IMP

Process View

Mus musculus

4 genes annotated in mouse

negative regulation of b cell receptor signaling pathway

Any process that stops, prevents, or reduces the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B cell.

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of b cell receptor signaling pathway"

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Name	Description	Probability	Func Analog Organism
Inpp5d	inositol polyphosphate-5-phosphatase D	0.953
Cd22	CD22 antigen	0.625
Trp53	transformation related protein 53	0.604
Grb2	growth factor receptor bound protein 2	0.440
Lyn	Yamaguchi sarcoma viral (v-yes-1) oncogene homolog	0.380
Nf1	neurofibromatosis 1	0.261
Cd79a	CD79A antigen (immunoglobulin-associated alpha)	0.251
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.208
Cbl	Casitas B-lineage lymphoma	0.179
Flt1	FMS-like tyrosine kinase 1	0.155
Shc1	src homology 2 domain-containing transforming protein C1	0.149
Vav1	vav 1 oncogene	0.140
Ptpn6	protein tyrosine phosphatase, non-receptor type 6	0.140
Igh	immunoglobulin heavy chain complex	0.140
Egfr	epidermal growth factor receptor	0.125
Homer1	homer homolog 1 (Drosophila)	0.120
Vegfa	vascular endothelial growth factor A	0.116
Lepr	leptin receptor	0.105
Shank2	SH3/ankyrin domain gene 2	0.104
Blnk	B-cell linker	0.097
Parvg	parvin, gamma	0.096
Btk	Bruton agammaglobulinemia tyrosine kinase	0.091
Nos3	nitric oxide synthase 3, endothelial cell	0.083
Cd72	CD72 antigen	0.075
Cd19	CD19 antigen	0.072
Dok1	docking protein 1	0.071
Rxra	retinoid X receptor alpha	0.067
Plcg2	phospholipase C, gamma 2	0.066	Mouse
Erbb2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.066
Cd37	CD37 antigen	0.060
Nfkb2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100	0.060
Spag8	sperm associated antigen 8	0.058
Sos1	son of sevenless homolog 1 (Drosophila)	0.058
Camk2a	calcium/calmodulin-dependent protein kinase II alpha	0.057
Plekhh2	pleckstrin homology domain containing, family H (with MyTH4 domain) member 2	0.056
Ikzf3	IKAROS family zinc finger 3	0.055
Bcar1	breast cancer anti-estrogen resistance 1	0.054
Jup	junction plakoglobin	0.053
Fgfr2	fibroblast growth factor receptor 2	0.051
Gab2	growth factor receptor bound protein 2-associated protein 2	0.050
Dynlt1b	dynein light chain Tctex-type 1D	0.050
Sfpi1	SFFV proviral integration 1	0.048
Src	Rous sarcoma oncogene	0.046
Traf3ip2	TRAF3 interacting protein 2	0.046
Myl9	myosin, light polypeptide 9, regulatory	0.044
Tnfrsf13b	tumor necrosis factor receptor superfamily, member 13b	0.044
Vhl	von Hippel-Lindau tumor suppressor	0.043
Slamf1	signaling lymphocytic activation molecule family member 1	0.043
Smtn	smoothelin	0.040
Dok3	docking protein 3	0.040
Fas	Fas (TNF receptor superfamily member 6)	0.040
Npdc1	neural proliferation, differentiation and control gene 1	0.039
Erbb3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.038
Cnn1	calponin 1	0.036
Ptk2	PTK2 protein tyrosine kinase 2	0.036
Epas1	endothelial PAS domain protein 1	0.036
Pstpip1	proline-serine-threonine phosphatase-interacting protein 1	0.035
Grm1	glutamate receptor, metabotropic 1	0.035
Dlg2	discs, large homolog 2 (Drosophila)	0.034
Ntf3	neurotrophin 3	0.034
Arhgef25	Rho guanine nucleotide exchange factor (GEF) 25	0.033
Tagln	transgelin	0.033
Isl1	ISL1 transcription factor, LIM/homeodomain	0.032
Prkcb	protein kinase C, beta	0.032
Lmna	lamin A	0.031
Atxn1	ataxin 1	0.031
Dnm1	dynamin 1	0.031
Tnfrsf13c	tumor necrosis factor receptor superfamily, member 13c	0.031
Grin2b	glutamate receptor, ionotropic, NMDA2B (epsilon 2)	0.031
Dscaml1	Down syndrome cell adhesion molecule-like 1	0.031
Zfpm2	zinc finger protein, multitype 2	0.030
Emp2	epithelial membrane protein 2	0.030
Nbl1	neuroblastoma, suppression of tumorigenicity 1	0.030
Dlgap1	discs, large (Drosophila) homolog-associated protein 1	0.029
Epb4.1l2	erythrocyte protein band 4.1-like 2	0.029
Ikzf1	IKAROS family zinc finger 1	0.029
Arc	activity regulated cytoskeletal-associated protein	0.029
Dvl2	dishevelled 2, dsh homolog (Drosophila)	0.028
Adam19	a disintegrin and metallopeptidase domain 19 (meltrin beta)	0.028
Hey2	hairy/enhancer-of-split related with YRPW motif 2	0.027
Ldlr	low density lipoprotein receptor	0.027
Dsg1a	desmoglein 1 alpha	0.027
Ptk2b	PTK2 protein tyrosine kinase 2 beta	0.027
Tnf	tumor necrosis factor	0.027
Acta2	actin, alpha 2, smooth muscle, aorta	0.026
Pik3cd	phosphatidylinositol 3-kinase catalytic delta polypeptide	0.026
Kdr	kinase insert domain protein receptor	0.026
Vav2	vav 2 oncogene	0.026
Fstl3	follistatin-like 3	0.026
Cd79b	CD79B antigen	0.025
Nes	nestin	0.025
Cnr2	cannabinoid receptor 2 (macrophage)	0.025
Prkch	protein kinase C, eta	0.025
Col1a1	collagen, type I, alpha 1	0.024
Dot1l	DOT1-like, histone H3 methyltransferase (S. cerevisiae)	0.024
Hcls1	hematopoietic cell specific Lyn substrate 1	0.024
Pou2af1	POU domain, class 2, associating factor 1	0.024
Grik2	glutamate receptor, ionotropic, kainate 2 (beta 2)	0.024
Prkcdbp	protein kinase C, delta binding protein	0.023
Ppp6r2	protein phosphatase 6, regulatory subunit 2	0.022
Acvr1	activin A receptor, type 1	0.022
Prkcd	protein kinase C, delta	0.021
Efnb2	ephrin B2	0.021
Sox4	SRY-box containing gene 4	0.021
Fcgr2b	Fc receptor, IgG, low affinity IIb	0.021
Rtkn	rhotekin	0.021
Lyz2	lysozyme 2	0.021
Bmp4	bone morphogenetic protein 4	0.021
Thbs3	thrombospondin 3	0.020
Epor	erythropoietin receptor	0.020
Sykb	spleen tyrosine kinase	0.020
Ncoa3	nuclear receptor coactivator 3	0.020
Cttn	cortactin	0.020
Tcrd	T-cell receptor delta chain	0.020
Cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.020
Kit	kit oncogene	0.019
Tnks1bp1	tankyrase 1 binding protein 1	0.019
Cit	citron	0.019
Hmha1	histocompatibility (minor) HA-1	0.019
Bcl2l11	BCL2-like 11 (apoptosis facilitator)	0.019
Krt19	keratin 19	0.018
Lrmp	lymphoid-restricted membrane protein	0.018
Nrg1	neuregulin 1	0.018
Ptpn22	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	0.018
Slamf6	SLAM family member 6	0.018
Fyb	FYN binding protein	0.018
Tep1	telomerase associated protein 1	0.018
Sash3	SAM and SH3 domain containing 3	0.018
2610015P09Rik	RIKEN cDNA 2610015P09 gene	0.017
Cryab	crystallin, alpha B	0.017
Klf5	Kruppel-like factor 5	0.017
Mcam	melanoma cell adhesion molecule	0.017
Cldn5	claudin 5	0.017
Capg	capping protein (actin filament), gelsolin-like	0.017
Ctnnd1	catenin (cadherin associated protein), delta 1	0.016
Stap1	signal transducing adaptor family member 1	0.016
Igfbp6	insulin-like growth factor binding protein 6	0.016
G6pd2	glucose-6-phosphate dehydrogenase 2	0.016
Rab3a	RAB3A, member RAS oncogene family	0.016
Nfkbia	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.016
Actn2	actinin alpha 2	0.016
Card11	caspase recruitment domain family, member 11	0.016
Sfn	stratifin	0.016
Gfra2	glial cell line derived neurotrophic factor family receptor alpha 2	0.016
Irf8	interferon regulatory factor 8	0.016
Aldh1a2	aldehyde dehydrogenase family 1, subfamily A2	0.016
Lyl1	lymphoblastomic leukemia 1	0.015
Plekhh3	pleckstrin homology domain containing, family H (with MyTH4 domain) member 3	0.015
Pparg	peroxisome proliferator activated receptor gamma	0.015
Glb1l	galactosidase, beta 1-like	0.015
Fermt3	fermitin family homolog 3 (Drosophila)	0.015
Smn1	survival motor neuron 1	0.015
Rnase6	ribonuclease, RNase A family, 6	0.015
Gmip	Gem-interacting protein	0.015
Cav1	caveolin 1, caveolae protein	0.015
Zbtb7b	zinc finger and BTB domain containing 7B	0.015
Hey1	hairy/enhancer-of-split related with YRPW motif 1	0.015
Ttn	titin	0.014
Psen1	presenilin 1	0.014
Nfam1	Nfat activating molecule with ITAM motif 1	0.014
Aif1	allograft inflammatory factor 1	0.014
Pik3cg	phosphoinositide-3-kinase, catalytic, gamma polypeptide	0.014
Ptprc	protein tyrosine phosphatase, receptor type, C	0.014
Adamtsl5	ADAMTS-like 5	0.014
Zfy2	zinc finger protein 2, Y linked	0.014
Mus81	MUS81 endonuclease homolog (yeast)	0.014
Mfsd11	major facilitator superfamily domain containing 11	0.014
Dok2	docking protein 2	0.014
Gna11	guanine nucleotide binding protein, alpha 11	0.014
Cyp4f18	cytochrome P450, family 4, subfamily f, polypeptide 18	0.014
Ace	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	0.014
Npy1r	neuropeptide Y receptor Y1	0.014
Aicda	activation-induced cytidine deaminase	0.014
Cd209a	CD209a antigen	0.014
Gab1	growth factor receptor bound protein 2-associated protein 1	0.014
Pdlim7	PDZ and LIM domain 7	0.014
2310046K01Rik	RIKEN cDNA 2310046K01 gene	0.014
Ceacam1	carcinoembryonic antigen-related cell adhesion molecule 1	0.014
Mid2	midline 2	0.013
Snx29	sorting nexin 29	0.013
Abl1	c-abl oncogene 1, non-receptor tyrosine kinase	0.013
Gys1	glycogen synthase 1, muscle	0.013
Fgd2	FYVE, RhoGEF and PH domain containing 2	0.013
Slamf9	SLAM family member 9	0.013
Jag1	jagged 1	0.013
Slamf7	SLAM family member 7	0.013
Tnfrsf14	tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)	0.013
Havcr2	hepatitis A virus cellular receptor 2	0.013
Sync	syncoilin	0.013
Pdgfa	platelet derived growth factor, alpha	0.013
Fn1	fibronectin 1	0.013
Plcb3	phospholipase C, beta 3	0.013	Mouse
Arrdc1	arrestin domain containing 1	0.013
Rpl37	ribosomal protein L37	0.013
Gja1	gap junction protein, alpha 1	0.013
Crem	cAMP responsive element modulator	0.012
Igf1	insulin-like growth factor 1	0.012
Grin1	glutamate receptor, ionotropic, NMDA1 (zeta 1)	0.012
Smad6	MAD homolog 6 (Drosophila)	0.012
Cd248	CD248 antigen, endosialin	0.012
Rapgef3	Rap guanine nucleotide exchange factor (GEF) 3	0.012
Sema3c	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C	0.012
Itga1	integrin alpha 1	0.012
Ptrf	polymerase I and transcript release factor	0.012
Tlr1	toll-like receptor 1	0.012
Osr1	odd-skipped related 1 (Drosophila)	0.012
2010106E10Rik	RIKEN cDNA 2010106E10 gene	0.012
Ndst1	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	0.012
Sox18	SRY-box containing gene 18	0.012
Fhl2	four and a half LIM domains 2	0.012
Ephb4	Eph receptor B4	0.012
Stat3	signal transducer and activator of transcription 3	0.012
Adcy1	adenylate cyclase 1	0.012
Pde3a	phosphodiesterase 3A, cGMP inhibited	0.012
F13a1	coagulation factor XIII, A1 subunit	0.012
Tmem59	transmembrane protein 59	0.012
Myh10	myosin, heavy polypeptide 10, non-muscle	0.012
Bcl7a	B-cell CLL/lymphoma 7A	0.012
Icosl	icos ligand	0.012
P2rx1	purinergic receptor P2X, ligand-gated ion channel, 1	0.012
Nsf	N-ethylmaleimide sensitive fusion protein	0.012
Nr4a3	nuclear receptor subfamily 4, group A, member 3	0.012
Csl	citrate synthase like	0.012
Spry2	sprouty homolog 2 (Drosophila)	0.012
Fbln1	fibulin 1	0.012
Cd209f	CD209f antigen	0.012
H2-DMb2	histocompatibility 2, class II, locus Mb2	0.012
Nos1	nitric oxide synthase 1, neuronal	0.012
Ephb3	Eph receptor B3	0.012
Dock8	dedicator of cytokinesis 8	0.012
Des	desmin	0.012
Catsper2	cation channel, sperm associated 2	0.011
Cxcr7	chemokine (C-X-C motif) receptor 7	0.011
Rps6ka1	ribosomal protein S6 kinase polypeptide 1	0.011
Nup210l	nucleoporin 210-like	0.011
Map4k1	mitogen-activated protein kinase kinase kinase kinase 1	0.011
Slc37a2	solute carrier family 37 (glycerol-3-phosphate transporter), member 2	0.011
Dqx1	DEAQ RNA-dependent ATPase	0.011
Cuedc1	CUE domain containing 1	0.011
Bhlhe41	basic helix-loop-helix family, member e41	0.011
Dusp4	dual specificity phosphatase 4	0.011
Daf2	decay accelerating factor 2	0.011
Eng	endoglin	0.011
Cnn2	calponin 2	0.011
BC013712	cDNA sequence BC013712	0.011
L1cam	L1 cell adhesion molecule	0.011
Prkce	protein kinase C, epsilon	0.011
Rara	retinoic acid receptor, alpha	0.011
Ctss	cathepsin S	0.011
Htra1	HtrA serine peptidase 1	0.011
Plekhg5	pleckstrin homology domain containing, family G (with RhoGef domain) member 5	0.011
Pcgf2	polycomb group ring finger 2	0.011
Spata4	spermatogenesis associated 4	0.011
Socs7	suppressor of cytokine signaling 7	0.011
Cap1	CAP, adenylate cyclase-associated protein 1 (yeast)	0.011
Prdm9	PR domain containing 9	0.011
Ltbp4	latent transforming growth factor beta binding protein 4	0.011
Pde7b	phosphodiesterase 7B	0.011
Atp2b4	ATPase, Ca++ transporting, plasma membrane 4	0.011
Dennd1c	DENN/MADD domain containing 1C	0.011
Mdk	midkine	0.011
Caskin2	CASK-interacting protein 2	0.011
A630001G21Rik	RIKEN cDNA A630001G21 gene	0.011
Dll4	delta-like 4 (Drosophila)	0.011
Tmc8	transmembrane channel-like gene family 8	0.011
Fhl5	four and a half LIM domains 5	0.011	Mouse
Tnfaip8l2	tumor necrosis factor, alpha-induced protein 8-like 2	0.011
Kcnn3	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3	0.011
Sh3tc1	SH3 domain and tetratricopeptide repeats 1	0.011
Rhbdf1	rhomboid family 1 (Drosophila)	0.011
Thrb	thyroid hormone receptor beta	0.011
Ccdc88b	coiled-coil domain containing 88B	0.011
Fadd	Fas (TNFRSF6)-associated via death domain	0.011
Armc7	armadillo repeat containing 7	0.011
Slc17a9	solute carrier family 17, member 9	0.011
Il10ra	interleukin 10 receptor, alpha	0.011
Ttl	tubulin tyrosine ligase	0.011
Myh11	myosin, heavy polypeptide 11, smooth muscle	0.011
Cxadr	coxsackie virus and adenovirus receptor	0.010
Ptgis	prostaglandin I2 (prostacyclin) synthase	0.010
Apbb1ip	amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein	0.010
Naaa	N-acylethanolamine acid amidase	0.010
Cdk14	cyclin-dependent kinase 14	0.010
Myo1f	myosin IF	0.010
Cacnb3	calcium channel, voltage-dependent, beta 3 subunit	0.010
Trim27	tripartite motif-containing 27	0.010
Mmp15	matrix metallopeptidase 15	0.010
Rarb	retinoic acid receptor, beta	0.010
Nckap1l	NCK associated protein 1 like	0.010
Il10	interleukin 10	0.010
Mapk7	mitogen-activated protein kinase 7	0.010
Kif21b	kinesin family member 21B	0.010
Dtx2	deltex 2 homolog (Drosophila)	0.010
1700001P01Rik	RIKEN cDNA 1700001P01 gene	0.010
Carns1	carnosine synthase 1	0.010
Tlr2	toll-like receptor 2	0.010
Mmp23	matrix metallopeptidase 23	0.010
Ebi3	Epstein-Barr virus induced gene 3	0.010
Cish	cytokine inducible SH2-containing protein	0.010
Utrn	utrophin	0.010
B3gnt8	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8	0.010
Nr2f6	nuclear receptor subfamily 2, group F, member 6	0.010
Myo1g	myosin IG	0.010
Hic1	hypermethylated in cancer 1	0.010
Gimap1	GTPase, IMAP family member 1	0.010
Rapgefl1	Rap guanine nucleotide exchange factor (GEF)-like 1	0.010
Aim2	absent in melanoma 2	0.010
Arhgap9	Rho GTPase activating protein 9	0.010