The network for 'b cell activation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

b cell activation

The change in morphology and behavior of a mature or immature B cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.

Mus musculus
Name Description Probability Func Analog Organism
Igh immunoglobulin heavy chain complex 1.000
Ikzf1 IKAROS family zinc finger 1 1.000
Pten phosphatase and tensin homolog 1.000
Cd19 CD19 antigen 0.999
Btk Bruton agammaglobulinemia tyrosine kinase 0.999
Pik3cd phosphatidylinositol 3-kinase catalytic delta polypeptide 0.998
Trp53 transformation related protein 53 0.997
Tlr4 toll-like receptor 4 0.996
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.995
Cd40 CD40 antigen 0.992
Tnf tumor necrosis factor 0.989
Fas Fas (TNF receptor superfamily member 6) 0.987
Myd88 myeloid differentiation primary response gene 88 0.983
Socs1 suppressor of cytokine signaling 1 0.977
Cd28 CD28 antigen 0.975
Sykb spleen tyrosine kinase 0.955
Map3k14 mitogen-activated protein kinase kinase kinase 14 0.950
Il10 interleukin 10 0.941
Sfpi1 SFFV proviral integration 1 0.938
Pax2 paired box gene 2 0.937
Esr1 estrogen receptor 1 (alpha) 0.930
Nr5a1 nuclear receptor subfamily 5, group A, member 1 0.929
Fyn Fyn proto-oncogene 0.928
Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 0.924
Lta lymphotoxin A 0.923
Stat3 signal transducer and activator of transcription 3 0.922
Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.921
Rag2 recombination activating gene 2 0.920
Tcf3 transcription factor 3 0.918
Rnf2 ring finger protein 2 0.916
Lyz2 lysozyme 2 0.913
Icos inducible T-cell co-stimulator 0.912
Bcl2 B-cell leukemia/lymphoma 2 0.911
Cd22 CD22 antigen 0.910
Lyn Yamaguchi sarcoma viral (v-yes-1) oncogene homolog 0.891
Pax8 paired box gene 8 0.882
Pik3r1 phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha) 0.874
Il2rg interleukin 2 receptor, gamma chain 0.867
Hand1 heart and neural crest derivatives expressed transcript 1 0.849
Ptprc protein tyrosine phosphatase, receptor type, C 0.845
Bcl6 B-cell leukemia/lymphoma 6 0.845
Pax5 paired box gene 5 0.843
Fasl Fas ligand (TNF superfamily, member 6) 0.840
Relb avian reticuloendotheliosis viral (v-rel) oncogene related B 0.840
Inpp5d inositol polyphosphate-5-phosphatase D 0.830
Cd180 CD180 antigen 0.828
Cd79a CD79A antigen (immunoglobulin-associated alpha) 0.825
Zeb1 zinc finger E-box binding homeobox 1 0.820
Chrnb2 cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal) 0.803
Foxp3 forkhead box P3 0.790
Otx2 orthodenticle homolog 2 (Drosophila) 0.784
Nr3c1 nuclear receptor subfamily 3, group C, member 1 0.773
Prf1 perforin 1 (pore forming protein) 0.765
Rybp RING1 and YY1 binding protein 0.760
Prkdc protein kinase, DNA activated, catalytic polypeptide 0.759
Pitx1 paired-like homeodomain transcription factor 1 0.754
Tcrd T-cell receptor delta chain 0.750
Runx1 runt related transcription factor 1 0.749
Plcg2 phospholipase C, gamma 2 0.744
Lhx3 LIM homeobox protein 3 0.730
Ikzf3 IKAROS family zinc finger 3 0.725
Irf8 interferon regulatory factor 8 0.710
Cd74 CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) 0.709
Casp1 caspase 1 0.690
Onecut1 one cut domain, family member 1 0.681
Tbx2 T-box 2 0.677
Gli2 GLI-Kruppel family member GLI2 0.676
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.672
Ptf1a pancreas specific transcription factor, 1a 0.670
Mdm2 transformed mouse 3T3 cell double minute 2 0.666
H2-Aa histocompatibility 2, class II antigen A, alpha 0.664
Fcer1g Fc receptor, IgE, high affinity I, gamma polypeptide 0.645
Cbl Casitas B-lineage lymphoma 0.639
Casp4 caspase 4, apoptosis-related cysteine peptidase 0.618
Tnfrsf13b tumor necrosis factor receptor superfamily, member 13b 0.606
2010106G01Rik RIKEN cDNA 2010106G01 gene 0.600
Csf1 colony stimulating factor 1 (macrophage) 0.598
Emx1 empty spiracles homolog 1 (Drosophila) 0.597
Rag1 recombination activating gene 1 0.594
Itgal integrin alpha L 0.591
Ifng interferon gamma 0.586
Pou2af1 POU domain, class 2, associating factor 1 0.580
Gdf3 growth differentiation factor 3 0.573
Sirt1 sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae) 0.557
Msx3 homeobox, msh-like 3 0.550
Notch2 Notch gene homolog 2 (Drosophila) 0.545
Card11 caspase recruitment domain family, member 11 0.545
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.540
Tgfb1 transforming growth factor, beta 1 0.532
Ccr7 chemokine (C-C motif) receptor 7 0.527
Atm ataxia telangiectasia mutated homolog (human) 0.526
Cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.523
Neurod1 neurogenic differentiation 1 0.516
Jak2 Janus kinase 2 0.514
Fgf5 fibroblast growth factor 5 0.506
Ltb lymphotoxin B 0.500
Ptpn6 protein tyrosine phosphatase, non-receptor type 6 0.495
Hic1 hypermethylated in cancer 1 0.492
Mdm4 transformed mouse 3T3 cell double minute 4 0.488
Lef1 lymphoid enhancer binding factor 1 0.487
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
cmyb transcription factor cmyb 0.527
tbx1 T-box 1 0.253
egr2b early growth response 2b 0.249
tp53 tumor protein p53 0.222
edn1 endothelin 1 0.221
rag1 recombination activating gene 1 0.157
mcm5 MCM5 minichromosome maintenance deficient 5 (S. cerevisiae) 0.146
tgfb3 transforming growth factor, beta 3 0.139
pcdh18b protocadherin 18b 0.135
rest RE1-silencing transcription factor 0.129
wnt9b wingless-type MMTV integration site family, member 9B 0.128
il7r interleukin 7 receptor 0.122
mpx myeloid-specific peroxidase 0.120
kita kit receptor a 0.119
mmp13a matrix metalloproteinase 13a 0.115
rspo3 R-spondin 3 homolog (Xenopus laevis) 0.113
col7a1l collagen type VII alpha 1-like 0.103
hbae1 hemoglobin alpha embryonic-1 0.099
ros1 v-ros UR2 sarcoma virus oncogene homolog 1 (avian) 0.092
srf serum response factor 0.089
runx1 runt-related transcription factor 1 0.088
lars leucyl-tRNA synthetase 0.087
im:7156396 im:7156396 0.082
nrp1b neuropilin 1b 0.080
chtf18 CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae) 0.078
hspa9 heat shock protein 9 0.074
abcb3l1 ATP-binding cassette, sub-family B (MDR/TAP), member 3 like 1 0.074
trim33 tripartite motif-containing 33 0.073
vdrb vitamin D receptor b 0.072
bmp2b bone morphogenetic protein 2b 0.072
lfng lunatic fringe homolog 0.071
eya2 eyes absent homolog 2 (Drosophila) 0.071
mitfa microphthalmia-associated transcription factor a 0.071
pdcd2 programmed cell death 2 0.071
rhoab ras homolog gene family, member Ab 0.070
mycl1b v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian) b 0.069
myca myelocytomatosis oncogene a 0.069
jak1 Janus kinase 1 0.068
mapk14a mitogen-activated protein kinase 14a 0.068
sema3aa semaphorin 3aa 0.068
zgc:64051 zgc:64051 0.067
tshb thyroid stimulating hormone, beta subunit 0.067
bcl2l1 bcl2-like 1 0.067
ildr1b immunoglobulin-like domain containing receptor 1b 0.067
fgfr1b fibroblast growth factor receptor 1b 0.066
f2r coagulation factor II (thrombin) receptor 0.064
mpll myeloproliferative leukemia virus oncogene, like 0.064
runx3 runt-related transcription factor 3 0.064
cobl cordon-bleu homolog (mouse) 0.062
LOC100148845 neurogenin-1-like 0.061
gmnn geminin, DNA replication inhibitor 0.061
wu:fc23b05 wu:fc23b05 0.061
pou4f1 POU domain, class 4, transcription factor 1 0.060
mep1a.1 meprin A, alpha.1 0.060
si:ch211-235f6.2 si:ch211-235f6.2 0.060
hirip3 HIRA interacting protein 3 0.059
lrrc33 leucine rich repeat containing 33 0.058
hmgb1b high-mobility group box 1b 0.058
ryk receptor-like tyrosine kinase 0.058
mesp2 mesoderm posterior 2 homolog (mouse) 0.057
csnk1a1 casein kinase 1, alpha 1 0.057
wnt3 wingless-type MMTV integration site family, member 3 0.057
bcl2l10 BCL2-like 10 (apoptosis facilitator) 0.055
efna2 ephrin A2 0.055
zfp36l1a zinc finger protein 36, C3H type-like 1a 0.055
csf1ra colony stimulating factor 1 receptor, a 0.055
cldn15a claudin 15a 0.054
dnmt4 DNA (cytosine-5-)-methyltransferase 4 0.054
myh6 myosin, heavy polypeptide 6, cardiac muscle, alpha 0.054
cdh17 cadherin 17, LI cadherin (liver-intestine) 0.053
rif1 RAP1 interacting factor homolog (yeast) 0.052
zgc:77517 zgc:77517 0.052
tgfb2 transforming growth factor, beta 2 0.052
taf3 TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated facto 0.051
tfeb transcription factor EB 0.051
tie1 endothelium-specific receptor tyrosine kinase 1 0.051
dlx6a distal-less homeobox gene 6a 0.051
mybl2 myeloblastosis oncogene-like 2 0.051
tlr2 toll-like receptor 2 0.051
cflar CASP8 and FADD-like apoptosis regulator 0.051
foxe3 forkhead box E3 0.051
ctr9 Ctr9, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) 0.050
tprb translocated promoter region b (to activated MET oncogene) 0.050
alk anaplastic lymphoma kinase (Ki-1) 0.050
zgc:193613 zgc:193613 0.049
gmps guanine monphosphate synthetase 0.049
mtmr8 myotubularin related protein 8 0.049
wls wntless homolog (Drosophila) 0.049
numbl numb homolog (Drosophila)-like 0.049
stc1l stanniocalcin 1, like 0.049
mafba v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian) 0.048
zgc:92661 zgc:92661 0.048
c1qa complement component 1, q subcomponent, A chain 0.048
jam2b junctional adhesion molecule 2b 0.048
dnm2 dynamin 2 0.048
ddr2b discoidin domain receptor family, member 2b 0.048
itga2b integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41B) 0.047
hbbe1.1 hemoglobin beta embryonic-1.1 0.047
phf6 PHD finger protein 6 0.047
mib mind bomb 0.047
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
PTPN6 protein tyrosine phosphatase, non-receptor type 6 0.964
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.939
IL4R interleukin 4 receptor 0.918
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.907
SYK spleen tyrosine kinase 0.891
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.869
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.845
INSR insulin receptor 0.707
BCL2 B-cell CLL/lymphoma 2 0.607
BRCA1 breast cancer 1, early onset 0.574
LAPTM5 lysosomal protein transmembrane 5 0.566
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.498
LAT linker for activation of T cells 0.459
SH3KBP1 SH3-domain kinase binding protein 1 0.426
IL2RG interleukin 2 receptor, gamma 0.395
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 0.366
LYN v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.356
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.349
IRAK1 interleukin-1 receptor-associated kinase 1 0.345
RUNX1 runt-related transcription factor 1 0.327
BCL2L1 BCL2-like 1 0.311
CTLA4 cytotoxic T-lymphocyte-associated protein 4 0.306
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.276
APLF aprataxin and PNKP like factor 0.261
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 0.259
SH3BP2 SH3-domain binding protein 2 0.255
CD80 CD80 molecule 0.251
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4 0.248
MAP3K8 mitogen-activated protein kinase kinase kinase 8 0.215
TGIF1 TGFB-induced factor homeobox 1 0.192
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein 0.186
IRS1 insulin receptor substrate 1 0.171
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.170
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.168
PARP1 poly (ADP-ribose) polymerase 1 0.157
HDAC9 histone deacetylase 9 0.152
BLNK B-cell linker 0.140
GHR growth hormone receptor 0.122
IL10RA interleukin 10 receptor, alpha 0.118
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.118
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.118
APAF1 apoptotic peptidase activating factor 1 0.112
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B 0.111
MYD88 myeloid differentiation primary response gene (88) 0.108
TRAF6 TNF receptor-associated factor 6 0.108
MS4A1 membrane-spanning 4-domains, subfamily A, member 1 0.106
PML promyelocytic leukemia 0.105
DDIT3 DNA-damage-inducible transcript 3 0.104
PTK2B PTK2B protein tyrosine kinase 2 beta 0.103
ATM ataxia telangiectasia mutated 0.103
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 0.102
JAK2 Janus kinase 2 0.101
BCL10 B-cell CLL/lymphoma 10 0.101
TNIP1 TNFAIP3 interacting protein 1 0.097
MYC v-myc myelocytomatosis viral oncogene homolog (avian) 0.095
TCF12 transcription factor 12 0.093
ABL1 c-abl oncogene 1, non-receptor tyrosine kinase 0.092
NOTCH1 notch 1 0.088
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.085
THOC4 THO complex 4 0.084
GRB7 growth factor receptor-bound protein 7 0.084
TP53BP1 tumor protein p53 binding protein 1 0.083
LY96 lymphocyte antigen 96 0.082
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced 0.080
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 0.080
CARD11 caspase recruitment domain family, member 11 0.080
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 0.079
MSH3 mutS homolog 3 (E. coli) 0.077
SIRT1 sirtuin 1 0.077
BCL2L11 BCL2-like 11 (apoptosis facilitator) 0.077
IRF4 interferon regulatory factor 4 0.076
GAS7 growth arrest-specific 7 0.074
SOS1 son of sevenless homolog 1 (Drosophila) 0.074
IKZF3 IKAROS family zinc finger 3 (Aiolos) 0.073
PIK3CG phosphoinositide-3-kinase, catalytic, gamma polypeptide 0.072
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 0.071
TAL1 T-cell acute lymphocytic leukemia 1 0.070
EP300 E1A binding protein p300 0.069
CD86 CD86 molecule 0.068
SLA Src-like-adaptor 0.068
VIM vimentin 0.067
IL2RB interleukin 2 receptor, beta 0.062
CDK6 cyclin-dependent kinase 6 0.061
GRAP2 GRB2-related adaptor protein 2 0.060
RBBP8 retinoblastoma binding protein 8 0.060
SMC1A structural maintenance of chromosomes 1A 0.059
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 0.059
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.059
GRB10 growth factor receptor-bound protein 10 0.058
EPOR erythropoietin receptor 0.057
NCOR2 nuclear receptor corepressor 2 0.055
BLM Bloom syndrome, RecQ helicase-like 0.055
IQGAP1 IQ motif containing GTPase activating protein 1 0.054
ICAM1 intercellular adhesion molecule 1 0.051
CDK2 cyclin-dependent kinase 2 0.051
IL4 interleukin 4 0.051
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 0.051
BID BH3 interacting domain death agonist 0.051
UHRF2 ubiquitin-like with PHD and ring finger domains 2 0.050
CALCOCO2 calcium binding and coiled-coil domain 2 0.049
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Rattus norvegicus
Name Description Probability Func Analog Organism
RT1-Ba RT1 class II, locus Ba 0.025
Hck hemopoietic cell kinase 0.022
Cd37 CD37 molecule 0.015
Inpp5d inositol polyphosphate-5-phosphatase D 0.012
Rassf5 Ras association (RalGDS/AF-6) domain family member 5 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism