IMP
Process View
dna catabolic process endonucleolytic
The chemical reactions and pathways resulting in the breakdown of DNA, involving the hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of deoxyribonucleotides.
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| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| Casp4 | caspase 4, apoptosis-related cysteine peptidase | 0.969 | Mouse | |
| Dffb | DNA fragmentation factor, beta subunit | 0.847 | ||
| Gbp5 | guanylate binding protein 5 | 0.831 | ||
| Pycard | PYD and CARD domain containing | 0.795 | ||
| Casp1 | caspase 1 | 0.705 | Mouse | |
| Aim2 | absent in melanoma 2 | 0.567 | ||
| Il18 | interleukin 18 | 0.360 | ||
| Rb1 | retinoblastoma 1 | 0.343 | ||
| Tlr4 | toll-like receptor 4 | 0.248 | ||
| Apaf1 | apoptotic peptidase activating factor 1 | 0.192 | ||
| Fadd | Fas (TNFRSF6)-associated via death domain | 0.168 | ||
| Bak1 | BCL2-antagonist/killer 1 | 0.137 | ||
| Brca1 | breast cancer 1 | 0.133 | ||
| Plin1 | perilipin 1 | 0.116 | ||
| Pms2 | postmeiotic segregation increased 2 (S. cerevisiae) | 0.089 | ||
| Prkab1 | protein kinase, AMP-activated, beta 1 non-catalytic subunit | 0.081 | ||
| Ints7 | integrator complex subunit 7 | 0.081 | ||
| Cox5a | cytochrome c oxidase, subunit Va | 0.079 | ||
| Uqcrb | ubiquinol-cytochrome c reductase binding protein | 0.077 | ||
| Wrn | Werner syndrome homolog (human) | 0.076 | ||
| Hells | helicase, lymphoid specific | 0.076 | ||
| Cidec | cell death-inducing DFFA-like effector c | 0.070 | Mouse | |
| Drosha | drosha, ribonuclease type III | 0.068 | ||
| Nlrp3 | NLR family, pyrin domain containing 3 | 0.066 | ||
| Mcm7 | minichromosome maintenance deficient 7 (S. cerevisiae) | 0.065 | ||
| Prkdc | protein kinase, DNA activated, catalytic polypeptide | 0.065 | ||
| Bid | BH3 interacting domain death agonist | 0.064 | ||
| Ndufab1 | NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1 | 0.063 | ||
| Uqcrc2 | ubiquinol cytochrome c reductase core protein 2 | 0.063 | ||
| Bub1 | budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae) | 0.063 | ||
| Ptpn11 | protein tyrosine phosphatase, non-receptor type 11 | 0.062 | ||
| Il1b | interleukin 1 beta | 0.061 | ||
| Tgfbr2 | transforming growth factor, beta receptor II | 0.056 | ||
| Hif1a | hypoxia inducible factor 1, alpha subunit | 0.055 | ||
| Bcl2l11 | BCL2-like 11 (apoptosis facilitator) | 0.053 | ||
| Alx1 | ALX homeobox 1 | 0.052 | ||
| Ripk3 | receptor-interacting serine-threonine kinase 3 | 0.051 | ||
| Mcm10 | minichromosome maintenance deficient 10 (S. cerevisiae) | 0.048 | ||
| Stk11 | serine/threonine kinase 11 | 0.047 | ||
| Mlh1 | mutL homolog 1 (E. coli) | 0.046 | ||
| Casp8 | caspase 8 | 0.046 | Mouse | |
| Eif2ak2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.045 | ||
| Rbl1 | retinoblastoma-like 1 (p107) | 0.043 | ||
| Ints9 | integrator complex subunit 9 | 0.041 | ||
| Idua | iduronidase, alpha-L- | 0.041 | ||
| Gcsh | glycine cleavage system protein H (aminomethyl carrier) | 0.041 | ||
| Plk4 | polo-like kinase 4 (Drosophila) | 0.039 | ||
| Xpa | xeroderma pigmentosum, complementation group A | 0.039 | ||
| Cidea | cell death-inducing DNA fragmentation factor, alpha subunit-like effector A | 0.037 | ||
| Fancd2 | Fanconi anemia, complementation group D2 | 0.035 | ||
| Prkag1 | protein kinase, AMP-activated, gamma 1 non-catalytic subunit | 0.033 | ||
| Plin4 | perilipin 4 | 0.033 | ||
| Mybl2 | myeloblastosis oncogene-like 2 | 0.033 | ||
| Vdac3 | voltage-dependent anion channel 3 | 0.032 | ||
| Pole2 | polymerase (DNA directed), epsilon 2 (p59 subunit) | 0.032 | ||
| Cfd | complement factor D (adipsin) | 0.031 | ||
| Casp3 | caspase 3 | 0.031 | ||
| Ndufa12 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 12 | 0.030 | ||
| Ndufa5 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5 | 0.030 | ||
| U2af1 | U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 1 | 0.029 | ||
| Srsf9 | serine/arginine-rich splicing factor 9 | 0.029 | ||
| Cbx7 | chromobox homolog 7 | 0.028 | ||
| Apobec1 | apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 | 0.028 | ||
| Mrpl13 | mitochondrial ribosomal protein L13 | 0.027 | ||
| Sod2 | superoxide dismutase 2, mitochondrial | 0.027 | ||
| Cdkn2c | cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) | 0.026 | ||
| Tmpo | thymopoietin | 0.026 | ||
| Hdac1 | histone deacetylase 1 | 0.025 | ||
| Trip13 | thyroid hormone receptor interactor 13 | 0.025 | ||
| Clic1 | chloride intracellular channel 1 | 0.025 | ||
| Prim2 | DNA primase, p58 subunit | 0.024 | ||
| Nudt1 | nudix (nucleoside diphosphate linked moiety X)-type motif 1 | 0.023 | ||
| Casp7 | caspase 7 | 0.023 | Mouse | |
| Dhfr | dihydrofolate reductase | 0.023 | ||
| Commd4 | COMM domain containing 4 | 0.023 | ||
| Adig | adipogenin | 0.023 | ||
| Mtbp | Mdm2, transformed 3T3 cell double minute p53 binding protein | 0.022 | ||
| Taf3 | TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor | 0.022 | ||
| Atr | ataxia telangiectasia and Rad3 related | 0.022 | ||
| Cycs | cytochrome c, somatic | 0.022 | Human | |
| Pola1 | polymerase (DNA directed), alpha 1 | 0.022 | ||
| Safb | scaffold attachment factor B | 0.022 | ||
| Orc1 | origin recognition complex, subunit 1 | 0.022 | ||
| Fancm | Fanconi anemia, complementation group M | 0.022 | ||
| Mastl | microtubule associated serine/threonine kinase-like | 0.021 | ||
| Atp5f1 | ATP synthase, H+ transporting, mitochondrial F0 complex, subunit B1 | 0.021 | ||
| Wdhd1 | WD repeat and HMG-box DNA binding protein 1 | 0.021 | ||
| Mcm8 | minichromosome maintenance deficient 8 (S. cerevisiae) | 0.021 | ||
| Ppara | peroxisome proliferator activated receptor alpha | 0.021 | ||
| Dtl | denticleless homolog (Drosophila) | 0.020 | ||
| Chek2 | CHK2 checkpoint homolog (S. pombe) | 0.020 | ||
| Xrcc6 | X-ray repair complementing defective repair in Chinese hamster cells 6 | 0.020 | ||
| Cops7b | COP9 (constitutive photomorphogenic) homolog, subunit 7b (Arabidopsis thaliana) | 0.020 | ||
| Mms22l | MMS22-like, DNA repair protein | 0.020 | ||
| Mre11a | meiotic recombination 11 homolog A (S. cerevisiae) | 0.020 | Yeast | |
| Prdx1 | peroxiredoxin 1 | 0.020 | ||
| Hhat | hedgehog acyltransferase | 0.020 | ||
| Gfm1 | G elongation factor, mitochondrial 1 | 0.019 | ||
| Rad54l | RAD54 like (S. cerevisiae) | 0.019 | Yeast | |
| Nthl1 | nth (endonuclease III)-like 1 (E.coli) | 0.019 | ||
| Rttn | rotatin | 0.019 | ||
| Prmt1 | protein arginine N-methyltransferase 1 | 0.019 | ||
| Khk | ketohexokinase | 0.019 | ||
| Ndufs1 | NADH dehydrogenase (ubiquinone) Fe-S protein 1 | 0.018 | ||
| Sucla2 | succinate-Coenzyme A ligase, ADP-forming, beta subunit | 0.018 | ||
| 1110038F14Rik | RIKEN cDNA 1110038F14 gene | 0.018 | ||
| Pgm1 | phosphoglucomutase 1 | 0.018 | ||
| Kif11 | kinesin family member 11 | 0.018 | ||
| Igh | immunoglobulin heavy chain complex | 0.018 | ||
| Fam136a | family with sequence similarity 136, member A | 0.018 | ||
| Armc10 | armadillo repeat containing 10 | 0.018 | ||
| Blm | Bloom syndrome, RecQ helicase-like | 0.017 | ||
| Pqlc3 | PQ loop repeat containing | 0.017 | ||
| Fam54a | family with sequence similarity 54, member A | 0.017 | ||
| Huwe1 | HECT, UBA and WWE domain containing 1 | 0.017 | ||
| Efemp2 | epidermal growth factor-containing fibulin-like extracellular matrix protein 2 | 0.017 | ||
| Hibch | 3-hydroxyisobutyryl-Coenzyme A hydrolase | 0.017 | ||
| Terf1 | telomeric repeat binding factor 1 | 0.017 | ||
| Parp2 | poly (ADP-ribose) polymerase family, member 2 | 0.017 | ||
| Fabp4 | fatty acid binding protein 4, adipocyte | 0.017 | ||
| Flt3l | FMS-like tyrosine kinase 3 ligand | 0.017 | ||
| Azi1 | 5-azacytidine induced gene 1 | 0.017 | ||
| Ccne1 | cyclin E1 | 0.017 | ||
| Plac8 | placenta-specific 8 | 0.017 | ||
| Fh1 | fumarate hydratase 1 | 0.017 | ||
| Tpmt | thiopurine methyltransferase | 0.016 | ||
| Mdh1 | malate dehydrogenase 1, NAD (soluble) | 0.016 | ||
| Eme1 | essential meiotic endonuclease 1 homolog 1 (S. pombe) | 0.016 | ||
| Cdca7l | cell division cycle associated 7 like | 0.016 | ||
| Sae1 | SUMO1 activating enzyme subunit 1 | 0.016 | ||
| Smc2 | structural maintenance of chromosomes 2 | 0.016 | ||
| Lyst | lysosomal trafficking regulator | 0.016 | ||
| Casc5 | cancer susceptibility candidate 5 | 0.016 | ||
| Ndufaf4 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 4 | 0.016 | ||
| 1500001M20Rik | RIKEN cDNA 1500001M20 gene | 0.016 | ||
| Adam10 | a disintegrin and metallopeptidase domain 10 | 0.016 | ||
| Psma5 | proteasome (prosome, macropain) subunit, alpha type 5 | 0.015 | ||
| Mobkl1b | MOB1, Mps One Binder kinase activator-like 1B (yeast) | 0.015 | ||
| Impa2 | inositol (myo)-1(or 4)-monophosphatase 2 | 0.015 | ||
| Nmi | N-myc (and STAT) interactor | 0.015 | ||
| Ccnb1ip1 | cyclin B1 interacting protein 1 | 0.015 | ||
| Lrr1 | leucine rich repeat protein 1 | 0.015 | ||
| E2f1 | E2F transcription factor 1 | 0.015 | ||
| Atp5g3 | ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C3 (subunit 9) | 0.014 | ||
| Fam73b | family with sequence similarity 73, member B | 0.014 | ||
| Fancb | Fanconi anemia, complementation group B | 0.014 | ||
| Mrpl35 | mitochondrial ribosomal protein L35 | 0.014 | ||
| Elavl1 | ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R) | 0.014 | ||
| Cxcl9 | chemokine (C-X-C motif) ligand 9 | 0.014 | ||
| Mr1 | major histocompatibility complex, class I-related | 0.014 | ||
| Psapl1 | prosaposin-like 1 | 0.014 | ||
| Rars2 | arginyl-tRNA synthetase 2, mitochondrial | 0.014 | ||
| Gpr172b | G protein-coupled receptor 172B | 0.014 | ||
| Sar1b | SAR1 gene homolog B (S. cerevisiae) | 0.014 | ||
| Birc3 | baculoviral IAP repeat-containing 3 | 0.014 | ||
| Dsn1 | DSN1, MIND kinetochore complex component, homolog (S. cerevisiae) | 0.014 | ||
| Zdhhc6 | zinc finger, DHHC domain containing 6 | 0.014 | ||
| Fbn1 | fibrillin 1 | 0.014 | ||
| Dlat | dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) | 0.013 | ||
| Sdhd | succinate dehydrogenase complex, subunit D, integral membrane protein | 0.013 | ||
| Cldn2 | claudin 2 | 0.013 | ||
| Zbtb12 | zinc finger and BTB domain containing 12 | 0.013 | ||
| Cpsf3 | cleavage and polyadenylation specificity factor 3 | 0.013 | ||
| Brip1 | BRCA1 interacting protein C-terminal helicase 1 | 0.013 | ||
| Olfr90 | olfactory receptor 90 | 0.013 | ||
| Wls | wntless homolog (Drosophila) | 0.013 | ||
| Mgmt | O-6-methylguanine-DNA methyltransferase | 0.013 | ||
| Hadhb | hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta subunit | 0.013 | ||
| Vdac1 | voltage-dependent anion channel 1 | 0.013 | ||
| Nme4 | non-metastatic cells 4, protein expressed in | 0.013 | ||
| Cdk2 | cyclin-dependent kinase 2 | 0.013 | ||
| Ndufs4 | NADH dehydrogenase (ubiquinone) Fe-S protein 4 | 0.013 | ||
| Pot1a | protection of telomeres 1A | 0.013 | ||
| Ppp1r7 | protein phosphatase 1, regulatory (inhibitor) subunit 7 | 0.013 | ||
| Nans | N-acetylneuraminic acid synthase (sialic acid synthase) | 0.013 | ||
| Tnfsf10 | tumor necrosis factor (ligand) superfamily, member 10 | 0.013 | ||
| Aspm | asp (abnormal spindle)-like, microcephaly associated (Drosophila) | 0.013 | ||
| Tcf19 | transcription factor 19 | 0.012 | ||
| Fam96a | family with sequence similarity 96, member A | 0.012 | ||
| Tmem126a | transmembrane protein 126A | 0.012 | ||
| Vrk1 | vaccinia related kinase 1 | 0.012 | ||
| Epo | erythropoietin | 0.012 | ||
| Polh | polymerase (DNA directed), eta (RAD 30 related) | 0.012 | ||
| Rtel1 | regulator of telomere elongation helicase 1 | 0.012 | ||
| Nfya | nuclear transcription factor-Y alpha | 0.012 | ||
| Shmt1 | serine hydroxymethyltransferase 1 (soluble) | 0.012 | ||
| Mt4 | metallothionein 4 | 0.012 | ||
| Ndufv2 | NADH dehydrogenase (ubiquinone) flavoprotein 2 | 0.012 | ||
| Ankzf1 | ankyrin repeat and zinc finger domain containing 1 | 0.012 | ||
| Thrsp | thyroid hormone responsive SPOT14 homolog (Rattus) | 0.012 | ||
| Pdhb | pyruvate dehydrogenase (lipoamide) beta | 0.012 | ||
| Mrpl39 | mitochondrial ribosomal protein L39 | 0.012 | ||
| Hprt | hypoxanthine guanine phosphoribosyl transferase | 0.012 | ||
| Cdk4 | cyclin-dependent kinase 4 | 0.012 | ||
| Chek1 | checkpoint kinase 1 homolog (S. pombe) | 0.012 | ||
| Mtx2 | metaxin 2 | 0.012 | ||
| Tyms | thymidylate synthase | 0.012 | ||
| Irf8 | interferon regulatory factor 8 | 0.012 | ||
| Bard1 | BRCA1 associated RING domain 1 | 0.011 | ||
| Mstn | myostatin | 0.011 | ||
| Gins3 | GINS complex subunit 3 (Psf3 homolog) | 0.011 | ||
| Commd9 | COMM domain containing 9 | 0.011 | ||
| Bcl2 | B-cell leukemia/lymphoma 2 | 0.011 | ||
| C330027C09Rik | RIKEN cDNA C330027C09 gene | 0.011 | ||
| Intu | inturned planar cell polarity effector homolog (Drosophila) | 0.011 | ||
| Cdca7 | cell division cycle associated 7 | 0.011 | ||
| Pask | PAS domain containing serine/threonine kinase | 0.011 | ||
| D2hgdh | D-2-hydroxyglutarate dehydrogenase | 0.011 | ||
| Mbd4 | methyl-CpG binding domain protein 4 | 0.011 | ||
| Oip5 | Opa interacting protein 5 | 0.011 | ||
| Nucks1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.011 | ||
| Map3k7 | mitogen-activated protein kinase kinase kinase 7 | 0.011 | ||
| Sdha | succinate dehydrogenase complex, subunit A, flavoprotein (Fp) | 0.011 | ||
| Htt | huntingtin | 0.011 | ||
| BC055324 | cDNA sequence BC055324 | 0.011 | ||
| Mlkl | mixed lineage kinase domain-like | 0.011 | ||
| Ikbkb | inhibitor of kappaB kinase beta | 0.011 | ||
| Ffar3 | free fatty acid receptor 3 | 0.011 | ||
| Dclre1a | DNA cross-link repair 1A, PSO2 homolog (S. cerevisiae) | 0.011 | ||
| Skp2 | S-phase kinase-associated protein 2 (p45) | 0.011 | ||
| Il1a | interleukin 1 alpha | 0.011 | ||
| Rnaseh2a | ribonuclease H2, large subunit | 0.011 | ||
| Trp53 | transformation related protein 53 | 0.011 | ||
| Arhgap18 | Rho GTPase activating protein 18 | 0.011 | ||
| Adrb3 | adrenergic receptor, beta 3 | 0.011 | ||
| Il15 | interleukin 15 | 0.011 | ||
| Gtf2h3 | general transcription factor IIH, polypeptide 3 | 0.011 | ||
| Kif24 | kinesin family member 24 | 0.011 | ||
| Helb | helicase (DNA) B | 0.011 | ||
| Tgfbr1 | transforming growth factor, beta receptor I | 0.011 | ||
| Parn | poly(A)-specific ribonuclease (deadenylation nuclease) | 0.011 | ||
| Cyld | cylindromatosis (turban tumor syndrome) | 0.011 | ||
| Atm | ataxia telangiectasia mutated homolog (human) | 0.011 | ||
| Ska1 | spindle and kinetochore associated complex subunit 1 | 0.011 | ||
| 6720463M24Rik | RIKEN cDNA 6720463M24 gene | 0.011 | ||
| Pars2 | prolyl-tRNA synthetase (mitochondrial)(putative) | 0.011 | ||
| Slc10a7 | solute carrier family 10 (sodium/bile acid cotransporter family), member 7 | 0.011 | ||
| Lrpprc | leucine-rich PPR-motif containing | 0.011 | ||
| Zfp444 | zinc finger protein 444 | 0.010 | ||
| Etfdh | electron transferring flavoprotein, dehydrogenase | 0.010 | ||
| Cox6c | cytochrome c oxidase, subunit VIc | 0.010 | ||
| Nat2 | N-acetyltransferase 2 (arylamine N-acetyltransferase) | 0.010 | ||
| Clspn | claspin homolog (Xenopus laevis) | 0.010 | ||
| Nup93 | nucleoporin 93 | 0.010 | ||
| Skap2 | src family associated phosphoprotein 2 | 0.010 | ||
| Gjb4 | gap junction protein, beta 4 | 0.010 | ||
| Dclre1c | DNA cross-link repair 1C, PSO2 homolog (S. cerevisiae) | 0.010 | ||
| Oma1 | OMA1 homolog, zinc metallopeptidase (S. cerevisiae) | 0.010 | ||
| 4632434I11Rik | RIKEN cDNA 4632434I11 gene | 0.010 | ||
| Rad9 | RAD9 homolog (S. pombe) | 0.010 | ||
| 2610109H07Rik | RIKEN cDNA 2610109H07 gene | 0.010 |