The network for 'regulation of reactive oxygen species biosynthetic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of reactive oxygen species biosynthetic process

Any process that modulates the frequency, rate or extent of reactive oxygen species biosynthetic process.

Mus musculus
Name Description Probability Func Analog Organism
Tlr4 toll-like receptor 4 1.000
Lyz2 lysozyme 2 0.993
Nos3 nitric oxide synthase 3, endothelial cell 0.987
Il6 interleukin 6 0.979
Lepr leptin receptor 0.971
Ccr2 chemokine (C-C motif) receptor 2 0.966
Nos1 nitric oxide synthase 1, neuronal 0.955
Cd44 CD44 antigen 0.952
H2-D1 histocompatibility 2, D region locus 1 0.951
Nos2 nitric oxide synthase 2, inducible 0.946
B2m beta-2 microglobulin 0.945
H2-K1 histocompatibility 2, K1, K region 0.926
Tnf tumor necrosis factor 0.923
Klrk1 killer cell lectin-like receptor subfamily K, member 1 0.918
Klra9 killer cell lectin-like receptor subfamily A, member 9 0.914
Pparg peroxisome proliferator activated receptor gamma 0.912
Tgfb1 transforming growth factor, beta 1 0.912
Myd88 myeloid differentiation primary response gene 88 0.882
Relb avian reticuloendotheliosis viral (v-rel) oncogene related B 0.876
Pten phosphatase and tensin homolog 0.825
Il10 interleukin 10 0.769
Vdr vitamin D receptor 0.736
Ccl2 chemokine (C-C motif) ligand 2 0.724
Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.720
Slc12a1 solute carrier family 12, member 1 0.704
Apoe apolipoprotein E 0.703
Lep leptin 0.671
Col1a1 collagen, type I, alpha 1 0.664
Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.623
Unc93b1 unc-93 homolog B1 (C. elegans) 0.612
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.562
Lyst lysosomal trafficking regulator 0.550
Casp4 caspase 4, apoptosis-related cysteine peptidase 0.534
Lif leukemia inhibitory factor 0.517
Fasl Fas ligand (TNF superfamily, member 6) 0.504
Klrd1 killer cell lectin-like receptor, subfamily D, member 1 0.503
Smad3 MAD homolog 3 (Drosophila) 0.476
Stat1 signal transducer and activator of transcription 1 0.469
Ncr1 natural cytotoxicity triggering receptor 1 0.457
Socs1 suppressor of cytokine signaling 1 0.449
Ptgs2 prostaglandin-endoperoxide synthase 2 0.442
Tlr2 toll-like receptor 2 0.426
Gnas GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus 0.420
Mef2d myocyte enhancer factor 2D 0.417
Stat3 signal transducer and activator of transcription 3 0.406
Ar androgen receptor 0.405
Itgal integrin alpha L 0.405
C3 complement component 3 0.399
Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b 0.397
Ren1 renin 1 structural 0.375
Insr insulin receptor 0.374
Il1a interleukin 1 alpha 0.366
H2-Q7 histocompatibility 2, Q region locus 7 0.365
Ptrf polymerase I and transcript release factor 0.365
Csf1 colony stimulating factor 1 (macrophage) 0.356
Esr1 estrogen receptor 1 (alpha) 0.353
Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 0.346
Klrc1 killer cell lectin-like receptor subfamily C, member 1 0.342
Ccr5 chemokine (C-C motif) receptor 5 0.338
Ctnnb1 catenin (cadherin associated protein), beta 1 0.336
Mmp9 matrix metallopeptidase 9 0.335
Sytl5 synaptotagmin-like 5 0.324
Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) 0.301
Plau plasminogen activator, urokinase 0.300
Hspa8 heat shock protein 8 0.299
Casp1 caspase 1 0.291
Klrb1b killer cell lectin-like receptor subfamily B member 1B 0.282
Spp1 secreted phosphoprotein 1 0.276
H2-Q6 histocompatibility 2, Q region locus 6 0.276
Agtr1a angiotensin II receptor, type 1a 0.272
H2-Eb1 histocompatibility 2, class II antigen E beta 0.271
Cav1 caveolin 1, caveolae protein 0.269
Adora3 adenosine A3 receptor 0.268
Cd14 CD14 antigen 0.266
Ms4a4c membrane-spanning 4-domains, subfamily A, member 4C 0.266
Ostm1 osteopetrosis associated transmembrane protein 1 0.265
Klra2 killer cell lectin-like receptor, subfamily A, member 2 0.258
Dusp1 dual specificity phosphatase 1 0.245
Nr3c1 nuclear receptor subfamily 3, group C, member 1 0.241
