The network for 'positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

Any process that activates or increases the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata.

Mus musculus
Name Description Probability Func Analog Organism
Lyz2 lysozyme 2 0.998
Cd40 CD40 antigen 0.995
Stat3 signal transducer and activator of transcription 3 0.989
Lta lymphotoxin A 0.982
Igh immunoglobulin heavy chain complex 0.970
Tnf tumor necrosis factor 0.947
Il4 interleukin 4 0.941
Foxp3 forkhead box P3 0.936
Cd19 CD19 antigen 0.927
Map3k14 mitogen-activated protein kinase kinase kinase 14 0.924
Lepr leptin receptor 0.922
H2-K1 histocompatibility 2, K1, K region 0.867
Ccr1 chemokine (C-C motif) receptor 1 0.862
Fas Fas (TNF receptor superfamily member 6) 0.861
Ikzf1 IKAROS family zinc finger 1 0.860
Pdcd1 programmed cell death 1 0.844
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.815
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.800
Cd74 CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) 0.791
Il6 interleukin 6 0.758
Ltb lymphotoxin B 0.738
Ifng interferon gamma 0.737
H2-Ab1 histocompatibility 2, class II antigen A, beta 1 0.705
Cxcr5 chemokine (C-X-C motif) receptor 5 0.704
Il2rg interleukin 2 receptor, gamma chain 0.698
Tapbp TAP binding protein 0.697
B2m beta-2 microglobulin 0.681
Cxcl13 chemokine (C-X-C motif) ligand 13 0.674
Il1r1 interleukin 1 receptor, type I 0.644
C3 complement component 3 0.636
Zeb1 zinc finger E-box binding homeobox 1 0.627
Ccl2 chemokine (C-C motif) ligand 2 0.620
Ccr2 chemokine (C-C motif) receptor 2 0.613
Traf6 TNF receptor-associated factor 6 0.595
Folr2 folate receptor 2 (fetal) 0.564
Socs1 suppressor of cytokine signaling 1 0.560
Apoe apolipoprotein E 0.546
H2-Aa histocompatibility 2, class II antigen A, alpha 0.541
Tnfaip3 tumor necrosis factor, alpha-induced protein 3 0.533
Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.524
H2-Q7 histocompatibility 2, Q region locus 7 0.492
Bcl3 B-cell leukemia/lymphoma 3 0.488
Irf1 interferon regulatory factor 1 0.471
Casp8 caspase 8 0.470
Il4ra interleukin 4 receptor, alpha 0.469
Cd44 CD44 antigen 0.468
Ccr7 chemokine (C-C motif) receptor 7 0.467
Gdf3 growth differentiation factor 3 0.463
H2-D1 histocompatibility 2, D region locus 1 0.461
Ciita class II transactivator 0.460
Stat5a signal transducer and activator of transcription 5A 0.450
Cd28 CD28 antigen 0.440
Stat5b signal transducer and activator of transcription 5B 0.438
H2-DMb2 histocompatibility 2, class II, locus Mb2 0.437
Clec4d C-type lectin domain family 4, member d 0.431
Lyn Yamaguchi sarcoma viral (v-yes-1) oncogene homolog 0.422
Pik3cd phosphatidylinositol 3-kinase catalytic delta polypeptide 0.416
Map3k7 mitogen-activated protein kinase kinase kinase 7 0.412
Siglec1 sialic acid binding Ig-like lectin 1, sialoadhesin 0.395
Psmb8 proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7) 0.391
Prdm1 PR domain containing 1, with ZNF domain 0.373
Pax5 paired box gene 5 0.366
Tap2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) 0.361
Tnfsf11 tumor necrosis factor (ligand) superfamily, member 11 0.356
Tbx3 T-box 3 0.346
Casp4 caspase 4, apoptosis-related cysteine peptidase 0.333
Sh2d2a SH2 domain protein 2A 0.332
Cd79a CD79A antigen (immunoglobulin-associated alpha) 0.325
Il6st interleukin 6 signal transducer 0.310
Prf1 perforin 1 (pore forming protein) 0.304
Tnfrsf4 tumor necrosis factor receptor superfamily, member 4 0.288
Saa4 serum amyloid A 4 0.280
Psmb9 proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2) 0.279
Pou5f1 POU domain, class 5, transcription factor 1 0.279
Emr1 EGF-like module containing, mucin-like, hormone receptor-like sequence 1 0.277
