The network for 'positive regulation of reactive oxygen species biosynthetic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of reactive oxygen species biosynthetic process

Any process that activates or increases the frequency, rate or extent of reactive oxygen species biosynthetic process.

Mus musculus
Name Description Probability Func Analog Organism
Tnf tumor necrosis factor 0.998
Ccr2 chemokine (C-C motif) receptor 2 0.993
Tlr4 toll-like receptor 4 0.993
Myd88 myeloid differentiation primary response gene 88 0.986
Nos2 nitric oxide synthase 2, inducible 0.977
Il10 interleukin 10 0.962
B2m beta-2 microglobulin 0.951
Klra9 killer cell lectin-like receptor subfamily A, member 9 0.921
H2-D1 histocompatibility 2, D region locus 1 0.892
Rag1 recombination activating gene 1 0.877
Pten phosphatase and tensin homolog 0.864
Il6 interleukin 6 0.855
H2-K1 histocompatibility 2, K1, K region 0.850
Relb avian reticuloendotheliosis viral (v-rel) oncogene related B 0.809
Ifng interferon gamma 0.802
Lyz2 lysozyme 2 0.750
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.748
Mef2d myocyte enhancer factor 2D 0.727
Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b 0.722
Vdr vitamin D receptor 0.696
Il1a interleukin 1 alpha 0.666
Klrk1 killer cell lectin-like receptor subfamily K, member 1 0.589
H2-Q7 histocompatibility 2, Q region locus 7 0.576
Lepr leptin receptor 0.554
Akt1 thymoma viral proto-oncogene 1 0.553
Ncr1 natural cytotoxicity triggering receptor 1 0.540
Fcer1g Fc receptor, IgE, high affinity I, gamma polypeptide 0.531
Nos3 nitric oxide synthase 3, endothelial cell 0.525
Il2rg interleukin 2 receptor, gamma chain 0.506
Mmp9 matrix metallopeptidase 9 0.487
Stat3 signal transducer and activator of transcription 3 0.457
Fas Fas (TNF receptor superfamily member 6) 0.444
Cd19 CD19 antigen 0.443
Map3k14 mitogen-activated protein kinase kinase kinase 14 0.442
Esr1 estrogen receptor 1 (alpha) 0.428
Lyst lysosomal trafficking regulator 0.425
Stat1 signal transducer and activator of transcription 1 0.423
Prf1 perforin 1 (pore forming protein) 0.421
Cd44 CD44 antigen 0.407
Socs1 suppressor of cytokine signaling 1 0.389
Tcra T-cell receptor alpha chain 0.387
Ccl2 chemokine (C-C motif) ligand 2 0.385
Ren1 renin 1 structural 0.375
Hspa8 heat shock protein 8 0.356
Tgfb1 transforming growth factor, beta 1 0.340
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.330
Klrd1 killer cell lectin-like receptor, subfamily D, member 1 0.319
Il6st interleukin 6 signal transducer 0.319
Hsp90ab1 heat shock protein 90 alpha (cytosolic), class B member 1 0.305
Tnfsf11 tumor necrosis factor (ligand) superfamily, member 11 0.289
Spp1 secreted phosphoprotein 1 0.282
Ostm1 osteopetrosis associated transmembrane protein 1 0.280
Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 0.279
Lair1 leukocyte-associated Ig-like receptor 1 0.278
Klrc1 killer cell lectin-like receptor subfamily C, member 1 0.278
Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.277
Klra5 killer cell lectin-like receptor, subfamily A, member 5 0.255
Sytl5 synaptotagmin-like 5 0.246
Cp ceruloplasmin 0.244
Ptprc protein tyrosine phosphatase, receptor type, C 0.239
Gzmb granzyme B 0.234
Slc40a1 solute carrier family 40 (iron-regulated transporter), member 1 0.228
Ptgs2 prostaglandin-endoperoxide synthase 2 0.225
Il7r interleukin 7 receptor 0.216
Trp53 transformation related protein 53 0.213
Cblb Casitas B-lineage lymphoma b 0.212
Col1a1 collagen, type I, alpha 1 0.206
Hsp90aa1 heat shock protein 90, alpha (cytosolic), class A member 1 0.203
Stx11 syntaxin 11 0.201
Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.198
Agtr1a angiotensin II receptor, type 1a 0.195
Mapk14 mitogen-activated protein kinase 14 0.191
Fasl Fas ligand (TNF superfamily, member 6) 0.191
Invs inversin 0.191
Clec4e C-type lectin domain family 4, member e 0.188
Klra7 killer cell lectin-like receptor, subfamily A, member 7 0.187
Crim1 cysteine rich transmembrane BMP regulator 1 (chordin like) 0.187
Slc12a1 solute carrier family 12, member 1 0.186
Smad3 MAD homolog 3 (Drosophila) 0.184
Nfkbie nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 0.184
H2-Q6 histocompatibility 2, Q region locus 6 0.180
Adamts1 a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1 0.170
Zbtb37 zinc finger and BTB domain containing 37 0.167
Clec4n C-type lectin domain family 4, member n 0.164
Klra6 killer cell lectin-like receptor, subfamily A, member 6 0.162
Cd14 CD14 antigen 0.153
Flt3 FMS-like tyrosine kinase 3 0.151
Pyhin1 pyrin and HIN domain family, member 1 0.151
Clec4a2 C-type lectin domain family 4, member a2 0.151
Tnfsf14 tumor necrosis factor (ligand) superfamily, member 14 0.150
F9 coagulation factor IX 0.149
Apoe apolipoprotein E 0.149
Vhl von Hippel-Lindau tumor suppressor 0.147
Emr4 EGF-like module containing, mucin-like, hormone receptor-like sequence 4 0.147
Pkd1 polycystic kidney disease 1 homolog 0.144
Lta lymphotoxin A 0.143
Gzma granzyme A 0.136
Adora3 adenosine A3 receptor 0.133
Fcrla Fc receptor-like A 0.132
Chordc1 cysteine and histidine-rich domain (CHORD)-containing, zinc-binding protein 1 0.127
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
Pi3K92E CG4141 gene product from transcript CG4141-RB 0.083
spi spitz 0.053
InR Insulin-like receptor 0.039
hep hemipterous 0.021
EcR Ecdysone receptor 0.019
foxo forkhead box, sub-group O 0.016
kay kayak 0.014
chico CG5686 gene product from transcript CG5686-RB 0.013
S6k RPS6-p70-protein kinase 0.012
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Homo sapiens
Name Description Probability Func Analog Organism
EGFR epidermal growth factor receptor 0.999
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.883
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.841
IL8 interleukin 8 0.679
IL1R1 interleukin 1 receptor, type I 0.667
GOPC golgi-associated PDZ and coiled-coil motif containing 0.631
IGF1R insulin-like growth factor 1 receptor 0.553
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.538
TICAM2 toll-like receptor adaptor molecule 2 0.515
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.504
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.460
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 0.415
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.344
FOS FBJ murine osteosarcoma viral oncogene homolog 0.325
ZFP36 zinc finger protein 36, C3H type, homolog (mouse) 0.321
NOXA1 NADPH oxidase activator 1 0.314
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 0.279
PPP5C protein phosphatase 5, catalytic subunit 0.258
CAV1 caveolin 1, caveolae protein, 22kDa 0.249
TNIP1 TNFAIP3 interacting protein 1 0.242
STAT5A signal transducer and activator of transcription 5A 0.234
KLF4 Kruppel-like factor 4 (gut) 0.218
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.214
MPDZ multiple PDZ domain protein 0.213
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 0.196
MALT1 mucosa associated lymphoid tissue lymphoma translocation gene 1 0.186
PICK1 protein interacting with PRKCA 1 0.181
PKD1 polycystic kidney disease 1 (autosomal dominant) 0.167
MAP2K4 mitogen-activated protein kinase kinase 4 0.167
INSR insulin receptor 0.167
ALDOB aldolase B, fructose-bisphosphate 0.149
RIPK2 receptor-interacting serine-threonine kinase 2 0.148
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.146
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 0.141
ESR1 estrogen receptor 1 0.141
TNIP2 TNFAIP3 interacting protein 2 0.140
TRPC1 transient receptor potential cation channel, subfamily C, member 1 0.134
EPOR erythropoietin receptor 0.131
HNF4A hepatocyte nuclear factor 4, alpha 0.129
SOCS1 suppressor of cytokine signaling 1 0.125
MLPH melanophilin 0.119
BCL3 B-cell CLL/lymphoma 3 0.113
RELB v-rel reticuloendotheliosis viral oncogene homolog B 0.113
MEF2A myocyte enhancer factor 2A 0.112
NCF1 neutrophil cytosolic factor 1 0.111
MYLK2 myosin light chain kinase 2 0.111
TRADD TNFRSF1A-associated via death domain 0.110
SOCS3 suppressor of cytokine signaling 3 0.108
GHR growth hormone receptor 0.107
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.103
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1 0.101
IRS1 insulin receptor substrate 1 0.100
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.095
PARD6A par-6 partitioning defective 6 homolog alpha (C. elegans) 0.094
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 0.094
YAP1 Yes-associated protein 1 0.094
MAPT microtubule-associated protein tau 0.093
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein 0.092
IL1RAP interleukin 1 receptor accessory protein 0.092
SSTR2 somatostatin receptor 2 0.091
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.091
PARD6B par-6 partitioning defective 6 homolog beta (C. elegans) 0.088
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.082
NR0B2 nuclear receptor subfamily 0, group B, member 2 0.082
CFLAR CASP8 and FADD-like apoptosis regulator 0.081
LAT linker for activation of T cells 0.080
SOD1 superoxide dismutase 1, soluble 0.078
XPO7 exportin 7 0.077
PPARG peroxisome proliferator-activated receptor gamma 0.073
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 0.072
IL1RN interleukin 1 receptor antagonist 0.072
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.071
CTBP1 C-terminal binding protein 1 0.069
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 0.068
SRSF5 serine/arginine-rich splicing factor 5 0.066
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 0.066
APP amyloid beta (A4) precursor protein 0.066
CCL14 chemokine (C-C motif) ligand 14 0.064
MEF2C myocyte enhancer factor 2C 0.062
IL1B interleukin 1, beta 0.061
IL1R2 interleukin 1 receptor, type II 0.061
GAB2 GRB2-associated binding protein 2 0.061
SH3RF1 SH3 domain containing ring finger 1 0.060
KLF6 Kruppel-like factor 6 0.060
SLC4A1 solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group) 0.059
DLG2 discs, large homolog 2 (Drosophila) 0.059
SSTR3 somatostatin receptor 3 0.058
BAD BCL2-associated agonist of cell death 0.057
LY96 lymphocyte antigen 96 0.057
AR androgen receptor 0.057
MIF4GD MIF4G domain containing 0.057
RNF19B ring finger protein 19B 0.057
BCAR1 breast cancer anti-estrogen resistance 1 0.057
PRKCZ protein kinase C, zeta 0.056
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta) 0.056
SYTL4 synaptotagmin-like 4 0.056
JUN jun proto-oncogene 0.054
STAT5B signal transducer and activator of transcription 5B 0.051
SHANK1 SH3 and multiple ankyrin repeat domains 1 0.051
GRB10 growth factor receptor-bound protein 10 0.050
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Rattus norvegicus
Name Description Probability Func Analog Organism
LOC100359522 LRRGT00191-like 0.149
LOC100364265 ribosomal protein L19-like 0.135
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.035
Serpina3k serine (or cysteine) peptidase inhibitor, clade A, member 3K 0.031
Hspa5 heat shock protein 5 0.031
Olr1 oxidized low density lipoprotein (lectin-like) receptor 1 0.030
Slc2a3 solute carrier family 2 (facilitated glucose transporter), member 3 0.028
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.028
Eef2 eukaryotic translation elongation factor 2 0.027
Htr2b 5-hydroxytryptamine (serotonin) receptor 2B 0.026
Alb albumin 0.025
Irf1 interferon regulatory factor 1 0.025
Ccl2 chemokine (C-C motif) ligand 2 0.025
Proc protein C 0.025
Ptpn12 protein tyrosine phosphatase, non-receptor type 12 0.024
Dnaja1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.024
Dmgdh dimethylglycine dehydrogenase 0.024
Cxcl10 chemokine (C-X-C motif) ligand 10 0.023
Ptgs2 prostaglandin-endoperoxide synthase 2 0.023
C3 complement component 3 0.023
Gna12 guanine nucleotide binding protein (G protein) alpha 12 0.023
Atp1a1 ATPase, Na+/K+ transporting, alpha 1 polypeptide 0.023
Syk spleen tyrosine kinase 0.023
Prkacb protein kinase, cAMP dependent, catalytic, beta 0.022
Mbl1 mannose-binding lectin (protein A) 1 0.022
Acsm5 acyl-CoA synthetase medium-chain family member 5 0.022
Grm8 glutamate receptor, metabotropic 8 0.022
Gpam glycerol-3-phosphate acyltransferase, mitochondrial 0.022
Fga fibrinogen alpha chain 0.022
Il18 interleukin 18 0.022
Syt4 synaptotagmin IV 0.021
Ccl3 chemokine (C-C motif) ligand 3 0.021
Slco2a1 solute carrier organic anion transporter family, member 2a1 0.021
Aqp9 aquaporin 9 0.021
A1i3 alpha-1-inhibitor III 0.021
Ccr2 chemokine (C-C motif) receptor 2 0.021
Dcc deleted in colorectal carcinoma 0.021
Cxcl2 chemokine (C-X-C motif) ligand 2 0.021
Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 0.020
Klrg1 killer cell lectin-like receptor subfamily G, member 1 0.020
Prkcd protein kinase C, delta 0.020
Selp selectin P 0.020
Litaf lipopolysaccharide-induced TNF factor 0.020
Tmigd1 transmembrane and immunoglobulin domain containing 1 0.020
RGD1564599 RGD1564599 0.020
Odf3b outer dense fiber of sperm tails 3B 0.020
Il1rn interleukin 1 receptor antagonist 0.020
Stat6 signal transducer and activator of transcription 6 0.019
Mmp12 matrix metallopeptidase 12 0.019
Ceacam11 carcinoembryonic antigen-related cell adhesion molecule 11 0.019
Mca32 mast cell antigen 32 0.019
Apoa5 apolipoprotein A-V 0.019
Agtr1a angiotensin II receptor, type 1a 0.019
Slc5a5 solute carrier family 5 (sodium iodide symporter), member 5 0.019
Jak1 Janus kinase 1 0.019
Gckr glucokinase (hexokinase 4) regulator 0.019
Jun Jun oncogene 0.019
Gif gastric intrinsic factor 0.019
Smad2 SMAD family member 2 0.019
Hsph1 heat shock 105/110 protein 1 0.018
Adm adrenomedullin 0.018
C8b complement component 8, beta polypeptide 0.018
Zfp36l1 zinc finger protein 36, C3H type-like 1 0.018
Edn1 endothelin 1 0.018
Tnf tumor necrosis factor (TNF superfamily, member 2) 0.018
Arf6 ADP-ribosylation factor 6 0.018
LOC100361261 rCG23560-like 0.018
Csf2rb colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 0.018
Tff3 trefoil factor 3, intestinal 0.018
Cpb1 carboxypeptidase B1 (tissue) 0.018
Cyp2c22 cytochrome P450, family 2, subfamily c, polypeptide 22 0.018
Cd2 Cd2 molecule 0.018
Map2k4 mitogen activated protein kinase kinase 4 0.018
Serpina4 serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4 0.018
Serpine1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.018
Cxcl1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.018
Pyy peptide YY (mapped) 0.018
Rara retinoic acid receptor, alpha 0.018
Phkg1 phosphorylase kinase, gamma 1 0.017
Hck hemopoietic cell kinase 0.017
Arhgap1 Rho GTPase activating protein 1 0.017
Spp2 secreted phosphoprotein 2 0.017
Spink3 serine peptidase inhibitor, Kazal type 3 0.017
Ptprc protein tyrosine phosphatase, receptor type, C 0.017
Hspa8 heat shock protein 8 0.017
Cd83 CD83 molecule 0.017
Lgr4 leucine-rich repeat-containing G protein-coupled receptor 4 0.017
Cops7a COP9 constitutive photomorphogenic homolog subunit 7A (Arabidopsis) 0.017
Il1b interleukin 1 beta 0.017
Il17re interleukin 17 receptor E 0.017
Arl5c ADP-ribosylation factor-like 5C 0.017
Gria2 glutamate receptor, ionotropic, AMPA 2 0.017
Stat3 signal transducer and activator of transcription 3 0.017
Arl5a ADP-ribosylation factor-like 5A 0.017
Gulo gulonolactone (L-) oxidase 0.017
Abcc6 ATP-binding cassette, subfamily C (CFTR/MRP), member 6 0.017
LOC286992 peptide HP (rs14) 0.017
RGD1359529 similar to chromosome 1 open reading frame 63 0.017
Adam10 ADAM metallopeptidase domain 10 0.017
Adam5 a disintegrin and metallopeptidase domain 5 0.017
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism