IMP

Process View

Homo sapiens

4 genes annotated in human

t cell selection

The process in which T cells that express T cell receptors that are restricted by self MHC protein complexes and tolerant to self antigens are selected for further maturation.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "t cell selection"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "t cell selection" (in gray)

Name	Description	Probability	Func Analog Organism
LCK	lymphocyte-specific protein tyrosine kinase	0.999
CD247	CD247 molecule	0.999
ZAP70	zeta-chain (TCR) associated protein kinase 70kDa	0.999
CD3E	CD3e molecule, epsilon (CD3-TCR complex)	0.998	Mouse
IL4R	interleukin 4 receptor	0.997
NOTCH1	notch 1	0.963
LAT	linker for activation of T cells	0.943
NOTCH3	notch 3	0.877
SYK	spleen tyrosine kinase	0.854	Human Mouse
HLA-DRA	major histocompatibility complex, class II, DR alpha	0.833
BCL2L1	BCL2-like 1	0.809
PTPN22	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	0.799
HLA-DMB	major histocompatibility complex, class II, DM beta	0.687
HLA-DRB1	major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 1	0.660
VAV1	vav 1 guanine nucleotide exchange factor	0.613
STRADA	STE20-related kinase adaptor alpha	0.583
HLA-DPA1	major histocompatibility complex, class II, DP alpha 1	0.457
HLA-DRB5	major histocompatibility complex, class II, DR beta 5	0.434
GRAP2	GRB2-related adaptor protein 2	0.403
GHR	growth hormone receptor	0.386
IL12B	interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)	0.334
BCL10	B-cell CLL/lymphoma 10	0.278
HLA-DMA	major histocompatibility complex, class II, DM alpha	0.275	Mouse
IL6R	interleukin 6 receptor	0.238
MKL1	megakaryoblastic leukemia (translocation) 1	0.233
CD74	CD74 molecule, major histocompatibility complex, class II invariant chain	0.205	Mouse
GFI1B	growth factor independent 1B transcription repressor	0.196
LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	0.182
PTPN6	protein tyrosine phosphatase, non-receptor type 6	0.158
HLA-DPB1	major histocompatibility complex, class II, DP beta 1	0.138
STRADB	STE20-related kinase adaptor beta	0.128
CXCR4	chemokine (C-X-C motif) receptor 4	0.126
KSR1	kinase suppressor of ras 1	0.110
FADD	Fas (TNFRSF6)-associated via death domain	0.109
NOTCH2	notch 2	0.107
ARAF	v-raf murine sarcoma 3611 viral oncogene homolog	0.102
JAG1	jagged 1	0.101	Human
CASP8	caspase 8, apoptosis-related cysteine peptidase	0.098
CD3G	CD3g molecule, gamma (CD3-TCR complex)	0.098
ITGAL	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)	0.098
DAXX	death-domain associated protein	0.098
UBASH3B	ubiquitin associated and SH3 domain containing B	0.095
MYOCD	myocardin	0.094
CD2	CD2 molecule	0.090
CD7	CD7 molecule	0.085
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.084
CD8A	CD8a molecule	0.082
FCGR2A	Fc fragment of IgG, low affinity IIa, receptor (CD32)	0.082
PRKCE	protein kinase C, epsilon	0.082
IL15RA	interleukin 15 receptor, alpha	0.076
PDPK1	3-phosphoinositide dependent protein kinase-1	0.073
AMBRA1	autophagy/beclin-1 regulator 1	0.072
RBPJ	recombination signal binding protein for immunoglobulin kappa J region	0.068
CFLAR	CASP8 and FADD-like apoptosis regulator	0.067
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.066
ITGB2	integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)	0.065
MKL2	MKL/myocardin-like 2	0.062
MYOG	myogenin (myogenic factor 4)	0.061
SUV39H1	suppressor of variegation 3-9 homolog 1 (Drosophila)	0.061
MAP4K1	mitogen-activated protein kinase kinase kinase kinase 1	0.059
SH2D2A	SH2 domain containing 2A	0.055
FGR	Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog	0.054
ITGA1	integrin, alpha 1	0.052
FCER1G	Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide	0.051
NCOR2	nuclear receptor corepressor 2	0.050
CD6	CD6 molecule	0.049
BID	BH3 interacting domain death agonist	0.049
CASP10	caspase 10, apoptosis-related cysteine peptidase	0.048
FKBP8	FK506 binding protein 8, 38kDa	0.048
MCL1	myeloid cell leukemia sequence 1 (BCL2-related)	0.048
SEMA4D	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D	0.048
IL2RG	interleukin 2 receptor, gamma	0.044
MYOD1	myogenic differentiation 1	0.043
CD38	CD38 molecule	0.043
PLCG1	phospholipase C, gamma 1	0.042
CD5	CD5 molecule	0.041
STK36	serine/threonine kinase 36	0.040
BLNK	B-cell linker	0.039
HCLS1	hematopoietic cell-specific Lyn substrate 1	0.038
PRKCQ	protein kinase C, theta	0.037
IRF4	interferon regulatory factor 4	0.036	Mouse
BCL2L11	BCL2-like 11 (apoptosis facilitator)	0.036
PTPRC	protein tyrosine phosphatase, receptor type, C	0.035	Mouse
JAG2	jagged 2	0.035
FASLG	Fas ligand (TNF superfamily, member 6)	0.034
GATAD2A	GATA zinc finger domain containing 2A	0.033
SH3BP2	SH3-domain binding protein 2	0.033
RUNX3	runt-related transcription factor 3	0.032
SLA	Src-like-adaptor	0.032
PTPRCAP	protein tyrosine phosphatase, receptor type, C-associated protein	0.031
IL2RB	interleukin 2 receptor, beta	0.031
TAL1	T-cell acute lymphocytic leukemia 1	0.030
JAK3	Janus kinase 3	0.029
CMIP	c-Maf-inducing protein	0.029
PTPRB	protein tyrosine phosphatase, receptor type, B	0.029
MAPK8	mitogen-activated protein kinase 8	0.029
CD27	CD27 molecule	0.028
CD48	CD48 molecule	0.028
BTK	Bruton agammaglobulinemia tyrosine kinase	0.028
IL16	interleukin 16 (lymphocyte chemoattractant factor)	0.027
DLL1	delta-like 1 (Drosophila)	0.027	Human
LYN	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	0.027
MARK4	MAP/microtubule affinity-regulating kinase 4	0.027
ICOS	inducible T-cell co-stimulator	0.026
BAX	BCL2-associated X protein	0.026
SIT1	signaling threshold regulating transmembrane adaptor 1	0.026
LRMP	lymphoid-restricted membrane protein	0.025
PML	promyelocytic leukemia	0.025
ARHGDIB	Rho GDP dissociation inhibitor (GDI) beta	0.025
CD80	CD80 molecule	0.025
TNIP2	TNFAIP3 interacting protein 2	0.025
RIPK1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.024
SH2D1A	SH2 domain containing 1A	0.024
ATN1	atrophin 1	0.024
MAP2K1	mitogen-activated protein kinase kinase 1	0.023
TLR3	toll-like receptor 3	0.023
GFER	growth factor, augmenter of liver regeneration	0.023
SLAMF1	signaling lymphocytic activation molecule family member 1	0.022
RAF1	v-raf-1 murine leukemia viral oncogene homolog 1	0.022
IL2RA	interleukin 2 receptor, alpha	0.022
TRAT1	T cell receptor associated transmembrane adaptor 1	0.022
TYROBP	TYRO protein tyrosine kinase binding protein	0.022
GBP2	guanylate binding protein 2, interferon-inducible	0.022
IRF8	interferon regulatory factor 8	0.022
IL21R	interleukin 21 receptor	0.022
HIPK2	homeodomain interacting protein kinase 2	0.022
CCL19	chemokine (C-C motif) ligand 19	0.022
CCR5	chemokine (C-C motif) receptor 5	0.022
HLA-DRB4	major histocompatibility complex, class II, DR beta 4	0.022
MAML1	mastermind-like 1 (Drosophila)	0.021
NR3C1	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	0.021
CD1C	CD1c molecule	0.021
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.021
TRAF1	TNF receptor-associated factor 1	0.021
PIK3CD	phosphoinositide-3-kinase, catalytic, delta polypeptide	0.021
GPR18	G protein-coupled receptor 18	0.021
HLA-DQA1	major histocompatibility complex, class II, DQ alpha 1	0.020
HDAC2	histone deacetylase 2	0.020
CD37	CD37 molecule	0.020
SKAP1	src kinase associated phosphoprotein 1	0.020
CXCR3	chemokine (C-X-C motif) receptor 3	0.020
ITK	IL2-inducible T-cell kinase	0.020
EGFL7	EGF-like-domain, multiple 7	0.019
MAP3K5	mitogen-activated protein kinase kinase kinase 5	0.019
PLEK	pleckstrin	0.019
CARM1	coactivator-associated arginine methyltransferase 1	0.019
MAP3K1	mitogen-activated protein kinase kinase kinase 1	0.019
CCR7	chemokine (C-C motif) receptor 7	0.019	Mouse
PTPN13	protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)	0.019
SBF1	SET binding factor 1	0.019
KRTAP4-12	keratin associated protein 4-12	0.018
BANP	BTG3 associated nuclear protein	0.018
DDIT3	DNA-damage-inducible transcript 3	0.018
XIAP	X-linked inhibitor of apoptosis	0.018
BIK	BCL2-interacting killer (apoptosis-inducing)	0.018
CD3D	CD3d molecule, delta (CD3-TCR complex)	0.018	Mouse
ARHGAP15	Rho GTPase activating protein 15	0.018
GADD45A	growth arrest and DNA-damage-inducible, alpha	0.018
HLA-DQA2	major histocompatibility complex, class II, DQ alpha 2	0.018
TRAF3IP3	TRAF3 interacting protein 3	0.017
HLA-DQB1	major histocompatibility complex, class II, DQ beta 1	0.017
KCNA3	potassium voltage-gated channel, shaker-related subfamily, member 3	0.017
ETS1	v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)	0.017
BBC3	BCL2 binding component 3	0.017
GATA2	GATA binding protein 2	0.017
P2RY10	purinergic receptor P2Y, G-protein coupled, 10	0.017
RCOR1	REST corepressor 1	0.017
TCF7	transcription factor 7 (T-cell specific, HMG-box)	0.017
CD40	CD40 molecule, TNF receptor superfamily member 5	0.017
BCL2A1	BCL2-related protein A1	0.017
CD69	CD69 molecule	0.017
NFATC1	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1	0.017
LAPTM5	lysosomal protein transmembrane 5	0.017
CTSW	cathepsin W	0.017
PRKCB	protein kinase C, beta	0.017
RNASE6	ribonuclease, RNase A family, k6	0.016
SPOCK2	sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2	0.016
PLD2	phospholipase D2	0.016
BAG1	BCL2-associated athanogene	0.016
CD28	CD28 molecule	0.016	Mouse
IL13	interleukin 13	0.016
HES1	hairy and enhancer of split 1, (Drosophila)	0.016
TMEM173	transmembrane protein 173	0.016
EVI2B	ecotropic viral integration site 2B	0.016
DMPK	dystrophia myotonica-protein kinase	0.016
GATA3	GATA binding protein 3	0.016	Mouse
MS4A1	membrane-spanning 4-domains, subfamily A, member 1	0.016
TNFRSF1B	tumor necrosis factor receptor superfamily, member 1B	0.016
RUNX1	runt-related transcription factor 1	0.016
GIGYF1	GRB10 interacting GYF protein 1	0.016
EFNB2	ephrin-B2	0.016
TP53BP2	tumor protein p53 binding protein, 2	0.016
UVRAG	UV radiation resistance associated gene	0.015
IKZF1	IKAROS family zinc finger 1 (Ikaros)	0.015
GZMA	granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)	0.015
RCN3	reticulocalbin 3, EF-hand calcium binding domain	0.015
EGFR	epidermal growth factor receptor	0.015
ITGB7	integrin, beta 7	0.015
CCR9	chemokine (C-C motif) receptor 9	0.015
BAIAP2	BAI1-associated protein 2	0.015
BCAM	basal cell adhesion molecule (Lutheran blood group)	0.015
CD8B	CD8b molecule	0.015
CCL22	chemokine (C-C motif) ligand 22	0.014
PTPRJ	protein tyrosine phosphatase, receptor type, J	0.014
CCR2	chemokine (C-C motif) receptor 2	0.014
NAF1	nuclear assembly factor 1 homolog (S. cerevisiae)	0.014
IL12A	interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)	0.014
CCR6	chemokine (C-C motif) receptor 6	0.014
CHD4	chromodomain helicase DNA binding protein 4	0.014
GATA1	GATA binding protein 1 (globin transcription factor 1)	0.014
SAP30	Sin3A-associated protein, 30kDa	0.014
EPS8L1	EPS8-like 1	0.014
PMAIP1	phorbol-12-myristate-13-acetate-induced protein 1	0.014
BCL2L2	BCL2-like 2	0.014
MAVS	mitochondrial antiviral signaling protein	0.014
RASGRP1	RAS guanyl releasing protein 1 (calcium and DAG-regulated)	0.014
IKBKG	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma	0.013
C1orf93	chromosome 1 open reading frame 93	0.013
PVRIG	poliovirus receptor related immunoglobulin domain containing	0.013
IL18R1	interleukin 18 receptor 1	0.013
TNFAIP8	tumor necrosis factor, alpha-induced protein 8	0.013
GPR171	G protein-coupled receptor 171	0.013
PTPN23	protein tyrosine phosphatase, non-receptor type 23	0.013
BECN1	beclin 1, autophagy related	0.013
UBASH3A	ubiquitin associated and SH3 domain containing A	0.013
PPP3R1	protein phosphatase 3, regulatory subunit B, alpha	0.013
TNFSF8	tumor necrosis factor (ligand) superfamily, member 8	0.013
GIMAP5	GTPase, IMAP family member 5	0.013
PIP5K1C	phosphatidylinositol-4-phosphate 5-kinase, type I, gamma	0.013
GIT1	G protein-coupled receptor kinase interacting ArfGAP 1	0.013
HRH1	histamine receptor H1	0.013
CYBB	cytochrome b-245, beta polypeptide	0.013
NR4A1	nuclear receptor subfamily 4, group A, member 1	0.013
TNFRSF25	tumor necrosis factor receptor superfamily, member 25	0.013
ZNF331	zinc finger protein 331	0.013
MAPK1	mitogen-activated protein kinase 1	0.013
GATA4	GATA binding protein 4	0.013
CCR8	chemokine (C-C motif) receptor 8	0.013
GFI1	growth factor independent 1 transcription repressor	0.013
SIRPB1	signal-regulatory protein beta 1	0.013
CD53	CD53 molecule	0.013
HMHA1	histocompatibility (minor) HA-1	0.013
IL2	interleukin 2	0.013
TCF3	transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)	0.013
CYTIP	cytohesin 1 interacting protein	0.013
SCML4	sex comb on midleg-like 4 (Drosophila)	0.013
VAMP2	vesicle-associated membrane protein 2 (synaptobrevin 2)	0.012
CD1D	CD1d molecule	0.012	Mouse
PCSK1N	proprotein convertase subtilisin/kexin type 1 inhibitor	0.012
GAB1	GRB2-associated binding protein 1	0.012
SPIB	Spi-B transcription factor (Spi-1/PU.1 related)	0.012
FCER2	Fc fragment of IgE, low affinity II, receptor for (CD23)	0.012
CIC	capicua homolog (Drosophila)	0.012
IL12RB1	interleukin 12 receptor, beta 1	0.012
SELL	selectin L	0.012
SOX1	SRY (sex determining region Y)-box 1	0.012
TARP	TCR gamma alternate reading frame protein	0.012
DAPK1	death-associated protein kinase 1	0.012
DLL4	delta-like 4 (Drosophila)	0.012	Human
PPARA	peroxisome proliferator-activated receptor alpha	0.012
HOXB13	homeobox B13	0.012
BLK	B lymphoid tyrosine kinase	0.012
TNFRSF18	tumor necrosis factor receptor superfamily, member 18	0.012
IL7R	interleukin 7 receptor	0.012
HES5	hairy and enhancer of split 5 (Drosophila)	0.012
GPR65	G protein-coupled receptor 65	0.012
C16orf87	chromosome 16 open reading frame 87	0.012
CD52	CD52 molecule	0.012
MBD2	methyl-CpG binding domain protein 2	0.012
SYVN1	synovial apoptosis inhibitor 1, synoviolin	0.012
FLI1	Friend leukemia virus integration 1	0.012
C13orf18	chromosome 13 open reading frame 18	0.012
TEAD1	TEA domain family member 1 (SV40 transcriptional enhancer factor)	0.012
YAP1	Yes-associated protein 1	0.012
SMARCB1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1	0.012
INPP5D	inositol polyphosphate-5-phosphatase, 145kDa	0.012
SPNS1	spinster homolog 1 (Drosophila)	0.012
CD4	CD4 molecule	0.012
CXCR6	chemokine (C-X-C motif) receptor 6	0.012
FGL2	fibrinogen-like 2	0.012
SELE	selectin E	0.011
NPAS1	neuronal PAS domain protein 1	0.011
OGFR	opioid growth factor receptor	0.011
LY75	lymphocyte antigen 75	0.011
SLA2	Src-like-adaptor 2	0.011
UBD	ubiquitin D	0.011
HLA-F	major histocompatibility complex, class I, F	0.011
CRTAM	cytotoxic and regulatory T cell molecule	0.011
NPR1	natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)	0.011
STK17A	serine/threonine kinase 17a	0.011
BCL11A	B-cell CLL/lymphoma 11A (zinc finger protein)	0.011
ARID1B	AT rich interactive domain 1B (SWI1-like)	0.011
STC1	stanniocalcin 1	0.011
SH3BP1	SH3-domain binding protein 1	0.011
CXCL9	chemokine (C-X-C motif) ligand 9	0.011
LTB	lymphotoxin beta (TNF superfamily, member 3)	0.011
ELK1	ELK1, member of ETS oncogene family	0.011
SLAMF7	SLAM family member 7	0.011
IL23A	interleukin 23, alpha subunit p19	0.011	Mouse
GZMM	granzyme M (lymphocyte met-ase 1)	0.011
CD96	CD96 molecule	0.011
CTSH	cathepsin H	0.011
CXCL13	chemokine (C-X-C motif) ligand 13	0.011
FGF3	fibroblast growth factor 3	0.011
IL3	interleukin 3 (colony-stimulating factor, multiple)	0.011
DENND2D	DENN/MADD domain containing 2D	0.011
IRF2	interferon regulatory factor 2	0.011
CH25H	cholesterol 25-hydroxylase	0.011
CCDC88A	coiled-coil domain containing 88A	0.011
CD1E	CD1e molecule	0.011
NOS3	nitric oxide synthase 3 (endothelial cell)	0.011
GM2A	GM2 ganglioside activator	0.011
GBX2	gastrulation brain homeobox 2	0.011
KIT	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	0.011
WIZ	widely interspaced zinc finger motifs	0.011
BATF	basic leucine zipper transcription factor, ATF-like	0.011	Mouse
SPI1	spleen focus forming virus (SFFV) proviral integration oncogene spi1	0.011
LCP1	lymphocyte cytosolic protein 1 (L-plastin)	0.011
MAPK7	mitogen-activated protein kinase 7	0.011
ARHGAP25	Rho GTPase activating protein 25	0.011
LTBP4	latent transforming growth factor beta binding protein 4	0.011
ZIC1	Zic family member 1 (odd-paired homolog, Drosophila)	0.011
DNASE1L3	deoxyribonuclease I-like 3	0.011
LPHN1	latrophilin 1	0.011
TBX21	T-box 21	0.011
CDC42	cell division cycle 42 (GTP binding protein, 25kDa)	0.011
TTC9B	tetratricopeptide repeat domain 9B	0.011
SOX11	SRY (sex determining region Y)-box 11	0.011
ASB3	ankyrin repeat and SOCS box containing 3	0.011
SNRK	SNF related kinase	0.010
CARD10	caspase recruitment domain family, member 10	0.010
CALCR	calcitonin receptor	0.010
DNTTIP1	deoxynucleotidyltransferase, terminal, interacting protein 1	0.010
TBX5	T-box 5	0.010
CLC	Charcot-Leyden crystal protein	0.010
FCGBP	Fc fragment of IgG binding protein	0.010
BTN2A2	butyrophilin, subfamily 2, member A2	0.010
SLC30A3	solute carrier family 30 (zinc transporter), member 3	0.010
HAND2	heart and neural crest derivatives expressed 2	0.010
AZU1	azurocidin 1	0.010
RHOH	ras homolog gene family, member H	0.010
NRARP	NOTCH-regulated ankyrin repeat protein	0.010
CLEC10A	C-type lectin domain family 10, member A	0.010
TXK	TXK tyrosine kinase	0.010
EOMES	eomesodermin	0.010
KIFC2	kinesin family member C2	0.010
CAMK4	calcium/calmodulin-dependent protein kinase IV	0.010
CAV2	caveolin 2	0.010
NKX2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.010
EFNA3	ephrin-A3	0.010
IL7	interleukin 7	0.010