IMP

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Homo sapiens

41 genes annotated in human

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macromolecule deacylation

GO:0098732

The removal of an acyl group, any group or radical of the form RCO- where R is an organic group, from a macromolecule.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "macromolecule deacylation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "macromolecule deacylation" (in gray)

Name	Description	Probability	Func Analog Organism
HDAC1	histone deacetylase 1	1.000
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.997
HDAC2	histone deacetylase 2	0.995
NCOR2	nuclear receptor corepressor 2	0.914
DHX30	DEAH (Asp-Glu-Ala-His) box polypeptide 30	0.891
KDM1A	lysine (K)-specific demethylase 1A	0.789
TGIF1	TGFB-induced factor homeobox 1	0.760
RBBP4	retinoblastoma binding protein 4	0.663
SNTA1	syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component)	0.607
ATF2	activating transcription factor 2	0.554
FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	0.499
HIPK2	homeodomain interacting protein kinase 2	0.468
IRF2BP1	interferon regulatory factor 2 binding protein 1	0.442
TP53	tumor protein p53	0.397	Mouse
NRP1	neuropilin 1	0.369
RB1	retinoblastoma 1	0.363
MRFAP1	Morf4 family associated protein 1	0.351
CHD4	chromodomain helicase DNA binding protein 4	0.229
MAPK14	mitogen-activated protein kinase 14	0.226	Human
MAP2K4	mitogen-activated protein kinase kinase 4	0.223
ENG	endoglin	0.211
SMARCE1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1	0.202
HDAC9	histone deacetylase 9	0.194
BRMS1	breast cancer metastasis suppressor 1	0.185
HDAC4	histone deacetylase 4	0.181
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.172
BCL6	B-cell CLL/lymphoma 6	0.169	Mouse
MTA3	metastasis associated 1 family, member 3	0.164
HDAC6	histone deacetylase 6	0.154
SUDS3	suppressor of defective silencing 3 homolog (S. cerevisiae)	0.143
JUN	jun proto-oncogene	0.139
TBL1XR1	transducin (beta)-like 1 X-linked receptor 1	0.132	Fly
RCOR1	REST corepressor 1	0.116
CDC14B	CDC14 cell division cycle 14 homolog B (S. cerevisiae)	0.114
CDC5L	CDC5 cell division cycle 5-like (S. pombe)	0.108
CREBBP	CREB binding protein	0.105	Human
LATS2	LATS, large tumor suppressor, homolog 2 (Drosophila)	0.105
MAP3K1	mitogen-activated protein kinase kinase kinase 1	0.101
MEF2C	myocyte enhancer factor 2C	0.094
ARRB1	arrestin, beta 1	0.092
CSNK1E	casein kinase 1, epsilon	0.092
EP300	E1A binding protein p300	0.087
NCOR1	nuclear receptor corepressor 1	0.086	Mouse
MTA1	metastasis associated 1	0.084
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.084
SMARCC1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1	0.083
CUX1	cut-like homeobox 1	0.083
YWHAE	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	0.080
IKZF3	IKAROS family zinc finger 3 (Aiolos)	0.076
RIPK1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.076
ADRBK1	adrenergic, beta, receptor kinase 1	0.075
RBBP7	retinoblastoma binding protein 7	0.068
C16orf70	chromosome 16 open reading frame 70	0.060
CEP70	centrosomal protein 70kDa	0.059
SMAD4	SMAD family member 4	0.056
ESR1	estrogen receptor 1	0.055
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.051
SIRT3	sirtuin 3	0.050
KAT2B	K(lysine) acetyltransferase 2B	0.049
FZR1	fizzy/cell division cycle 20 related 1 (Drosophila)	0.049
GATAD2A	GATA zinc finger domain containing 2A	0.048
SETD7	SET domain containing (lysine methyltransferase) 7	0.046
YWHAG	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	0.044
MDM4	Mdm4 p53 binding protein homolog (mouse)	0.043
KIAA0182	KIAA0182	0.043
CUL7	cullin 7	0.042
HDAC3	histone deacetylase 3	0.042
VIM	vimentin	0.041
SNAI1	snail homolog 1 (Drosophila)	0.041	Fly
HDAC7	histone deacetylase 7	0.040	Human Fly
GATAD2B	GATA zinc finger domain containing 2B	0.039
HCFC1	host cell factor C1 (VP16-accessory protein)	0.039
SIRT1	sirtuin 1	0.039
CPNE6	copine VI (neuronal)	0.038
PDGFRB	platelet-derived growth factor receptor, beta polypeptide	0.038
MPRIP	myosin phosphatase Rho interacting protein	0.037
PDGFA	platelet-derived growth factor alpha polypeptide	0.037	Human
PPP1R9B	protein phosphatase 1, regulatory (inhibitor) subunit 9B	0.035
MAPK8	mitogen-activated protein kinase 8	0.035
SAP30	Sin3A-associated protein, 30kDa	0.034
CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	0.032
NONO	non-POU domain containing, octamer-binding	0.031
DUSP1	dual specificity phosphatase 1	0.030
TSC22D1	TSC22 domain family, member 1	0.030
HES1	hairy and enhancer of split 1, (Drosophila)	0.030
PTPRB	protein tyrosine phosphatase, receptor type, B	0.030
MYST1	MYST histone acetyltransferase 1	0.030
DYRK1B	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B	0.030
BBS10	Bardet-Biedl syndrome 10	0.029
ARID2	AT rich interactive domain 2 (ARID, RFX-like)	0.029
CHD3	chromodomain helicase DNA binding protein 3	0.029
YY1	YY1 transcription factor	0.028
HDAC5	histone deacetylase 5	0.028
SIRT5	sirtuin 5	0.027
DCAF7	DDB1 and CUL4 associated factor 7	0.027
MED15	mediator complex subunit 15	0.027
GNAQ	guanine nucleotide binding protein (G protein), q polypeptide	0.026
BAZ2B	bromodomain adjacent to zinc finger domain, 2B	0.026
OGT	O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)	0.026
TRIM28	tripartite motif containing 28	0.026
MBD3	methyl-CpG binding domain protein 3	0.025
ETV6	ets variant 6	0.025
STAT3	signal transducer and activator of transcription 3 (acute-phase response factor)	0.025
NRIP1	nuclear receptor interacting protein 1	0.025
MECP2	methyl CpG binding protein 2 (Rett syndrome)	0.025
ZBTB16	zinc finger and BTB domain containing 16	0.025
BAZ1B	bromodomain adjacent to zinc finger domain, 1B	0.024
PHF12	PHD finger protein 12	0.024
NR4A1	nuclear receptor subfamily 4, group A, member 1	0.024
SOCS3	suppressor of cytokine signaling 3	0.024
AKAP9	A kinase (PRKA) anchor protein (yotiao) 9	0.024
JUB	jub, ajuba homolog (Xenopus laevis)	0.024
KDM2A	lysine (K)-specific demethylase 2A	0.024
CCDC101	coiled-coil domain containing 101	0.024
SIRT2	sirtuin 2	0.023
STAG2	stromal antigen 2	0.023
XPO7	exportin 7	0.022
EED	embryonic ectoderm development	0.022
MBD2	methyl-CpG binding domain protein 2	0.022
SAP30L	SAP30-like	0.022
ZNF217	zinc finger protein 217	0.022
HIC1	hypermethylated in cancer 1	0.022
PKN1	protein kinase N1	0.021
IRS2	insulin receptor substrate 2	0.021
UBE2I	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	0.021
LZTS2	leucine zipper, putative tumor suppressor 2	0.021
CNOT6	CCR4-NOT transcription complex, subunit 6	0.020
NFIX	nuclear factor I/X (CCAAT-binding transcription factor)	0.020
THRAP3	thyroid hormone receptor associated protein 3	0.020
THBS1	thrombospondin 1	0.020
PKN2	protein kinase N2	0.020
GABARAP	GABA(A) receptor-associated protein	0.020
BANP	BTG3 associated nuclear protein	0.019
RARA	retinoic acid receptor, alpha	0.019
WDR77	WD repeat domain 77	0.019
SSU72	SSU72 RNA polymerase II CTD phosphatase homolog (S. cerevisiae)	0.019
NR2E3	nuclear receptor subfamily 2, group E, member 3	0.019
TTC19	tetratricopeptide repeat domain 19	0.019
HNRNPM	heterogeneous nuclear ribonucleoprotein M	0.019
ZMYM3	zinc finger, MYM-type 3	0.019
MAPK3	mitogen-activated protein kinase 3	0.019
SGSM2	small G protein signaling modulator 2	0.019
SAP25	sin3A-binding protein 25	0.019
BCL11B	B-cell CLL/lymphoma 11B (zinc finger protein)	0.019
HDAC11	histone deacetylase 11	0.019
STAG1	stromal antigen 1	0.019
ARFGEF1	ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited)	0.018
HSPA1L	heat shock 70kDa protein 1-like	0.018
NINL	ninein-like	0.018
NUDT3	nudix (nucleoside diphosphate linked moiety X)-type motif 3	0.018
ZNF148	zinc finger protein 148	0.018
RRBP1	ribosome binding protein 1 homolog 180kDa (dog)	0.018
CYLD	cylindromatosis (turban tumor syndrome)	0.018
DICER1	dicer 1, ribonuclease type III	0.018
USP17	ubiquitin specific peptidase 17	0.017
MLL3	myeloid/lymphoid or mixed-lineage leukemia 3	0.017
MIER1	mesoderm induction early response 1 homolog (Xenopus laevis)	0.017
BRWD1	bromodomain and WD repeat domain containing 1	0.017
FAM118B	family with sequence similarity 118, member B	0.017
OSGEP	O-sialoglycoprotein endopeptidase	0.017
FOXP3	forkhead box P3	0.017
IKZF4	IKAROS family zinc finger 4 (Eos)	0.017
REST	RE1-silencing transcription factor	0.017
FAM117B	family with sequence similarity 117, member B	0.017
AHR	aryl hydrocarbon receptor	0.017
THAP11	THAP domain containing 11	0.017
USF2	upstream transcription factor 2, c-fos interacting	0.017
XPNPEP1	X-prolyl aminopeptidase (aminopeptidase P) 1, soluble	0.017
RPS6KB1	ribosomal protein S6 kinase, 70kDa, polypeptide 1	0.016
NCOA6	nuclear receptor coactivator 6	0.016
RSF1	remodeling and spacing factor 1	0.016
RBL2	retinoblastoma-like 2 (p130)	0.016
SIRT4	sirtuin 4	0.016	Mouse
ATF3	activating transcription factor 3	0.016
TBL1X	transducin (beta)-like 1X-linked	0.016	Fly
MAPKAPK3	mitogen-activated protein kinase-activated protein kinase 3	0.016
ARRB2	arrestin, beta 2	0.016
SMARCA5	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5	0.016
SFN	stratifin	0.016
PHF21A	PHD finger protein 21A	0.016
CDK17	cyclin-dependent kinase 17	0.016
MRFAP1L1	Morf4 family associated protein 1-like 1	0.016
GORASP1	golgi reassembly stacking protein 1, 65kDa	0.016
FSTL1	follistatin-like 1	0.016
LDLR	low density lipoprotein receptor	0.016
DIP2A	DIP2 disco-interacting protein 2 homolog A (Drosophila)	0.015
DNMT3A	DNA (cytosine-5-)-methyltransferase 3 alpha	0.015
KIF1C	kinesin family member 1C	0.015
UBR5	ubiquitin protein ligase E3 component n-recognin 5	0.015
CDK6	cyclin-dependent kinase 6	0.015
VEZF1	vascular endothelial zinc finger 1	0.015
SFPQ	splicing factor proline/glutamine-rich	0.015	Mouse
OBSL1	obscurin-like 1	0.015
ZMYM2	zinc finger, MYM-type 2	0.015
TP53BP2	tumor protein p53 binding protein, 2	0.015
PRKACA	protein kinase, cAMP-dependent, catalytic, alpha	0.015
C14orf43	chromosome 14 open reading frame 43	0.015
HNRNPA0	heterogeneous nuclear ribonucleoprotein A0	0.015
TLE1	transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)	0.015
SPRY4	sprouty homolog 4 (Drosophila)	0.015
UHRF2	ubiquitin-like with PHD and ring finger domains 2	0.015
MSL2	male-specific lethal 2 homolog (Drosophila)	0.015
PCDH9	protocadherin 9	0.014
SNF8	SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae)	0.014
RREB1	ras responsive element binding protein 1	0.014
FOXO3	forkhead box O3	0.014
CCND1	cyclin D1	0.014
RUNX2	runt-related transcription factor 2	0.014
FOXO1	forkhead box O1	0.014
SOX13	SRY (sex determining region Y)-box 13	0.014
SRRM2	serine/arginine repetitive matrix 2	0.014
CTTN	cortactin	0.014
SAMD3	sterile alpha motif domain containing 3	0.014
TUBA1A	tubulin, alpha 1a	0.014
GAK	cyclin G associated kinase	0.014
KDM5B	lysine (K)-specific demethylase 5B	0.014
PELP1	proline, glutamate and leucine rich protein 1	0.014
TGFBR1	transforming growth factor, beta receptor 1	0.014
MAPK15	mitogen-activated protein kinase 15	0.013
MAP3K2	mitogen-activated protein kinase kinase kinase 2	0.013
BHLHE40	basic helix-loop-helix family, member e40	0.013
KAT5	K(lysine) acetyltransferase 5	0.013
SP3	Sp3 transcription factor	0.013
NR3C1	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	0.013
SMARCA2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	0.013
EML3	echinoderm microtubule associated protein like 3	0.013
ZFPM1	zinc finger protein, multitype 1	0.013
KAT2A	K(lysine) acetyltransferase 2A	0.013
NFATC1	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1	0.013
RABEP1	rabaptin, RAB GTPase binding effector protein 1	0.013
CUL9	cullin 9	0.013
CDYL	chromodomain protein, Y-like	0.013
GOLGA7	golgin A7	0.013
ALDH2	aldehyde dehydrogenase 2 family (mitochondrial)	0.013
MAPK1	mitogen-activated protein kinase 1	0.013
PRKCA	protein kinase C, alpha	0.013
LOXL4	lysyl oxidase-like 4	0.013
DNTTIP1	deoxynucleotidyltransferase, terminal, interacting protein 1	0.013
MUL1	mitochondrial E3 ubiquitin protein ligase 1	0.013
SMARCA4	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	0.013
EPC2	enhancer of polycomb homolog 2 (Drosophila)	0.013
SPIN1	spindlin 1	0.013
USF1	upstream transcription factor 1	0.013
RAB3GAP2	RAB3 GTPase activating protein subunit 2 (non-catalytic)	0.013
AKAP8L	A kinase (PRKA) anchor protein 8-like	0.013
POLR3D	polymerase (RNA) III (DNA directed) polypeptide D, 44kDa	0.013
TYK2	tyrosine kinase 2	0.013
ACACA	acetyl-CoA carboxylase alpha	0.012
RYK	RYK receptor-like tyrosine kinase	0.012
DDIT4	DNA-damage-inducible transcript 4	0.012
RCOR2	REST corepressor 2	0.012	Human
SYVN1	synovial apoptosis inhibitor 1, synoviolin	0.012
FAM20C	family with sequence similarity 20, member C	0.012
YBX2	Y box binding protein 2	0.012
STX19	syntaxin 19	0.012
CDK2AP1	cyclin-dependent kinase 2 associated protein 1	0.012
BAZ1A	bromodomain adjacent to zinc finger domain, 1A	0.012
TARBP2	TAR (HIV-1) RNA binding protein 2	0.012
NXF1	nuclear RNA export factor 1	0.012
ZC3H11A	zinc finger CCCH-type containing 11A	0.012
HHIP	hedgehog interacting protein	0.012
ELF5	E74-like factor 5 (ets domain transcription factor)	0.012
FBXO11	F-box protein 11	0.012
RFX7	regulatory factor X, 7	0.012
H2AFY	H2A histone family, member Y	0.012
MLL5	myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila)	0.012
KDR	kinase insert domain receptor (a type III receptor tyrosine kinase)	0.012
CMYA5	cardiomyopathy associated 5	0.012
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.012
DYRK1A	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A	0.012	Mouse
MAGEA2	melanoma antigen family A, 2	0.012
NCOA2	nuclear receptor coactivator 2	0.011
CSNK2A1	casein kinase 2, alpha 1 polypeptide	0.011
DNAJB2	DnaJ (Hsp40) homolog, subfamily B, member 2	0.011
MT2A	metallothionein 2A	0.011
INTS6	integrator complex subunit 6	0.011
REV3L	REV3-like, catalytic subunit of DNA polymerase zeta (yeast)	0.011
RYBP	RING1 and YY1 binding protein	0.011
DNAJB6	DnaJ (Hsp40) homolog, subfamily B, member 6	0.011
SP1	Sp1 transcription factor	0.011
BBX	bobby sox homolog (Drosophila)	0.011
CPT1A	carnitine palmitoyltransferase 1A (liver)	0.011
CRY2	cryptochrome 2 (photolyase-like)	0.011
MLL	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)	0.011
C7orf36	chromosome 7 open reading frame 36	0.011
PUM2	pumilio homolog 2 (Drosophila)	0.011
EHMT1	euchromatic histone-lysine N-methyltransferase 1	0.011
TPR	translocated promoter region (to activated MET oncogene)	0.011
SMAD7	SMAD family member 7	0.011
NFYA	nuclear transcription factor Y, alpha	0.011
GFI1	growth factor independent 1 transcription repressor	0.011
MAP2K7	mitogen-activated protein kinase kinase 7	0.011
APPL1	adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1	0.011
EGLN1	egl nine homolog 1 (C. elegans)	0.011
LMBR1L	limb region 1 homolog (mouse)-like	0.011
PRR14	proline rich 14	0.011
INPP5E	inositol polyphosphate-5-phosphatase, 72 kDa	0.011
RICTOR	RPTOR independent companion of MTOR, complex 2	0.011
EHMT2	euchromatic histone-lysine N-methyltransferase 2	0.011
STC1	stanniocalcin 1	0.011
CRK	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.011
PRIC285	peroxisomal proliferator-activated receptor A interacting complex 285	0.011
ING2	inhibitor of growth family, member 2	0.011
PURA	purine-rich element binding protein A	0.011
BDH1	3-hydroxybutyrate dehydrogenase, type 1	0.011
MED23	mediator complex subunit 23	0.011
MAK	male germ cell-associated kinase	0.010
ETS1	v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)	0.010
ADNP	activity-dependent neuroprotector homeobox	0.010
DUSP4	dual specificity phosphatase 4	0.010
EPC1	enhancer of polycomb homolog 1 (Drosophila)	0.010
HSF1	heat shock transcription factor 1	0.010
CCNG1	cyclin G1	0.010
AR	androgen receptor	0.010
SUMO2	SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae)	0.010
NPIP	nuclear pore complex interacting protein	0.010
PLRG1	pleiotropic regulator 1 (PRL1 homolog, Arabidopsis)	0.010
E2F3	E2F transcription factor 3	0.010
AMMECR1L	AMME chromosomal region gene 1-like	0.010
MYO1D	myosin ID	0.010
HIST2H2AB	histone cluster 2, H2ab	0.010
ETV5	ets variant 5	0.010
SMAD3	SMAD family member 3	0.010
FUS	fused in sarcoma	0.010
TPM3	tropomyosin 3	0.010
CHD1	chromodomain helicase DNA binding protein 1	0.010
RAF1	v-raf-1 murine leukemia viral oncogene homolog 1	0.010
SS18	synovial sarcoma translocation, chromosome 18	0.010
USP26	ubiquitin specific peptidase 26	0.010
MLL4	myeloid/lymphoid or mixed-lineage leukemia 4	0.010