IMP

Process View

Mus musculus

15 genes annotated in mouse

cellular response to drug

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "cellular response to drug"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "cellular response to drug" (in gray)

Name	Description	Probability	Func Analog Organism
Pten	phosphatase and tensin homolog	0.997
Kras	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	0.893
Apc	adenomatosis polyposis coli	0.846
Ptgs2	prostaglandin-endoperoxide synthase 2	0.824
Lepr	leptin receptor	0.810
Gstm1	glutathione S-transferase, mu 1	0.793
Klra9	killer cell lectin-like receptor subfamily A, member 9	0.764
C1qc	complement component 1, q subcomponent, C chain	0.739	Mouse
Mdm2	transformed mouse 3T3 cell double minute 2	0.546
Nr3c1	nuclear receptor subfamily 3, group C, member 1	0.487
Nf1	neurofibromatosis 1	0.352
Gzma	granzyme A	0.344
Vhl	von Hippel-Lindau tumor suppressor	0.294
Esr1	estrogen receptor 1 (alpha)	0.285
Ar	androgen receptor	0.266
Rb1	retinoblastoma 1	0.262
Ncr1	natural cytotoxicity triggering receptor 1	0.249
Gzmk	granzyme K	0.214
Ctnnb1	catenin (cadherin associated protein), beta 1	0.184
Nos3	nitric oxide synthase 3, endothelial cell	0.170
Klrk1	killer cell lectin-like receptor subfamily K, member 1	0.170	Mouse
Dicer1	Dicer1, Dcr-1 homolog (Drosophila)	0.167
Ppp3r1	protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I)	0.160
Klrd1	killer cell lectin-like receptor, subfamily D, member 1	0.146	Mouse
Hdac4	histone deacetylase 4	0.137
Braf	Braf transforming gene	0.136
Hdac5	histone deacetylase 5	0.127
Klrc1	killer cell lectin-like receptor subfamily C, member 1	0.121	Mouse
Xcl1	chemokine (C motif) ligand 1	0.116
Col1a1	collagen, type I, alpha 1	0.112
Bcl2	B-cell leukemia/lymphoma 2	0.112
Pik3ca	phosphatidylinositol 3-kinase, catalytic, alpha polypeptide	0.107
Map3k5	mitogen-activated protein kinase kinase kinase 5	0.107
Tyrobp	TYRO protein tyrosine kinase binding protein	0.102
Mapk8	mitogen-activated protein kinase 8	0.098
Skil	SKI-like	0.097
Vdr	vitamin D receptor	0.092
Fgfr2	fibroblast growth factor receptor 2	0.090
Klrb1c	killer cell lectin-like receptor subfamily B member 1C	0.090
Notch1	Notch gene homolog 1 (Drosophila)	0.089
Ep300	E1A binding protein p300	0.086
Mdm4	transformed mouse 3T3 cell double minute 4	0.086
Rbpj	recombination signal binding protein for immunoglobulin kappa J region	0.085
Pnpla2	patatin-like phospholipase domain containing 2	0.084
Hprt	hypoxanthine guanine phosphoribosyl transferase	0.079
Il1a	interleukin 1 alpha	0.078
Drd2	dopamine receptor D2	0.078
Rock2	Rho-associated coiled-coil containing protein kinase 2	0.076
Runx1	runt related transcription factor 1	0.069
Slc6a3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	0.066
Klra7	killer cell lectin-like receptor, subfamily A, member 7	0.065	Mouse
Ace	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	0.064
Il6	interleukin 6	0.064
Atp2a2	ATPase, Ca++ transporting, cardiac muscle, slow twitch 2	0.063
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.062
Insr	insulin receptor	0.061
Lair1	leukocyte-associated Ig-like receptor 1	0.061
Notch2	Notch gene homolog 2 (Drosophila)	0.060
Klrb1b	killer cell lectin-like receptor subfamily B member 1B	0.059
Cav1	caveolin 1, caveolae protein	0.058
Max	Max protein	0.057
Fos	FBJ osteosarcoma oncogene	0.057
Gzmb	granzyme B	0.055
Smad3	MAD homolog 3 (Drosophila)	0.055
Ghr	growth hormone receptor	0.054
Klrg1	killer cell lectin-like receptor subfamily G, member 1	0.054	Mouse
Klra2	killer cell lectin-like receptor, subfamily A, member 2	0.053	Mouse
Lep	leptin	0.051
Agtr1a	angiotensin II receptor, type 1a	0.051
Pparg	peroxisome proliferator activated receptor gamma	0.049
Mecp2	methyl CpG binding protein 2	0.048
Mef2a	myocyte enhancer factor 2A	0.048	Mouse
Cdkn1b	cyclin-dependent kinase inhibitor 1B	0.048
H2-Eb1	histocompatibility 2, class II antigen E beta	0.047
Npc1	Niemann Pick type C1	0.045
Gstm2	glutathione S-transferase, mu 2	0.045	Mouse
Errfi1	ERBB receptor feedback inhibitor 1	0.043
Slc12a1	solute carrier family 12, member 1	0.042
Pax6	paired box gene 6	0.041	Rat
Foxa2	forkhead box A2	0.040
C1qa	complement component 1, q subcomponent, alpha polypeptide	0.039	Mouse
Gnas	GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus	0.039
Thra	thyroid hormone receptor alpha	0.039
Grxcr1	glutaredoxin, cysteine rich 1	0.039
Trp53	transformation related protein 53	0.038	Human
Gstm6	glutathione S-transferase, mu 6	0.038	Mouse
Huwe1	HECT, UBA and WWE domain containing 1	0.037
Cbl	Casitas B-lineage lymphoma	0.037
Hoxa10	homeobox A10	0.036
Tlr4	toll-like receptor 4	0.035
Qk	quaking	0.035
Casp4	caspase 4, apoptosis-related cysteine peptidase	0.035
Smad4	MAD homolog 4 (Drosophila)	0.035
Kl	klotho	0.034
Fasl	Fas ligand (TNF superfamily, member 6)	0.034
Trp73	transformation related protein 73	0.034
Pgr	progesterone receptor	0.034
Kiss1	KiSS-1 metastasis-suppressor	0.034
Dusp1	dual specificity phosphatase 1	0.034
Tlr2	toll-like receptor 2	0.034
Rxra	retinoid X receptor alpha	0.033
Cdkn1a	cyclin-dependent kinase inhibitor 1A (P21)	0.033
En2	engrailed 2	0.032
Cnr1	cannabinoid receptor 1 (brain)	0.032
Il18rap	interleukin 18 receptor accessory protein	0.032
Fpr1	formyl peptide receptor 1	0.032
Foxo1	forkhead box O1	0.031
Il10	interleukin 10	0.031
Jun	Jun oncogene	0.031
Klra5	killer cell lectin-like receptor, subfamily A, member 5	0.030	Mouse
Htt	huntingtin	0.030
Zeb1	zinc finger E-box binding homeobox 1	0.030
Pkd1	polycystic kidney disease 1 homolog	0.029
Cxcl9	chemokine (C-X-C motif) ligand 9	0.029
Cyr61	cysteine rich protein 61	0.029
Cxcl2	chemokine (C-X-C motif) ligand 2	0.029
Tgfb1	transforming growth factor, beta 1	0.029
Pax2	paired box gene 2	0.028
Mapk14	mitogen-activated protein kinase 14	0.028
Hsd17b3	hydroxysteroid (17-beta) dehydrogenase 3	0.027
Nkg7	natural killer cell group 7 sequence	0.027
Tcte1	t-complex-associated testis expressed 1	0.027
Ctsw	cathepsin W	0.027
Kiss1r	KISS1 receptor	0.027
Cdkn2a	cyclin-dependent kinase inhibitor 2A	0.027
Apoe	apolipoprotein E	0.026
Junb	Jun-B oncogene	0.026
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.026
Nr4a1	nuclear receptor subfamily 4, group A, member 1	0.026
Thrb	thyroid hormone receptor beta	0.026
Clec4n	C-type lectin domain family 4, member n	0.025
Nfe2l2	nuclear factor, erythroid derived 2, like 2	0.025
Cd7	CD7 antigen	0.025
Lyz2	lysozyme 2	0.025
Emx1	empty spiracles homolog 1 (Drosophila)	0.024
Egr2	early growth response 2	0.024
Plaur	plasminogen activator, urokinase receptor	0.024
Hivep2	human immunodeficiency virus type I enhancer binding protein 2	0.023
Gnao1	guanine nucleotide binding protein, alpha O	0.023
Gnrh1	gonadotropin releasing hormone 1	0.023
Mpeg1	macrophage expressed gene 1	0.023
Amhr2	anti-Mullerian hormone type 2 receptor	0.023
Nos1	nitric oxide synthase 1, neuronal	0.022
Pias1	protein inhibitor of activated STAT 1	0.022
Bhlhe40	basic helix-loop-helix family, member e40	0.022
Ncoa1	nuclear receptor coactivator 1	0.022
Agt	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	0.021
Map4k2	mitogen-activated protein kinase kinase kinase kinase 2	0.021
Crebbp	CREB binding protein	0.021
Klra3	killer cell lectin-like receptor, subfamily A, member 3	0.021	Mouse
Pilrb1	paired immunoglobin-like type 2 receptor beta 1	0.020
Klrb1f	killer cell lectin-like receptor subfamily B member 1F	0.020
Cd180	CD180 antigen	0.020
Kcna2	potassium voltage-gated channel, shaker-related subfamily, member 2	0.020
Lhx9	LIM homeobox protein 9	0.020
Flt3	FMS-like tyrosine kinase 3	0.020
Emr4	EGF-like module containing, mucin-like, hormone receptor-like sequence 4	0.020
Klhl24	kelch-like 24 (Drosophila)	0.020
Tnfsf10	tumor necrosis factor (ligand) superfamily, member 10	0.020
Cxcr6	chemokine (C-X-C motif) receptor 6	0.020
C3ar1	complement component 3a receptor 1	0.020
Smarcd1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1	0.020
Emr1	EGF-like module containing, mucin-like, hormone receptor-like sequence 1	0.020
Cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.019
Mitf	microphthalmia-associated transcription factor	0.019
Hif1a	hypoxia inducible factor 1, alpha subunit	0.019	Rat
Nos2	nitric oxide synthase 2, inducible	0.019
Clec7a	C-type lectin domain family 7, member a	0.019	Mouse
Carm1	coactivator-associated arginine methyltransferase 1	0.018
Stat3	signal transducer and activator of transcription 3	0.018
Myod1	myogenic differentiation 1	0.018
Eomes	eomesodermin homolog (Xenopus laevis)	0.018
Icos	inducible T-cell co-stimulator	0.018
Fcgr4	Fc receptor, IgG, low affinity IV	0.017
Lgr4	leucine-rich repeat-containing G protein-coupled receptor 4	0.017
P2ry13	purinergic receptor P2Y, G-protein coupled 13	0.017
Atp2b2	ATPase, Ca++ transporting, plasma membrane 2	0.017
Egr1	early growth response 1	0.017	Rat
Ly86	lymphocyte antigen 86	0.017
Il18r1	interleukin 18 receptor 1	0.017
Myl2	myosin, light polypeptide 2, regulatory, cardiac, slow	0.017
Slamf7	SLAM family member 7	0.017
Sox2	SRY-box containing gene 2	0.017
Kcnd3	potassium voltage-gated channel, Shal-related family, member 3	0.017
C1qb	complement component 1, q subcomponent, beta polypeptide	0.017	Mouse
Ifng	interferon gamma	0.017
Ubl3	ubiquitin-like 3	0.016
Spam1	sperm adhesion molecule 1	0.016
Celf2	CUGBP, Elav-like family member 2	0.016
Csf2	colony stimulating factor 2 (granulocyte-macrophage)	0.016
Gjd2	gap junction protein, delta 2	0.016
Tert	telomerase reverse transcriptase	0.016
Atxn1	ataxin 1	0.016
Irs2	insulin receptor substrate 2	0.016
Cebpa	CCAAT/enhancer binding protein (C/EBP), alpha	0.015
Ulk2	Unc-51 like kinase 2 (C. elegans)	0.015
Dlg1	discs, large homolog 1 (Drosophila)	0.015
Fcrla	Fc receptor-like A	0.015
Nr0b1	nuclear receptor subfamily 0, group B, member 1	0.015
Sema5b	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B	0.015
Ppp3ca	protein phosphatase 3, catalytic subunit, alpha isoform	0.015	Human
Glis2	GLIS family zinc finger 2	0.015
Nr3c2	nuclear receptor subfamily 3, group C, member 2	0.015
Jph3	junctophilin 3	0.015
Vegfa	vascular endothelial growth factor A	0.015
Synj2	synaptojanin 2	0.015
Tnrc6c	trinucleotide repeat containing 6C	0.015
Ccl12	chemokine (C-C motif) ligand 12	0.015
Prdx1	peroxiredoxin 1	0.015
Cma1	chymase 1, mast cell	0.014
Nr5a1	nuclear receptor subfamily 5, group A, member 1	0.014
Star	steroidogenic acute regulatory protein	0.014
Spnb2	spectrin beta 2	0.014
Rbl2	retinoblastoma-like 2	0.014
Hdac7	histone deacetylase 7	0.014
Phf1	PHD finger protein 1	0.014
Rictor	RPTOR independent companion of MTOR, complex 2	0.014
Gsta3	glutathione S-transferase, alpha 3	0.014
Cd160	CD160 antigen	0.014
Dio3	deiodinase, iodothyronine type III	0.014
Cd244	CD244 natural killer cell receptor 2B4	0.014
Ncoa3	nuclear receptor coactivator 3	0.014	Mouse
AF251705	cDNA sequence AF251705	0.014
Calb2	calbindin 2	0.014
Ahr	aryl-hydrocarbon receptor	0.014
Gpr33	G protein-coupled receptor 33	0.014
Pik3r1	phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)	0.013
Rora	RAR-related orphan receptor alpha	0.013
Gbp1	guanylate binding protein 1	0.013
Itm2b	integral membrane protein 2B	0.013
Fosl2	fos-like antigen 2	0.013
Nlrp3	NLR family, pyrin domain containing 3	0.013
Klrb1a	killer cell lectin-like receptor subfamily B member 1A	0.013
Cplx1	complexin 1	0.013
Ttn	titin	0.013
Syn1	synapsin I	0.013
Irg1	immunoresponsive gene 1	0.013
Klra6	killer cell lectin-like receptor, subfamily A, member 6	0.013	Mouse
Mybbp1a	MYB binding protein (P160) 1a	0.013
Kit	kit oncogene	0.013
Serpine1	serine (or cysteine) peptidase inhibitor, clade E, member 1	0.013	Rat
Gucy2e	guanylate cyclase 2e	0.013
Ndst1	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	0.013
Gstt1	glutathione S-transferase, theta 1	0.013
Fosb	FBJ osteosarcoma oncogene B	0.013
Raf1	v-raf-leukemia viral oncogene 1	0.013	Mouse
Aif1	allograft inflammatory factor 1	0.013
Apbb1	amyloid beta (A4) precursor protein-binding, family B, member 1	0.013
Gsk3b	glycogen synthase kinase 3 beta	0.013
Msr1	macrophage scavenger receptor 1	0.012
Clu	clusterin	0.012
Itgax	integrin alpha X	0.012
Ms4a6c	membrane-spanning 4-domains, subfamily A, member 6C	0.012
Kcnh2	potassium voltage-gated channel, subfamily H (eag-related), member 2	0.012	Human
C4b	complement component 4B (Childo blood group)	0.012
Cnot6l	CCR4-NOT transcription complex, subunit 6-like	0.012
Ubd	ubiquitin D	0.012
Ms4a1	membrane-spanning 4-domains, subfamily A, member 1	0.012
Zmynd11	zinc finger, MYND domain containing 11	0.012
Brca1	breast cancer 1	0.012
Aatk	apoptosis-associated tyrosine kinase	0.012
Arhgef2	rho/rac guanine nucleotide exchange factor (GEF) 2	0.012
Bex6	brain expressed gene 6	0.012
Gm11428	predicted gene 11428	0.012
Ppargc1a	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	0.012
Pick1	protein interacting with C kinase 1	0.012
Hrh2	histamine receptor H2	0.012
Ret	ret proto-oncogene	0.012
Sema4f	sema domain, immunoglobulin domain (Ig), TM domain, and short cytoplasmic domain	0.012
F2rl2	coagulation factor II (thrombin) receptor-like 2	0.012
Tnf	tumor necrosis factor	0.011
Ctss	cathepsin S	0.011
Srrm4	serine/arginine repetitive matrix 4	0.011
Ephx1	epoxide hydrolase 1, microsomal	0.011
C1ql1	complement component 1, q subcomponent-like 1	0.011	Mouse
Camk2b	calcium/calmodulin-dependent protein kinase II, beta	0.011
Akap5	A kinase (PRKA) anchor protein 5	0.011
Thbs1	thrombospondin 1	0.011
Lmna	lamin A	0.011
Tcf4	transcription factor 4	0.011
Eef1a2	eukaryotic translation elongation factor 1 alpha 2	0.011
Cxcr3	chemokine (C-X-C motif) receptor 3	0.011
Lrp1	low density lipoprotein receptor-related protein 1	0.011
Tyr	tyrosinase	0.011
Syt7	synaptotagmin VII	0.011
Gpatch2	G patch domain containing 2	0.011
Arnt	aryl hydrocarbon receptor nuclear translocator	0.011
Ranbp9	RAN binding protein 9	0.011
Sncb	synuclein, beta	0.011
Vnn3	vanin 3	0.011
Hr	hairless	0.011
Polr2a	polymerase (RNA) II (DNA directed) polypeptide A	0.010
Gstm3	glutathione S-transferase, mu 3	0.010
Gpr3	G-protein coupled receptor 3	0.010
Pilra	paired immunoglobin-like type 2 receptor alpha	0.010
Myc	myelocytomatosis oncogene	0.010
Fpr2	formyl peptide receptor 2	0.010
Yap1	yes-associated protein 1	0.010
Klre1	killer cell lectin-like receptor family E member 1	0.010	Mouse
Zfp36	zinc finger protein 36	0.010
Glrp1	glutamine repeat protein 1	0.010
Inca1	inhibitor of CDK, cyclin A1 interacting protein 1	0.010
Ier2	immediate early response 2	0.010
Serpinb9f	serine (or cysteine) peptidase inhibitor, clade B, member 9f	0.010
Chi3l3	chitinase 3-like 3	0.010
Gnaq	guanine nucleotide binding protein, alpha q polypeptide	0.010
Sav1	salvador homolog 1 (Drosophila)	0.010