The network for 'adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments encoding immunoglobulin superfamily domains, and allowing for enhanced responses upon subsequent exposures to the same antigen (immunological memory). Recombined receptors for antigen encoded by immunoglobulin superfamily domains include T cell receptors and immunoglobulins (antibodies). An example of this is the adaptive immune response found in Mus musculus.

Mus musculus
Name Description Probability Func Analog Organism
Tnf tumor necrosis factor 1.000
Ifng interferon gamma 1.000
Lyz2 lysozyme 2 1.000
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 1.000
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 1.000
Igh immunoglobulin heavy chain complex 0.999
Cd40 CD40 antigen 0.999
Relb avian reticuloendotheliosis viral (v-rel) oncogene related B 0.998
Lyn Yamaguchi sarcoma viral (v-yes-1) oncogene homolog 0.997
Prf1 perforin 1 (pore forming protein) 0.997
Fcer1g Fc receptor, IgE, high affinity I, gamma polypeptide 0.997
Il10 interleukin 10 0.987
Cd44 CD44 antigen 0.986
Il1r1 interleukin 1 receptor, type I 0.984
Il2rg interleukin 2 receptor, gamma chain 0.983
Stat3 signal transducer and activator of transcription 3 0.981
Ccl2 chemokine (C-C motif) ligand 2 0.978
Il4 interleukin 4 0.975
Fasl Fas ligand (TNF superfamily, member 6) 0.974
Cd19 CD19 antigen 0.973
Foxp3 forkhead box P3 0.973
Socs1 suppressor of cytokine signaling 1 0.971
Cd74 CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) 0.970
Ccr1 chemokine (C-C motif) receptor 1 0.969
Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 0.963
Ccr2 chemokine (C-C motif) receptor 2 0.957
Fas Fas (TNF receptor superfamily member 6) 0.954
Ptprc protein tyrosine phosphatase, receptor type, C 0.947
Klrk1 killer cell lectin-like receptor subfamily K, member 1 0.943
Il6 interleukin 6 0.942
Lepr leptin receptor 0.941
Zeb1 zinc finger E-box binding homeobox 1 0.932
Itgb2 integrin beta 2 0.930
C3 complement component 3 0.924
H2-Eb1 histocompatibility 2, class II antigen E beta 0.923
Tnfaip3 tumor necrosis factor, alpha-induced protein 3 0.923
Pik3cd phosphatidylinositol 3-kinase catalytic delta polypeptide 0.921
H2-Ab1 histocompatibility 2, class II antigen A, beta 1 0.909
Ccr7 chemokine (C-C motif) receptor 7 0.903
Pax2 paired box gene 2 0.890
Ifngr1 interferon gamma receptor 1 0.889
Prdm1 PR domain containing 1, with ZNF domain 0.887
Fcgr2b Fc receptor, IgG, low affinity IIb 0.880
Casp4 caspase 4, apoptosis-related cysteine peptidase 0.860
Apoe apolipoprotein E 0.859
Mmp9 matrix metallopeptidase 9 0.847
Sfpi1 SFFV proviral integration 1 0.847
H2-Aa histocompatibility 2, class II antigen A, alpha 0.847
H2-K1 histocompatibility 2, K1, K region 0.840
Stat6 signal transducer and activator of transcription 6 0.836
Jak2 Janus kinase 2 0.835
Ccl3 chemokine (C-C motif) ligand 3 0.834
Tnfrsf4 tumor necrosis factor receptor superfamily, member 4 0.831
Ccl8 chemokine (C-C motif) ligand 8 0.827
Il27ra interleukin 27 receptor, alpha 0.823
Map3k14 mitogen-activated protein kinase kinase kinase 14 0.821
Ccl5 chemokine (C-C motif) ligand 5 0.816
Il1b interleukin 1 beta 0.798
Stat5a signal transducer and activator of transcription 5A 0.787
B2m beta-2 microglobulin 0.780
Batf basic leucine zipper transcription factor, ATF-like 0.779
Rab27a RAB27A, member RAS oncogene family 0.778
Pten phosphatase and tensin homolog 0.773
Cxcl13 chemokine (C-X-C motif) ligand 13 0.771
Selp selectin, platelet 0.770
Irf1 interferon regulatory factor 1 0.770
Atm ataxia telangiectasia mutated homolog (human) 0.769
Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b 0.765
Bcl2 B-cell leukemia/lymphoma 2 0.757
Csf2rb2 colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage) 0.754
Clec4d C-type lectin domain family 4, member d 0.749
Ccl22 chemokine (C-C motif) ligand 22 0.748
Nos2 nitric oxide synthase 2, inducible 0.746
C1qb complement component 1, q subcomponent, beta polypeptide 0.738
Il6st interleukin 6 signal transducer 0.726
Il1rl1 interleukin 1 receptor-like 1 0.723
Tnfrsf9 tumor necrosis factor receptor superfamily, member 9 0.720
Btk Bruton agammaglobulinemia tyrosine kinase 0.718
Itgax integrin alpha X 0.711
Tlr2 toll-like receptor 2 0.710
Itgal integrin alpha L 0.707
Tnfrsf11a tumor necrosis factor receptor superfamily, member 11a 0.700
Icos inducible T-cell co-stimulator 0.699
Map3k7 mitogen-activated protein kinase kinase kinase 7 0.692
Il10ra interleukin 10 receptor, alpha 0.687
Inpp5d inositol polyphosphate-5-phosphatase D 0.681
Card11 caspase recruitment domain family, member 11 0.678
Cd86 CD86 antigen 0.677
Il1r2 interleukin 1 receptor, type II 0.677
Sh2d2a SH2 domain protein 2A 0.676
Cd4 CD4 antigen 0.675
Pdcd1 programmed cell death 1 0.666
Cish cytokine inducible SH2-containing protein 0.653
Casp8 caspase 8 0.653
Pax5 paired box gene 5 0.641
Ptgir prostaglandin I receptor (IP) 0.637
Cxcl9 chemokine (C-X-C motif) ligand 9 0.635
Rc3h1 RING CCCH (C3H) domains 1 0.635
Lag3 lymphocyte-activation gene 3 0.635
Csf2rb colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 0.631
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
grna granulin a 0.306
nod1 nucleotide-binding oligomerization domain containing 1 0.247
c1qc complement component 1, q subcomponent, C chain 0.231
tlr3 toll-like receptor 3 0.225
adipoql2 adiponectin, C1Q and collagen domain containing, like 2 0.178
tlr9 toll-like receptor 9 0.164
irak4 interleukin-1 receptor-associated kinase 4 0.154
chtf18 CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae) 0.143
polr2d polymerase (RNA) II (DNA directed) polypeptide D 0.138
dlg2 discs, large (Drosophila) homolog 2 0.109
jag1b jagged 1b 0.107
wasb Wiskott-Aldrich syndrome (eczema-thrombocytopenia) b 0.107
cd247l CD247 antigen like 0.106
dlg4 discs, large (Drosophila) homolog 4 and discs, large homolog 4 (Drosophila) 0.104
adipoql adiponectin, C1Q and collagen domain containing, like 0.102
il7r interleukin 7 receptor 0.090
LOC100000934 hypothetical protein LOC100000934 0.089
grn1 granulin 1 0.081
crestin crestin 0.081
slc25a14 solute carrier family 25 (mitochondrial carrier, brain), member 14 0.078
mybl2 myeloblastosis oncogene-like 2 0.076
rpe65b retinal pigment epithelium-specific protein 65b 0.076
eomesb eomesodermin homolog b 0.075
stat1b signal transducer and activator of transcription 1b 0.075
illr1 immune-related, lectin-like receptor 1 0.071
pcsk2 proprotein convertase subtilisin/kexin type 2 0.070
oprd1b opioid receptor, delta 1b 0.069
coro1a coronin, actin binding protein, 1A 0.068
tbx21 T-box 21 0.068
irf11 interferon regulatory factor 11 0.068
vdrb vitamin D receptor b 0.067
mafba v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian) 0.066
isg15 ISG15 ubiquitin-like modifier 0.066
tmprss4b transmembrane protease, serine 4b 0.065
tlr21 toll-like receptor 21 0.065
hhip hedgehog interacting protein 0.065
cxcr3.2 chemokine (C-X-C motif) receptor 3.2 0.064
tnfa tumor necrosis factor a (TNF superfamily, member 2) 0.063
cat catalase 0.063
mef2ca myocyte enhancer factor 2ca 0.062
foxp3a forkhead box P3a 0.062
eya2 eyes absent homolog 2 (Drosophila) 0.061
nitr5 novel immune-type receptor 5 and immune-type receptor 5-like 0.060
crfa31.2 IL-4RA-like protein 2 0.059
tlr2 toll-like receptor 2 0.059
adipor2 adiponectin receptor 2 0.059
hsd17b2 hydroxysteroid (17-beta) dehydrogenase 2 0.059
tph2 tryptophan hydroxylase 2 (tryptophan 5-monooxygenase) 0.059
mef2cb myocyte enhancer factor 2cb 0.058
cd40lg CD40 ligand 0.058
fcer1g Fc receptor, IgE, high affinity I, gamma polypeptide 0.057
tnfsf10l4 tumor necrosis factor (ligand) superfamily, member 10 like 4 0.057
cd247 CD247 antigen 0.057
lndc1 ly6/neurotoxin domain containing 1 0.056
cxc46 CXC chemokine 46 0.056
olig1 oligodendrocyte lineage transcription factor 1 0.056
mef2a myocyte enhancer factor 2a 0.055
nitr13 novel immune-type receptor 13 0.055
si:dkey-236e20.6 si:dkey-236e20.6 0.053
hirip3 HIRA interacting protein 3 0.053
zgc:63831 zgc:63831 0.052
s100a10a S100 calcium binding protein A10a 0.051
mbtps1 membrane-bound transcription factor protease, site 1 0.051
LOC100534776 toll-like receptor 7-like 0.051
calcr calcitonin receptor 0.051
kitlga kit ligand a 0.050
ptger4b prostaglandin E receptor 4 (subtype EP4) b 0.050
lrrc33 leucine rich repeat containing 33 0.050
fcer1gl Fc receptor, IgE, high affinity I, gamma polypeptide like 0.047
ada adenosine deaminase 0.047
adipor1a adiponectin receptor 1a 0.046
scpep1 serine carboxypeptidase 1 0.046
tsc22d1 TSC22 domain family, member 1 0.046
tbx5b T-box 5b 0.045
ugt5c2 UDP glucuronosyltransferase 5 family, polypeptide C2 0.045
angptl1 angiopoietin-like 1 0.045
tfec transcription factor EC 0.045
itga2b integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41B) 0.044
il22 interleukin 22 0.044
lmx1b.1 LIM homeobox transcription factor 1, beta 1 0.044
ifng1-2 interferon, gamma 1-2 0.043
wu:fl55e11 wu:fl55e11 0.043
ptk6a PTK6 protein tyrosine kinase 6a 0.043
ikbkg inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.043
nfyc nuclear transcription factor Y, gamma 0.043
zgc:153941 zgc:153941 0.042
vcanb versican b 0.042
rorca RAR-related orphan receptor C a 0.042
crfb7 cytokine receptor family member b7 0.042
acsl1 acyl-CoA synthetase long-chain family member 1 0.042
rhogb ras homolog gene family, member Gb 0.042
itk IL2-inducible T-cell kinase 0.042
cftr cystic fibrosis transmembrane conductance regulator, ATP-binding cassette (sub-family C, member 7) 0.041
g6pd glucose-6-phosphate dehydrogenase 0.041
tnfb tumor necrosis factor b (TNF superfamily, member 2) 0.041
prkcha protein kinase C, eta, a 0.041
LOC100332193 growth hormone secretagogue receptor type 1-like 0.041
LOC566708 FL cytokine receptor-like 0.041
otc ornithine carbamoyltransferase 0.041
vcl vinculin 0.041
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
IL4R interleukin 4 receptor 0.966
PTPN6 protein tyrosine phosphatase, non-receptor type 6 0.951
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.880
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 0.877
NOTCH1 notch 1 0.773
TRAF1 TNF receptor-associated factor 1 0.722
HLA-A major histocompatibility complex, class I, A 0.716
HLA-C major histocompatibility complex, class I, C 0.666
B2M beta-2-microglobulin 0.643
CD80 CD80 molecule 0.595
HLA-DMB major histocompatibility complex, class II, DM beta 0.574
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.564
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.563
HLA-DRA major histocompatibility complex, class II, DR alpha 0.563
IL2RG interleukin 2 receptor, gamma 0.540
TRAF6 TNF receptor-associated factor 6 0.531
CCL5 chemokine (C-C motif) ligand 5 0.512
BTN3A2 butyrophilin, subfamily 3, member A2 0.493
HLA-G major histocompatibility complex, class I, G 0.476
CCR5 chemokine (C-C motif) receptor 5 0.475
CD40 CD40 molecule, TNF receptor superfamily member 5 0.474
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 0.446
LTA lymphotoxin alpha (TNF superfamily, member 1) 0.442
CCL4 chemokine (C-C motif) ligand 4 0.428
LAPTM5 lysosomal protein transmembrane 5 0.425
C1QA complement component 1, q subcomponent, A chain 0.415
BTN3A1 butyrophilin, subfamily 3, member A1 0.405
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 0.402
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.381
HLA-B major histocompatibility complex, class I, B 0.362
LCK lymphocyte-specific protein tyrosine kinase 0.352
HLA-F major histocompatibility complex, class I, F 0.346
HLA-E major histocompatibility complex, class I, E 0.342
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 0.328
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.308
BIRC3 baculoviral IAP repeat containing 3 0.290
NR0B1 nuclear receptor subfamily 0, group B, member 1 0.272
CALCOCO2 calcium binding and coiled-coil domain 2 0.270
CXCL9 chemokine (C-X-C motif) ligand 9 0.256
TNF tumor necrosis factor 0.255
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B 0.229
APLF aprataxin and PNKP like factor 0.220
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 0.220
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 0.211
NRP1 neuropilin 1 0.211
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.202
CCR7 chemokine (C-C motif) receptor 7 0.199
MSH2 mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) 0.197
CCL8 chemokine (C-C motif) ligand 8 0.196
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin 0.185
BTN3A3 butyrophilin, subfamily 3, member A3 0.183
IL2RB interleukin 2 receptor, beta 0.179
IL4 interleukin 4 0.177
DLG1 discs, large homolog 1 (Drosophila) 0.172
IRF4 interferon regulatory factor 4 0.172
CD2 CD2 molecule 0.171
BCL3 B-cell CLL/lymphoma 3 0.170
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain 0.167
GRAP2 GRB2-related adaptor protein 2 0.165
CD48 CD48 molecule 0.160
BRCA1 breast cancer 1, early onset 0.153
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 0.153
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.151
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 0.150
FASLG Fas ligand (TNF superfamily, member 6) 0.146
C1QC complement component 1, q subcomponent, C chain 0.137
CD3E CD3e molecule, epsilon (CD3-TCR complex) 0.129
CTLA4 cytotoxic T-lymphocyte-associated protein 4 0.126
ICAM1 intercellular adhesion molecule 1 0.124
CD86 CD86 molecule 0.123
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 0.122
SOCS3 suppressor of cytokine signaling 3 0.112
TRAF2 TNF receptor-associated factor 2 0.106
MDC1 mediator of DNA-damage checkpoint 1 0.104
IL8 interleukin 8 0.099
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 0.098
SH2D2A SH2 domain containing 2A 0.096
CD22 CD22 molecule 0.095
CCR1 chemokine (C-C motif) receptor 1 0.094
CARD11 caspase recruitment domain family, member 11 0.093
SIGLEC7 sialic acid binding Ig-like lectin 7 0.092
CASP10 caspase 10, apoptosis-related cysteine peptidase 0.090
IFNG interferon, gamma 0.086
MALT1 mucosa associated lymphoid tissue lymphoma translocation gene 1 0.085
HDAC9 histone deacetylase 9 0.083
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 0.083
IL6R interleukin 6 receptor 0.082
SLC15A3 solute carrier family 15, member 3 0.081
PILRA paired immunoglobin-like type 2 receptor alpha 0.079
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) 0.079
TAPBP TAP binding protein (tapasin) 0.079
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 0.079
SYK spleen tyrosine kinase 0.077
IRAK1 interleukin-1 receptor-associated kinase 1 0.077
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae) 0.076
IL10 interleukin 10 0.076
VAMP4 vesicle-associated membrane protein 4 0.075
CASP1 caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) 0.074
ZBP1 Z-DNA binding protein 1 0.073
NOTCH3 notch 3 0.072
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Rattus norvegicus
Name Description Probability Func Analog Organism
Hsp90aa1 heat shock protein 90, alpha (cytosolic), class A member 1 0.072
RT1-Da RT1 class II, locus Da 0.061
Cd37 CD37 molecule 0.045
RT1-Ba RT1 class II, locus Ba 0.045
RT1-Db1 RT1 class II, locus Db1 0.039
Gbp2 guanylate binding protein 2 0.029
Il1b interleukin 1 beta 0.026
Lyn v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.026
Tap2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) 0.025
Irf1 interferon regulatory factor 1 0.025
Casp1 caspase 1 0.024
LOC100359522 LRRGT00191-like 0.022
Hck hemopoietic cell kinase 0.021
Hsph1 heat shock 105/110 protein 1 0.020
Cxcl10 chemokine (C-X-C motif) ligand 10 0.019
Aif1 allograft inflammatory factor 1 0.019
LOC100363106 LRRG00130-like 0.019
Anpep alanyl (membrane) aminopeptidase 0.018
Plcg2 phospholipase C, gamma 2 0.017
RT1-DMb RT1 class II, locus DMb 0.017
Hspb1 heat shock protein 1 0.015
Fgg fibrinogen gamma chain 0.015
St8sia4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 0.015
Slfn2 schlafen 2 0.015
Fgr Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog 0.014
Tap1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 0.014
RT1-EC2 RT1 class Ib, locus EC2 0.014
C1qb complement component 1, q subcomponent, B chain 0.014
Apol3 apolipoprotein L, 3 0.013
Il2rb interleukin 2 receptor, beta 0.013
LOC100364265 ribosomal protein L19-like 0.013
Cp ceruloplasmin 0.013
Tcf21 transcription factor 21 0.012
Cd53 Cd53 molecule 0.012
Fth1 ferritin, heavy polypeptide 1 0.011
Tpt1 tumor protein, translationally-controlled 1 0.011
Il1r1 interleukin 1 receptor, type I 0.011
Mapk1 mitogen activated protein kinase 1 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism