The network for 'positive regulation of b cell activation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of b cell activation

Any process that activates or increases the frequency, rate or extent of B cell activation.

Mus musculus
Name Description Probability Func Analog Organism
Igh immunoglobulin heavy chain complex 0.997
Tlr4 toll-like receptor 4 0.997
Rnf2 ring finger protein 2 0.988
Tnf tumor necrosis factor 0.984
Myd88 myeloid differentiation primary response gene 88 0.959
Cd40 CD40 antigen 0.913
Lta lymphotoxin A 0.906
Rybp RING1 and YY1 binding protein 0.878
Foxp3 forkhead box P3 0.877
Pik3cd phosphatidylinositol 3-kinase catalytic delta polypeptide 0.876
Rag2 recombination activating gene 2 0.873
Il2 interleukin 2 0.837
Fyn Fyn proto-oncogene 0.830
Ikzf1 IKAROS family zinc finger 1 0.820
Lck lymphocyte protein tyrosine kinase 0.770
Ifng interferon gamma 0.738
Btk Bruton agammaglobulinemia tyrosine kinase 0.677
Tbx3 T-box 3 0.572
Pax2 paired box gene 2 0.570
Tnfsf14 tumor necrosis factor (ligand) superfamily, member 14 0.568
Sykb spleen tyrosine kinase 0.547
Chrnb4 cholinergic receptor, nicotinic, beta polypeptide 4 0.515
Pou2af1 POU domain, class 2, associating factor 1 0.499
Cd28 CD28 antigen 0.485
Tgfb1 transforming growth factor, beta 1 0.477
Lepr leptin receptor 0.441
Clec4n C-type lectin domain family 4, member n 0.409
Fgf10 fibroblast growth factor 10 0.398
Il2rg interleukin 2 receptor, gamma chain 0.388
Map3k14 mitogen-activated protein kinase kinase kinase 14 0.380
Ticam1 toll-like receptor adaptor molecule 1 0.376
H2-Eb1 histocompatibility 2, class II antigen E beta 0.369
Socs1 suppressor of cytokine signaling 1 0.365
Pnp2 purine-nucleoside phosphorylase 2 0.354
Il4ra interleukin 4 receptor, alpha 0.313
Lat linker for activation of T cells 0.309
Ptprc protein tyrosine phosphatase, receptor type, C 0.308
Prf1 perforin 1 (pore forming protein) 0.306
Cbx7 chromobox homolog 7 0.268
Cd79a CD79A antigen (immunoglobulin-associated alpha) 0.266
Fasl Fas ligand (TNF superfamily, member 6) 0.263
Rag1 recombination activating gene 1 0.258
Icos inducible T-cell co-stimulator 0.246
Lyn Yamaguchi sarcoma viral (v-yes-1) oncogene homolog 0.233
Cd4 CD4 antigen 0.228
Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.225
Scn5a sodium channel, voltage-gated, type V, alpha 0.220
Ikzf3 IKAROS family zinc finger 3 0.217
Stat3 signal transducer and activator of transcription 3 0.199
Lhx1 LIM homeobox protein 1 0.197
Cd22 CD22 antigen 0.192
Cxcl13 chemokine (C-X-C motif) ligand 13 0.189
Tnfrsf9 tumor necrosis factor receptor superfamily, member 9 0.184
Gja5 gap junction protein, alpha 5 0.179
Lhx3 LIM homeobox protein 3 0.178
Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b 0.175
Tnfsf11 tumor necrosis factor (ligand) superfamily, member 11 0.173
Cd40lg CD40 ligand 0.172
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.172
Il1r1 interleukin 1 receptor, type I 0.172
Aicda activation-induced cytidine deaminase 0.171
Mmp9 matrix metallopeptidase 9 0.168
Il6 interleukin 6 0.166
Il10 interleukin 10 0.166
Cd19 CD19 antigen 0.165
Il4 interleukin 4 0.164
Pitx2 paired-like homeodomain transcription factor 2 0.164
Cd5 CD5 antigen 0.161
Cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.160
Hdac4 histone deacetylase 4 0.160
Nos3 nitric oxide synthase 3, endothelial cell 0.158
Il2rb interleukin 2 receptor, beta chain 0.155
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.153
Gimap1 GTPase, IMAP family member 1 0.148
Pik3r1 phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha) 0.143
Pdcd1 programmed cell death 1 0.143
Irf4 interferon regulatory factor 4 0.142
H2-Ab1 histocompatibility 2, class II antigen A, beta 1 0.142
Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 0.141
Pou3f4 POU domain, class 3, transcription factor 4 0.138
Traf2 TNF receptor-associated factor 2 0.135
Fas Fas (TNF receptor superfamily member 6) 0.130
Mef2c myocyte enhancer factor 2C 0.130
T brachyury 0.130
Pitx1 paired-like homeodomain transcription factor 1 0.129
Ccr6 chemokine (C-C motif) receptor 6 0.127
Gpr132 G protein-coupled receptor 132 0.125
Ptgs2 prostaglandin-endoperoxide synthase 2 0.120
Wnt10b wingless related MMTV integration site 10b 0.119
Grb2 growth factor receptor bound protein 2 0.117
Esr1 estrogen receptor 1 (alpha) 0.117
Fcer1g Fc receptor, IgE, high affinity I, gamma polypeptide 0.116
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.115
Blnk B-cell linker 0.113
Tnfaip3 tumor necrosis factor, alpha-induced protein 3 0.106
Cbx8 chromobox homolog 8 (Drosophila Pc class) 0.105
Pcsk5 proprotein convertase subtilisin/kexin type 5 0.104
Vav1 vav 1 oncogene 0.104
Cd247 CD247 antigen 0.104
Pax8 paired box gene 8 0.103
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
BCL2 B-cell CLL/lymphoma 2 0.985
BCL2L1 BCL2-like 1 0.962
IL4R interleukin 4 receptor 0.895
PTPN6 protein tyrosine phosphatase, non-receptor type 6 0.706
BCL2L11 BCL2-like 11 (apoptosis facilitator) 0.301
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.247
TICAM2 toll-like receptor adaptor molecule 2 0.220
BAX BCL2-associated X protein 0.168
GRAP2 GRB2-related adaptor protein 2 0.157
MYD88 myeloid differentiation primary response gene (88) 0.157
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.143
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein 0.076
TAL1 T-cell acute lymphocytic leukemia 1 0.068
BAD BCL2-associated agonist of cell death 0.068
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced 0.065
IRAK1 interleukin-1 receptor-associated kinase 1 0.061
IL4 interleukin 4 0.060
SLC9A3R1 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 0.060
SYK spleen tyrosine kinase 0.056
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B 0.055
BID BH3 interacting domain death agonist 0.050
LAT linker for activation of T cells 0.049
CSNK1G1 casein kinase 1, gamma 1 0.046
RIPK2 receptor-interacting serine-threonine kinase 2 0.046
NCOA3 nuclear receptor coactivator 3 0.044
MCL1 myeloid cell leukemia sequence 1 (BCL2-related) 0.042
MAP3K8 mitogen-activated protein kinase kinase kinase 8 0.041
IL6R interleukin 6 receptor 0.036
SH3BP2 SH3-domain binding protein 2 0.033
TNIP1 TNFAIP3 interacting protein 1 0.033
HDAC4 histone deacetylase 4 0.032
BTK Bruton agammaglobulinemia tyrosine kinase 0.032
TP53BP1 tumor protein p53 binding protein 1 0.031
IL2RG interleukin 2 receptor, gamma 0.030
IRAK4 interleukin-1 receptor-associated kinase 4 0.030
NCF2 neutrophil cytosolic factor 2 0.026
CXCR4 chemokine (C-X-C motif) receptor 4 0.025
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.024
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 0.024
ABL1 c-abl oncogene 1, non-receptor tyrosine kinase 0.023
IRAK2 interleukin-1 receptor-associated kinase 2 0.023
TNFRSF17 tumor necrosis factor receptor superfamily, member 17 0.023
BAK1 BCL2-antagonist/killer 1 0.023
STAP2 signal transducing adaptor family member 2 0.023
AMBRA1 autophagy/beclin-1 regulator 1 0.022
GAS7 growth arrest-specific 7 0.021
MS4A1 membrane-spanning 4-domains, subfamily A, member 1 0.021
STK11 serine/threonine kinase 11 0.020
DDX17 DEAD (Asp-Glu-Ala-Asp) box polypeptide 17 0.020
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 0.020
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein 0.020
SLA Src-like-adaptor 0.020
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 0.019
TRAF3IP3 TRAF3 interacting protein 3 0.019
IL2RB interleukin 2 receptor, beta 0.018
CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.018
DDX5 DEAD (Asp-Glu-Ala-Asp) box polypeptide 5 0.018
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.018
PIK3AP1 phosphoinositide-3-kinase adaptor protein 1 0.018
CTLA4 cytotoxic T-lymphocyte-associated protein 4 0.017
FERMT2 fermitin family member 2 0.017
BLNK B-cell linker 0.017
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 1 0.017
PCDH9 protocadherin 9 0.017
BCL10 B-cell CLL/lymphoma 10 0.016
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.016
BIK BCL2-interacting killer (apoptosis-inducing) 0.016
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 0.016
EP300 E1A binding protein p300 0.016
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.015
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 0.015
SH3KBP1 SH3-domain kinase binding protein 1 0.015
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 0.015
MMP9 matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) 0.015
CDK2 cyclin-dependent kinase 2 0.014
WAS Wiskott-Aldrich syndrome (eczema-thrombocytopenia) 0.013
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.013
RNF144B ring finger protein 144B 0.013
PIK3CG phosphoinositide-3-kinase, catalytic, gamma polypeptide 0.013
MALT1 mucosa associated lymphoid tissue lymphoma translocation gene 1 0.013
FOXO1 forkhead box O1 0.013
TCF12 transcription factor 12 0.012
NCOA2 nuclear receptor coactivator 2 0.012
JAK3 Janus kinase 3 0.012
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 0.012
BCL2A1 BCL2-related protein A1 0.012
LY96 lymphocyte antigen 96 0.012
TRAF1 TNF receptor-associated factor 1 0.012
C16orf53 chromosome 16 open reading frame 53 0.011
ENG endoglin 0.011
TP53BP2 tumor protein p53 binding protein, 2 0.011
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta 0.011
SELL selectin L 0.011
CD22 CD22 molecule 0.011
IL7R interleukin 7 receptor 0.011
FGR Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog 0.011
TRAF2 TNF receptor-associated factor 2 0.011
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.011
SLAMF1 signaling lymphocytic activation molecule family member 1 0.011
NCOR2 nuclear receptor corepressor 2 0.010
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Rattus norvegicus
Name Description Probability Func Analog Organism
RT1-Db1 RT1 class II, locus Db1 0.073
Cd37 CD37 molecule 0.027
Ly86 lymphocyte antigen 86 0.016
Laptm5 lysosomal protein transmembrane 5 0.013
RT1-Ba RT1 class II, locus Ba 0.012
Lyn v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.011
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism