The network for 'immunoglobulin production' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

immunoglobulin production

The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.

Mus musculus
Name Description Probability Func Analog Organism
Ifng interferon gamma 0.993
Cd40 CD40 antigen 0.950
Cd28 CD28 antigen 0.948
Atm ataxia telangiectasia mutated homolog (human) 0.937
Il4 interleukin 4 0.930
Fcer1g Fc receptor, IgE, high affinity I, gamma polypeptide 0.902
Igh immunoglobulin heavy chain complex 0.887
Stat3 signal transducer and activator of transcription 3 0.870
Prkdc protein kinase, DNA activated, catalytic polypeptide 0.861
Fas Fas (TNF receptor superfamily member 6) 0.842
Rag2 recombination activating gene 2 0.838
Socs1 suppressor of cytokine signaling 1 0.817
Foxp3 forkhead box P3 0.814
Ccl2 chemokine (C-C motif) ligand 2 0.812
Il10 interleukin 10 0.811
Pou5f1 POU domain, class 5, transcription factor 1 0.796
Stat6 signal transducer and activator of transcription 6 0.788
Traf2 TNF receptor-associated factor 2 0.752
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.732
Lyz2 lysozyme 2 0.709
Pik3cd phosphatidylinositol 3-kinase catalytic delta polypeptide 0.672
Tnfrsf4 tumor necrosis factor receptor superfamily, member 4 0.645
Lat linker for activation of T cells 0.632
Sox2 SRY-box containing gene 2 0.603
Cd19 CD19 antigen 0.596
Csf2rb2 colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage) 0.572
Il4ra interleukin 4 receptor, alpha 0.569
Stat5b signal transducer and activator of transcription 5B 0.557
Batf basic leucine zipper transcription factor, ATF-like 0.542
Casp4 caspase 4, apoptosis-related cysteine peptidase 0.495
Ccr1 chemokine (C-C motif) receptor 1 0.482
Ccr7 chemokine (C-C motif) receptor 7 0.440
Fyn Fyn proto-oncogene 0.432
Tnfaip3 tumor necrosis factor, alpha-induced protein 3 0.373
Csf2rb colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 0.371
Irf9 interferon regulatory factor 9 0.360
Hcn4 hyperpolarization-activated, cyclic nucleotide-gated K+ 4 0.338
Pdcd1 programmed cell death 1 0.337
Tnfrsf9 tumor necrosis factor receptor superfamily, member 9 0.336
Il1r1 interleukin 1 receptor, type I 0.335
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.329
Msr1 macrophage scavenger receptor 1 0.319
Tcra T-cell receptor alpha chain 0.299
S1pr2 sphingosine-1-phosphate receptor 2 0.289
Nanog Nanog homeobox 0.287
Il6 interleukin 6 0.274
Il1b interleukin 1 beta 0.263
C3ar1 complement component 3a receptor 1 0.262
Casp1 caspase 1 0.259
Myd88 myeloid differentiation primary response gene 88 0.258
Otx2 orthodenticle homolog 2 (Drosophila) 0.248
Ccl22 chemokine (C-C motif) ligand 22 0.240
Il10ra interleukin 10 receptor, alpha 0.237
Lyn Yamaguchi sarcoma viral (v-yes-1) oncogene homolog 0.231
Aire autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy) 0.223
Ccl12 chemokine (C-C motif) ligand 12 0.222
Il2rg interleukin 2 receptor, gamma chain 0.220
Il6st interleukin 6 signal transducer 0.218
Prf1 perforin 1 (pore forming protein) 0.218
Ptgs2 prostaglandin-endoperoxide synthase 2 0.211
Ctss cathepsin S 0.199
Cbfa2t3 core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human) 0.198
Birc3 baculoviral IAP repeat-containing 3 0.193
Ctla4 cytotoxic T-lymphocyte-associated protein 4 0.189
Dll4 delta-like 4 (Drosophila) 0.184
Fasl Fas ligand (TNF superfamily, member 6) 0.183
Nckap1l NCK associated protein 1 like 0.183
Ltb lymphotoxin B 0.181
Brca2 breast cancer 2 0.179
Socs3 suppressor of cytokine signaling 3 0.173
Tnfsf11 tumor necrosis factor (ligand) superfamily, member 11 0.173
Lag3 lymphocyte-activation gene 3 0.172
Stat5a signal transducer and activator of transcription 5A 0.171
Pitx1 paired-like homeodomain transcription factor 1 0.171
Il2 interleukin 2 0.171
Gpr132 G protein-coupled receptor 132 0.170
Rc3h1 RING CCCH (C3H) domains 1 0.170
Wt1 Wilms tumor 1 homolog 0.167
Sall4 sal-like 4 (Drosophila) 0.165
Irf4 interferon regulatory factor 4 0.164
Cd14 CD14 antigen 0.163
Serpina3n serine (or cysteine) peptidase inhibitor, clade A, member 3N 0.159
Sall3 sal-like 3 (Drosophila) 0.158
H2-Aa histocompatibility 2, class II antigen A, alpha 0.155
Ptpn22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 0.151
Mdm2 transformed mouse 3T3 cell double minute 2 0.151
Cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.151
Selp selectin, platelet 0.150
Ccl8 chemokine (C-C motif) ligand 8 0.149
Batf3 basic leucine zipper transcription factor, ATF-like 3 0.146
Tcf3 transcription factor 3 0.145
Rag1 recombination activating gene 1 0.144
Fcgr2b Fc receptor, IgG, low affinity IIb 0.141
Cd40lg CD40 ligand 0.139
Rarg retinoic acid receptor, gamma 0.137
Map3k7 mitogen-activated protein kinase kinase kinase 7 0.137
Tbx3 T-box 3 0.129
Tal1 T-cell acute lymphocytic leukemia 1 0.128
Pycard PYD and CARD domain containing 0.126
Ch25h cholesterol 25-hydroxylase 0.125
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
nod1 nucleotide-binding oligomerization domain containing 1 0.238
LOC557072 caspase recruitment domain-containing protein 11-like 0.180
mybl2 myeloblastosis oncogene-like 2 0.107
mcm5 MCM5 minichromosome maintenance deficient 5 (S. cerevisiae) 0.102
nap1l1 nucleosome assembly protein 1, like 1 0.090
chtf18 CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae) 0.067
msh2 mutS homolog 2 (E. coli) 0.065
msh6 mutS homolog 6 (E. coli) 0.064
grna granulin a 0.063
tlr3 toll-like receptor 3 0.059
atad5a ATPase family, AAA domain containing 5a 0.054
pds5b PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae) 0.051
si:dkeyp-22b2.3 si:dkeyp-22b2.3 0.043
dusp6 dual specificity phosphatase 6 0.036
c1qc complement component 1, q subcomponent, C chain 0.033
ets1a v-ets erythroblastosis virus E26 oncogene homolog 1a 0.032
mafba v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian) 0.031
ext1b exostoses (multiple) 1b 0.030
LOC100000934 hypothetical protein LOC100000934 0.030
si:ch211-195h23.3 si:ch211-195h23.3 0.030
tlr9 toll-like receptor 9 0.030
crb2a crumbs homolog 2a 0.029
mbtps1 membrane-bound transcription factor protease, site 1 0.028
myca myelocytomatosis oncogene a 0.027
efna2 ephrin A2 0.027
ptger4b prostaglandin E receptor 4 (subtype EP4) b 0.027
mcm4 MCM4 minichromosome maintenance deficient 4, mitotin (S. cerevisiae) 0.027
pola1 polymerase (DNA directed), alpha 1 0.026
mtmr8 myotubularin related protein 8 0.025
zgc:56197 zgc:56197 0.025
lrrc33 leucine rich repeat containing 33 0.025
zfr zinc finger RNA binding protein 0.024
khdrbs1b KH domain containing, RNA binding, signal transduction associated 1b 0.023
tert telomerase reverse transcriptase 0.023
cx43 connexin 43 0.023
zgc:86870 zgc:86870 0.022
brip1 BRCA1 interacting protein C-terminal helicase 1 0.022
grn1 granulin 1 0.022
phf16 PHD finger protein 16 0.022
tbx21 T-box 21 0.022
pole2 polymerase (DNA directed), epsilon 2 0.021
pola2 polymerase (DNA directed), alpha 2 0.021
nitr5 novel immune-type receptor 5 and immune-type receptor 5-like 0.021
setdb1a SET domain, bifurcated 1a 0.021
stc1l stanniocalcin 1, like 0.021
c1qb complement component 1, q subcomponent, B chain 0.021
zgc:100817 zgc:100817 0.021
lipc lipase, hepatic 0.021
sox19a SRY-box containing gene 19a 0.021
ahr2 aryl hydrocarbon receptor 2 0.020
dntt deoxynucleotidyltransferase, terminal 0.020
hirip3 HIRA interacting protein 3 0.020
flot1b flotillin 1b 0.020
olig4 oligodendrocyte transcription factor 4 0.020
lgals2a lectin, galactoside-binding, soluble, 2a 0.020
wasb Wiskott-Aldrich syndrome (eczema-thrombocytopenia) b 0.020
cd40lg CD40 ligand 0.020
kiss1 KiSS-1 metastasis-suppressor 0.020
aldh18a1 aldehyde dehydrogenase 18 family, member A1 0.020
casrl calcium-sensing receptor, like 0.019
glud1a glutamate dehydrogenase 1a 0.019
zgc:103580 zgc:103580 0.019
igfbp1b insulin-like growth factor binding protein 1b 0.019
pold2 polymerase (DNA directed), delta 2, regulatory subunit 0.019
irak4 interleukin-1 receptor-associated kinase 4 0.019
rmi1 RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae) 0.019
tfeb transcription factor EB 0.019
senp6a SUMO1/sentrin specific peptidase 6a 0.018
ptp4a3 protein tyrosine phosphatase type IVA, member 3 0.018
pold1 polymerase (DNA directed), delta 1, catalytic subunit 0.018
pcsk9 proprotein convertase subtilisin/kexin type 9 0.018
LOC566020 Gig2-like protein DreO 0.018
foxp3a forkhead box P3a 0.018
rorca RAR-related orphan receptor C a 0.018
ighm immunoglobulin heavy constant mu and immunoglobulin heavy constant mu 0.018
lgr8.2 hypothetical LOC566888 0.018
ezh2 enhancer of zeste homolog 2 (Drosophila) 0.018
hspa9 heat shock protein 9 0.018
npat nuclear protein, ataxia-telangiectasia locus 0.018
zgc:174506 zgc:174506 0.018
rac1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 0.018
cyp2aa2 y cytochrome P450, family 2, subfamily AA, polypeptide 2 0.017
tgm2b transglutaminase 2b 0.017
rnasen ribonuclease type III, nuclear 0.017
ifnphi1 interferon phi 1 0.017
hmgb1b high-mobility group box 1b 0.017
acp5b acid phosphatase 5b, tartrate resistant 0.017
il8 interleukin 8 0.017
med24 mediator complex subunit 24 0.017
ighz immunoglobulin heavy constant zeta 0.017
chek2 CHK2 checkpoint homolog (S. pombe) 0.017
rest RE1-silencing transcription factor 0.017
atp2b4 ATPase, Ca++ transporting, plasma membrane 4 0.017
gga1 golgi associated, gamma adaptin ear containing, ARF binding protein 1 0.016
zgc:86841 zgc:86841 0.016
tnfrsf18 tumor necrosis factor receptor superfamily, member 18 0.016
defbl3 defensin, beta-like 3 0.016
pth1a parathyroid hormone 1a 0.016
ercc2 excision repair cross-complementing rodent repair deficiency, complementation group 2 0.016
slc2a1a solute carrier family 2 (facilitated glucose transporter), member 1a 0.016
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
BRCA1 breast cancer 1, early onset 0.331
MLH1 mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) 0.258
INPP5D inositol polyphosphate-5-phosphatase, 145kDa 0.150
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain 0.142
SYK spleen tyrosine kinase 0.091
APLF aprataxin and PNKP like factor 0.076
RAD50 RAD50 homolog (S. cerevisiae) 0.065
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 1 0.064
HLA-DRA major histocompatibility complex, class II, DR alpha 0.057
IL4R interleukin 4 receptor 0.054
MSH2 mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) 0.044
HLA-DMA major histocompatibility complex, class II, DM alpha 0.042
MSH6 mutS homolog 6 (E. coli) 0.042
HLA-DRB5 major histocompatibility complex, class II, DR beta 5 0.034
HLA-DMB major histocompatibility complex, class II, DM beta 0.033
GRAP2 GRB2-related adaptor protein 2 0.030
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.028
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B 0.027
LAPTM5 lysosomal protein transmembrane 5 0.024
ZNF830 zinc finger protein 830 0.021
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4 0.021
TRAF1 TNF receptor-associated factor 1 0.021
IL2RG interleukin 2 receptor, gamma 0.021
RNF11 ring finger protein 11 0.019
FANCD2 Fanconi anemia, complementation group D2 0.019
TAL1 T-cell acute lymphocytic leukemia 1 0.017
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.015
PTPN6 protein tyrosine phosphatase, non-receptor type 6 0.015
CD40 CD40 molecule, TNF receptor superfamily member 5 0.014
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 0.013
MSH3 mutS homolog 3 (E. coli) 0.013
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced 0.012
HLA-DPB1 major histocompatibility complex, class II, DP beta 1 0.012
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 0.011
PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae) 0.011
HLA-DRB4 major histocompatibility complex, class II, DR beta 4 0.011
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae) 0.011
TRAF3 TNF receptor-associated factor 3 0.010
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism