IMP
Process View
The network for 'positive regulation of isotype switching to igg isotypes' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.
Multiple Organisms
positive regulation of isotype switching to igg isotypes
Any process that activates or increases the frequency, rate or extent of isotype switching to IgG isotypes.
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| Ifng | interferon gamma | 1.000 | |
| Tnf | tumor necrosis factor | 1.000 | |
| Rag1 | recombination activating gene 1 | 0.999 | |
| Tcra | T-cell receptor alpha chain | 0.996 | |
| Il4 | interleukin 4 | 0.996 | |
| Map3k14 | mitogen-activated protein kinase kinase kinase 14 | 0.995 | |
| Foxp3 | forkhead box P3 | 0.991 | |
| Nfkb2 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 | 0.986 | |
| Il10 | interleukin 10 | 0.986 | |
| Cd19 | CD19 antigen | 0.983 | |
| Fyn | Fyn proto-oncogene | 0.975 | |
| Rag2 | recombination activating gene 2 | 0.971 | |
| Ikzf1 | IKAROS family zinc finger 1 | 0.964 | |
| Fas | Fas (TNF receptor superfamily member 6) | 0.963 | |
| Tnfrsf1a | tumor necrosis factor receptor superfamily, member 1a | 0.959 | |
| Cd28 | CD28 antigen | 0.942 | |
| Lta | lymphotoxin A | 0.899 | |
| Il2rg | interleukin 2 receptor, gamma chain | 0.879 | |
| Igh | immunoglobulin heavy chain complex | 0.869 | |
| Prf1 | perforin 1 (pore forming protein) | 0.770 | |
| Il6 | interleukin 6 | 0.682 | |
| Pitx1 | paired-like homeodomain transcription factor 1 | 0.614 | |
| Foxn1 | forkhead box N1 | 0.598 | |
| Lat | linker for activation of T cells | 0.564 | |
| Il2 | interleukin 2 | 0.540 | |
| Tnfsf11 | tumor necrosis factor (ligand) superfamily, member 11 | 0.450 | |
| Tbx3 | T-box 3 | 0.440 | |
| Cd247 | CD247 antigen | 0.297 | |
| Socs1 | suppressor of cytokine signaling 1 | 0.266 | |
| Mmp9 | matrix metallopeptidase 9 | 0.218 | |
| Hoxa1 | homeobox A1 | 0.203 | |
| Icos | inducible T-cell co-stimulator | 0.195 | |
| Inpp5d | inositol polyphosphate-5-phosphatase D | 0.191 | |
| Nkx2-5 | NK2 transcription factor related, locus 5 (Drosophila) | 0.179 | |
| Tnfrsf9 | tumor necrosis factor receptor superfamily, member 9 | 0.177 | |
| Card11 | caspase recruitment domain family, member 11 | 0.163 | |
| Nos2 | nitric oxide synthase 2, inducible | 0.152 | |
| Tbx5 | T-box 5 | 0.132 | |
| Cd40 | CD40 antigen | 0.125 | |
| Lyn | Yamaguchi sarcoma viral (v-yes-1) oncogene homolog | 0.112 | |
| Sh2d1a | SH2 domain protein 1A | 0.098 | |
| Zap70 | zeta-chain (TCR) associated protein kinase | 0.098 | |
| Cd40lg | CD40 ligand | 0.094 | |
| Lyz2 | lysozyme 2 | 0.091 | |
| Hcn4 | hyperpolarization-activated, cyclic nucleotide-gated K+ 4 | 0.083 | |
| Fasl | Fas ligand (TNF superfamily, member 6) | 0.083 | |
| Foxg1 | forkhead box G1 | 0.081 | |
| Aire | autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy) | 0.080 | |
| Scn5a | sodium channel, voltage-gated, type V, alpha | 0.077 | |
| Chd7 | chromodomain helicase DNA binding protein 7 | 0.069 | |
| Btk | Bruton agammaglobulinemia tyrosine kinase | 0.065 | |
| Tlr4 | toll-like receptor 4 | 0.063 | |
| Cd4 | CD4 antigen | 0.054 | |
| Pdcd1 | programmed cell death 1 | 0.054 | |
| Ptgs2 | prostaglandin-endoperoxide synthase 2 | 0.051 | |
| Relb | avian reticuloendotheliosis viral (v-rel) oncogene related B | 0.051 | |
| Nlrp3 | NLR family, pyrin domain containing 3 | 0.044 | |
| Nfkb1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 | 0.042 | |
| Il2rb | interleukin 2 receptor, beta chain | 0.041 | |
| Tnfsf14 | tumor necrosis factor (ligand) superfamily, member 14 | 0.040 | |
| Il27ra | interleukin 27 receptor, alpha | 0.040 | |
| Cd79a | CD79A antigen (immunoglobulin-associated alpha) | 0.038 | |
| Pik3cd | phosphatidylinositol 3-kinase catalytic delta polypeptide | 0.035 | |
| Il17a | interleukin 17A | 0.035 | |
| Il21r | interleukin 21 receptor | 0.035 | |
| Ltb | lymphotoxin B | 0.034 | |
| Tbx21 | T-box 21 | 0.032 | |
| Lck | lymphocyte protein tyrosine kinase | 0.030 | |
| Gja5 | gap junction protein, alpha 5 | 0.029 | |
| Itk | IL2-inducible T-cell kinase | 0.029 | |
| Lif | leukemia inhibitory factor | 0.028 | |
| Ccl2 | chemokine (C-C motif) ligand 2 | 0.026 | |
| Slamf1 | signaling lymphocytic activation molecule family member 1 | 0.022 | |
| Il13 | interleukin 13 | 0.021 | |
| B2m | beta-2 microglobulin | 0.021 | |
| Ccr6 | chemokine (C-C motif) receptor 6 | 0.021 | |
| Cebpb | CCAAT/enhancer binding protein (C/EBP), beta | 0.021 | |
| Tnfrsf4 | tumor necrosis factor receptor superfamily, member 4 | 0.021 | |
| Traf6 | TNF receptor-associated factor 6 | 0.021 | |
| Zeb1 | zinc finger E-box binding homeobox 1 | 0.019 | |
| Six1 | sine oculis-related homeobox 1 homolog (Drosophila) | 0.019 | |
| Sall4 | sal-like 4 (Drosophila) | 0.019 | |
| Hmx3 | H6 homeobox 3 | 0.019 | |
| Pax2 | paired box gene 2 | 0.018 | |
| Tnfrsf1b | tumor necrosis factor receptor superfamily, member 1b | 0.018 | |
| Gata3 | GATA binding protein 3 | 0.018 | |
| Map3k7 | mitogen-activated protein kinase kinase kinase 7 | 0.018 | |
| Traf2 | TNF receptor-associated factor 2 | 0.018 | |
| Mefv | Mediterranean fever | 0.017 | |
| Pou5f1 | POU domain, class 5, transcription factor 1 | 0.016 | |
| Cxcr5 | chemokine (C-X-C motif) receptor 5 | 0.016 | |
| Ighmbp2 | immunoglobulin mu binding protein 2 | 0.014 | |
| Lmx1a | LIM homeobox transcription factor 1 alpha | 0.013 | |
| Fcer1g | Fc receptor, IgE, high affinity I, gamma polypeptide | 0.012 | |
| Csf2 | colony stimulating factor 2 (granulocyte-macrophage) | 0.012 | |
| Smad6 | MAD homolog 6 (Drosophila) | 0.012 | |
| H2-Ab1 | histocompatibility 2, class II antigen A, beta 1 | 0.012 | |
| T | brachyury | 0.011 | |
| Fgf10 | fibroblast growth factor 10 | 0.011 | |
| Ccr1 | chemokine (C-C motif) receptor 1 | 0.011 |
Loading network...
Rattus norvegicus
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| Igsf6 | immunoglobulin superfamily, member 6 | 0.261 | |
| Il1b | interleukin 1 beta | 0.141 | |
| Lcp1 | lymphocyte cytosolic protein 1 | 0.141 | |
| Ctse | cathepsin E | 0.107 | |
| Hck | hemopoietic cell kinase | 0.098 | |
| Plek | pleckstrin | 0.095 | |
| Ets1 | v-ets erythroblastosis virus E26 oncogene homolog 1 (avian) | 0.081 | |
| Spn | sialophorin | 0.065 | |
| Clec9a | C-type lectin domain family 9, member a | 0.059 | |
| Arhgap25 | Rho GTPase activating protein 25 | 0.059 | |
| Tnfrsf14 | tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) | 0.058 | |
| Syk | spleen tyrosine kinase | 0.053 | |
| Cd53 | Cd53 molecule | 0.049 | |
| Cybb | cytochrome b-245, beta polypeptide | 0.046 | |
| Tlr7 | toll-like receptor 7 | 0.045 | |
| Ptpro | protein tyrosine phosphatase, receptor type, O | 0.041 | |
| Psd4 | pleckstrin and Sec7 domain containing 4 | 0.040 | |
| Bcl2a1d | B-cell leukemia/lymphoma 2 related protein A1d | 0.036 | |
| Vcam1 | vascular cell adhesion molecule 1 | 0.034 | |
| Vav1 | vav 1 guanine nucleotide exchange factor | 0.032 | |
| Il16 | interleukin 16 | 0.029 | |
| Casp1 | caspase 1 | 0.029 | |
| Lcp2 | lymphocyte cytosolic protein 2 | 0.028 | |
| RT1-Da | RT1 class II, locus Da | 0.026 | |
| Arl5c | ADP-ribosylation factor-like 5C | 0.026 | |
| Sla | src-like adaptor | 0.024 | |
| Ccl3 | chemokine (C-C motif) ligand 3 | 0.023 | |
| Cd37 | CD37 molecule | 0.023 | |
| Ptpn7 | protein tyrosine phosphatase, non-receptor type 7 | 0.023 | |
| Ms4a11 | membrane-spanning 4-domains, subfamily A, member 11 | 0.023 | |
| Laptm5 | lysosomal protein transmembrane 5 | 0.022 | |
| Il7r | interleukin 7 receptor | 0.020 | |
| Bin2 | bridging integrator 2 | 0.020 | |
| Atxn3 | ataxin 3 | 0.018 | |
| Olr1 | oxidized low density lipoprotein (lectin-like) receptor 1 | 0.018 | |
| Ptpn6 | protein tyrosine phosphatase, non-receptor type 6 | 0.018 | |
| Fgr | Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog | 0.017 | |
| Rab6a | RAB6A, member RAS oncogene family | 0.017 | |
| Atp1b1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.017 | |
| Map3k8 | mitogen-activated protein kinase kinase kinase 8 | 0.016 | |
| Mca32 | mast cell antigen 32 | 0.016 | |
| Cd8a | CD8a molecule | 0.016 | |
| Itgam | integrin, alpha M | 0.015 | |
| Acap1 | ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 | 0.015 | |
| Mmp8 | matrix metallopeptidase 8 | 0.015 | |
| Glipr1 | GLI pathogenesis-related 1 | 0.015 | |
| Pkib | protein kinase (cAMP-dependent, catalytic) inhibitor beta | 0.014 | |
| Cd3g | CD3 molecule, gamma | 0.014 | |
| Cd247 | Cd247 molecule | 0.014 | |
| Prf1 | perforin 1 (pore forming protein) | 0.014 | |
| Cxcr4 | chemokine (C-X-C motif) receptor 4 | 0.014 | |
| Rnase1 | ribonuclease, RNase A family, 1 (pancreatic) | 0.014 | |
| Ankra2 | ankyrin repeat, family A (RFXANK-like), 2 | 0.013 | |
| Lst1 | leukocyte specific transcript 1 | 0.013 | |
| Cd22 | CD22 molecule | 0.013 | |
| Stk17b | serine/threonine kinase 17b | 0.013 | |
| Lipc | lipase, hepatic | 0.012 | |
| Ly86 | lymphocyte antigen 86 | 0.012 | |
| Chrne | cholinergic receptor, nicotinic, epsilon | 0.012 | |
| Il2rb | interleukin 2 receptor, beta | 0.011 | |
| Myo1g | myosin IG | 0.011 | |
| Fez1 | fasciculation and elongation protein zeta 1 (zygin I) | 0.011 | |
| Klrd1 | killer cell lectin-like receptor, subfamily D, member 1 | 0.011 | |
| Slc15a3 | solute carrier family 15, member 3 | 0.010 | |
| Ptafr | platelet-activating factor receptor | 0.010 | |
| Rassf5 | Ras association (RalGDS/AF-6) domain family member 5 | 0.010 | |
| Clec4a3 | C-type lectin domain family 4, member a3 | 0.010 |