The network for 'interferon gamma production' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

interferon gamma production

The appearance of interferon-gamma due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Interferon-gamma is also known as type II interferon.

Mus musculus
Name Description Probability Func Analog Organism
Map3k14 mitogen-activated protein kinase kinase kinase 14 0.961
Tnf tumor necrosis factor 0.930
Klrk1 killer cell lectin-like receptor subfamily K, member 1 0.866
Pik3cd phosphatidylinositol 3-kinase catalytic delta polypeptide 0.824
Cd40 CD40 antigen 0.815
Icos inducible T-cell co-stimulator 0.813
Tlr4 toll-like receptor 4 0.806
Pax2 paired box gene 2 0.702
Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 0.693
Csf2 colony stimulating factor 2 (granulocyte-macrophage) 0.676
Ifng interferon gamma 0.672
Klrd1 killer cell lectin-like receptor, subfamily D, member 1 0.651
Ikzf1 IKAROS family zinc finger 1 0.634
Socs1 suppressor of cytokine signaling 1 0.561
Slamf1 signaling lymphocytic activation molecule family member 1 0.545
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.515
Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b 0.484
Gzmk granzyme K 0.483
Il2rb interleukin 2 receptor, beta chain 0.478
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.475
Cd44 CD44 antigen 0.474
Btk Bruton agammaglobulinemia tyrosine kinase 0.461
Fgf8 fibroblast growth factor 8 0.456
Emx2 empty spiracles homolog 2 (Drosophila) 0.450
Il18rap interleukin 18 receptor accessory protein 0.448
Il1rl1 interleukin 1 receptor-like 1 0.424
Pitx1 paired-like homeodomain transcription factor 1 0.421
Ccr7 chemokine (C-C motif) receptor 7 0.416
Casp4 caspase 4, apoptosis-related cysteine peptidase 0.414
Nr5a1 nuclear receptor subfamily 5, group A, member 1 0.413
Gzmb granzyme B 0.405
Klra9 killer cell lectin-like receptor subfamily A, member 9 0.400
Il27ra interleukin 27 receptor, alpha 0.398
Fasl Fas ligand (TNF superfamily, member 6) 0.396
Sykb spleen tyrosine kinase 0.377
Rel reticuloendotheliosis oncogene 0.371
Casp1 caspase 1 0.367
Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.367
Myd88 myeloid differentiation primary response gene 88 0.364
Gzma granzyme A 0.364
H2-Q7 histocompatibility 2, Q region locus 7 0.364
Ccr2 chemokine (C-C motif) receptor 2 0.359
Cd86 CD86 antigen 0.357
Lat linker for activation of T cells 0.328
Itk IL2-inducible T-cell kinase 0.317
Ccl4 chemokine (C-C motif) ligand 4 0.310
Ccl5 chemokine (C-C motif) ligand 5 0.307
Fas Fas (TNF receptor superfamily member 6) 0.306
Prdm1 PR domain containing 1, with ZNF domain 0.302
Tbx3 T-box 3 0.298
Tnfaip3 tumor necrosis factor, alpha-induced protein 3 0.294
Ncr1 natural cytotoxicity triggering receptor 1 0.291
Cd28 CD28 antigen 0.289
Batf basic leucine zipper transcription factor, ATF-like 0.286
Itgal integrin alpha L 0.284
Tcra T-cell receptor alpha chain 0.279
Relb avian reticuloendotheliosis viral (v-rel) oncogene related B 0.275
Il18r1 interleukin 18 receptor 1 0.274
Pou2af1 POU domain, class 2, associating factor 1 0.271
Inpp5d inositol polyphosphate-5-phosphatase D 0.259
Lhx3 LIM homeobox protein 3 0.256
Map3k8 mitogen-activated protein kinase kinase kinase 8 0.256
Gpr132 G protein-coupled receptor 132 0.256
Hoxa1 homeobox A1 0.252
Il10 interleukin 10 0.245
Il2ra interleukin 2 receptor, alpha chain 0.239
B2m beta-2 microglobulin 0.239
Il10ra interleukin 10 receptor, alpha 0.230
Cd160 CD160 antigen 0.225
Il2rg interleukin 2 receptor, gamma chain 0.221
Cd5 CD5 antigen 0.220
Gimap7 GTPase, IMAP family member 7 0.209
Ctsw cathepsin W 0.205
Ccr5 chemokine (C-C motif) receptor 5 0.197
Sh2d2a SH2 domain protein 2A 0.197
Xcl1 chemokine (C motif) ligand 1 0.196
Scn5a sodium channel, voltage-gated, type V, alpha 0.186
Klrg1 killer cell lectin-like receptor subfamily G, member 1 0.183
Pdcd1 programmed cell death 1 0.181
Il4 interleukin 4 0.180
Spib Spi-B transcription factor (Spi-1/PU.1 related) 0.174
Irf1 interferon regulatory factor 1 0.171
Ifnar1 interferon (alpha and beta) receptor 1 0.169
Pyhin1 pyrin and HIN domain family, member 1 0.168
Sfpi1 SFFV proviral integration 1 0.163
Wnt9a wingless-type MMTV integration site 9A 0.159
Cd80 CD80 antigen 0.159
Tnfrsf9 tumor necrosis factor receptor superfamily, member 9 0.158
Gata4 GATA binding protein 4 0.156
Tnfsf10 tumor necrosis factor (ligand) superfamily, member 10 0.156
Nkg7 natural killer cell group 7 sequence 0.156
Rarg retinoic acid receptor, gamma 0.152
Lif leukemia inhibitory factor 0.152
Dkk1 dickkopf homolog 1 (Xenopus laevis) 0.150
Cxcl9 chemokine (C-X-C motif) ligand 9 0.150
Cd180 CD180 antigen 0.150
Niacr1 niacin receptor 1 0.150
Lta lymphotoxin A 0.149
Nlrp3 NLR family, pyrin domain containing 3 0.148
Ccrl2 chemokine (C-C motif) receptor-like 2 0.147
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
HCK hemopoietic cell kinase 0.956
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.939
HLA-A major histocompatibility complex, class I, A 0.937
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.918
HLA-B major histocompatibility complex, class I, B 0.890
B2M beta-2-microglobulin 0.814
LCK lymphocyte-specific protein tyrosine kinase 0.792
IL12B interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) 0.785
HLA-G major histocompatibility complex, class I, G 0.777
HLA-DRA major histocompatibility complex, class II, DR alpha 0.776
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 0.747
HLA-F major histocompatibility complex, class I, F 0.741
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.717
TRAF1 TNF receptor-associated factor 1 0.716
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.698
BTN3A2 butyrophilin, subfamily 3, member A2 0.693
SYK spleen tyrosine kinase 0.683
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.679
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.668
BTN3A3 butyrophilin, subfamily 3, member A3 0.649
SPRR2A small proline-rich protein 2A 0.629
IL1R1 interleukin 1 receptor, type I 0.580
NLRC4 NLR family, CARD domain containing 4 0.563
HLA-DMA major histocompatibility complex, class II, DM alpha 0.547
CD84 CD84 molecule 0.539
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.500
EGFR epidermal growth factor receptor 0.450
CCR5 chemokine (C-C motif) receptor 5 0.448
HLA-C major histocompatibility complex, class I, C 0.433
CCL5 chemokine (C-C motif) ligand 5 0.426
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1 0.394
BIRC3 baculoviral IAP repeat containing 3 0.383
CD86 CD86 molecule 0.361
BTN3A1 butyrophilin, subfamily 3, member A1 0.351
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 0.303
GAS6 growth arrest-specific 6 0.293
WAS Wiskott-Aldrich syndrome (eczema-thrombocytopenia) 0.283
FAS Fas (TNF receptor superfamily, member 6) 0.277
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 0.276
HLA-E major histocompatibility complex, class I, E 0.272
CD80 CD80 molecule 0.270
RXRA retinoid X receptor, alpha 0.252
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 0.251
HLA-DRB5 major histocompatibility complex, class II, DR beta 5 0.245
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.230
CRK v-crk sarcoma virus CT10 oncogene homolog (avian) 0.223
CXCL9 chemokine (C-X-C motif) ligand 9 0.219
CCR7 chemokine (C-C motif) receptor 7 0.213
FASLG Fas ligand (TNF superfamily, member 6) 0.207
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein 0.192
STAT4 signal transducer and activator of transcription 4 0.177
CCR1 chemokine (C-C motif) receptor 1 0.165
DDIT3 DNA-damage-inducible transcript 3 0.164
FYN FYN oncogene related to SRC, FGR, YES 0.161
IL1B interleukin 1, beta 0.158
MYD88 myeloid differentiation primary response gene (88) 0.146
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2 0.143
PILRA paired immunoglobin-like type 2 receptor alpha 0.141
CCL8 chemokine (C-C motif) ligand 8 0.140
NOD2 nucleotide-binding oligomerization domain containing 2 0.138
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain 0.137
GRB2 growth factor receptor-bound protein 2 0.134
GRB7 growth factor receptor-bound protein 7 0.134
IL6 interleukin 6 (interferon, beta 2) 0.129
CCL4 chemokine (C-C motif) ligand 4 0.125
AXL AXL receptor tyrosine kinase 0.117
IL10 interleukin 10 0.112
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 0.111
RELB v-rel reticuloendotheliosis viral oncogene homolog B 0.105
SP110 SP110 nuclear body protein 0.104
MEFV Mediterranean fever 0.102
FGR Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog 0.096
BLNK B-cell linker 0.095
CASP1 caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) 0.095
CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.093
CXCL2 chemokine (C-X-C motif) ligand 2 0.092
NCK1 NCK adaptor protein 1 0.090
TICAM2 toll-like receptor adaptor molecule 2 0.087
IL23A interleukin 23, alpha subunit p19 0.084
CD247 CD247 molecule 0.082
HLA-DRB4 major histocompatibility complex, class II, DR beta 4 0.081
IL10RA interleukin 10 receptor, alpha 0.081
TNF tumor necrosis factor 0.080
IL1R2 interleukin 1 receptor, type II 0.079
CCL2 chemokine (C-C motif) ligand 2 0.077
CASP10 caspase 10, apoptosis-related cysteine peptidase 0.077
CTLA4 cytotoxic T-lymphocyte-associated protein 4 0.076
IL1RN interleukin 1 receptor antagonist 0.076
CYBB cytochrome b-245, beta polypeptide 0.070
MED25 mediator complex subunit 25 0.069
IRF1 interferon regulatory factor 1 0.069
ESR1 estrogen receptor 1 0.068
RIN1 Ras and Rab interactor 1 0.068
CCL22 chemokine (C-C motif) ligand 22 0.067
IFITM1 interferon induced transmembrane protein 1 (9-27) 0.066
CCL7 chemokine (C-C motif) ligand 7 0.066
PHYHIPL phytanoyl-CoA 2-hydroxylase interacting protein-like 0.066
ICAM1 intercellular adhesion molecule 1 0.064
RARA retinoic acid receptor, alpha 0.064
CTBP2 C-terminal binding protein 2 0.063
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Rattus norvegicus
Name Description Probability Func Analog Organism
Klrd1 killer cell lectin-like receptor, subfamily D, member 1 0.023
Sell selectin L 0.022
Ccl4 chemokine (C-C motif) ligand 4 0.022
Cxcl10 chemokine (C-X-C motif) ligand 10 0.021
Il1b interleukin 1 beta 0.020
Nkg7 natural killer cell group 7 sequence 0.019
Il6 interleukin 6 0.019
RT1-A3 RT1 class I, locus A3 0.019
Cd5 Cd5 molecule 0.017
Ccl5 chemokine (C-C motif) ligand 5 0.017
Olr1 oxidized low density lipoprotein (lectin-like) receptor 1 0.017
Cd86 CD86 molecule 0.017
Ccl3 chemokine (C-C motif) ligand 3 0.017
Bcl2a1d B-cell leukemia/lymphoma 2 related protein A1d 0.017
Vcan versican 0.017
Cxcl1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.017
Ccl2 chemokine (C-C motif) ligand 2 0.016
Prl8a7 prolactin family 8, subfamily a, member 7 0.015
Serpine1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.015
Hoxb7 homeo box B7 0.015
Gja5 gap junction protein, alpha 5 0.015
Ciita class II, major histocompatibility complex, transactivator 0.015
Ccr2 chemokine (C-C motif) receptor 2 0.014
Gimap4 GTPase, IMAP family member 4 0.014
Il1a interleukin 1 alpha 0.014
Ncr1 natural cytotoxicity triggering receptor 1 0.014
Cd44 Cd44 molecule 0.014
RT1-EC2 RT1 class Ib, locus EC2 0.014
LOC100364212 heterogeneous nuclear ribonucleoprotein K-like 0.014
LOC100364500 RT1 class I, locus CE11-like 0.014
Gzmb granzyme B 0.014
LOC286992 peptide HP (rs14) 0.013
RT1-N3 RT1 class Ib, locus N3 0.013
Gfi1 growth factor independent 1 transcription repressor 0.013
Pgc progastricsin (pepsinogen C) 0.013
Prl8a9 prolactin family 8, subfamily a, member 9 0.013
Mcpt1 mast cell protease 1 0.012
Il2rb interleukin 2 receptor, beta 0.012
Slc18a2 solute carrier family 18 (vesicular monoamine), member 2 0.012
Reg3g regenerating islet-derived 3 gamma 0.012
Tnfrsf26 tumor necrosis factor receptor superfamily, member 26 0.012
Il1rl1 interleukin 1 receptor-like 1 0.012
Tcrb T-cell receptor beta chain 0.012
C3ar1 complement component 3a receptor 1 0.012
Pde3a phosphodiesterase 3A, cGMP inhibited 0.012
Slfn2 schlafen 2 0.012
Gnrhr gonadotropin releasing hormone receptor 0.012
Trh thyrotropin releasing hormone 0.012
Spink5 serine peptidase inhibitor, Kazal type 5 0.012
Cd22 CD22 molecule 0.012
Ifng interferon gamma 0.012
Csf2rb colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 0.012
Pax8 paired box 8 0.012
Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b 0.012
Acap1 ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 0.011
Defb1 defensin beta 1 0.011
Pth parathyroid hormone 0.011
RT1-Ha RT1 class II, locus Ha 0.011
Csf1 colony stimulating factor 1 (macrophage) 0.011
Sh2d1a SH2 domain protein 1A 0.011
Nrg2 neuregulin 2 0.011
Cd40 CD40 molecule, TNF receptor superfamily member 5 0.011
Klra5 killer cell lectin-like receptor, subfamily A, member 5 0.011
Ube2g1 ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast) 0.011
Sh3tc1 SH3 domain and tetratricopeptide repeats 1 0.011
Neurl3 neuralized homolog 3 (Drosophila) 0.011
Il17f interleukin 17F 0.011
Vom1r90 vomeronasal 1 receptor 90 0.011
Ccr1 chemokine (C-C motif) receptor 1 0.011
Casp12 caspase 12 0.011
Spam1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) 0.011
Prl prolactin 0.011
Cd2 Cd2 molecule 0.011
Ms4a7 membrane-spanning 4-domains, subfamily A, member 7 0.010
Map3k8 mitogen-activated protein kinase kinase kinase 8 0.010
Unc13d unc-13 homolog D (C. elegans) 0.010
Casp1 caspase 1 0.010
RatNP-3b defensin RatNP-3 precursor 0.010
Cd3g CD3 molecule, gamma 0.010
Cycs cytochrome c, somatic 0.010
Vom2r27 vomeronasal 2 receptor, 27 0.010
Lepr leptin receptor 0.010
Itgb7 integrin, beta 7 0.010
Epor erythropoietin receptor 0.010
Ednrb endothelin receptor type B 0.010
Noxo1 NADPH oxidase organizer 1 0.010
RGD1559588 similar to cell surface receptor FDFACT 0.010
Ifit3 interferon-induced protein with tetratricopeptide repeats 3 0.010
Fgr Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog 0.010
Plaur plasminogen activator, urokinase receptor 0.010
Nus1 nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) 0.010
Cd247 Cd247 molecule 0.010
Pla1a phospholipase A1 member A 0.010
Tnf tumor necrosis factor (TNF superfamily, member 2) 0.010
LOC689770 similar to osteoclast inhibitory lectin 0.010
Fosl1 fos-like antigen 1 0.010
Fabp2 fatty acid binding protein 2, intestinal 0.010
Calca calcitonin-related polypeptide alpha 0.010
Olr1469 olfactory receptor Olr1469 0.010
Scn4a sodium channel, voltage-gated, type IV, alpha subunit 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism