IMP

Process View

Homo sapiens

30 genes annotated in human

regulation of tyrosine phosphorylation of stat protein

Any process that modulates the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "regulation of tyrosine phosphorylation of stat protein"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "regulation of tyrosine phosphorylation of stat protein" (in gray)

Name	Description	Probability	Func Analog Organism
EGFR	epidermal growth factor receptor	1.000	Human
IL6ST	interleukin 6 signal transducer (gp130, oncostatin M receptor)	0.999
ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.997	Human
GHR	growth hormone receptor	0.993
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.989
SOCS3	suppressor of cytokine signaling 3	0.983
JAK2	Janus kinase 2	0.946	Mouse
SHC1	SHC (Src homology 2 domain containing) transforming protein 1	0.941
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.912
TRADD	TNFRSF1A-associated via death domain	0.846
PLCG1	phospholipase C, gamma 1	0.821
IL4R	interleukin 4 receptor	0.815
TNFRSF10B	tumor necrosis factor receptor superfamily, member 10b	0.810	Human
CASP10	caspase 10, apoptosis-related cysteine peptidase	0.809
PDGFRB	platelet-derived growth factor receptor, beta polypeptide	0.764	Human
INSR	insulin receptor	0.732
CASP8	caspase 8, apoptosis-related cysteine peptidase	0.701
CCR5	chemokine (C-C motif) receptor 5	0.692
FGF1	fibroblast growth factor 1 (acidic)	0.691
TNF	tumor necrosis factor	0.678
CSH1	chorionic somatomammotropin hormone 1 (placental lactogen)	0.643	Human
TRAF2	TNF receptor-associated factor 2	0.581
STAT3	signal transducer and activator of transcription 3 (acute-phase response factor)	0.551
GAB1	GRB2-associated binding protein 1	0.528
TRAF1	TNF receptor-associated factor 1	0.521
GRB2	growth factor receptor-bound protein 2	0.520
LAT	linker for activation of T cells	0.514
ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.497	Human
GH1	growth hormone 1	0.485
SYK	spleen tyrosine kinase	0.484
CD44	CD44 molecule (Indian blood group)	0.481
NR4A1	nuclear receptor subfamily 4, group A, member 1	0.478
IL6	interleukin 6 (interferon, beta 2)	0.478
IGF1R	insulin-like growth factor 1 receptor	0.458
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.435	Human
TNFRSF9	tumor necrosis factor receptor superfamily, member 9	0.433
ICAM1	intercellular adhesion molecule 1	0.425
PTPN11	protein tyrosine phosphatase, non-receptor type 11	0.409
VEGFA	vascular endothelial growth factor A	0.408
CCL4	chemokine (C-C motif) ligand 4	0.402	Human
FADD	Fas (TNFRSF6)-associated via death domain	0.401
PTPRB	protein tyrosine phosphatase, receptor type, B	0.377
IL8	interleukin 8	0.371
IL12B	interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)	0.370
TRAF5	TNF receptor-associated factor 5	0.352
TNFRSF10A	tumor necrosis factor receptor superfamily, member 10a	0.351	Human
FGFR1	fibroblast growth factor receptor 1	0.327	Human
RIPK1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.323
EPOR	erythropoietin receptor	0.292
CXCL2	chemokine (C-X-C motif) ligand 2	0.292
KDR	kinase insert domain receptor (a type III receptor tyrosine kinase)	0.290	Human
CXCL9	chemokine (C-X-C motif) ligand 9	0.287
IL1B	interleukin 1, beta	0.280
CRKL	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.279
CCL2	chemokine (C-C motif) ligand 2	0.277	Human
CAV1	caveolin 1, caveolae protein, 22kDa	0.261	Mouse
CXCL1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	0.249
TRAF3	TNF receptor-associated factor 3	0.246
TNFRSF1A	tumor necrosis factor receptor superfamily, member 1A	0.231
CFLAR	CASP8 and FADD-like apoptosis regulator	0.226
IRS1	insulin receptor substrate 1	0.219
TNFRSF1B	tumor necrosis factor receptor superfamily, member 1B	0.199	Human
TNFSF10	tumor necrosis factor (ligand) superfamily, member 10	0.183
CXCL3	chemokine (C-X-C motif) ligand 3	0.176
CCL8	chemokine (C-C motif) ligand 8	0.164	Human
STAT4	signal transducer and activator of transcription 4	0.160
VCAM1	vascular cell adhesion molecule 1	0.157
CSH2	chorionic somatomammotropin hormone 2	0.154	Human
LYN	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	0.151
GH2	growth hormone 2	0.138	Human
TNFAIP3	tumor necrosis factor, alpha-induced protein 3	0.137
SCHIP1	schwannomin interacting protein 1	0.137
LIF	leukemia inhibitory factor (cholinergic differentiation factor)	0.131
CCL5	chemokine (C-C motif) ligand 5	0.130
IDE	insulin-degrading enzyme	0.126
FASLG	Fas ligand (TNF superfamily, member 6)	0.123
FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	0.122	Human
JAK1	Janus kinase 1	0.116
STAT1	signal transducer and activator of transcription 1, 91kDa	0.111
GAB2	GRB2-associated binding protein 2	0.102
CCL7	chemokine (C-C motif) ligand 7	0.100	Human
SOCS1	suppressor of cytokine signaling 1	0.100	Mouse
NRP1	neuropilin 1	0.100
CXCL10	chemokine (C-X-C motif) ligand 10	0.099
LIFR	leukemia inhibitory factor receptor alpha	0.096	Human
CCR7	chemokine (C-C motif) receptor 7	0.094
PPARGC1A	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	0.094
CCL11	chemokine (C-C motif) ligand 11	0.083	Human
MAP3K5	mitogen-activated protein kinase kinase kinase 5	0.079
CXCL13	chemokine (C-X-C motif) ligand 13	0.076
ITGB1BP3	integrin beta 1 binding protein 3	0.074
FGFR2	fibroblast growth factor receptor 2	0.074	Human
FRS2	fibroblast growth factor receptor substrate 2	0.072
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.070
CSF2RB	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	0.068
BCAR1	breast cancer anti-estrogen resistance 1	0.068
IFNG	interferon, gamma	0.066
EZR	ezrin	0.066	Human
CSHL1	chorionic somatomammotropin hormone-like 1	0.063	Human
MET	met proto-oncogene (hepatocyte growth factor receptor)	0.061
PTPN6	protein tyrosine phosphatase, non-receptor type 6	0.060
SELE	selectin E	0.060
CSF1	colony stimulating factor 1 (macrophage)	0.059
CDH5	cadherin 5, type 2 (vascular endothelium)	0.059
RAC1	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	0.056
CCL13	chemokine (C-C motif) ligand 13	0.054	Human
CXCL11	chemokine (C-X-C motif) ligand 11	0.054
MED28	mediator complex subunit 28	0.054
CCL20	chemokine (C-C motif) ligand 20	0.052	Human
KIT	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	0.051
FGF10	fibroblast growth factor 10	0.049
CXCL5	chemokine (C-X-C motif) ligand 5	0.049
CD40	CD40 molecule, TNF receptor superfamily member 5	0.048
PGF	placental growth factor	0.048
PLEK	pleckstrin	0.046
TIRAP	toll-interleukin 1 receptor (TIR) domain containing adaptor protein	0.045
PDGFB	platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)	0.044
IL12A	interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)	0.043
STAT5A	signal transducer and activator of transcription 5A	0.043
SLC9A3R1	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1	0.043
BCL2	B-cell CLL/lymphoma 2	0.042
CXCL6	chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)	0.042
SLAMF1	signaling lymphocytic activation molecule family member 1	0.042
IL10	interleukin 10	0.042
CSF2RA	colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)	0.042
IL23A	interleukin 23, alpha subunit p19	0.041
SH2D4A	SH2 domain containing 4A	0.039
IL13	interleukin 13	0.039
OSM	oncostatin M	0.037
IGF2R	insulin-like growth factor 2 receptor	0.036
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.035	Human
IL4	interleukin 4	0.034	Mouse
FGR	Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog	0.034
BCL2A1	BCL2-related protein A1	0.034
PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	0.033
IL3	interleukin 3 (colony-stimulating factor, multiple)	0.033
SOCS2	suppressor of cytokine signaling 2	0.033
PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	0.033
CCL22	chemokine (C-C motif) ligand 22	0.033
CSF3	colony stimulating factor 3 (granulocyte)	0.033
CCL19	chemokine (C-C motif) ligand 19	0.032	Human
CCL18	chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)	0.032	Human
NNMT	nicotinamide N-methyltransferase	0.031
CCL3	chemokine (C-C motif) ligand 3	0.031	Human
CMIP	c-Maf-inducing protein	0.030
IRF4	interferon regulatory factor 4	0.030
TNFSF14	tumor necrosis factor (ligand) superfamily, member 14	0.030
KITLG	KIT ligand	0.029
TIFA	TRAF-interacting protein with forkhead-associated domain	0.028
IL2RB	interleukin 2 receptor, beta	0.028
CCR1	chemokine (C-C motif) receptor 1	0.028
IL9	interleukin 9	0.027
ICA1	islet cell autoantigen 1, 69kDa	0.027
FYN	FYN oncogene related to SRC, FGR, YES	0.027
CD28	CD28 molecule	0.026
NTRK1	neurotrophic tyrosine kinase, receptor, type 1	0.026
OSMR	oncostatin M receptor	0.026	Human
JAK3	Janus kinase 3	0.026
COMMD1	copper metabolism (Murr1) domain containing 1	0.026
IL7R	interleukin 7 receptor	0.026
SREBF2	sterol regulatory element binding transcription factor 2	0.025
CXCR6	chemokine (C-X-C motif) receptor 6	0.025
ANKS1B	ankyrin repeat and sterile alpha motif domain containing 1B	0.025
CD14	CD14 molecule	0.025
CH25H	cholesterol 25-hydroxylase	0.024
IFNB1	interferon, beta 1, fibroblast	0.024	Human
FGFR3	fibroblast growth factor receptor 3	0.024
ARHGDIA	Rho GDP dissociation inhibitor (GDI) alpha	0.024
FOSL1	FOS-like antigen 1	0.023
ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	0.023
UBD	ubiquitin D	0.023
SIGLEC1	sialic acid binding Ig-like lectin 1, sialoadhesin	0.023
PDGFA	platelet-derived growth factor alpha polypeptide	0.022
DARC	Duffy blood group, chemokine receptor	0.022
PECAM1	platelet/endothelial cell adhesion molecule	0.022
ARRB1	arrestin, beta 1	0.022
EXT1	exostosin 1	0.022
BIRC3	baculoviral IAP repeat containing 3	0.022
NR0B2	nuclear receptor subfamily 0, group B, member 2	0.022
CD33	CD33 molecule	0.021
MMP12	matrix metallopeptidase 12 (macrophage elastase)	0.021
IL10RA	interleukin 10 receptor, alpha	0.021
CAPN1	calpain 1, (mu/I) large subunit	0.021
LDLR	low density lipoprotein receptor	0.020
PTEN	phosphatase and tensin homolog	0.020
IL2RG	interleukin 2 receptor, gamma	0.020
IL2RA	interleukin 2 receptor, alpha	0.020
SHC2	SHC (Src homology 2 domain containing) transforming protein 2	0.020
IL1R1	interleukin 1 receptor, type I	0.020
WIPF1	WAS/WASL interacting protein family, member 1	0.019
MPZL1	myelin protein zero-like 1	0.019
CCR4	chemokine (C-C motif) receptor 4	0.019
PIK3CA	phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.019
TRO	trophinin	0.019
LTA	lymphotoxin alpha (TNF superfamily, member 1)	0.019
IL2	interleukin 2	0.018
FGF2	fibroblast growth factor 2 (basic)	0.018
NSF	N-ethylmaleimide-sensitive factor	0.018
SIT1	signaling threshold regulating transmembrane adaptor 1	0.018
DPP4	dipeptidyl-peptidase 4	0.018
IL21R	interleukin 21 receptor	0.018
NR4A3	nuclear receptor subfamily 4, group A, member 3	0.018
HLA-DOA	major histocompatibility complex, class II, DO alpha	0.018
AKT2	v-akt murine thymoma viral oncogene homolog 2	0.018
NR2E3	nuclear receptor subfamily 2, group E, member 3	0.018
STC1	stanniocalcin 1	0.017
IDO1	indoleamine 2,3-dioxygenase 1	0.017
RELB	v-rel reticuloendotheliosis viral oncogene homolog B	0.017
IL32	interleukin 32	0.017
IL1A	interleukin 1, alpha	0.017
STAT5B	signal transducer and activator of transcription 5B	0.017
VEGFC	vascular endothelial growth factor C	0.017
APP	amyloid beta (A4) precursor protein	0.016
CXCR3	chemokine (C-X-C motif) receptor 3	0.016
SLA	Src-like-adaptor	0.016
PDGFC	platelet derived growth factor C	0.016
GRB10	growth factor receptor-bound protein 10	0.016
ZMYND11	zinc finger, MYND-type containing 11	0.016
TGM2	transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)	0.016
RHOA	ras homolog gene family, member A	0.016
EIF3F	eukaryotic translation initiation factor 3, subunit F	0.016
CTLA4	cytotoxic T-lymphocyte-associated protein 4	0.015
TLR3	toll-like receptor 3	0.015
CD7	CD7 molecule	0.015
MYH9	myosin, heavy chain 9, non-muscle	0.015
CD83	CD83 molecule	0.015
CCL1	chemokine (C-C motif) ligand 1	0.015
IL5	interleukin 5 (colony-stimulating factor, eosinophil)	0.015
INHBA	inhibin, beta A	0.015
ITGB3	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	0.015
ITGA1	integrin, alpha 1	0.015
MSC	musculin	0.015
RGS16	regulator of G-protein signaling 16	0.014
ESRRG	estrogen-related receptor gamma	0.014
IL12RB2	interleukin 12 receptor, beta 2	0.014	Human
IL6R	interleukin 6 receptor	0.014
PTPN3	protein tyrosine phosphatase, non-receptor type 3	0.014
PPARG	peroxisome proliferator-activated receptor gamma	0.014
KIR2DL1	killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1	0.014
IL11	interleukin 11	0.014
PTPRJ	protein tyrosine phosphatase, receptor type, J	0.014
PIK3CD	phosphoinositide-3-kinase, catalytic, delta polypeptide	0.014
ABL2	v-abl Abelson murine leukemia viral oncogene homolog 2	0.014
XCL1	chemokine (C motif) ligand 1	0.014	Human
FPR3	formyl peptide receptor 3	0.014
CD80	CD80 molecule	0.013
PIK3R2	phosphoinositide-3-kinase, regulatory subunit 2 (beta)	0.013
VHL	von Hippel-Lindau tumor suppressor	0.013
CCR3	chemokine (C-C motif) receptor 3	0.013
CNTF	ciliary neurotrophic factor	0.013
CRK	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.013
CAV2	caveolin 2	0.013
XCL2	chemokine (C motif) ligand 2	0.013
UBASH3B	ubiquitin associated and SH3 domain containing B	0.013
PHLDA1	pleckstrin homology-like domain, family A, member 1	0.012
SOS1	son of sevenless homolog 1 (Drosophila)	0.012
FLT4	fms-related tyrosine kinase 4	0.012	Human
TBC1D10A	TBC1 domain family, member 10A	0.012
LAMP3	lysosomal-associated membrane protein 3	0.012
C3	complement component 3	0.012
ID1	inhibitor of DNA binding 1, dominant negative helix-loop-helix protein	0.012
ICOS	inducible T-cell co-stimulator	0.012
HDAC2	histone deacetylase 2	0.012
ADAMDEC1	ADAM-like, decysin 1	0.012
BCL3	B-cell CLL/lymphoma 3	0.012
EDN1	endothelin 1	0.012
IL12RB1	interleukin 12 receptor, beta 1	0.012
TNC	tenascin C	0.011
UBE2R2	ubiquitin-conjugating enzyme E2R 2	0.011
NOS2	nitric oxide synthase 2, inducible	0.011
TNFRSF13B	tumor necrosis factor receptor superfamily, member 13B	0.011
TRAF3IP2	TRAF3 interacting protein 2	0.011
IL15RA	interleukin 15 receptor, alpha	0.011
GRB7	growth factor receptor-bound protein 7	0.011
CCL3L3	chemokine (C-C motif) ligand 3-like 3	0.011
PLAUR	plasminogen activator, urokinase receptor	0.011
CSF2	colony stimulating factor 2 (granulocyte-macrophage)	0.011
SLAMF7	SLAM family member 7	0.011
NKG7	natural killer cell group 7 sequence	0.011
CD247	CD247 molecule	0.011
RUNX3	runt-related transcription factor 3	0.011
EGR3	early growth response 3	0.011
CELA3B	chymotrypsin-like elastase family, member 3B	0.011
CCL17	chemokine (C-C motif) ligand 17	0.011
MMP3	matrix metallopeptidase 3 (stromelysin 1, progelatinase)	0.011
RGS1	regulator of G-protein signaling 1	0.011
PTK2	PTK2 protein tyrosine kinase 2	0.011
HSD11B1	hydroxysteroid (11-beta) dehydrogenase 1	0.011
FCER1G	Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide	0.011
DLG3	discs, large homolog 3 (Drosophila)	0.011
AXL	AXL receptor tyrosine kinase	0.011
MMP10	matrix metallopeptidase 10 (stromelysin 2)	0.010
TNFAIP2	tumor necrosis factor, alpha-induced protein 2	0.010
PTK2B	PTK2B protein tyrosine kinase 2 beta	0.010
IFNA16	interferon, alpha 16	0.010	Human
FAS	Fas (TNF receptor superfamily, member 6)	0.010	Human
IGFBP3	insulin-like growth factor binding protein 3	0.010
CD40LG	CD40 ligand	0.010
IFNA10	interferon, alpha 10	0.010	Human