IMP

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Homo sapiens

24 genes annotated in human

Multi-species View

negative regulation of leukocyte differentiation

GO:1902106

Any process that stops, prevents or reduces the frequency, rate or extent of leukocyte differentiation.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of leukocyte differentiation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of leukocyte differentiation" (in gray)

Name	Description	Probability	Func Analog Organism
C1QA	complement component 1, q subcomponent, A chain	0.998	Human
HLA-C	major histocompatibility complex, class I, C	0.996	Human
B2M	beta-2-microglobulin	0.986
ZNF43	zinc finger protein 43	0.985
HLA-A	major histocompatibility complex, class I, A	0.982	Human
HLA-B	major histocompatibility complex, class I, B	0.974
CD80	CD80 molecule	0.883
IL4R	interleukin 4 receptor	0.881	Mouse
PTPN6	protein tyrosine phosphatase, non-receptor type 6	0.861
LILRB1	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1	0.849
LILRA6	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6	0.834
PILRA	paired immunoglobin-like type 2 receptor alpha	0.791	Mouse
HOXB5	homeobox B5	0.787	Human
ZNF253	zinc finger protein 253	0.776
TAL1	T-cell acute lymphocytic leukemia 1	0.731
HLA-E	major histocompatibility complex, class I, E	0.726	Human
CD86	CD86 molecule	0.630
BMPR1A	bone morphogenetic protein receptor, type IA	0.606
ZNF675	zinc finger protein 675	0.558
HLA-G	major histocompatibility complex, class I, G	0.549
CCR5	chemokine (C-C motif) receptor 5	0.535
ZNF273	zinc finger protein 273	0.533	Human
NCOR2	nuclear receptor corepressor 2	0.502
HLA-F	major histocompatibility complex, class I, F	0.480	Human
ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.470
CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	0.458
HLA-DMA	major histocompatibility complex, class II, DM alpha	0.455
CDK6	cyclin-dependent kinase 6	0.435
RXRA	retinoid X receptor, alpha	0.424
HOXA10	homeobox A10	0.409
CDKN2A	cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)	0.403
FSTL1	follistatin-like 1	0.336	Human
CCL4	chemokine (C-C motif) ligand 4	0.311	Human
CCND1	cyclin D1	0.290
EPOR	erythropoietin receptor	0.290
RUNX1	runt-related transcription factor 1	0.268
ZNF430	zinc finger protein 430	0.255	Human
ZNF117	zinc finger protein 117	0.252	Human
CXCL9	chemokine (C-X-C motif) ligand 9	0.208
MDFI	MyoD family inhibitor	0.207
LILRB2	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2	0.198	Human
GRAP2	GRB2-related adaptor protein 2	0.175
CCL2	chemokine (C-C motif) ligand 2	0.170	Human
HOXA7	homeobox A7	0.169
GHR	growth hormone receptor	0.165
ZNF91	zinc finger protein 91	0.165
CXCL10	chemokine (C-X-C motif) ligand 10	0.162
TAPBP	TAP binding protein (tapasin)	0.158
CCL18	chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)	0.151	Human
SIGLEC1	sialic acid binding Ig-like lectin 1, sialoadhesin	0.150
HOXA5	homeobox A5	0.150	Human
ZNF93	zinc finger protein 93	0.149
DIP2A	DIP2 disco-interacting protein 2 homolog A (Drosophila)	0.145
HLA-DPB1	major histocompatibility complex, class II, DP beta 1	0.139
LILRB3	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3	0.132
ICAM1	intercellular adhesion molecule 1	0.132
BMP2	bone morphogenetic protein 2	0.131	Human
GAB1	GRB2-associated binding protein 1	0.130
ZNF254	zinc finger protein 254	0.128	Human
CCL13	chemokine (C-C motif) ligand 13	0.128	Human
ZNF708	zinc finger protein 708	0.127	Human
C1QC	complement component 1, q subcomponent, C chain	0.121
HOXB3	homeobox B3	0.117
SKI	v-ski sarcoma viral oncogene homolog (avian)	0.115
CD14	CD14 molecule	0.106
C1QB	complement component 1, q subcomponent, B chain	0.105	Human
HOXA11	homeobox A11	0.104
CCL8	chemokine (C-C motif) ligand 8	0.102	Human
CCND3	cyclin D3	0.100
IL4	interleukin 4	0.098	Mouse
TCF3	transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)	0.098
TUBA1A	tubulin, alpha 1a	0.095
HOXB9	homeobox B9	0.094
CCR1	chemokine (C-C motif) receptor 1	0.094
TMEM176B	transmembrane protein 176B	0.088
RBBP4	retinoblastoma binding protein 4	0.088
ZNF85	zinc finger protein 85	0.082	Human
IL2RG	interleukin 2 receptor, gamma	0.081
ITCH	itchy E3 ubiquitin protein ligase homolog (mouse)	0.079
FCGR2B	Fc fragment of IgG, low affinity IIb, receptor (CD32)	0.078
PINK1	PTEN induced putative kinase 1	0.077
VDR	vitamin D (1,25- dihydroxyvitamin D3) receptor	0.076
ZNF680	zinc finger protein 680	0.075	Human
SH3BP2	SH3-domain binding protein 2	0.075
RARA	retinoic acid receptor, alpha	0.071
CCL22	chemokine (C-C motif) ligand 22	0.069	Human
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.067
CCL5	chemokine (C-C motif) ligand 5	0.067	Human
HOXB6	homeobox B6	0.067	Human
NFKBIA	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.066
MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	0.063
SIGLEC7	sialic acid binding Ig-like lectin 7	0.059
DDB1	damage-specific DNA binding protein 1, 127kDa	0.057
CCL19	chemokine (C-C motif) ligand 19	0.057	Human
STAT6	signal transducer and activator of transcription 6, interleukin-4 induced	0.055
SLAMF1	signaling lymphocytic activation molecule family member 1	0.054
CD40	CD40 molecule, TNF receptor superfamily member 5	0.054
CCR7	chemokine (C-C motif) receptor 7	0.054
HOXB7	homeobox B7	0.054	Human
TYMP	thymidine phosphorylase	0.051
CD28	CD28 molecule	0.050	Human
VSIG4	V-set and immunoglobulin domain containing 4	0.048
DPP4	dipeptidyl-peptidase 4	0.047
SOCS3	suppressor of cytokine signaling 3	0.047
HLA-DPA1	major histocompatibility complex, class II, DP alpha 1	0.047
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.045
LILRA1	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1	0.043	Human
ZNF92	zinc finger protein 92	0.043	Human
SLAMF8	SLAM family member 8	0.043
PECAM1	platelet/endothelial cell adhesion molecule	0.041
IRF4	interferon regulatory factor 4	0.041
TNIP1	TNFAIP3 interacting protein 1	0.040
NME2	non-metastatic cells 2, protein (NM23B) expressed in	0.040	Rat
HLA-DQA1	major histocompatibility complex, class II, DQ alpha 1	0.039
NGFR	nerve growth factor receptor	0.038
NCOA1	nuclear receptor coactivator 1	0.038
TMSB4X	thymosin beta 4, X-linked	0.037
TLE1	transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)	0.037
HOXA2	homeobox A2	0.037
KIT	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	0.037
SMAD3	SMAD family member 3	0.037
ADAMTS10	ADAM metallopeptidase with thrombospondin type 1 motif, 10	0.036
INHBA	inhibin, beta A	0.035
NEDD9	neural precursor cell expressed, developmentally down-regulated 9	0.035
PPARA	peroxisome proliferator-activated receptor alpha	0.035
CCL3	chemokine (C-C motif) ligand 3	0.035
CD33	CD33 molecule	0.033
SMAD7	SMAD family member 7	0.033
HOXA4	homeobox A4	0.033	Human
MED25	mediator complex subunit 25	0.032
GATA2	GATA binding protein 2	0.032	Mouse
NLRP3	NLR family, pyrin domain containing 3	0.032
CD163	CD163 molecule	0.032
NME4	non-metastatic cells 4, protein expressed in	0.031
HOXC10	homeobox C10	0.031
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.030	Mouse
ZNF107	zinc finger protein 107	0.030
MARCO	macrophage receptor with collagenous structure	0.029
HOXA6	homeobox A6	0.029	Human
ZBTB16	zinc finger and BTB domain containing 16	0.029
BMP4	bone morphogenetic protein 4	0.029
TIRAP	toll-interleukin 1 receptor (TIR) domain containing adaptor protein	0.029
C2	complement component 2	0.027
TCF7L2	transcription factor 7-like 2 (T-cell specific, HMG-box)	0.027
CSF2RB	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	0.027
TP73	tumor protein p73	0.027
XRCC6	X-ray repair complementing defective repair in Chinese hamster cells 6	0.027
BAD	BCL2-associated agonist of cell death	0.026
CCND2	cyclin D2	0.026
IRF8	interferon regulatory factor 8	0.025
FCN2	ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin)	0.025
NCOA6	nuclear receptor coactivator 6	0.025
PCDH9	protocadherin 9	0.025
LAIR1	leukocyte-associated immunoglobulin-like receptor 1	0.025	Human
FPR3	formyl peptide receptor 3	0.025
LILRA2	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2	0.025
KAT2B	K(lysine) acetyltransferase 2B	0.025
THRA	thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)	0.024	Human
IL6	interleukin 6 (interferon, beta 2)	0.024
FST	follistatin	0.024	Human
IFNG	interferon, gamma	0.024
HIPK2	homeodomain interacting protein kinase 2	0.023
HLA-DRB1	major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 1	0.023
HLA-DRB5	major histocompatibility complex, class II, DR beta 5	0.023
LILRA3	leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3	0.023	Human
DARC	Duffy blood group, chemokine receptor	0.023
MIF	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	0.023
BIRC3	baculoviral IAP repeat containing 3	0.022
CREBBP	CREB binding protein	0.022
IL2RA	interleukin 2 receptor, alpha	0.022
ID3	inhibitor of DNA binding 3, dominant negative helix-loop-helix protein	0.022
NKG7	natural killer cell group 7 sequence	0.022
HFE	hemochromatosis	0.022	Human
EBI3	Epstein-Barr virus induced 3	0.020
VPRBP	Vpr (HIV-1) binding protein	0.020
ATXN3	ataxin 3	0.020
SPIN1	spindlin 1	0.020
CCL7	chemokine (C-C motif) ligand 7	0.020	Human
CXCL13	chemokine (C-X-C motif) ligand 13	0.020
HIC1	hypermethylated in cancer 1	0.019
CEBPA	CCAAT/enhancer binding protein (C/EBP), alpha	0.019
PIK3CA	phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.019
ZNF136	zinc finger protein 136	0.019
PGR	progesterone receptor	0.019
TGFB1	transforming growth factor, beta 1	0.019
SMAD6	SMAD family member 6	0.019
HK3	hexokinase 3 (white cell)	0.019
C1S	complement component 1, s subcomponent	0.019
ATP2B2	ATPase, Ca++ transporting, plasma membrane 2	0.018
GZMB	granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)	0.018
TNF	tumor necrosis factor	0.018
RUNX2	runt-related transcription factor 2	0.018	Human
KIR2DL1	killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1	0.018
RFWD2	ring finger and WD repeat domain 2	0.018
CMKLR1	chemokine-like receptor 1	0.018
ANKRD12	ankyrin repeat domain 12	0.018
SPI1	spleen focus forming virus (SFFV) proviral integration oncogene spi1	0.017	Zebrafish
CCR4	chemokine (C-C motif) receptor 4	0.017
TNFRSF9	tumor necrosis factor receptor superfamily, member 9	0.017
SNX9	sorting nexin 9	0.017
PLEK	pleckstrin	0.017
CH25H	cholesterol 25-hydroxylase	0.017
TAP1	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	0.016
AKT2	v-akt murine thymoma viral oncogene homolog 2	0.016
HCK	hemopoietic cell kinase	0.016
ZNF644	zinc finger protein 644	0.016
HLA-DRB4	major histocompatibility complex, class II, DR beta 4	0.016
PDGFB	platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)	0.016
IL3	interleukin 3 (colony-stimulating factor, multiple)	0.016
AR	androgen receptor	0.016
WNT11	wingless-type MMTV integration site family, member 11	0.016
CTLA4	cytotoxic T-lymphocyte-associated protein 4	0.016
CRKL	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.016
STAB1	stabilin 1	0.016
ADAMDEC1	ADAM-like, decysin 1	0.015
CMIP	c-Maf-inducing protein	0.015
HOXB8	homeobox B8	0.015	Human
SGK3	serum/glucocorticoid regulated kinase family, member 3	0.015
RBAK	RB-associated KRAB zinc finger	0.015
APOE	apolipoprotein E	0.015
CCR3	chemokine (C-C motif) receptor 3	0.015
HOXC6	homeobox C6	0.015	Human
PPAP2B	phosphatidic acid phosphatase type 2B	0.015
HDAC5	histone deacetylase 5	0.015
HLA-DRA	major histocompatibility complex, class II, DR alpha	0.015
TREM1	triggering receptor expressed on myeloid cells 1	0.015
CD84	CD84 molecule	0.015
CCL17	chemokine (C-C motif) ligand 17	0.015	Human
ESR1	estrogen receptor 1	0.014
ZNF682	zinc finger protein 682	0.014	Human
HLA-DQB1	major histocompatibility complex, class II, DQ beta 1	0.014
ITGB1BP2	integrin beta 1 binding protein (melusin) 2	0.014
STAT4	signal transducer and activator of transcription 4	0.014
F13A1	coagulation factor XIII, A1 polypeptide	0.014
SLCO2B1	solute carrier organic anion transporter family, member 2B1	0.014
CLEC10A	C-type lectin domain family 10, member A	0.014
IFITM1	interferon induced transmembrane protein 1 (9-27)	0.014
NME1	non-metastatic cells 1, protein (NM23A) expressed in	0.014
PIK3R5	phosphoinositide-3-kinase, regulatory subunit 5	0.014
HOXA3	homeobox A3	0.014
TRAF1	TNF receptor-associated factor 1	0.014
LILRB4	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4	0.014
CD83	CD83 molecule	0.013
CAMK2D	calcium/calmodulin-dependent protein kinase II delta	0.013
HOXA1	homeobox A1	0.013
CUL1	cullin 1	0.013
AOAH	acyloxyacyl hydrolase (neutrophil)	0.013
SOD1	superoxide dismutase 1, soluble	0.013
TP53	tumor protein p53	0.013
BATF	basic leucine zipper transcription factor, ATF-like	0.013
CTSB	cathepsin B	0.013
SIRPA	signal-regulatory protein alpha	0.013
DOCK7	dedicator of cytokinesis 7	0.013
MAX	MYC associated factor X	0.013
SLAMF7	SLAM family member 7	0.013
HOXC9	homeobox C9	0.013
MS4A6A	membrane-spanning 4-domains, subfamily A, member 6A	0.013
HDAC9	histone deacetylase 9	0.013
IFNA4	interferon, alpha 4	0.013
DCUN1D2	DCN1, defective in cullin neddylation 1, domain containing 2 (S. cerevisiae)	0.013
POU2F2	POU class 2 homeobox 2	0.013
SIRPB1	signal-regulatory protein beta 1	0.012
SELE	selectin E	0.012
CHIT1	chitinase 1 (chitotriosidase)	0.012
CCL11	chemokine (C-C motif) ligand 11	0.012	Human
C3	complement component 3	0.012
CDK4	cyclin-dependent kinase 4	0.012
EP300	E1A binding protein p300	0.012
MS4A4A	membrane-spanning 4-domains, subfamily A, member 4	0.012
IL13	interleukin 13	0.012
ZNF100	zinc finger protein 100	0.012	Human
CXCL3	chemokine (C-X-C motif) ligand 3	0.012
ROS1	c-ros oncogene 1 , receptor tyrosine kinase	0.012
HOXC5	homeobox C5	0.012	Human
TNFAIP2	tumor necrosis factor, alpha-induced protein 2	0.012
TGIF1	TGFB-induced factor homeobox 1	0.012
APOC1	apolipoprotein C-I	0.012
ITGA1	integrin, alpha 1	0.012
GFI1	growth factor independent 1 transcription repressor	0.012
LILRB5	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5	0.012	Human
HOXC11	homeobox C11	0.012
IRF9	interferon regulatory factor 9	0.012
HOXD9	homeobox D9	0.012
NME3	non-metastatic cells 3, protein expressed in	0.011
XCL1	chemokine (C motif) ligand 1	0.011	Human
IGL@	immunoglobulin lambda locus	0.011
SPIB	Spi-B transcription factor (Spi-1/PU.1 related)	0.011
SOCS2	suppressor of cytokine signaling 2	0.011
HOXD8	homeobox D8	0.011	Human
SH3KBP1	SH3-domain kinase binding protein 1	0.011
GATA1	GATA binding protein 1 (globin transcription factor 1)	0.011
ZNF138	zinc finger protein 138	0.011
NR4A3	nuclear receptor subfamily 4, group A, member 3	0.011
SERPING1	serpin peptidase inhibitor, clade G (C1 inhibitor), member 1	0.011
CCL21	chemokine (C-C motif) ligand 21	0.011
ZFYVE9	zinc finger, FYVE domain containing 9	0.011
CSF1	colony stimulating factor 1 (macrophage)	0.011
IFNA21	interferon, alpha 21	0.011	Human
MSC	musculin	0.011
CD209	CD209 molecule	0.011
FMNL1	formin-like 1	0.011
HOXD12	homeobox D12	0.011
CCL3L3	chemokine (C-C motif) ligand 3-like 3	0.011
C1R	complement component 1, r subcomponent	0.011
ABHD16A	abhydrolase domain containing 16A	0.010
XCL2	chemokine (C motif) ligand 2	0.010	Human
KLRD1	killer cell lectin-like receptor subfamily D, member 1	0.010
PRKD2	protein kinase D2	0.010
HOXC8	homeobox C8	0.010	Human
TUBB3	tubulin, beta 3	0.010
CCBP2	chemokine binding protein 2	0.010
IRF5	interferon regulatory factor 5	0.010
IL12B	interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)	0.010
FCN1	ficolin (collagen/fibrinogen domain containing) 1	0.010
PPARGC1A	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	0.010
PTGIS	prostaglandin I2 (prostacyclin) synthase	0.010
EMR1	egf-like module containing, mucin-like, hormone receptor-like 1	0.010
MMP12	matrix metallopeptidase 12 (macrophage elastase)	0.010
SORBS3	sorbin and SH3 domain containing 3	0.010