Ghr growth hormone receptor 0.241
Cp ceruloplasmin 0.238
Hsp90ab1 heat shock protein 90 alpha (cytosolic), class B member 1 0.238
Klra3 killer cell lectin-like receptor, subfamily A, member 3 0.237
Pyhin1 pyrin and HIN domain family, member 1 0.236
Gzmk granzyme K 0.225
Cd74 CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) 0.219
Lair1 leukocyte-associated Ig-like receptor 1 0.218
Tnfsf11 tumor necrosis factor (ligand) superfamily, member 11 0.210
Tapbp TAP binding protein 0.208
H2-Ab1 histocompatibility 2, class II antigen A, beta 1 0.200
Il7r interleukin 7 receptor 0.197
Stat6 signal transducer and activator of transcription 6 0.195
Akt1 thymoma viral proto-oncogene 1 0.195
Src Rous sarcoma oncogene 0.194
Fas Fas (TNF receptor superfamily member 6) 0.189
Runx2 runt related transcription factor 2 0.188
Invs inversin 0.183
H2-Aa histocompatibility 2, class II antigen A, alpha 0.183
Ccl5 chemokine (C-C motif) ligand 5 0.182
AF251705 cDNA sequence AF251705 0.180
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
pum pumilio 0.021
alpha-Cat alpha Catenin 0.018
e(r) enhancer of rudimentary 0.017
RpL19 Ribosomal protein L19 0.016
RpL13A Ribosomal protein L13A 0.015
Aos1 CG12276 gene product from transcript CG12276-RA 0.014
RnpS1 RNA-binding protein S1 0.013
pnut peanut 0.013
Su(var)205 Suppressor of variegation 205 0.013
tsu tsunagi 0.013
Axn Axin 0.013
Dref DNA replication-related element factor 0.013
Rm62 CG10279 gene product from transcript CG10279-RD 0.012
BEAF-32 Boundary element-associated factor of 32kD 0.012
His2Av Histone H2A variant 0.011
exd extradenticle 0.011
dx deltex 0.011
Fib Fibrillarin 0.010
fu fused 0.010
H Hairless 0.010
Rpd3 CG7471 gene product from transcript CG7471-RA 0.010
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Homo sapiens
Name Description Probability Func Analog Organism
IL1R1 interleukin 1 receptor, type I 0.994
EGFR epidermal growth factor receptor 0.994
ESR1 estrogen receptor 1 0.990
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.968
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.961
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.916
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.814
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 0.758
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.725
KLF6 Kruppel-like factor 6 0.713
BCL3 B-cell CLL/lymphoma 3 0.689
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.670
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.650
ZFP36 zinc finger protein 36, C3H type, homolog (mouse) 0.585
RELB v-rel reticuloendotheliosis viral oncogene homolog B 0.571
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.571
IGF1R insulin-like growth factor 1 receptor 0.542
BCAR1 breast cancer anti-estrogen resistance 1 0.531
TRAF6 TNF receptor-associated factor 6 0.524
STAT5A signal transducer and activator of transcription 5A 0.520
FYN FYN oncogene related to SRC, FGR, YES 0.498
TNIP2 TNFAIP3 interacting protein 2 0.474
IRAK2 interleukin-1 receptor-associated kinase 2 0.442
FOS FBJ murine osteosarcoma viral oncogene homolog 0.438
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.398
LAT linker for activation of T cells 0.390
DLG1 discs, large homolog 1 (Drosophila) 0.385
TICAM2 toll-like receptor adaptor molecule 2 0.366
PRKCZ protein kinase C, zeta 0.364
IL8 interleukin 8 0.351
NOXA1 NADPH oxidase activator 1 0.323
IL10RA interleukin 10 receptor, alpha 0.315
IRS1 insulin receptor substrate 1 0.302
MYD88 myeloid differentiation primary response gene (88) 0.281
MPDZ multiple PDZ domain protein 0.247
GOPC golgi-associated PDZ and coiled-coil motif containing 0.240
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.238
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 0.216
MEF2A myocyte enhancer factor 2A 0.212
MAP3K8 mitogen-activated protein kinase kinase kinase 8 0.211
DLG2 discs, large homolog 2 (Drosophila) 0.209
JAK2 Janus kinase 2 0.199
TNIP1 TNFAIP3 interacting protein 1 0.190
CAV1 caveolin 1, caveolae protein, 22kDa 0.188
PICK1 protein interacting with PRKCA 1 0.183
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.179
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 0.169
IFNGR1 interferon gamma receptor 1 0.164
GHR growth hormone receptor 0.164
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 0.163
PKD1 polycystic kidney disease 1 (autosomal dominant) 0.162
MYLK2 myosin light chain kinase 2 0.161
FOSL2 FOS-like antigen 2 0.159
PARD6A par-6 partitioning defective 6 homolog alpha (C. elegans) 0.157
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.156
MGEA5 meningioma expressed antigen 5 (hyaluronidase) 0.153
EPOR erythropoietin receptor 0.152
PPP5C protein phosphatase 5, catalytic subunit 0.148
SOCS3 suppressor of cytokine signaling 3 0.148
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) 0.140
NCOA3 nuclear receptor coactivator 3 0.140
INSR insulin receptor 0.138
JUN jun proto-oncogene 0.138
PARD6B par-6 partitioning defective 6 homolog beta (C. elegans) 0.135
AR androgen receptor 0.135
BIRC3 baculoviral IAP repeat containing 3 0.127
TRPC1 transient receptor potential cation channel, subfamily C, member 1 0.126
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.123
KLF4 Kruppel-like factor 4 (gut) 0.121
SMAD3 SMAD family member 3 0.120
IL1R2 interleukin 1 receptor, type II 0.120
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.118
NRIP1 nuclear receptor interacting protein 1 0.115
SQSTM1 sequestosome 1 0.115
NCOA1 nuclear receptor coactivator 1 0.114
NCOA2 nuclear receptor coactivator 2 0.114
MLPH melanophilin 0.113
CAPN1 calpain 1, (mu/I) large subunit 0.113
CDCP1 CUB domain containing protein 1 0.113
MET met proto-oncogene (hepatocyte growth factor receptor) 0.112
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein 0.109
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.108
CTBP1 C-terminal binding protein 1 0.108
SH3RF1 SH3 domain containing ring finger 1 0.108
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.107
ALDOB aldolase B, fructose-bisphosphate 0.103
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1 0.102
DDR2 discoidin domain receptor tyrosine kinase 2 0.099
MATK megakaryocyte-associated tyrosine kinase 0.098
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 0.098
MAPT microtubule-associated protein tau 0.095
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.094
DUSP1 dual specificity phosphatase 1 0.094
SOD1 superoxide dismutase 1, soluble 0.093
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.091
CALCA calcitonin-related polypeptide alpha 0.090
TRAF1 TNF receptor-associated factor 1 0.090
SSTR3 somatostatin receptor 3 0.089
RIPK2 receptor-interacting serine-threonine kinase 2 0.088
PARD3 par-3 partitioning defective 3 homolog (C. elegans) 0.087
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Rattus norvegicus
Name Description Probability Func Analog Organism
Hspd1 heat shock protein 1 (chaperonin) 0.079
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.075
Slc2a3 solute carrier family 2 (facilitated glucose transporter), member 3 0.075
Dcc deleted in colorectal carcinoma 0.072
Hspe1 heat shock protein 1 (chaperonin 10) 0.070
Itpkb inositol 1,4,5-trisphosphate 3-kinase B 0.063
Rab1b RAB1B, member RAS oncogene family 0.062
Serpina3k serine (or cysteine) peptidase inhibitor, clade A, member 3K 0.058
Prkacb protein kinase, cAMP dependent, catalytic, beta 0.057
Hsph1 heat shock 105/110 protein 1 0.056
Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.056
Gnb2 guanine nucleotide binding protein (G protein), beta polypeptide 2 0.054
Agtr1a angiotensin II receptor, type 1a 0.052
LOC100359522 LRRGT00191-like 0.052
Sirpa signal-regulatory protein alpha 0.052
Aqp9 aquaporin 9 0.051
Mbl1 mannose-binding lectin (protein A) 1 0.050
Gpam glycerol-3-phosphate acyltransferase, mitochondrial 0.048
Dmgdh dimethylglycine dehydrogenase 0.048
Atp5f1 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit B1 0.047
Stat3 signal transducer and activator of transcription 3 0.047
Hspb1 heat shock protein 1 0.046
Cxcl10 chemokine (C-X-C motif) ligand 10 0.046
Cxcl2 chemokine (C-X-C motif) ligand 2 0.045
Htr2b 5-hydroxytryptamine (serotonin) receptor 2B 0.045
Proc protein C 0.044
Foxa2 forkhead box A2 0.044
Apoh apolipoprotein H (beta-2-glycoprotein I) 0.044
Irf1 interferon regulatory factor 1 0.042
LOC100365106 rCG32755-like 0.042
Slco2a1 solute carrier organic anion transporter family, member 2a1 0.042
Orm1 orosomucoid 1 0.042
Zfc3h1 zinc finger, C3H1-type containing 0.042
Litaf lipopolysaccharide-induced TNF factor 0.041
Runx1 runt-related transcription factor 1 0.041
Cpb2 carboxypeptidase B2 (plasma) 0.041
Tgfbr3 transforming growth factor, beta receptor III 0.041
Cyp2a2 cytochrome P450, family 2, subfamily a, polypeptide 2 0.039
C8b complement component 8, beta polypeptide 0.039
Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 0.039
Fga fibrinogen alpha chain 0.039
Sfpq splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated) 0.039
Eef2 eukaryotic translation elongation factor 2 0.039
Myh9 myosin, heavy chain 9, non-muscle 0.039
Akap1 A kinase (PRKA) anchor protein 1 0.039
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.038
LOC299282 Serine protease inhibitor 0.038
Tff3 trefoil factor 3, intestinal 0.038
Klf6 Kruppel-like factor 6 0.038
Ptpn1 protein tyrosine phosphatase, non-receptor type 1 0.038
Ceacam10 carcinoembryonic antigen-related cell adhesion molecule 10 0.037
Hsp90ab1 heat shock protein 90 alpha (cytosolic), class B member 1 0.037
Agxt2 alanine-glyoxylate aminotransferase 2 0.037
Cx3cl1 chemokine (C-X3-C motif) ligand 1 0.037
Kng1 kininogen 1 0.037
Il18 interleukin 18 0.037
Spp2 secreted phosphoprotein 2 0.037
Fgg fibrinogen gamma chain 0.036
Rgs14 regulator of G-protein signaling 14 0.036
Rara retinoic acid receptor, alpha 0.036
Nrgn neurogranin 0.035
LOC100363106 LRRG00130-like 0.035
A2m alpha-2-macroglobulin 0.035
Olr1 oxidized low density lipoprotein (lectin-like) receptor 1 0.035
RGD1564599 RGD1564599 0.034
Mvp major vault protein 0.034
Ptger3 prostaglandin E receptor 3 (subtype EP3) 0.034
Ncf4 neutrophil cytosolic factor 4 0.034
Pbsn probasin 0.034
C4bpa complement component 4 binding protein, alpha 0.034
Tfeb transcription factor EB 0.033
Ahnak AHNAK nucleoprotein 0.033
Abcc6 ATP-binding cassette, subfamily C (CFTR/MRP), member 6 0.033
Pip4k2b phosphatidylinositol-5-phosphate 4-kinase, type II, beta 0.032
Mst1 Macrophage stimulating 1 (hepatocyte growth factor-like) 0.032
Acsm2 acyl-CoA synthetase medium-chain family member 2 0.032
Ahsg alpha-2-HS-glycoprotein 0.031
Fmnl1 formin-like 1 0.031
A1i3 alpha-1-inhibitor III 0.031
Cyfip2 cytoplasmic FMR1 interacting protein 2 0.031
Jak1 Janus kinase 1 0.031
Odf3b outer dense fiber of sperm tails 3B 0.031
Il1a interleukin 1 alpha 0.030
Atp2b1 ATPase, Ca++ transporting, plasma membrane 1 0.030
Serpina11 serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11 0.030
Mmp12 matrix metallopeptidase 12 0.030
Dnaja1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.030
Ccl20 chemokine (C-C motif) ligand 20 0.030
Rap1b RAP1B, member of RAS oncogene family 0.030
Nek9 NIMA (never in mitosis gene a)- related kinase 9 0.030
LOC100361261 rCG23560-like 0.030
Hist1h1a histone cluster 1, H1a 0.030
Lipc lipase, hepatic 0.030
Gria2 glutamate receptor, ionotropic, AMPA 2 0.029
Ccl3 chemokine (C-C motif) ligand 3 0.029
Ptgs2 prostaglandin-endoperoxide synthase 2 0.029
Acap1 ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 0.029
Atp1b3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.029
Gprc5a G protein-coupled receptor, family C, group 5, member A 0.029
Il1rl1 interleukin 1 receptor-like 1 0.028
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism