IMP
Process View
The network for 'type 2 immune response' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.
Multiple Organisms
type 2 immune response
An immune response which is associated with resistance to extracellular organisms such as helminths and pathological conditions such as allergy, which is orchestrated by the production of particular cytokines, most notably IL-4, IL-5, IL-10, and IL-13, by any of a variety of cell types including T-helper 2 cells, eosinophils, basophils, mast cells, and nuocytes, resulting in enhanced production of certain antibody isotypes and other effects.
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| Stat3 | signal transducer and activator of transcription 3 | 0.934 | |
| Ccl2 | chemokine (C-C motif) ligand 2 | 0.837 | |
| Ccr1 | chemokine (C-C motif) receptor 1 | 0.821 | |
| Il10 | interleukin 10 | 0.760 | |
| Tnf | tumor necrosis factor | 0.662 | |
| Cd40 | CD40 antigen | 0.661 | |
| Lepr | leptin receptor | 0.585 | |
| Stat5b | signal transducer and activator of transcription 5B | 0.579 | |
| Tnfrsf4 | tumor necrosis factor receptor superfamily, member 4 | 0.564 | |
| Relb | avian reticuloendotheliosis viral (v-rel) oncogene related B | 0.546 | |
| Ccr2 | chemokine (C-C motif) receptor 2 | 0.527 | |
| Csf2rb2 | colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage) | 0.521 | |
| Lyz2 | lysozyme 2 | 0.496 | |
| Ifng | interferon gamma | 0.493 | |
| Il4ra | interleukin 4 receptor, alpha | 0.467 | |
| Stat5a | signal transducer and activator of transcription 5A | 0.456 | |
| Cd28 | CD28 antigen | 0.420 | |
| Ccr7 | chemokine (C-C motif) receptor 7 | 0.410 | |
| Ccl3 | chemokine (C-C motif) ligand 3 | 0.402 | |
| Rela | v-rel reticuloendotheliosis viral oncogene homolog A (avian) | 0.398 | |
| Csf2rb | colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) | 0.361 | |
| Socs1 | suppressor of cytokine signaling 1 | 0.359 | |
| Nfkb2 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 | 0.357 | |
| Tnfrsf1a | tumor necrosis factor receptor superfamily, member 1a | 0.343 | |
| Csf1 | colony stimulating factor 1 (macrophage) | 0.342 | |
| Foxp3 | forkhead box P3 | 0.327 | |
| Batf | basic leucine zipper transcription factor, ATF-like | 0.295 | |
| C3ar1 | complement component 3a receptor 1 | 0.285 | |
| Jak2 | Janus kinase 2 | 0.280 | |
| Ccl4 | chemokine (C-C motif) ligand 4 | 0.276 | |
| Ikzf1 | IKAROS family zinc finger 1 | 0.250 | |
| Il6st | interleukin 6 signal transducer | 0.250 | |
| Nfkbia | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.221 | |
| Il1r1 | interleukin 1 receptor, type I | 0.215 | |
| Il1b | interleukin 1 beta | 0.211 | |
| Cd44 | CD44 antigen | 0.208 | |
| Prdm1 | PR domain containing 1, with ZNF domain | 0.200 | |
| Folr2 | folate receptor 2 (fetal) | 0.182 | |
| Cish | cytokine inducible SH2-containing protein | 0.168 | |
| Icam1 | intercellular adhesion molecule 1 | 0.165 | |
| Fasl | Fas ligand (TNF superfamily, member 6) | 0.162 | |
| Irf9 | interferon regulatory factor 9 | 0.158 | |
| Il2rb | interleukin 2 receptor, beta chain | 0.158 | |
| Il6 | interleukin 6 | 0.156 | |
| Pdcd1 | programmed cell death 1 | 0.152 | |
| Il4 | interleukin 4 | 0.138 | |
| Klrk1 | killer cell lectin-like receptor subfamily K, member 1 | 0.133 | |
| H2-Ab1 | histocompatibility 2, class II antigen A, beta 1 | 0.124 | |
| Mx2 | myxovirus (influenza virus) resistance 2 | 0.121 | |
| Il2 | interleukin 2 | 0.120 | |
| Tlr4 | toll-like receptor 4 | 0.119 | |
| Nkx2-5 | NK2 transcription factor related, locus 5 (Drosophila) | 0.119 | |
| Stat6 | signal transducer and activator of transcription 6 | 0.118 | |
| Socs3 | suppressor of cytokine signaling 3 | 0.117 | |
| Rxra | retinoid X receptor alpha | 0.114 | |
| Ccr5 | chemokine (C-C motif) receptor 5 | 0.113 | |
| Nfkb1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 | 0.112 | |
| Il1rl1 | interleukin 1 receptor-like 1 | 0.111 | |
| Tbx21 | T-box 21 | 0.111 | |
| Fas | Fas (TNF receptor superfamily member 6) | 0.110 | |
| Ctsw | cathepsin W | 0.109 | |
| Vegfa | vascular endothelial growth factor A | 0.103 | |
| Tnfrsf9 | tumor necrosis factor receptor superfamily, member 9 | 0.100 | |
| Itgax | integrin alpha X | 0.100 | |
| Lag3 | lymphocyte-activation gene 3 | 0.092 | |
| Bcl2 | B-cell leukemia/lymphoma 2 | 0.091 | |
| Il10ra | interleukin 10 receptor, alpha | 0.091 | |
| Ccl12 | chemokine (C-C motif) ligand 12 | 0.090 | |
| Cyld | cylindromatosis (turban tumor syndrome) | 0.090 | |
| Lta | lymphotoxin A | 0.087 | |
| Icos | inducible T-cell co-stimulator | 0.085 | |
| Cxcl9 | chemokine (C-X-C motif) ligand 9 | 0.084 | |
| Gzmb | granzyme B | 0.084 | |
| H2-Eb1 | histocompatibility 2, class II antigen E beta | 0.082 | |
| H2-Aa | histocompatibility 2, class II antigen A, alpha | 0.081 | |
| Zfp36 | zinc finger protein 36 | 0.079 | |
| Ccl8 | chemokine (C-C motif) ligand 8 | 0.078 | |
| Ubd | ubiquitin D | 0.073 | |
| Ptpn11 | protein tyrosine phosphatase, non-receptor type 11 | 0.073 | |
| Tgfb1 | transforming growth factor, beta 1 | 0.072 | |
| Casp4 | caspase 4, apoptosis-related cysteine peptidase | 0.072 | |
| Ar | androgen receptor | 0.072 | |
| Csf2 | colony stimulating factor 2 (granulocyte-macrophage) | 0.071 | |
| Il12rb2 | interleukin 12 receptor, beta 2 | 0.070 | |
| Irf4 | interferon regulatory factor 4 | 0.069 | |
| Cd7 | CD7 antigen | 0.067 | |
| Ccl7 | chemokine (C-C motif) ligand 7 | 0.067 | |
| Il18rap | interleukin 18 receptor accessory protein | 0.066 | |
| Ccrl2 | chemokine (C-C motif) receptor-like 2 | 0.064 | |
| Tnfrsf1b | tumor necrosis factor receptor superfamily, member 1b | 0.063 | |
| Mesp1 | mesoderm posterior 1 | 0.063 | |
| Elk4 | ELK4, member of ETS oncogene family | 0.063 | |
| Ncr1 | natural cytotoxicity triggering receptor 1 | 0.062 | |
| Tlr2 | toll-like receptor 2 | 0.062 | |
| Rc3h1 | RING CCCH (C3H) domains 1 | 0.062 | |
| Pparg | peroxisome proliferator activated receptor gamma | 0.059 | |
| Klra5 | killer cell lectin-like receptor, subfamily A, member 5 | 0.059 | |
| Zfpm2 | zinc finger protein, multitype 2 | 0.058 | |
| Cxcl10 | chemokine (C-X-C motif) ligand 10 | 0.057 | |
| Sh2d2a | SH2 domain protein 2A | 0.057 |
Loading network...
Homo sapiens
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.978 | |
| STAT6 | signal transducer and activator of transcription 6, interleukin-4 induced | 0.939 | |
| NFKB2 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) | 0.917 | |
| IL4R | interleukin 4 receptor | 0.760 | |
| RXRA | retinoid X receptor, alpha | 0.746 | |
| RELA | v-rel reticuloendotheliosis viral oncogene homolog A (avian) | 0.742 | |
| RELB | v-rel reticuloendotheliosis viral oncogene homolog B | 0.727 | |
| SIN3A | SIN3 homolog A, transcription regulator (yeast) | 0.560 | |
| NFKBIE | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon | 0.540 | |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.536 | |
| REL | v-rel reticuloendotheliosis viral oncogene homolog (avian) | 0.515 | |
| HLA-DRA | major histocompatibility complex, class II, DR alpha | 0.491 | |
| MED25 | mediator complex subunit 25 | 0.309 | |
| NCOR2 | nuclear receptor corepressor 2 | 0.270 | |
| IL2RG | interleukin 2 receptor, gamma | 0.098 | |
| ZNF71 | zinc finger protein 71 | 0.080 | |
| PTPN6 | protein tyrosine phosphatase, non-receptor type 6 | 0.075 | |
| VDR | vitamin D (1,25- dihydroxyvitamin D3) receptor | 0.057 | |
| IKBKB | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta | 0.047 | |
| IL4 | interleukin 4 | 0.046 | |
| MAP3K8 | mitogen-activated protein kinase kinase kinase 8 | 0.046 | |
| IL6R | interleukin 6 receptor | 0.040 | |
| NFKBIB | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta | 0.032 | |
| INPP5D | inositol polyphosphate-5-phosphatase, 145kDa | 0.031 | |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.024 | |
| NCOA1 | nuclear receptor coactivator 1 | 0.023 | |
| HLA-DPA1 | major histocompatibility complex, class II, DP alpha 1 | 0.021 | |
| PPARA | peroxisome proliferator-activated receptor alpha | 0.018 | |
| IL8 | interleukin 8 | 0.018 | |
| RIPK2 | receptor-interacting serine-threonine kinase 2 | 0.017 | |
| CXCR4 | chemokine (C-X-C motif) receptor 4 | 0.017 | |
| RARA | retinoic acid receptor, alpha | 0.016 | |
| TNIP2 | TNFAIP3 interacting protein 2 | 0.016 | |
| RXRB | retinoid X receptor, beta | 0.015 | |
| ITGB1BP2 | integrin beta 1 binding protein (melusin) 2 | 0.013 | |
| PRKD2 | protein kinase D2 | 0.013 | |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.011 | |
| PYDC2 | pyrin domain containing 2 | 0.011 | |
| HLA-DRB4 | major histocompatibility complex, class II, DR beta 4 | 0.011 | |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | 0.011 |