The network for 'negative regulation of leukocyte proliferation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of leukocyte proliferation

Any process that stops, prevents, or reduces the frequency, rate or extent of leukocyte proliferation.

Mus musculus
Name Description Probability Func Analog Organism
Pten phosphatase and tensin homolog 0.985
Trp53 transformation related protein 53 0.979
Fgfr2 fibroblast growth factor receptor 2 0.965
Ptprc protein tyrosine phosphatase, receptor type, C 0.948
Ctnnb1 catenin (cadherin associated protein), beta 1 0.907
Cd19 CD19 antigen 0.885
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.850
Gli2 GLI-Kruppel family member GLI2 0.826
Lyn Yamaguchi sarcoma viral (v-yes-1) oncogene homolog 0.814
Tcra T-cell receptor alpha chain 0.809
Rc3h1 RING CCCH (C3H) domains 1 0.796
Rb1 retinoblastoma 1 0.791
Foxp3 forkhead box P3 0.773
Casp4 caspase 4, apoptosis-related cysteine peptidase 0.744
Stat3 signal transducer and activator of transcription 3 0.721
Cd40 CD40 antigen 0.704
Tnf tumor necrosis factor 0.704
Fcer1g Fc receptor, IgE, high affinity I, gamma polypeptide 0.685
Nf1 neurofibromatosis 1 0.679
Foxc1 forkhead box C1 0.644
Hif1a hypoxia inducible factor 1, alpha subunit 0.634
Fas Fas (TNF receptor superfamily member 6) 0.567
Tlr4 toll-like receptor 4 0.552
Myd88 myeloid differentiation primary response gene 88 0.543
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.521
Sox9 SRY-box containing gene 9 0.505
Lyz2 lysozyme 2 0.503
Grb2 growth factor receptor bound protein 2 0.448
Zeb1 zinc finger E-box binding homeobox 1 0.440
Ccr7 chemokine (C-C motif) receptor 7 0.410
Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.409
Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) 0.388
Cd80 CD80 antigen 0.387
Tnfrsf4 tumor necrosis factor receptor superfamily, member 4 0.386
Vangl2 vang-like 2 (van gogh, Drosophila) 0.360
Ifng interferon gamma 0.355
Il1b interleukin 1 beta 0.342
Ticam1 toll-like receptor adaptor molecule 1 0.326
Gli3 GLI-Kruppel family member GLI3 0.321
Stat6 signal transducer and activator of transcription 6 0.311
Smad4 MAD homolog 4 (Drosophila) 0.292
Il2rg interleukin 2 receptor, gamma chain 0.288
Mdm2 transformed mouse 3T3 cell double minute 2 0.279
Meox2 mesenchyme homeobox 2 0.279
Smo smoothened homolog (Drosophila) 0.274
Pik3cd phosphatidylinositol 3-kinase catalytic delta polypeptide 0.252
Fgfr1 fibroblast growth factor receptor 1 0.248
Cbl Casitas B-lineage lymphoma 0.241
Cyld cylindromatosis (turban tumor syndrome) 0.236
Pax3 paired box gene 3 0.232
Fgfr3 fibroblast growth factor receptor 3 0.225
Il6 interleukin 6 0.217
Ret ret proto-oncogene 0.213
Cd4 CD4 antigen 0.207
Apc adenomatosis polyposis coli 0.200
Sox4 SRY-box containing gene 4 0.200
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.200
Cxcr4 chemokine (C-X-C motif) receptor 4 0.191
Hck hemopoietic cell kinase 0.182
Nlrp3 NLR family, pyrin domain containing 3 0.182
Dlg1 discs, large homolog 1 (Drosophila) 0.179
Foxp1 forkhead box P1 0.175
Pthlh parathyroid hormone-like peptide 0.171
Ccl24 chemokine (C-C motif) ligand 24 0.168
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.166
Bmpr1a bone morphogenetic protein receptor, type 1A 0.164
Rarb retinoic acid receptor, beta 0.157
Fasl Fas ligand (TNF superfamily, member 6) 0.153
Il10 interleukin 10 0.152
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.150
Fcgr1 Fc receptor, IgG, high affinity I 0.145
Casp1 caspase 1 0.144
Fpr2 formyl peptide receptor 2 0.141
Cd28 CD28 antigen 0.139
Vegfa vascular endothelial growth factor A 0.137
Shc1 src homology 2 domain-containing transforming protein C1 0.137
Tgfbr2 transforming growth factor, beta receptor II 0.137
Runx2 runt related transcription factor 2 0.135
Ptk2 PTK2 protein tyrosine kinase 2 0.133
Dok1 docking protein 1 0.132
Map3k14 mitogen-activated protein kinase kinase kinase 14 0.132
Was Wiskott-Aldrich syndrome homolog (human) 0.131
Csf1 colony stimulating factor 1 (macrophage) 0.130
Fgf8 fibroblast growth factor 8 0.130
Src Rous sarcoma oncogene 0.129
Tlr2 toll-like receptor 2 0.128
Siglec1 sialic acid binding Ig-like lectin 1, sialoadhesin 0.128
Ifngr1 interferon gamma receptor 1 0.127
Rara retinoic acid receptor, alpha 0.126
Rac1 RAS-related C3 botulinum substrate 1 0.123
Mmp14 matrix metallopeptidase 14 (membrane-inserted) 0.122
Ptgs2 prostaglandin-endoperoxide synthase 2 0.120
Tnfsf11 tumor necrosis factor (ligand) superfamily, member 11 0.117
Cd74 CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) 0.116
Bmp4 bone morphogenetic protein 4 0.115
Il10ra interleukin 10 receptor, alpha 0.113
Csf1r colony stimulating factor 1 receptor 0.112
Msr1 macrophage scavenger receptor 1 0.111
Il2rb interleukin 2 receptor, beta chain 0.111
Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) 0.110
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
HLA-B major histocompatibility complex, class I, B 0.677
B2M beta-2-microglobulin 0.638
HLA-C major histocompatibility complex, class I, C 0.553
CD80 CD80 molecule 0.525
HLA-G major histocompatibility complex, class I, G 0.439
HLA-A major histocompatibility complex, class I, A 0.427
HLA-F major histocompatibility complex, class I, F 0.348
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 0.301
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 0.271
CD86 CD86 molecule 0.184
PILRA paired immunoglobin-like type 2 receptor alpha 0.178
HLA-E major histocompatibility complex, class I, E 0.176
TRAF1 TNF receptor-associated factor 1 0.157
FSTL1 follistatin-like 1 0.139
INPP5D inositol polyphosphate-5-phosphatase, 145kDa 0.128
CCL4 chemokine (C-C motif) ligand 4 0.092
HLA-DMA major histocompatibility complex, class II, DM alpha 0.072
TFF1 trefoil factor 1 0.071
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 0.070
HLA-DRB5 major histocompatibility complex, class II, DR beta 5 0.053
CXCL9 chemokine (C-X-C motif) ligand 9 0.053
POU3F2 POU class 3 homeobox 2 0.052
BMPR1A bone morphogenetic protein receptor, type IA 0.049
PTPN6 protein tyrosine phosphatase, non-receptor type 6 0.048
CCR5 chemokine (C-C motif) receptor 5 0.047
DPP4 dipeptidyl-peptidase 4 0.045
IL22RA1 interleukin 22 receptor, alpha 1 0.044
CCR1 chemokine (C-C motif) receptor 1 0.041
IDE insulin-degrading enzyme 0.041
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.041
HLA-DRB4 major histocompatibility complex, class II, DR beta 4 0.040
APP amyloid beta (A4) precursor protein 0.040
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.038
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.038
SLAMF1 signaling lymphocytic activation molecule family member 1 0.034
CCL2 chemokine (C-C motif) ligand 2 0.033
CD33 CD33 molecule 0.030
IL10RA interleukin 10 receptor, alpha 0.030
CCL5 chemokine (C-C motif) ligand 5 0.029
CCL8 chemokine (C-C motif) ligand 8 0.029
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin 0.029
BTN3A2 butyrophilin, subfamily 3, member A2 0.029
IL10 interleukin 10 0.028
ADAM17 ADAM metallopeptidase domain 17 0.027
HK3 hexokinase 3 (white cell) 0.027
LILRA1 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1 0.026
GRAP2 GRB2-related adaptor protein 2 0.026
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 1 0.025
SYK spleen tyrosine kinase 0.023
FPR3 formyl peptide receptor 3 0.023
FCGR2C Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene) 0.023
CXCL10 chemokine (C-X-C motif) ligand 10 0.023
IFNG interferon, gamma 0.022
ICAM1 intercellular adhesion molecule 1 0.022
MARCO macrophage receptor with collagenous structure 0.022
HLA-DRA major histocompatibility complex, class II, DR alpha 0.022
CD40 CD40 molecule, TNF receptor superfamily member 5 0.022
IL1B interleukin 1, beta 0.021
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) 0.020
TRAF5 TNF receptor-associated factor 5 0.020
CCL13 chemokine (C-C motif) ligand 13 0.019
CCL7 chemokine (C-C motif) ligand 7 0.017
CCR7 chemokine (C-C motif) receptor 7 0.017
CXCL3 chemokine (C-X-C motif) ligand 3 0.017
AIF1 allograft inflammatory factor 1 0.017
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14 0.016
RIPK2 receptor-interacting serine-threonine kinase 2 0.015
CDK6 cyclin-dependent kinase 6 0.015
EPOR erythropoietin receptor 0.015
NLRP3 NLR family, pyrin domain containing 3 0.015
XIAP X-linked inhibitor of apoptosis 0.014
IL22RA2 interleukin 22 receptor, alpha 2 0.014
LILRA2 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2 0.014
CCR4 chemokine (C-C motif) receptor 4 0.014
IL6 interleukin 6 (interferon, beta 2) 0.014
CMKLR1 chemokine-like receptor 1 0.013
CD163 CD163 molecule 0.013
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide 0.013
IL8 interleukin 8 0.013
ENG endoglin 0.013
CYTH4 cytohesin 4 0.012
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 0.012
SIGLEC7 sialic acid binding Ig-like lectin 7 0.012
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.012
PAX3 paired box 3 0.012
HCK hemopoietic cell kinase 0.012
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 0.012
RNF111 ring finger protein 111 0.012
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.012
IL2RA interleukin 2 receptor, alpha 0.012
TNF tumor necrosis factor 0.012
PLK3 polo-like kinase 3 0.012
CCDC85B coiled-coil domain containing 85B 0.011
CLEC10A C-type lectin domain family 10, member A 0.011
ZFYVE9 zinc finger, FYVE domain containing 9 0.011
IDO1 indoleamine 2,3-dioxygenase 1 0.011
SLAMF7 SLAM family member 7 0.011
SMAD7 SMAD family member 7 0.011
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32) 0.011
SLAMF8 SLAM family member 8 0.011
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Rattus norvegicus
Name Description Probability Func Analog Organism
Cd74 Cd74 molecule, major histocompatibility complex, class II invariant chain 0.934
RT1-Db1 RT1 class II, locus Db1 0.857
RT1-Bb RT1 class II, locus Bb 0.849
RT1-Ba RT1 class II, locus Ba 0.834
RT1-Da RT1 class II, locus Da 0.672
RT1-DMb RT1 class II, locus DMb 0.309
RT1-DMa RT1 class II, locus DMa 0.134
Cd37 CD37 molecule 0.094
Aif1 allograft inflammatory factor 1 0.056
Laptm5 lysosomal protein transmembrane 5 0.011
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism