The network for 'intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator

A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage, and ends when the execution phase of apoptosis is triggered.

Homo sapiens
Name Description Probability Func Analog Organism
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 1.000
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 0.986
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 0.983
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.955
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.903
REL v-rel reticuloendotheliosis viral oncogene homolog (avian) 0.880
EP300 E1A binding protein p300 0.750
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.664
RELB v-rel reticuloendotheliosis viral oncogene homolog B 0.626
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 0.561
BRCA1 breast cancer 1, early onset 0.547
CREBBP CREB binding protein 0.465
BCL2 B-cell CLL/lymphoma 2 0.432
CHEK2 CHK2 checkpoint homolog (S. pombe) 0.400
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma 0.364
NBN nibrin 0.362
TP53 tumor protein p53 0.342
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 0.289
ESR1 estrogen receptor 1 0.284
BCL3 B-cell CLL/lymphoma 3 0.281
DCAF7 DDB1 and CUL4 associated factor 7 0.281
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta 0.263
IER3 immediate early response 3 0.257
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.241
ABL1 c-abl oncogene 1, non-receptor tyrosine kinase 0.219
HIPK2 homeodomain interacting protein kinase 2 0.215
TNIP2 TNFAIP3 interacting protein 2 0.201
PPP2R1B protein phosphatase 2, regulatory subunit A, beta 0.194
RASSF5 Ras association (RalGDS/AF-6) domain family member 5 0.181
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha 0.171
MCL1 myeloid cell leukemia sequence 1 (BCL2-related) 0.159
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.142
RAD18 RAD18 homolog (S. cerevisiae) 0.139
RB1 retinoblastoma 1 0.129
MAP3K8 mitogen-activated protein kinase kinase kinase 8 0.108
RAD51 RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae) 0.107
ICAM1 intercellular adhesion molecule 1 0.102
SETD7 SET domain containing (lysine methyltransferase) 7 0.098
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.096
CHUK conserved helix-loop-helix ubiquitous kinase 0.094
FANCD2 Fanconi anemia, complementation group D2 0.093
PML promyelocytic leukemia 0.093
LATS2 LATS, large tumor suppressor, homolog 2 (Drosophila) 0.093
UBE2I ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) 0.092
PARP1 poly (ADP-ribose) polymerase 1 0.088
BTRC beta-transducin repeat containing 0.087
DAXX death-domain associated protein 0.085
BAX BCL2-associated X protein 0.084
NLRC4 NLR family, CARD domain containing 4 0.082
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha 0.079
MSN moesin 0.079
BCL2L11 BCL2-like 11 (apoptosis facilitator) 0.079
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.077
KAT2B K(lysine) acetyltransferase 2B 0.077
SNIP1 Smad nuclear interacting protein 1 0.077
LZTS2 leucine zipper, putative tumor suppressor 2 0.076
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.069
HDAC1 histone deacetylase 1 0.061
PCNA proliferating cell nuclear antigen 0.059
KRT5 keratin 5 0.056
SIN3A SIN3 homolog A, transcription regulator (yeast) 0.056
CASP1 caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) 0.055
TP53BP2 tumor protein p53 binding protein, 2 0.055
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.054
BID BH3 interacting domain death agonist 0.054
BCL2L1 BCL2-like 1 0.052
RPA1 replication protein A1, 70kDa 0.052
MOBKL1A MOB1, Mps One Binder kinase activator-like 1A (yeast) 0.046
IK IK cytokine, down-regulator of HLA II 0.044
SP100 SP100 nuclear antigen 0.044
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.042
PRKACA protein kinase, cAMP-dependent, catalytic, alpha 0.040
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 0.039
GSK3B glycogen synthase kinase 3 beta 0.039
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) 0.039
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.038
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.038
FAS Fas (TNF receptor superfamily, member 6) 0.037
WWOX WW domain containing oxidoreductase 0.036
IL8 interleukin 8 0.036
BRCA2 breast cancer 2, early onset 0.034
SNAI1 snail homolog 1 (Drosophila) 0.034
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 0.031
YAP1 Yes-associated protein 1 0.030
SMAD2 SMAD family member 2 0.030
TNIP1 TNFAIP3 interacting protein 1 0.030
BAK1 BCL2-antagonist/killer 1 0.029
MSH3 mutS homolog 3 (E. coli) 0.028
IRF1 interferon regulatory factor 1 0.028
AMOTL1 angiomotin like 1 0.027
CXCR4 chemokine (C-X-C motif) receptor 4 0.027
MOBKL1B MOB1, Mps One Binder kinase activator-like 1B (yeast) 0.027
AR androgen receptor 0.027
DVL2 dishevelled, dsh homolog 2 (Drosophila) 0.027
STX5 syntaxin 5 0.025
STK4 serine/threonine kinase 4 0.025
UBE2D1 ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast) 0.024
PTK2 PTK2 protein tyrosine kinase 2 0.023
POLH polymerase (DNA directed), eta 0.023
STK3 serine/threonine kinase 3 0.023
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
heatr5a HEAT repeat containing 5a 0.023
wu:fi26e04 wu:fi26e04 0.023
usp37 ubiquitin specific peptidase 37 0.021
sox4b SRY-box containing gene 4b 0.017
LOC557001 tetratricopeptide repeat protein 34-like 0.017
si:dkey-12h9.13 si:dkey-12h9.13 0.017
gfra1a gdnf family receptor alpha 1a 0.017
uts1 urotensin 1 0.015
gpr173 G-protein coupled receptor 173 0.015
cacna1c calcium channel, voltage-dependent, L type, alpha 1C subunit 0.015
LOC565632 BTB/POZ domain-containing protein 16-like 0.014
adra2a adrenergic, alpha-2A-, receptor 0.014
inadl InaD-like (Drosophila) 0.013
LOC570311 calpain-10-like 0.013
has3 hyaluronan synthase 3 0.011
uts2b urotensin 2, beta 0.011
zgc:194138 zgc:194138 0.010
notch1b notch homolog 1b 0.010
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
Trp53 transformation related protein 53 0.985
Rb1 retinoblastoma 1 0.650
Mdm2 transformed mouse 3T3 cell double minute 2 0.619
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.518
Apc adenomatosis polyposis coli 0.450
Pten phosphatase and tensin homolog 0.342
Skil SKI-like 0.264
Brca1 breast cancer 1 0.134
H2-Aa histocompatibility 2, class II antigen A, alpha 0.082
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.075
Cyld cylindromatosis (turban tumor syndrome) 0.060
Mcl1 myeloid cell leukemia sequence 1 0.050
Gbp5 guanylate binding protein 5 0.049
Ctnnb1 catenin (cadherin associated protein), beta 1 0.048
Cdkn2c cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) 0.044
Casp4 caspase 4, apoptosis-related cysteine peptidase 0.043
Csf1 colony stimulating factor 1 (macrophage) 0.042
Trp63 transformation related protein 63 0.041
Esr1 estrogen receptor 1 (alpha) 0.041
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.036
Ifi203 interferon activated gene 203 0.036
Ccnd1 cyclin D1 0.033
Casp1 caspase 1 0.031
Kdm2b lysine (K)-specific demethylase 2B 0.029
Foxo3 forkhead box O3 0.029
Relb avian reticuloendotheliosis viral (v-rel) oncogene related B 0.027
Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.027
Icam1 intercellular adhesion molecule 1 0.026
Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 0.026
Cdkn2a cyclin-dependent kinase inhibitor 2A 0.025
Trp73 transformation related protein 73 0.025
Kit kit oncogene 0.024
Smad3 MAD homolog 3 (Drosophila) 0.023
Stk4 serine/threonine kinase 4 0.022
Bcl2l1 BCL2-like 1 0.021
Il6st interleukin 6 signal transducer 0.021
Ptch1 patched homolog 1 0.021
Thbs1 thrombospondin 1 0.021
Lyz2 lysozyme 2 0.020
Braf Braf transforming gene 0.020
Kiss1 KiSS-1 metastasis-suppressor 0.019
Nlrp3 NLR family, pyrin domain containing 3 0.019
Stk11 serine/threonine kinase 11 0.019
Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.019
Cdkn2d cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) 0.018
Mndal myeloid nuclear differentiation antigen like 0.017
Ar androgen receptor 0.016
Klf5 Kruppel-like factor 5 0.016
Sav1 salvador homolog 1 (Drosophila) 0.016
Aim2 absent in melanoma 2 0.016
Stat3 signal transducer and activator of transcription 3 0.016
Nbn nibrin 0.016
Rnf2 ring finger protein 2 0.015
Tlr4 toll-like receptor 4 0.015
Nfe2l2 nuclear factor, erythroid derived 2, like 2 0.014
Pik3r1 phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha) 0.014
Msh2 mutS homolog 2 (E. coli) 0.014
Runx1 runt related transcription factor 1 0.014
Fgfr1 fibroblast growth factor receptor 1 0.014
H2-DMa histocompatibility 2, class II, locus DMa 0.014
Per2 period homolog 2 (Drosophila) 0.013
Smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.013
Hbb-b1 hemoglobin, beta adult major chain 0.013
Ccl2 chemokine (C-C motif) ligand 2 0.013
Hnrnpd heterogeneous nuclear ribonucleoprotein D 0.013
Nf2 neurofibromatosis 2 0.012
Kiss1r KISS1 receptor 0.012
Daxx Fas death domain-associated protein 0.012
Socs3 suppressor of cytokine signaling 3 0.012
Ddx5 DEAD (Asp-Glu-Ala-Asp) box polypeptide 5 0.012
Yap1 yes-associated protein 1 0.011
Ahr aryl-hydrocarbon receptor 0.011
Xpa xeroderma pigmentosum, complementation group A 0.011
Wwox WW domain-containing oxidoreductase 0.011
Osmr oncostatin M receptor 0.011
Notch1 Notch gene homolog 1 (Drosophila) 0.011
Smad4 MAD homolog 4 (Drosophila) 0.011
Nf1 neurofibromatosis 1 0.011
Igh immunoglobulin heavy chain complex 0.011
Prkdc protein kinase, DNA activated, catalytic polypeptide 0.011
AI607873 expressed sequence AI607873 0.010
Mvp major vault protein 0.010
Tsc1 tuberous sclerosis 1 0.010
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism