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Homo sapiens

36 genes annotated in human

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regulation of protein tyrosine kinase activity

GO:0061097

Any process that modulates the rate, frequency, or extent of protein tyrosine kinase activity.

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "regulation of protein tyrosine kinase activity"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "regulation of protein tyrosine kinase activity" (in gray)

Name	Description	Probability	Func Analog Organism
EGFR	epidermal growth factor receptor	1.000	Human
SRC	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	0.992	Human
GRB2	growth factor receptor-bound protein 2	0.989	Fly
ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.986
ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.962	Human
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.956	Human Fly
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.946
SHC1	SHC (Src homology 2 domain containing) transforming protein 1	0.807
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.774	Human
NCK1	NCK adaptor protein 1	0.710
PAK2	p21 protein (Cdc42/Rac)-activated kinase 2	0.601
VEGFA	vascular endothelial growth factor A	0.569	Human
FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	0.467	Human
MPDZ	multiple PDZ domain protein	0.464
APBB1	amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)	0.450
PDCD6IP	programmed cell death 6 interacting protein	0.424
CCR5	chemokine (C-C motif) receptor 5	0.409
BTK	Bruton agammaglobulinemia tyrosine kinase	0.346	Human
WAS	Wiskott-Aldrich syndrome (eczema-thrombocytopenia)	0.330
CRKL	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.280
KDR	kinase insert domain receptor (a type III receptor tyrosine kinase)	0.276	Human
SOCS1	suppressor of cytokine signaling 1	0.235	Human
ITCH	itchy E3 ubiquitin protein ligase homolog (mouse)	0.215
EPOR	erythropoietin receptor	0.196
MAGI3	membrane associated guanylate kinase, WW and PDZ domain containing 3	0.186
PLCG1	phospholipase C, gamma 1	0.185
SPRR2A	small proline-rich protein 2A	0.185
SH3KBP1	SH3-domain kinase binding protein 1	0.181
PIK3R2	phosphoinositide-3-kinase, regulatory subunit 2 (beta)	0.175
CCL4	chemokine (C-C motif) ligand 4	0.155	Human
NRP1	neuropilin 1	0.149
XAB2	XPA binding protein 2	0.143
GAB1	GRB2-associated binding protein 1	0.143
FYN	FYN oncogene related to SRC, FGR, YES	0.133	Human
ABI2	abl-interactor 2	0.132
ARHGEF7	Rho guanine nucleotide exchange factor (GEF) 7	0.130
AXL	AXL receptor tyrosine kinase	0.126
CDC42	cell division cycle 42 (GTP binding protein, 25kDa)	0.121
PTK2	PTK2 protein tyrosine kinase 2	0.114
BLNK	B-cell linker	0.114
SOCS3	suppressor of cytokine signaling 3	0.113	Human
HCK	hemopoietic cell kinase	0.113	Human
ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	0.108
ZNF496	zinc finger protein 496	0.105
SH3GL2	SH3-domain GRB2-like 2	0.102
MAGI2	membrane associated guanylate kinase, WW and PDZ domain containing 2	0.092
SHC2	SHC (Src homology 2 domain containing) transforming protein 2	0.092
LYN	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	0.089
BAD	BCL2-associated agonist of cell death	0.086
BCAR1	breast cancer anti-estrogen resistance 1	0.083
CD28	CD28 molecule	0.083
NCKAP1	NCK-associated protein 1	0.078
YES1	v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1	0.074	Human
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.073
JAK2	Janus kinase 2	0.072
CCL18	chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)	0.071	Human
CCL5	chemokine (C-C motif) ligand 5	0.070
MAPK8IP2	mitogen-activated protein kinase 8 interacting protein 2	0.070
PGF	placental growth factor	0.069	Human
PTPN23	protein tyrosine phosphatase, non-receptor type 23	0.066
CXCL9	chemokine (C-X-C motif) ligand 9	0.066
TNS4	tensin 4	0.064
CBLB	Cas-Br-M (murine) ecotropic retroviral transforming sequence b	0.063	Human Fly
MUC1	mucin 1, cell surface associated	0.062
SNX9	sorting nexin 9	0.060
CCL2	chemokine (C-C motif) ligand 2	0.059	Human
CCL8	chemokine (C-C motif) ligand 8	0.058	Human
PTK6	PTK6 protein tyrosine kinase 6	0.057
PDGFB	platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)	0.056
LRRK2	leucine-rich repeat kinase 2	0.051
ARRB1	arrestin, beta 1	0.050
ANKS1B	ankyrin repeat and sterile alpha motif domain containing 1B	0.050
APBB2	amyloid beta (A4) precursor protein-binding, family B, member 2	0.048
SHC3	SHC (Src homology 2 domain containing) transforming protein 3	0.046
HSPA13	heat shock protein 70kDa family, member 13	0.046
TCEB1	transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)	0.045
RNF11	ring finger protein 11	0.043
SOCS2	suppressor of cytokine signaling 2	0.041	Human
EGF	epidermal growth factor	0.041
PIK3R3	phosphoinositide-3-kinase, regulatory subunit 3 (gamma)	0.041
IDE	insulin-degrading enzyme	0.039
SNX33	sorting nexin 33	0.038
DAB2	disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)	0.038
PTK2B	PTK2B protein tyrosine kinase 2 beta	0.038
STAT3	signal transducer and activator of transcription 3 (acute-phase response factor)	0.038
SFN	stratifin	0.037
SORBS3	sorbin and SH3 domain containing 3	0.035
SLA	Src-like-adaptor	0.035
GRB7	growth factor receptor-bound protein 7	0.034
PPP1R2	protein phosphatase 1, regulatory (inhibitor) subunit 2	0.034
MED28	mediator complex subunit 28	0.034
APP	amyloid beta (A4) precursor protein	0.033	Mouse
MAPT	microtubule-associated protein tau	0.032
DLG1	discs, large homolog 1 (Drosophila)	0.032
INPP5D	inositol polyphosphate-5-phosphatase, 145kDa	0.032
RASA1	RAS p21 protein activator (GTPase activating protein) 1	0.031
CCL3	chemokine (C-C motif) ligand 3	0.031	Human
PRKCA	protein kinase C, alpha	0.031
CDH1	cadherin 1, type 1, E-cadherin (epithelial)	0.030
MAD2L2	MAD2 mitotic arrest deficient-like 2 (yeast)	0.030
TNK2	tyrosine kinase, non-receptor, 2	0.029
PPP1CC	protein phosphatase 1, catalytic subunit, gamma isozyme	0.028
ESR1	estrogen receptor 1	0.028
VAV1	vav 1 guanine nucleotide exchange factor	0.028
CCL13	chemokine (C-C motif) ligand 13	0.028	Human
FCER1G	Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide	0.028
SIGLEC1	sialic acid binding Ig-like lectin 1, sialoadhesin	0.028
SH3GL3	SH3-domain GRB2-like 3	0.027
CAPRIN2	caprin family member 2	0.027
CCR7	chemokine (C-C motif) receptor 7	0.027
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.027
SH3D19	SH3 domain containing 19	0.027
ARRDC3	arrestin domain containing 3	0.026
FKBP8	FK506 binding protein 8, 38kDa	0.026
PDGFC	platelet derived growth factor C	0.026
CXCL13	chemokine (C-X-C motif) ligand 13	0.026
SOS1	son of sevenless homolog 1 (Drosophila)	0.026
ABL2	v-abl Abelson murine leukemia viral oncogene homolog 2	0.025
PAK1	p21 protein (Cdc42/Rac)-activated kinase 1	0.025	Human
PLCG2	phospholipase C, gamma 2 (phosphatidylinositol-specific)	0.025
ASAP1	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	0.025
TP73	tumor protein p73	0.025
UBASH3B	ubiquitin associated and SH3 domain containing B	0.025
COL6A2	collagen, type VI, alpha 2	0.025
IBTK	inhibitor of Bruton agammaglobulinemia tyrosine kinase	0.025
IGFBP3	insulin-like growth factor binding protein 3	0.024
FLT4	fms-related tyrosine kinase 4	0.024	Human
RAC1	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	0.023
SH3RF3	SH3 domain containing ring finger 3	0.023
DLG5	discs, large homolog 5 (Drosophila)	0.023
COL2A1	collagen, type II, alpha 1	0.023
PTPRB	protein tyrosine phosphatase, receptor type, B	0.022
ERBB4	v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)	0.022	Human
IL10	interleukin 10	0.022
CXCL10	chemokine (C-X-C motif) ligand 10	0.022
KITLG	KIT ligand	0.022
SLC9A3R1	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1	0.022
IL1B	interleukin 1, beta	0.022
CCDC6	coiled-coil domain containing 6	0.022
SYK	spleen tyrosine kinase	0.022
MMP12	matrix metallopeptidase 12 (macrophage elastase)	0.022
NRG1	neuregulin 1	0.021
CCL11	chemokine (C-C motif) ligand 11	0.021	Human
PACSIN3	protein kinase C and casein kinase substrate in neurons 3	0.021
GRB10	growth factor receptor-bound protein 10	0.020
POLR2A	polymerase (RNA) II (DNA directed) polypeptide A, 220kDa	0.020
BCL2L1	BCL2-like 1	0.020
MAP3K5	mitogen-activated protein kinase kinase kinase 5	0.020
PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	0.020
KCTD9	potassium channel tetramerisation domain containing 9	0.020
DVL2	dishevelled, dsh homolog 2 (Drosophila)	0.019	Mouse
BCL2	B-cell CLL/lymphoma 2	0.019
VAV2	vav 2 guanine nucleotide exchange factor	0.019
FCN2	ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin)	0.019
CRK	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.019
PDGFA	platelet-derived growth factor alpha polypeptide	0.019	Human
UBQLN2	ubiquilin 2	0.019
CFTR	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	0.019
LCK	lymphocyte-specific protein tyrosine kinase	0.018	Human
EPS15	epidermal growth factor receptor pathway substrate 15	0.018
SH2D3A	SH2 domain containing 3A	0.018
CRMP1	collapsin response mediator protein 1	0.018
IFNG	interferon, gamma	0.018
TMED7	transmembrane emp24 protein transport domain containing 7	0.018
CD2AP	CD2-associated protein	0.018
PTPRA	protein tyrosine phosphatase, receptor type, A	0.018
PKP4	plakophilin 4	0.018
LRP6	low density lipoprotein receptor-related protein 6	0.018	Human
CCR1	chemokine (C-C motif) receptor 1	0.018
CAV2	caveolin 2	0.018
IL7R	interleukin 7 receptor	0.018
MAPK8IP1	mitogen-activated protein kinase 8 interacting protein 1	0.017
CXCL11	chemokine (C-X-C motif) ligand 11	0.017
TLE1	transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)	0.017
PDCD6	programmed cell death 6	0.017
CDH5	cadherin 5, type 2 (vascular endothelium)	0.017
IQGAP1	IQ motif containing GTPase activating protein 1	0.017
AXIN1	axin 1	0.017
TP53BP2	tumor protein p53 binding protein, 2	0.017	Fly
SH2D1A	SH2 domain containing 1A	0.017
TNF	tumor necrosis factor	0.016
VCAM1	vascular cell adhesion molecule 1	0.016
FYB	FYN binding protein	0.016
CAV1	caveolin 1, caveolae protein, 22kDa	0.016
FZD1	frizzled homolog 1 (Drosophila)	0.016
ERCC8	excision repair cross-complementing rodent repair deficiency, complementation group 8	0.016
CCR3	chemokine (C-C motif) receptor 3	0.016
EPS8	epidermal growth factor receptor pathway substrate 8	0.016
CYTB	cytochrome b	0.016
RTKN	rhotekin	0.016
CTNND1	catenin (cadherin-associated protein), delta 1	0.016
PTPRJ	protein tyrosine phosphatase, receptor type, J	0.016
SPRY4	sprouty homolog 4 (Drosophila)	0.016
WNT3A	wingless-type MMTV integration site family, member 3A	0.016	Mouse
CMPK1	cytidine monophosphate (UMP-CMP) kinase 1, cytosolic	0.016
CMTM8	CKLF-like MARVEL transmembrane domain containing 8	0.016
APOE	apolipoprotein E	0.015
FSTL3	follistatin-like 3 (secreted glycoprotein)	0.015
CSF1	colony stimulating factor 1 (macrophage)	0.015
CISH	cytokine inducible SH2-containing protein	0.015	Human
IL6	interleukin 6 (interferon, beta 2)	0.015
COL6A1	collagen, type VI, alpha 1	0.015
DDR2	discoidin domain receptor tyrosine kinase 2	0.015
MMP14	matrix metallopeptidase 14 (membrane-inserted)	0.015
IL2RB	interleukin 2 receptor, beta	0.015
YAP1	Yes-associated protein 1	0.015
ZFYVE1	zinc finger, FYVE domain containing 1	0.015
ADAM15	ADAM metallopeptidase domain 15	0.015	Human
MMS22L	MMS22-like, DNA repair protein	0.015
PTEN	phosphatase and tensin homolog	0.015
ARL3	ADP-ribosylation factor-like 3	0.015
SRCIN1	SRC kinase signaling inhibitor 1	0.015
DLGAP1	discs, large (Drosophila) homolog-associated protein 1	0.014
SSR1	signal sequence receptor, alpha	0.014
SORBS2	sorbin and SH3 domain containing 2	0.014
INHBA	inhibin, beta A	0.014
RIOK3	RIO kinase 3 (yeast)	0.014
CCL19	chemokine (C-C motif) ligand 19	0.014	Human
LNX1	ligand of numb-protein X 1	0.014
GNMT	glycine N-methyltransferase	0.014
STAT4	signal transducer and activator of transcription 4	0.014
ICAM1	intercellular adhesion molecule 1	0.014
DKK1	dickkopf homolog 1 (Xenopus laevis)	0.014
HK2	hexokinase 2	0.014
CSF2RB	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	0.014
PPP1CB	protein phosphatase 1, catalytic subunit, beta isozyme	0.014
PPHLN1	periphilin 1	0.014
IRF8	interferon regulatory factor 8	0.013
IL12RB2	interleukin 12 receptor, beta 2	0.013
JAG1	jagged 1	0.013
IRS4	insulin receptor substrate 4	0.013
DARC	Duffy blood group, chemokine receptor	0.013
AKT2	v-akt murine thymoma viral oncogene homolog 2	0.013
STAM	signal transducing adaptor molecule (SH3 domain and ITAM motif) 1	0.013
MAPK10	mitogen-activated protein kinase 10	0.013
PTGER3	prostaglandin E receptor 3 (subtype EP3)	0.013
EZR	ezrin	0.013
IGF1R	insulin-like growth factor 1 receptor	0.013
UBR1	ubiquitin protein ligase E3 component n-recognin 1	0.013
CCL22	chemokine (C-C motif) ligand 22	0.013
VPS4B	vacuolar protein sorting 4 homolog B (S. cerevisiae)	0.013
DLG2	discs, large homolog 2 (Drosophila)	0.013
AKAP12	A kinase (PRKA) anchor protein 12	0.013
TGFA	transforming growth factor, alpha	0.013
UHRF2	ubiquitin-like with PHD and ring finger domains 2	0.013
COL5A1	collagen, type V, alpha 1	0.013
PDGFRB	platelet-derived growth factor receptor, beta polypeptide	0.013	Human
SELE	selectin E	0.013
CCL7	chemokine (C-C motif) ligand 7	0.013	Human
MAP4K3	mitogen-activated protein kinase kinase kinase kinase 3	0.013
DOK5	docking protein 5	0.013
BNIP2	BCL2/adenovirus E1B 19kDa interacting protein 2	0.013
PTGDS	prostaglandin D2 synthase 21kDa (brain)	0.012
IGFBP5	insulin-like growth factor binding protein 5	0.012
SNIP1	Smad nuclear interacting protein 1	0.012
CD83	CD83 molecule	0.012
PRKACA	protein kinase, cAMP-dependent, catalytic, alpha	0.012
TNFRSF9	tumor necrosis factor receptor superfamily, member 9	0.012
AMMECR1	Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1	0.012
ACACA	acetyl-CoA carboxylase alpha	0.012
COL4A2	collagen, type IV, alpha 2	0.012
LMTK2	lemur tyrosine kinase 2	0.012
SMURF2	SMAD specific E3 ubiquitin protein ligase 2	0.012
JAK3	Janus kinase 3	0.012
SPRY2	sprouty homolog 2 (Drosophila)	0.012
CHMP4B	chromatin modifying protein 4B	0.012
SGK3	serum/glucocorticoid regulated kinase family, member 3	0.012
SH3PXD2A	SH3 and PX domains 2A	0.012
GAS7	growth arrest-specific 7	0.012
PRNP	prion protein	0.012
APBA1	amyloid beta (A4) precursor protein-binding, family A, member 1	0.012
CXCL5	chemokine (C-X-C motif) ligand 5	0.011
DRD1	dopamine receptor D1	0.011	Human
ADRB2	adrenergic, beta-2-, receptor, surface	0.011	Human
A2M	alpha-2-macroglobulin	0.011
CCNE1	cyclin E1	0.011
KCNA1	potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)	0.011
ADORA2A	adenosine A2a receptor	0.011
SOCS4	suppressor of cytokine signaling 4	0.011
DNAJB2	DnaJ (Hsp40) homolog, subfamily B, member 2	0.011
C1QA	complement component 1, q subcomponent, A chain	0.011
MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	0.011
NCK2	NCK adaptor protein 2	0.011
RUNDC3A	RUN domain containing 3A	0.011
C2	complement component 2	0.011
GAB2	GRB2-associated binding protein 2	0.011
ARHGAP5	Rho GTPase activating protein 5	0.011
PTPRF	protein tyrosine phosphatase, receptor type, F	0.011
RGS1	regulator of G-protein signaling 1	0.011
TNS3	tensin 3	0.011
VAV3	vav 3 guanine nucleotide exchange factor	0.011
CUL2	cullin 2	0.011
CH25H	cholesterol 25-hydroxylase	0.011
DLG4	discs, large homolog 4 (Drosophila)	0.011
RGS16	regulator of G-protein signaling 16	0.011
TRAF1	TNF receptor-associated factor 1	0.011
HLA-DRB4	major histocompatibility complex, class II, DR beta 4	0.011
TCTEX1D4	Tctex1 domain containing 4	0.011
COL1A1	collagen, type I, alpha 1	0.011
GSK3B	glycogen synthase kinase 3 beta	0.011
CD80	CD80 molecule	0.011
UBE2D1	ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)	0.011
GRIN2A	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	0.011
ACVR1	activin A receptor, type I	0.010
PHLDA1	pleckstrin homology-like domain, family A, member 1	0.010
NACAD	NAC alpha domain containing	0.010
PAK3	p21 protein (Cdc42/Rac)-activated kinase 3	0.010	Human
CLIC4	chloride intracellular channel 4	0.010
TRAF4	TNF receptor-associated factor 4	0.010
C11orf66	chromosome 11 open reading frame 66	0.010
ADAM10	ADAM metallopeptidase domain 10	0.010
ATXN7	ataxin 7	0.010
STAM2	signal transducing adaptor molecule (SH3 domain and ITAM motif) 2	0.010
IRF4	interferon regulatory factor 4	0.010
CCR4	chemokine (C-C motif) receptor 4	0.010
LDLR	low density lipoprotein receptor	0.010
IL12B	interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)	0.010
MYO6	myosin VI	0.010
CXCL1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	0.010
PRKCB	protein kinase C, beta	0.010
COPG2	coatomer protein complex, subunit gamma 2	0.010
FBXW2	F-box and WD repeat domain containing 2	0.010
PPP1R9B	protein phosphatase 1, regulatory (inhibitor) subunit 9B	0.010
BBC3	BCL2 binding component 3	0.010
ZAP70	zeta-chain (TCR) associated protein kinase 70kDa	0.010
PLD3	phospholipase D family, member 3	0.010
DAPP1	dual adaptor of phosphotyrosine and 3-phosphoinositides	0.010