IMP

Process View

Mus musculus

13 genes annotated in mouse

Multi-species View

positive regulation of bone remodeling

GO:0046852

Any process that activates or increases the frequency, rate or extent of bone remodeling.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "positive regulation of bone remodeling"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "positive regulation of bone remodeling" (in gray)

Name	Description	Probability	Func Analog Organism
Ltbp2	latent transforming growth factor beta binding protein 2	0.729	Mouse
Col1a1	collagen, type I, alpha 1	0.432
Tgfbr2	transforming growth factor, beta receptor II	0.398
Eln	elastin	0.352
Adam19	a disintegrin and metallopeptidase domain 19 (meltrin beta)	0.340	Mouse
Pdgfrb	platelet derived growth factor receptor, beta polypeptide	0.316
Hspg2	perlecan (heparan sulfate proteoglycan 2)	0.307
Cav1	caveolin 1, caveolae protein	0.302
Fgr	Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog	0.278
Agtr2	angiotensin II receptor, type 2	0.272
Itgb3	integrin beta 3	0.264
Cd22	CD22 antigen	0.244
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.227
Fbn1	fibrillin 1	0.222
Gja1	gap junction protein, alpha 1	0.218
Hic1	hypermethylated in cancer 1	0.198
Jag1	jagged 1	0.192
Csf1	colony stimulating factor 1 (macrophage)	0.159
Mmp2	matrix metallopeptidase 2	0.146
Lox	lysyl oxidase	0.145
Adam15	a disintegrin and metallopeptidase domain 15 (metargidin)	0.141	Mouse
Pomc	pro-opiomelanocortin-alpha	0.126
Igk	immunoglobulin kappa chain complex	0.119
Tgfb2	transforming growth factor, beta 2	0.110
Idua	iduronidase, alpha-L-	0.102
Agtr1a	angiotensin II receptor, type 1a	0.102
Xcr1	chemokine (C motif) receptor 1	0.100
Foxc2	forkhead box C2	0.093
Ldlr	low density lipoprotein receptor	0.091
Bmp1	bone morphogenetic protein 1	0.090
Col6a2	collagen, type VI, alpha 2	0.087
Cx3cr1	chemokine (C-X3-C) receptor 1	0.083
Mmp14	matrix metallopeptidase 14 (membrane-inserted)	0.082
Adam12	a disintegrin and metallopeptidase domain 12 (meltrin alpha)	0.079	Mouse
Nos3	nitric oxide synthase 3, endothelial cell	0.078
Thbs2	thrombospondin 2	0.076
Acvrl1	activin A receptor, type II-like 1	0.075
Ngp	neutrophilic granule protein	0.072
Mc5r	melanocortin 5 receptor	0.068	Mouse
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.067
Pax1	paired box gene 1	0.065
Tnfrsf11a	tumor necrosis factor receptor superfamily, member 11a	0.059
Col6a1	collagen, type VI, alpha 1	0.058
Pdgfb	platelet derived growth factor, B polypeptide	0.058
Ciita	class II transactivator	0.052
Mcam	melanoma cell adhesion molecule	0.051
Aebp1	AE binding protein 1	0.050
Adam17	a disintegrin and metallopeptidase domain 17	0.050	Mouse
Ctsk	cathepsin K	0.050
Tnks1bp1	tankyrase 1 binding protein 1	0.050
Ppargc1a	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	0.049	Mouse
Lrp5	low density lipoprotein receptor-related protein 5	0.049	Mouse
Ppargc1b	peroxisome proliferative activated receptor, gamma, coactivator 1 beta	0.049
Egfr	epidermal growth factor receptor	0.049
Jup	junction plakoglobin	0.047
Wisp2	WNT1 inducible signaling pathway protein 2	0.047
Creb3l1	cAMP responsive element binding protein 3-like 1	0.046
Prg3	proteoglycan 3	0.045
Klra5	killer cell lectin-like receptor, subfamily A, member 5	0.044
Ndst1	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	0.042
Gp5	glycoprotein 5 (platelet)	0.042
Tgfb1i1	transforming growth factor beta 1 induced transcript 1	0.041
Col6a3	collagen, type VI, alpha 3	0.041
C1qtnf1	C1q and tumor necrosis factor related protein 1	0.040
Vangl2	vang-like 2 (van gogh, Drosophila)	0.040
Wwp1	WW domain containing E3 ubiquitin protein ligase 1	0.040
Fn1	fibronectin 1	0.039
Axin1	axin 1	0.038
Mageb3	melanoma antigen, family B, 3	0.037
Vipr2	vasoactive intestinal peptide receptor 2	0.037
Pparg	peroxisome proliferator activated receptor gamma	0.037
Lrp1	low density lipoprotein receptor-related protein 1	0.037	Mouse
Fut7	fucosyltransferase 7	0.035
Sod3	superoxide dismutase 3, extracellular	0.035
Apoe	apolipoprotein E	0.035
Prlr	prolactin receptor	0.035
Col5a1	collagen, type V, alpha 1	0.035
Tgfbr1	transforming growth factor, beta receptor I	0.035
Col1a2	collagen, type I, alpha 2	0.035
Lama5	laminin, alpha 5	0.034
Lamc2	laminin, gamma 2	0.034
Npy1r	neuropeptide Y receptor Y1	0.034
Gna15	guanine nucleotide binding protein, alpha 15	0.034
Ccr1l1	chemokine (C-C motif) receptor 1-like 1	0.033
Pck1	phosphoenolpyruvate carboxykinase 1, cytosolic	0.033
Tenc1	tensin like C1 domain-containing phosphatase	0.033
Slc11a2	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	0.032
Epha6	Eph receptor A6	0.032
Tgfb1	transforming growth factor, beta 1	0.031
Itga5	integrin alpha 5 (fibronectin receptor alpha)	0.030	Mouse
Svep1	sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	0.030
Star	steroidogenic acute regulatory protein	0.030
Ddr2	discoidin domain receptor family, member 2	0.029
Lat	linker for activation of T cells	0.029
P2rx1	purinergic receptor P2X, ligand-gated ion channel, 1	0.029
C5ar1	complement component 5a receptor 1	0.028
Hbegf	heparin-binding EGF-like growth factor	0.028
Igj	immunoglobulin joining chain	0.027
Chad	chondroadherin	0.027
Cd180	CD180 antigen	0.027
Fgf2	fibroblast growth factor 2	0.027
Tyr	tyrosinase	0.027
Nid1	nidogen 1	0.026
Mrc2	mannose receptor, C type 2	0.026
Aldh1a2	aldehyde dehydrogenase family 1, subfamily A2	0.026
Col16a1	collagen, type XVI, alpha 1	0.026
Figf	c-fos induced growth factor	0.026
Klrb1b	killer cell lectin-like receptor subfamily B member 1B	0.026
Epas1	endothelial PAS domain protein 1	0.026
Lat2	linker for activation of T cells family, member 2	0.026
Eda	ectodysplasin-A	0.026
Ctnnb1	catenin (cadherin associated protein), beta 1	0.026
Mmp9	matrix metallopeptidase 9	0.025
Timp1	tissue inhibitor of metalloproteinase 1	0.025
Cxcr7	chemokine (C-X-C motif) receptor 7	0.025
Scn1b	sodium channel, voltage-gated, type I, beta	0.025
Dmpk	dystrophia myotonica-protein kinase	0.025
Dmd	dystrophin, muscular dystrophy	0.024
Abp1	amiloride binding protein 1 (amine oxidase, copper-containing)	0.024
Cxcr3	chemokine (C-X-C motif) receptor 3	0.024
Cyp11a1	cytochrome P450, family 11, subfamily a, polypeptide 1	0.024
Phex	phosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets)	0.024
Tgfa	transforming growth factor alpha	0.024
Lpin1	lipin 1	0.023
Hoxa1	homeobox A1	0.023
Prrx2	paired related homeobox 2	0.023
Slc40a1	solute carrier family 40 (iron-regulated transporter), member 1	0.023
Bmp5	bone morphogenetic protein 5	0.023
Bex6	brain expressed gene 6	0.023
Cnr1	cannabinoid receptor 1 (brain)	0.023
Pou2af1	POU domain, class 2, associating factor 1	0.023
Vav1	vav 1 oncogene	0.022
Col8a1	collagen, type VIII, alpha 1	0.022
Fbln5	fibulin 5	0.022	Mouse
Itgal	integrin alpha L	0.022	Mouse
Ccr6	chemokine (C-C motif) receptor 6	0.022
Adam8	a disintegrin and metallopeptidase domain 8	0.022
Pecam1	platelet/endothelial cell adhesion molecule 1	0.022
Fpr-rs3	formyl peptide receptor, related sequence 3	0.022
Cd96	CD96 antigen	0.022
Gbx2	gastrulation brain homeobox 2	0.022
Ccr2	chemokine (C-C motif) receptor 2	0.022
Pick1	protein interacting with C kinase 1	0.021
Adig	adipogenin	0.021
Bmp4	bone morphogenetic protein 4	0.021
Elf4	E74-like factor 4 (ets domain transcription factor)	0.021
Nfam1	Nfat activating molecule with ITAM motif 1	0.021
Efnb2	ephrin B2	0.021
Slc12a4	solute carrier family 12, member 4	0.021
Itgax	integrin alpha X	0.021	Mouse
Olfr1509	olfactory receptor 1509	0.020
Ltbr	lymphotoxin B receptor	0.020
Ptrf	polymerase I and transcript release factor	0.020
Gli2	GLI-Kruppel family member GLI2	0.020
Spib	Spi-B transcription factor (Spi-1/PU.1 related)	0.020
Hemgn	hemogen	0.020
Fgfr2	fibroblast growth factor receptor 2	0.020
Olfr140	olfactory receptor 140	0.020
Col14a1	collagen, type XIV, alpha 1	0.019
Rrp1b	ribosomal RNA processing 1 homolog B (S. cerevisiae)	0.019
Lta	lymphotoxin A	0.019
Wnt5a	wingless-related MMTV integration site 5A	0.019
Eng	endoglin	0.019
Gpr132	G protein-coupled receptor 132	0.019
Camp	cathelicidin antimicrobial peptide	0.019
Icos	inducible T-cell co-stimulator	0.019
Sirpa	signal-regulatory protein alpha	0.019
Cd28	CD28 antigen	0.019
Epb4.1l2	erythrocyte protein band 4.1-like 2	0.019
Angptl2	angiopoietin-like 2	0.019
Cd19	CD19 antigen	0.019
Col12a1	collagen, type XII, alpha 1	0.019
Kcns2	K+ voltage-gated channel, subfamily S, 2	0.019
Il6st	interleukin 6 signal transducer	0.019
Gas1	growth arrest specific 1	0.019
Klrc1	killer cell lectin-like receptor subfamily C, member 1	0.018
Lair1	leukocyte-associated Ig-like receptor 1	0.018
Clec1b	C-type lectin domain family 1, member b	0.018
Hoxb3	homeobox B3	0.018
Thbs1	thrombospondin 1	0.018
Krtap13	keratin associated protein 13	0.017
Alox12	arachidonate 12-lipoxygenase	0.017
Prnp	prion protein	0.017
Mpo	myeloperoxidase	0.017
Hey2	hairy/enhancer-of-split related with YRPW motif 2	0.017
Mmp12	matrix metallopeptidase 12	0.017
P2rx7	purinergic receptor P2X, ligand-gated ion channel, 7	0.017
Tnc	tenascin C	0.017
Itga4	integrin alpha 4	0.017	Mouse
Slc6a2	solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2	0.017
Vav2	vav 2 oncogene	0.017
Col4a5	collagen, type IV, alpha 5	0.016
Krtap5-1	keratin associated protein 5-1	0.016
Clec4e	C-type lectin domain family 4, member e	0.016
Hmha1	histocompatibility (minor) HA-1	0.016
Opn1sw	opsin 1 (cone pigments), short-wave-sensitive (color blindness, tritan)	0.016
Igfbp6	insulin-like growth factor binding protein 6	0.016
Col4a3	collagen, type IV, alpha 3	0.016
Grem1	gremlin 1	0.016
Cenpj	centromere protein J	0.016
Wisp1	WNT1 inducible signaling pathway protein 1	0.016
Wls	wntless homolog (Drosophila)	0.016
Col3a1	collagen, type III, alpha 1	0.016
Nckap1l	NCK associated protein 1 like	0.016
Ccr3	chemokine (C-C motif) receptor 3	0.016
H2-M2	histocompatibility 2, M region locus 2	0.015
Nod2	nucleotide-binding oligomerization domain containing 2	0.015
Pde6b	phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide	0.015
Zan	zonadhesin	0.015
Itga3	integrin alpha 3	0.015	Mouse
Dact1	dapper homolog 1, antagonist of beta-catenin (xenopus)	0.015
4932425I24Rik	RIKEN cDNA 4932425I24 gene	0.015
Csf3r	colony stimulating factor 3 receptor (granulocyte)	0.015
Gdf9	growth differentiation factor 9	0.015
Lhcgr	luteinizing hormone/choriogonadotropin receptor	0.015
F7	coagulation factor VII	0.015
Cebpa	CCAAT/enhancer binding protein (C/EBP), alpha	0.015
Col5a2	collagen, type V, alpha 2	0.015
Blk	B lymphoid kinase	0.015
Sorbs3	sorbin and SH3 domain containing 3	0.015
BC100451	cDNA sequence BC100451	0.015
Scarf2	scavenger receptor class F, member 2	0.015
Fes	feline sarcoma oncogene	0.015
Loxl1	lysyl oxidase-like 1	0.015
Glipr2	GLI pathogenesis-related 2	0.015
Ttn	titin	0.015
Pofut1	protein O-fucosyltransferase 1	0.014
Vdr	vitamin D receptor	0.014
Apaf1	apoptotic peptidase activating factor 1	0.014
Zfp385a	zinc finger protein 385A	0.014
Snai1	snail homolog 1 (Drosophila)	0.014
Vegfa	vascular endothelial growth factor A	0.014
Sykb	spleen tyrosine kinase	0.014
Mmp8	matrix metallopeptidase 8	0.014
Flt3	FMS-like tyrosine kinase 3	0.014
Mfap5	microfibrillar associated protein 5	0.014
Rgs14	regulator of G-protein signaling 14	0.014
Cd7	CD7 antigen	0.014
Pax5	paired box gene 5	0.014
Sema6d	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D	0.014
Htr5b	5-hydroxytryptamine (serotonin) receptor 5B	0.014
Nr3c1	nuclear receptor subfamily 3, group C, member 1	0.014
Tlr2	toll-like receptor 2	0.014
Ggta1	glycoprotein galactosyltransferase alpha 1, 3	0.014
Ppyr1	pancreatic polypeptide receptor 1	0.014
Fgfr1	fibroblast growth factor receptor 1	0.014
Rfpl4	ret finger protein-like 4	0.014
Ntf3	neurotrophin 3	0.013
Kiss1	KiSS-1 metastasis-suppressor	0.013
Stom	stomatin	0.013
Lcat	lecithin cholesterol acyltransferase	0.013
Anpep	alanyl (membrane) aminopeptidase	0.013
Grin2a	glutamate receptor, ionotropic, NMDA2A (epsilon 1)	0.013
Lef1	lymphoid enhancer binding factor 1	0.013
Tnfsf8	tumor necrosis factor (ligand) superfamily, member 8	0.013
Htr7	5-hydroxytryptamine (serotonin) receptor 7	0.013
Tcf21	transcription factor 21	0.013
Marveld1	MARVEL (membrane-associating) domain containing 1	0.013
Fzd1	frizzled homolog 1 (Drosophila)	0.013
Dntt	deoxynucleotidyltransferase, terminal	0.013
Cd177	CD177 antigen	0.013
Cyp19a1	cytochrome P450, family 19, subfamily a, polypeptide 1	0.013
Treml1	triggering receptor expressed on myeloid cells-like 1	0.013
Myo1f	myosin IF	0.013
Tgfbr3	transforming growth factor, beta receptor III	0.013
Gcet2	germinal center expressed transcript 2	0.013
Irf4	interferon regulatory factor 4	0.013
Plod3	procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3	0.013
Loxl3	lysyl oxidase-like 3	0.013
Rab3il1	RAB3A interacting protein (rabin3)-like 1	0.013
Cd5l	CD5 antigen-like	0.013
Vmn1r44	vomeronasal 1 receptor 44	0.012
Tll1	tolloid-like	0.012
Mas1	MAS1 oncogene	0.012
Sh3pxd2b	SH3 and PX domains 2B	0.012
Ubd	ubiquitin D	0.012
Itga6	integrin alpha 6	0.012	Mouse
Slc30a3	solute carrier family 30 (zinc transporter), member 3	0.012
AF251705	cDNA sequence AF251705	0.012
Slc9a3r2	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2	0.012
Itga8	integrin alpha 8	0.012	Mouse
Nfkb2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100	0.012
Chrne	cholinergic receptor, nicotinic, epsilon polypeptide	0.012
Twsg1	twisted gastrulation homolog 1 (Drosophila)	0.012
Slamf1	signaling lymphocytic activation molecule family member 1	0.012
Tff1	trefoil factor 1	0.012
Per3	period homolog 3 (Drosophila)	0.012
Colq	collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase	0.012
Was	Wiskott-Aldrich syndrome homolog (human)	0.012
Spry4	sprouty homolog 4 (Drosophila)	0.012
Nfe2	nuclear factor, erythroid derived 2	0.012
Cd79a	CD79A antigen (immunoglobulin-associated alpha)	0.012
Ptch2	patched homolog 2	0.012
Ephb4	Eph receptor B4	0.012
Dnahc8	dynein, axonemal, heavy chain 8	0.012
Matn4	matrilin 4	0.012
Slc8a1	solute carrier family 8 (sodium/calcium exchanger), member 1	0.012
Mesdc2	mesoderm development candidate 2	0.012
Rarg	retinoic acid receptor, gamma	0.012
Lrp6	low density lipoprotein receptor-related protein 6	0.012
Adamdec1	ADAM-like, decysin 1	0.012	Mouse
Ate1	arginyltransferase 1	0.012
Notch2	Notch gene homolog 2 (Drosophila)	0.012
Sla	src-like adaptor	0.012
Gpr33	G protein-coupled receptor 33	0.012
Ptges	prostaglandin E synthase	0.011
Ms4a2	membrane-spanning 4-domains, subfamily A, member 2	0.011
Prelp	proline arginine-rich end leucine-rich repeat	0.011
Tgfb3	transforming growth factor, beta 3	0.011
Htra1	HtrA serine peptidase 1	0.011
Batf3	basic leucine zipper transcription factor, ATF-like 3	0.011
Plau	plasminogen activator, urokinase	0.011
Mfap4	microfibrillar-associated protein 4	0.011
Il1rl1	interleukin 1 receptor-like 1	0.011
Fpr3	formyl peptide receptor 3	0.011
Dmp1	dentin matrix protein 1	0.011
Itgav	integrin alpha V	0.011	Mouse
Ccl4	chemokine (C-C motif) ligand 4	0.011
Wt1	Wilms tumor 1 homolog	0.011
Stab1	stabilin 1	0.011
Tac2	tachykinin 2	0.011
Adcy4	adenylate cyclase 4	0.011
Dpf3	D4, zinc and double PHD fingers, family 3	0.011
Cel	carboxyl ester lipase	0.011
Plxnd1	plexin D1	0.011
Nr6a1	nuclear receptor subfamily 6, group A, member 1	0.011
Gsdma3	gasdermin A3	0.011
Klra9	killer cell lectin-like receptor subfamily A, member 9	0.011
Col18a1	collagen, type XVIII, alpha 1	0.011
Vav3	vav 3 oncogene	0.011
Acr	acrosin prepropeptide	0.011
Sypl	synaptophysin-like protein	0.011
Ccr9	chemokine (C-C motif) receptor 9	0.011
Fgfr3	fibroblast growth factor receptor 3	0.010
Soat1	sterol O-acyltransferase 1	0.010
Asprv1	aspartic peptidase, retroviral-like 1	0.010
Leprel2	leprecan-like 2	0.010
Sertad2	SERTA domain containing 2	0.010
C1qtnf3	C1q and tumor necrosis factor related protein 3	0.010
Krtap6-1	keratin associated protein 6-1	0.010
Tnfsf9	tumor necrosis factor (ligand) superfamily, member 9	0.010
Ncf1	neutrophil cytosolic factor 1	0.010
4933425L06Rik	RIKEN cDNA 4933425L06 gene	0.010
Il18rap	interleukin 18 receptor accessory protein	0.010
Ccl22	chemokine (C-C motif) ligand 22	0.010
C77144	expressed sequence C77144	0.010
Nfkb1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105	0.010