The network for 't cell differentiation in thymus' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

t cell differentiation in thymus

The process in which a precursor cell type acquires the specialized features of a T cell via a differentiation pathway dependent upon transit through the thymus.

Mus musculus
Name Description Probability Func Analog Organism
Ikzf1 IKAROS family zinc finger 1 1.000
Lat linker for activation of T cells 0.999
Fas Fas (TNF receptor superfamily member 6) 0.999
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.994
Fyn Fyn proto-oncogene 0.993
Lck lymphocyte protein tyrosine kinase 0.990
Trp53 transformation related protein 53 0.990
Gli3 GLI-Kruppel family member GLI3 0.987
Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.982
Tcra T-cell receptor alpha chain 0.979
Rybp RING1 and YY1 binding protein 0.977
Gli2 GLI-Kruppel family member GLI2 0.975
Foxp3 forkhead box P3 0.973
Foxn1 forkhead box N1 0.969
Cd247 CD247 antigen 0.968
Rag2 recombination activating gene 2 0.968
Map3k14 mitogen-activated protein kinase kinase kinase 14 0.968
Il2rg interleukin 2 receptor, gamma chain 0.943
Zfp36 zinc finger protein 36 0.939
Gata4 GATA binding protein 4 0.930
Ptprc protein tyrosine phosphatase, receptor type, C 0.922
Runx1 runt related transcription factor 1 0.913
Adam19 a disintegrin and metallopeptidase domain 19 (meltrin beta) 0.907
Il2 interleukin 2 0.905
Fgf10 fibroblast growth factor 10 0.899
Ntf3 neurotrophin 3 0.894
Bcl2 B-cell leukemia/lymphoma 2 0.874
Cd44 CD44 antigen 0.872
Socs1 suppressor of cytokine signaling 1 0.870
Fgfr2 fibroblast growth factor receptor 2 0.864
Tgfb2 transforming growth factor, beta 2 0.845
Grb2 growth factor receptor bound protein 2 0.834
Igh immunoglobulin heavy chain complex 0.828
Fos FBJ osteosarcoma oncogene 0.806
Cd19 CD19 antigen 0.798
Pax2 paired box gene 2 0.782
Tnf tumor necrosis factor 0.779
Ctnnb1 catenin (cadherin associated protein), beta 1 0.774
Tnfaip3 tumor necrosis factor, alpha-induced protein 3 0.773
Smad3 MAD homolog 3 (Drosophila) 0.766
Ltb lymphotoxin B 0.752
Ret ret proto-oncogene 0.747
Efnb2 ephrin B2 0.739
H2-Ab1 histocompatibility 2, class II antigen A, beta 1 0.718
Irf5 interferon regulatory factor 5 0.683
Fzd8 frizzled homolog 8 (Drosophila) 0.673
Erbb2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.667
Ptgs2 prostaglandin-endoperoxide synthase 2 0.666
Trp63 transformation related protein 63 0.662
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.655
Rarg retinoic acid receptor, gamma 0.650
Smad4 MAD homolog 4 (Drosophila) 0.650
Itk IL2-inducible T-cell kinase 0.642
Efna1 ephrin A1 0.632
Cd79a CD79A antigen (immunoglobulin-associated alpha) 0.627
Jun Jun oncogene 0.621
Ccr6 chemokine (C-C motif) receptor 6 0.613
Mcl1 myeloid cell leukemia sequence 1 0.611
Stat3 signal transducer and activator of transcription 3 0.595
Gdnf glial cell line derived neurotrophic factor 0.594
Bax BCL2-associated X protein 0.583
Zap70 zeta-chain (TCR) associated protein kinase 0.582
Lta lymphotoxin A 0.580
Fzd1 frizzled homolog 1 (Drosophila) 0.579
Notch1 Notch gene homolog 1 (Drosophila) 0.570
Tcrd T-cell receptor delta chain 0.570
Casp8 caspase 8 0.557
Pten phosphatase and tensin homolog 0.543
Ifng interferon gamma 0.534
Il6st interleukin 6 signal transducer 0.531
Hr hairless 0.524
Cd3e CD3 antigen, epsilon polypeptide 0.518
Ptpn22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 0.505
Rara retinoic acid receptor, alpha 0.503
H2-Eb1 histocompatibility 2, class II antigen E beta 0.501
Junb Jun-B oncogene 0.500
H2-K1 histocompatibility 2, K1, K region 0.490
Lhx1 LIM homeobox protein 1 0.488
Il27ra interleukin 27 receptor, alpha 0.486
Hes1 hairy and enhancer of split 1 (Drosophila) 0.479
Cd96 CD96 antigen 0.475
Cd4 CD4 antigen 0.463
Rnf2 ring finger protein 2 0.462
Ccnd1 cyclin D1 0.452
Atxn1 ataxin 1 0.442
Foxf1a forkhead box F1a 0.441
Vav1 vav 1 oncogene 0.434
Rxra retinoid X receptor alpha 0.431
Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 0.422
Cd3g CD3 antigen, gamma polypeptide 0.421
Ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 0.414
Rag1 recombination activating gene 1 0.410
Tcrb T-cell receptor beta chain 0.408
Stat1 signal transducer and activator of transcription 1 0.405
Ccnd2 cyclin D2 0.398
Ptpn14 protein tyrosine phosphatase, non-receptor type 14 0.397
Id2 inhibitor of DNA binding 2 0.390
Prkcd protein kinase C, delta 0.387
Mdm2 transformed mouse 3T3 cell double minute 2 0.384
Hic1 hypermethylated in cancer 1 0.373
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
rag1 recombination activating gene 1 0.945
il7r interleukin 7 receptor 0.477
lrrc33 leucine rich repeat containing 33 0.366
lft1 lefty1 0.334
dntt deoxynucleotidyltransferase, terminal 0.311
ikzf1 IKAROS family zinc finger 1 (Ikaros) 0.230
dld deltaD 0.176
cdh2 cadherin 2, neuronal 0.160
ptger4a prostaglandin E receptor 4 (subtype EP4) a 0.147
rpl7a ribosomal protein L7a 0.089
zgc:64115 zgc:64115 0.087
hoxd4a homeo box D4a 0.083
chd chordin 0.076
cdx4 caudal type homeo box transcription factor 4 0.074
boc brother of CDO 0.071
dbx1a developing brain homeobox 1a 0.066
rspo3 R-spondin 3 homolog (Xenopus laevis) 0.064
pdcd2 programmed cell death 2 0.062
abcg2a ATP-binding cassette, sub-family G (WHITE), member 2a 0.059
LOC100151531 zinc finger protein Gfi-1b-like 0.058
tshz1 teashirt family zinc finger 1 0.054
jak1 Janus kinase 1 0.050
bmp2a bone morphogenetic protein 2a 0.050
cxcr3.2 chemokine (C-X-C motif) receptor 3.2 0.050
rag2 recombination activating gene 2 0.050
fgfr1b fibroblast growth factor receptor 1b 0.047
foxd3 forkhead box D3 0.046
ptger2a prostaglandin E receptor 2a (subtype EP2) 0.045
cpne1 copine I 0.041
tsc22d3 TSC22 domain family, member 3 0.040
coro1a coronin, actin binding protein, 1A 0.039
si:dkey-27i16.2 si:dkey-27i16.2 0.038
foxa2 forkhead box A2 0.037
ighm immunoglobulin heavy constant mu and immunoglobulin heavy constant mu 0.036
erbb3b v-erb-b2 erythroblastic leukemia viral oncogene homolog 3b 0.035
rpl23a ribosomal protein L23a 0.035
znf703 zinc finger protein 703 0.034
ef1a elongation factor 1-alpha 0.034
lft2 lefty2 0.032
rnf128a ring finger protein 128a 0.030
spry2 sprouty homolog 2 0.030
plod1a procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1a 0.030
cxcr4b chemokine (C-X-C motif), receptor 4b 0.028
ccnd1 cyclin D1 0.028
cyp26c1 cytochrome P450, family 26, subfamily C, polypeptide 1 0.028
amotl2a angiomotin like 2a 0.028
npm4 nucleophosmin/nucleoplasmin, 4 0.028
her3 hairy-related 3 0.027
ighz immunoglobulin heavy constant zeta 0.027
mst1rb macrophage stimulating 1 receptor (c-met-related tyrosine kinase), b 0.026
scd stearoyl-CoA desaturase (delta-9-desaturase) 0.025
fzd7a frizzled homolog 7a 0.025
cmyb transcription factor cmyb 0.024
bcl2 B-cell leukemia/lymphoma 2 0.024
notch3 notch homolog 3 0.023
jag2 jagged 2 0.023
fas Fas (TNF receptor superfamily, member 6) 0.022
hnf1bb HNF1 homeobox Bb 0.022
otx1b orthodenticle homolog 1b 0.022
cdkn1a cyclin-dependent kinase inhibitor 1A 0.021
jak3 Janus kinase 3 (a protein tyrosine kinase, leukocyte) 0.021
pkd2 polycystic kidney disease 2 0.020
itga2b integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41B) 0.017
sox2 SRY-box containing gene 2 0.017
tcf7 transcription factor 7 (T-cell specific, HMG-box) 0.017
maff v-maf musculoaponeurotic fibrosarcoma oncogene homolog f (avian) 0.016
her6 hairy-related 6 0.016
ephb4b eph receptor B4b 0.016
lcp1 lymphocyte cytosolic plastin 1 0.016
fgf3 fibroblast growth factor 3 0.015
lycat lysocardiolipin acyltransferase 0.015
fzd5 frizzled homolog 5 0.015
npy8ar neuropeptide Y receptor Y8a 0.015
gbx2 gastrulation brain homeo box 2 0.015
wnt8b wingless-type MMTV integration site family, member 8b 0.015
crabp2b cellular retinoic acid binding protein 2, b 0.014
runx3 runt-related transcription factor 3 0.014
myb myeloblastosis oncogene 0.014
zgc:92868 zgc:92868 0.014
st14a suppression of tumorigenicity 14 (colon carcinoma) a 0.013
tbp TATA box binding protein 0.013
ptk6a PTK6 protein tyrosine kinase 6a 0.013
irf8 interferon regulatory factor 8 0.013
fgfr4 fibroblast growth factor receptor 4 0.012
ankrd6 ankyrin repeat domain 6 0.012
LOC566708 FL cytokine receptor-like 0.012
cdc14b CDC14 cell division cycle 14 homolog B 0.011
ddx46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 0.011
ripk2 receptor-interacting serine-threonine kinase 2 0.011
mc1r melanocortin 1 receptor 0.011
mc2r melanocortin 2 receptor 0.011
wasb Wiskott-Aldrich syndrome (eczema-thrombocytopenia) b 0.011
dlc deltaC 0.011
gata1a GATA binding protein 1a 0.011
gfi1.1 growth factor independent 1.1 0.011
abcg2c ATP-binding cassette, sub-family G (WHITE), member 2c 0.011
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
LAT linker for activation of T cells 0.988
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.971
NOTCH3 notch 3 0.927
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.721
CD247 CD247 molecule 0.689
APLF aprataxin and PNKP like factor 0.604
BMPR1A bone morphogenetic protein receptor, type IA 0.599
EGFR epidermal growth factor receptor 0.578
IL1R1 interleukin 1 receptor, type I 0.562
CCND1 cyclin D1 0.455
IL2RB interleukin 2 receptor, beta 0.444
CXCR4 chemokine (C-X-C motif) receptor 4 0.442
MPZL3 myelin protein zero-like 3 0.432
RUNX1 runt-related transcription factor 1 0.424
NOTCH1 notch 1 0.411
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 0.409
RB1 retinoblastoma 1 0.403
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.391
CTBP1 C-terminal binding protein 1 0.385
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4 0.373
DLG1 discs, large homolog 1 (Drosophila) 0.363
TAL1 T-cell acute lymphocytic leukemia 1 0.334
INSR insulin receptor 0.322
GHR growth hormone receptor 0.314
LCK lymphocyte-specific protein tyrosine kinase 0.312
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) 0.304
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.288
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.286
BCL10 B-cell CLL/lymphoma 10 0.263
IFNAR2 interferon (alpha, beta and omega) receptor 2 0.262
CDK6 cyclin-dependent kinase 6 0.252
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 0.243
CCND3 cyclin D3 0.238
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.207
IL4R interleukin 4 receptor 0.202
IL2RG interleukin 2 receptor, gamma 0.200
SYK spleen tyrosine kinase 0.195
LIG4 ligase IV, DNA, ATP-dependent 0.191
CD2 CD2 molecule 0.191
CD3G CD3g molecule, gamma (CD3-TCR complex) 0.188
MKL1 megakaryoblastic leukemia (translocation) 1 0.187
NOTCH2 notch 2 0.183
HLA-B major histocompatibility complex, class I, B 0.171
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.165
STRADA STE20-related kinase adaptor alpha 0.164
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.162
TP53 tumor protein p53 0.157
EGR1 early growth response 1 0.151
PLCG1 phospholipase C, gamma 1 0.149
HLA-A major histocompatibility complex, class I, A 0.149
CDKN2A cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) 0.149
BIRC3 baculoviral IAP repeat containing 3 0.144
CASP10 caspase 10, apoptosis-related cysteine peptidase 0.141
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.141
IKZF3 IKAROS family zinc finger 3 (Aiolos) 0.130
EGR2 early growth response 2 0.129
FSTL1 follistatin-like 1 0.127
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 0.126
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.126
IL7R interleukin 7 receptor 0.125
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.122
CD8A CD8a molecule 0.122
TRAF1 TNF receptor-associated factor 1 0.120
MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1 0.118
CD3E CD3e molecule, epsilon (CD3-TCR complex) 0.118
CCR7 chemokine (C-C motif) receptor 7 0.118
GRAP2 GRB2-related adaptor protein 2 0.113
JAK1 Janus kinase 1 0.111
MAPK14 mitogen-activated protein kinase 14 0.111
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein 0.111
ETS1 v-ets erythroblastosis virus E26 oncogene homolog 1 (avian) 0.104
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 0.103
GFI1B growth factor independent 1B transcription repressor 0.101
MAF v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian) 0.101
MYOD1 myogenic differentiation 1 0.100
JAK2 Janus kinase 2 0.097
HLA-C major histocompatibility complex, class I, C 0.096
CD80 CD80 molecule 0.096
STAP2 signal transducing adaptor family member 2 0.095
ZFYVE9 zinc finger, FYVE domain containing 9 0.093
KPNA1 karyopherin alpha 1 (importin alpha 5) 0.093
FAS Fas (TNF receptor superfamily, member 6) 0.090
UBASH3B ubiquitin associated and SH3 domain containing B 0.089
STRADB STE20-related kinase adaptor beta 0.089
TCF12 transcription factor 12 0.089
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 0.087
CD83 CD83 molecule 0.085
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.084
CD69 CD69 molecule 0.083
CD7 CD7 molecule 0.081
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) 0.080
RPS3A ribosomal protein S3A 0.077
IL7 interleukin 7 0.076
U2AF1 U2 small nuclear RNA auxiliary factor 1 0.075
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 0.075
HFE hemochromatosis 0.074
FAIM3 Fas apoptotic inhibitory molecule 3 0.074
MYOG myogenin (myogenic factor 4) 0.073
CSNK1G1 casein kinase 1, gamma 1 0.071
BCL2L1 BCL2-like 1 0.071
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Rattus norvegicus
Name Description Probability Func Analog Organism
RT1-Ba RT1 class II, locus Ba 0.014
Cd247 Cd247 molecule 0.014
RT1-Da RT1 class II, locus Da 0.013
Slfn2 schlafen 2 0.012
Cd44 Cd44 molecule 0.011
RT1-Bb RT1 class II, locus Bb 0.011
Cd5 Cd5 molecule 0.011
Cd3g CD3 molecule, gamma 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism