	ribosomal protein L36	0.016
RNF144B	ring finger protein 144B	0.016
MAP1LC3B	microtubule-associated protein 1 light chain 3 beta	0.016
PRDX2	peroxiredoxin 2	0.016	Rat
PGK1	phosphoglycerate kinase 1	0.016
CEBPG	CCAAT/enhancer binding protein (C/EBP), gamma	0.016
AURKB	aurora kinase B	0.016
TP53	tumor protein p53	0.016
JAK2	Janus kinase 2	0.016	Rat
TP53BP2	tumor protein p53 binding protein, 2	0.016
DRD2	dopamine receptor D2	0.016
PFN1	profilin 1	0.016
PRKCB	protein kinase C, beta	0.016
TUBB2B	tubulin, beta 2B	0.016
IL4R	interleukin 4 receptor	0.016
BECN1	beclin 1, autophagy related	0.016
LCAT	lecithin-cholesterol acyltransferase	0.015
ZNF146	zinc finger protein 146	0.015
SIAH1	seven in absentia homolog 1 (Drosophila)	0.015
PAK2	p21 protein (Cdc42/Rac)-activated kinase 2	0.015
KRAS	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	0.015	Mouse
PTGES3	prostaglandin E synthase 3 (cytosolic)	0.015
CHORDC1	cysteine and histidine-rich domain (CHORD) containing 1	0.015
SNCA	synuclein, alpha (non A4 component of amyloid precursor)	0.015	Mouse
NFKBIA	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.015
EIF3E	eukaryotic translation initiation factor 3, subunit E	0.015
PPA1	pyrophosphatase (inorganic) 1	0.015
NFIL3	nuclear factor, interleukin 3 regulated	0.015
DNAJB1	DnaJ (Hsp40) homolog, subfamily B, member 1	0.015
PPP1R9B	protein phosphatase 1, regulatory (inhibitor) subunit 9B	0.015
PRKCE	protein kinase C, epsilon	0.015
NTRK3	neurotrophic tyrosine kinase, receptor, type 3	0.015
UVRAG	UV radiation resistance associated gene	0.015
RBBP4	retinoblastoma binding protein 4	0.015
IL6	interleukin 6 (interferon, beta 2)	0.015
SLC6A3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	0.014
CBX5	chromobox homolog 5	0.014
PPP2R5C	protein phosphatase 2, regulatory subunit B', gamma	0.014
CCR4	chemokine (C-C motif) receptor 4	0.014
BTRC	beta-transducin repeat containing	0.014
CCR7	chemokine (C-C motif) receptor 7	0.014
PRDX4	peroxiredoxin 4	0.014
EXT1	exostosin 1	0.014
CCL14	chemokine (C-C motif) ligand 14	0.014	Human
YWHAB	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	0.014
C1QA	complement component 1, q subcomponent, A chain	0.014
NAP1L1	nucleosome assembly protein 1-like 1	0.014
MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	0.014
CXCL10	chemokine (C-X-C motif) ligand 10	0.014
H2AFX	H2A histone family, member X	0.014
FGFR1	fibroblast growth factor receptor 1	0.014
SOCS5	suppressor of cytokine signaling 5	0.014
SYK	spleen tyrosine kinase	0.014
GABBR2	gamma-aminobutyric acid (GABA) B receptor, 2	0.014
SNCAIP	synuclein, alpha interacting protein	0.014
SESN2	sestrin 2	0.014
ZFP36	zinc finger protein 36, C3H type, homolog (mouse)	0.014
CNOT8	CCR4-NOT transcription complex, subunit 8	0.014
ARAF	v-raf murine sarcoma 3611 viral oncogene homolog	0.014
HNRNPA1	heterogeneous nuclear ribonucleoprotein A1	0.014
IPO7	importin 7	0.013	Fly
ARNT	aryl hydrocarbon receptor nuclear translocator	0.013
UBE2I	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	0.013
EGR1	early growth response 1	0.013
SORT1	sortilin 1	0.013
YY1	YY1 transcription factor	0.013
XRCC5	X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)	0.013
YWHAZ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.013
AKT2	v-akt murine thymoma viral oncogene homolog 2	0.013	Human
BAG1	BCL2-associated athanogene	0.013	Mouse
MARS	methionyl-tRNA synthetase	0.013
BTG1	B-cell translocation gene 1, anti-proliferative	0.013
CRYAB	crystallin, alpha B	0.013
CDCP1	CUB domain containing protein 1	0.013
CACNA1G	calcium channel, voltage-dependent, T type, alpha 1G subunit	0.013
CAPRIN1	cell cycle associated protein 1	0.013
IRS1	insulin receptor substrate 1	0.013
SKI	v-ski sarcoma viral oncogene homolog (avian)	0.013
CD83	CD83 molecule	0.013
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.013
ICA1	islet cell autoantigen 1, 69kDa	0.013
RGS2	regulator of G-protein signaling 2, 24kDa	0.013
KSR1	kinase suppressor of ras 1	0.012
NTF4	neurotrophin 4	0.012
CAV2	caveolin 2	0.012
CDK4	cyclin-dependent kinase 4	0.012
CCND1	cyclin D1	0.012
KLF4	Kruppel-like factor 4 (gut)	0.012
TGM2	transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)	0.012
CCL22	chemokine (C-C motif) ligand 22	0.012	Human
KHDRBS1	KH domain containing, RNA binding, signal transduction associated 1	0.012
DDX21	DEAD (Asp-Glu-Ala-Asp) box polypeptide 21	0.012
FOSB	FBJ murine osteosarcoma viral oncogene homolog B	0.012
PRKCA	protein kinase C, alpha	0.012
DYRK1A	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A	0.012
TCP1	t-complex 1	0.012
CCND3	cyclin D3	0.012
BIRC2	baculoviral IAP repeat containing 2	0.012
RASSF5	Ras association (RalGDS/AF-6) domain family member 5	0.012
C14orf43	chromosome 14 open reading frame 43	0.012
RIN1	Ras and Rab interactor 1	0.012
CASP9	caspase 9, apoptosis-related cysteine peptidase	0.012
CNOT7	CCR4-NOT transcription complex, subunit 7	0.012
ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	0.012
LPHN1	latrophilin 1	0.012
APBB1	amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)	0.012
APC	adenomatous polyposis coli	0.012
SFN	stratifin	0.012
DLC1	deleted in liver cancer 1	0.012
PDPK1	3-phosphoinositide dependent protein kinase-1	0.012
ND1	NADH dehydrogenase, subunit 1 (complex I)	0.012
ABI1	abl-interactor 1	0.012
PXN	paxillin	0.011
HMGA1	high mobility group AT-hook 1	0.011
SCAMP1	secretory carrier membrane protein 1	0.011
EIF2C3	eukaryotic translation initiation factor 2C, 3	0.011
EIF1AX	eukaryotic translation initiation factor 1A, X-linked	0.011
TBL1XR1	transducin (beta)-like 1 X-linked receptor 1	0.011
PGF	placental growth factor	0.011	Human
RGS1	regulator of G-protein signaling 1	0.011
CXCL2	chemokine (C-X-C motif) ligand 2	0.011
MAP3K5	mitogen-activated protein kinase kinase kinase 5	0.011
SYNRG	synergin, gamma	0.011
DAPK1	death-associated protein kinase 1	0.011
CTSL1	cathepsin L1	0.011
CSF1	colony stimulating factor 1 (macrophage)	0.011
PTEN	phosphatase and tensin homolog	0.011
TRIM9	tripartite motif containing 9	0.011
PEBP4	phosphatidylethanolamine-binding protein 4	0.011
CDK5R1	cyclin-dependent kinase 5, regulatory subunit 1 (p35)	0.011
HSPA4	heat shock 70kDa protein 4	0.011
MAP2	microtubule-associated protein 2	0.011
TRIB1	tribbles homolog 1 (Drosophila)	0.011
DDB1	damage-specific DNA binding protein 1, 127kDa	0.011
TSC22D1	TSC22 domain family, member 1	0.011
CCL11	chemokine (C-C motif) ligand 11	0.011	Human
DDIT4	DNA-damage-inducible transcript 4	0.010
GEM	GTP binding protein overexpressed in skeletal muscle	0.010
FYB	FYN binding protein	0.010
BCL6	B-cell CLL/lymphoma 6	0.010
TNFRSF1A	tumor necrosis factor receptor superfamily, member 1A	0.010
ARHGAP22	Rho GTPase activating protein 22	0.010
PDGFA	platelet-derived growth factor alpha polypeptide	0.010	Human
NOS1	nitric oxide synthase 1 (neuronal)	0.010
CMIP	c-Maf-inducing protein	0.010
DNAJB6	DnaJ (Hsp40) homolog, subfamily B, member 6	0.010
CD320	CD320 molecule	0.010
APAF1	apoptotic peptidase activating factor 1	0.010
FUS	fused in sarcoma	0.010
VDAC1	voltage-dependent anion channel 1	0.010
GFI1B	growth factor independent 1B transcription repressor	0.010
PDGFC	platelet derived growth factor C	0.010
CBX1	chromobox homolog 1	0.010
CNOT6L	CCR4-NOT transcription complex, subunit 6-like	0.010
CXCL13	chemokine (C-X-C motif) ligand 13	0.010