Itgb2 integrin beta 2 0.269
Irf9 interferon regulatory factor 9 0.264
Icos inducible T-cell co-stimulator 0.261
Il1b interleukin 1 beta 0.259
Tap1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 0.252
Pou2af1 POU domain, class 2, associating factor 1 0.246
P2rx7 purinergic receptor P2X, ligand-gated ion channel, 7 0.236
Pnp2 purine-nucleoside phosphorylase 2 0.234
Ifngr1 interferon gamma receptor 1 0.233
C3ar1 complement component 3a receptor 1 0.222
Gpr132 G protein-coupled receptor 132 0.219
Cp ceruloplasmin 0.213
Ccl12 chemokine (C-C motif) ligand 12 0.213
Tcra T-cell receptor alpha chain 0.208
Jak2 Janus kinase 2 0.204
Tnfrsf9 tumor necrosis factor receptor superfamily, member 9 0.196
Lag3 lymphocyte-activation gene 3 0.196
Il27ra interleukin 27 receptor, alpha 0.193
Ubd ubiquitin D 0.187
Birc3 baculoviral IAP repeat-containing 3 0.187
Trim21 tripartite motif-containing 21 0.185
Ptprc protein tyrosine phosphatase, receptor type, C 0.182
Il12rb2 interleukin 12 receptor, beta 2 0.179
Ikbkg inhibitor of kappaB kinase gamma 0.176
Ccl5 chemokine (C-C motif) ligand 5 0.175
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
HLA-A major histocompatibility complex, class I, A 0.968
HLA-G major histocompatibility complex, class I, G 0.963
HLA-C major histocompatibility complex, class I, C 0.961
B2M beta-2-microglobulin 0.945
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 0.893
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 0.862
HLA-E major histocompatibility complex, class I, E 0.838
IL4R interleukin 4 receptor 0.803
HLA-B major histocompatibility complex, class I, B 0.763
TRAF2 TNF receptor-associated factor 2 0.712
HLA-DRA major histocompatibility complex, class II, DR alpha 0.634
BIRC3 baculoviral IAP repeat containing 3 0.607
TAPBP TAP binding protein (tapasin) 0.568
CD40 CD40 molecule, TNF receptor superfamily member 5 0.496
HLA-F major histocompatibility complex, class I, F 0.472
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain 0.350
TRAF6 TNF receptor-associated factor 6 0.345
SYK spleen tyrosine kinase 0.260
IL12B interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) 0.233
CCR5 chemokine (C-C motif) receptor 5 0.204
CCL5 chemokine (C-C motif) ligand 5 0.181
PTPN6 protein tyrosine phosphatase, non-receptor type 6 0.174
CCL4 chemokine (C-C motif) ligand 4 0.141
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B 0.141
GRAP2 GRB2-related adaptor protein 2 0.126
TRAF1 TNF receptor-associated factor 1 0.109
TRAF3 TNF receptor-associated factor 3 0.108
BIRC2 baculoviral IAP repeat containing 2 0.080
TGM2 transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase) 0.076
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.075
CXCL9 chemokine (C-X-C motif) ligand 9 0.075
INPP5D inositol polyphosphate-5-phosphatase, 145kDa 0.074
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 1 0.074
CXCL11 chemokine (C-X-C motif) ligand 11 0.073
IL2RG interleukin 2 receptor, gamma 0.065
ZMYND11 zinc finger, MYND-type containing 11 0.063
FGR Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog 0.058
PVRL4 poliovirus receptor-related 4 0.056
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) 0.055
IL23A interleukin 23, alpha subunit p19 0.053
ICAM1 intercellular adhesion molecule 1 0.052
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 0.048
TNFRSF14 tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) 0.046
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 0.045
VAMP4 vesicle-associated membrane protein 4 0.041
HLA-DRB5 major histocompatibility complex, class II, DR beta 5 0.041
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 0.039
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 0.034
CCR7 chemokine (C-C motif) receptor 7 0.033
HLA-DMB major histocompatibility complex, class II, DM beta 0.031
CCL22 chemokine (C-C motif) ligand 22 0.030
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7) 0.029
CCL8 chemokine (C-C motif) ligand 8 0.029
TPP1 tripeptidyl peptidase I 0.028
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.027
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) 0.026
TRADD TNFRSF1A-associated via death domain 0.025
NUMBL numb homolog (Drosophila)-like 0.024
IFITM2 interferon induced transmembrane protein 2 (1-8D) 0.023
CXCL10 chemokine (C-X-C motif) ligand 10 0.022
CCL19 chemokine (C-C motif) ligand 19 0.022
CCL3 chemokine (C-C motif) ligand 3 0.021
MAP3K14 mitogen-activated protein kinase kinase kinase 14 0.021
CD3E CD3e molecule, epsilon (CD3-TCR complex) 0.021
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D 0.020
GLRX3 glutaredoxin 3 0.020
CFH complement factor H 0.020
LCK lymphocyte-specific protein tyrosine kinase 0.019
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.019
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.019
TRAF5 TNF receptor-associated factor 5 0.018
CD48 CD48 molecule 0.017
IL2RB interleukin 2 receptor, beta 0.017
DPP4 dipeptidyl-peptidase 4 0.017
LMO2 LIM domain only 2 (rhombotin-like 1) 0.017
IDE insulin-degrading enzyme 0.016
CCR1 chemokine (C-C motif) receptor 1 0.016
IL4 interleukin 4 0.016
PVRL3 poliovirus receptor-related 3 0.016
CCL13 chemokine (C-C motif) ligand 13 0.016
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 0.016
CXCL13 chemokine (C-X-C motif) ligand 13 0.015
TNF tumor necrosis factor 0.015
TAB3 TGF-beta activated kinase 1/MAP3K7 binding protein 3 0.014
CD22 CD22 molecule 0.014
IRF4 interferon regulatory factor 4 0.014
HLA-DRB4 major histocompatibility complex, class II, DR beta 4 0.014
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 0.014
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a 0.014
TNFRSF17 tumor necrosis factor receptor superfamily, member 17 0.014
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.013
ENG endoglin 0.013
IL10RA interleukin 10 receptor, alpha 0.013
MALT1 mucosa associated lymphoid tissue lymphoma translocation gene 1 0.013
CCL2 chemokine (C-C motif) ligand 2 0.013
CCR4 chemokine (C-C motif) receptor 4 0.013
IL8 interleukin 8 0.012
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) 0.012
CASP10 caspase 10, apoptosis-related cysteine peptidase 0.012
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2) 0.012
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Rattus norvegicus
Name Description Probability Func Analog Organism
RT1-EC2 RT1 class Ib, locus EC2 0.318
RT1-Ba RT1 class II, locus Ba 0.236
Ubb ubiquitin B 0.229
Hsph1 heat shock 105/110 protein 1 0.103
RT1-Da RT1 class II, locus Da 0.063
RT1-Db1 RT1 class II, locus Db1 0.034
Psmb9 proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2) 0.033
Cd37 CD37 molecule 0.028
Cd74 Cd74 molecule, major histocompatibility complex, class II invariant chain 0.027
Tap2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) 0.025
RT1-CE12 RT1 class I, locus CE12 0.021
Casp1 caspase 1 0.020
RT1-Cl RT1 class Ib, locus Cl 0.015
Tap1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 0.015
Hspb1 heat shock protein 1 0.015
Cxcr4 chemokine (C-X-C motif) receptor 4 0.014
LOC100364500 RT1 class I, locus CE11-like 0.014
Lyn v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.013
Apol3 apolipoprotein L, 3 0.012
Hsp90ab1 heat shock protein 90 alpha (cytosolic), class B member 1 0.011
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism