IMP

Process View

Homo sapiens

28 genes annotated in human

positive regulation of tyrosine phosphorylation of stat protein

Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein.

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "positive regulation of tyrosine phosphorylation of stat protein"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "positive regulation of tyrosine phosphorylation of stat protein" (in gray)

Name	Description	Probability	Func Analog Organism
EGFR	epidermal growth factor receptor	1.000	Human
IL6ST	interleukin 6 signal transducer (gp130, oncostatin M receptor)	1.000
ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	1.000	Human
SOCS3	suppressor of cytokine signaling 3	0.993
IL12B	interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)	0.989
CASP10	caspase 10, apoptosis-related cysteine peptidase	0.970
TNFRSF10B	tumor necrosis factor receptor superfamily, member 10b	0.955	Human
IL6	interleukin 6 (interferon, beta 2)	0.946
TRAF1	TNF receptor-associated factor 1	0.929
IL4R	interleukin 4 receptor	0.924
JAK2	Janus kinase 2	0.896	Mouse
FGF1	fibroblast growth factor 1 (acidic)	0.850
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.824
CCR5	chemokine (C-C motif) receptor 5	0.816
LYN	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	0.761
TRADD	TNFRSF1A-associated via death domain	0.747
IGF1R	insulin-like growth factor 1 receptor	0.735
CCL4	chemokine (C-C motif) ligand 4	0.717	Human
TNF	tumor necrosis factor	0.706
CSH1	chorionic somatomammotropin hormone 1 (placental lactogen)	0.706	Human
CASP8	caspase 8, apoptosis-related cysteine peptidase	0.704
GH1	growth hormone 1	0.679
SHC1	SHC (Src homology 2 domain containing) transforming protein 1	0.668
NR4A1	nuclear receptor subfamily 4, group A, member 1	0.664
ICAM1	intercellular adhesion molecule 1	0.654
CXCL9	chemokine (C-X-C motif) ligand 9	0.639
FADD	Fas (TNFRSF6)-associated via death domain	0.639
ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.626	Human
VEGFA	vascular endothelial growth factor A	0.607
TRAF5	TNF receptor-associated factor 5	0.550
SYK	spleen tyrosine kinase	0.547
STAT3	signal transducer and activator of transcription 3 (acute-phase response factor)	0.539
CCL8	chemokine (C-C motif) ligand 8	0.467	Human
IL23A	interleukin 23, alpha subunit p19	0.463
GRB2	growth factor receptor-bound protein 2	0.463
CCL2	chemokine (C-C motif) ligand 2	0.461	Human
GAB1	GRB2-associated binding protein 1	0.459
TNFRSF10A	tumor necrosis factor receptor superfamily, member 10a	0.448	Human
PTPN11	protein tyrosine phosphatase, non-receptor type 11	0.438
CXCL2	chemokine (C-X-C motif) ligand 2	0.409
PLCG1	phospholipase C, gamma 1	0.394
IL1B	interleukin 1, beta	0.394
CRKL	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.357
IL8	interleukin 8	0.343
TNFSF10	tumor necrosis factor (ligand) superfamily, member 10	0.315
CXCL1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	0.312
CSH2	chorionic somatomammotropin hormone 2	0.300	Human
CCL7	chemokine (C-C motif) ligand 7	0.291	Human
HDAC2	histone deacetylase 2	0.276
TRAF2	TNF receptor-associated factor 2	0.265
EPOR	erythropoietin receptor	0.263
CFLAR	CASP8 and FADD-like apoptosis regulator	0.262
IL10	interleukin 10	0.253
STAT4	signal transducer and activator of transcription 4	0.248
INSR	insulin receptor	0.240
LAT	linker for activation of T cells	0.224
JAK1	Janus kinase 1	0.210
CDH5	cadherin 5, type 2 (vascular endothelium)	0.207
SOCS1	suppressor of cytokine signaling 1	0.201
CXCL10	chemokine (C-X-C motif) ligand 10	0.195
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.185
NRP1	neuropilin 1	0.184
CCL5	chemokine (C-C motif) ligand 5	0.182
CAV1	caveolin 1, caveolae protein, 22kDa	0.181
TNFRSF1B	tumor necrosis factor receptor superfamily, member 1B	0.180	Human
CSHL1	chorionic somatomammotropin hormone-like 1	0.177	Human
CXCL3	chemokine (C-X-C motif) ligand 3	0.170
IL2RG	interleukin 2 receptor, gamma	0.168
GAB2	GRB2-associated binding protein 2	0.166
GH2	growth hormone 2	0.166	Human
IGF2R	insulin-like growth factor 2 receptor	0.164
CCL13	chemokine (C-C motif) ligand 13	0.148	Human
IRS1	insulin receptor substrate 1	0.139
CCL11	chemokine (C-C motif) ligand 11	0.137	Human
CCR7	chemokine (C-C motif) receptor 7	0.136
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.134
SLAMF1	signaling lymphocytic activation molecule family member 1	0.133
CSF1	colony stimulating factor 1 (macrophage)	0.126
IL12A	interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)	0.115
WIPF1	WAS/WASL interacting protein family, member 1	0.114
GHR	growth hormone receptor	0.110
CXCL13	chemokine (C-X-C motif) ligand 13	0.109
CCL18	chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)	0.105	Human
SELE	selectin E	0.101
IDE	insulin-degrading enzyme	0.094
STAT5A	signal transducer and activator of transcription 5A	0.090
FGFR1	fibroblast growth factor receptor 1	0.089	Human
CCR1	chemokine (C-C motif) receptor 1	0.088
CCL3	chemokine (C-C motif) ligand 3	0.084	Human
PGF	placental growth factor	0.084
CSF2RB	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	0.083
VCAM1	vascular cell adhesion molecule 1	0.083
CXCL11	chemokine (C-X-C motif) ligand 11	0.082
FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	0.081	Human
CXCL5	chemokine (C-X-C motif) ligand 5	0.081
APP	amyloid beta (A4) precursor protein	0.078
PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	0.076
CD40	CD40 molecule, TNF receptor superfamily member 5	0.075
UBASH3B	ubiquitin associated and SH3 domain containing B	0.072
CCL22	chemokine (C-C motif) ligand 22	0.070
SLA	Src-like-adaptor	0.070
KDR	kinase insert domain receptor (a type III receptor tyrosine kinase)	0.070	Human
PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	0.069
TNFRSF9	tumor necrosis factor receptor superfamily, member 9	0.067
CSF2RA	colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)	0.066
CCL19	chemokine (C-C motif) ligand 19	0.062	Human
KIT	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	0.062
LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	0.061
LIF	leukemia inhibitory factor (cholinergic differentiation factor)	0.059
RIPK1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.059
DPP4	dipeptidyl-peptidase 4	0.057
OSMR	oncostatin M receptor	0.057	Human
IL6R	interleukin 6 receptor	0.057
FGFR2	fibroblast growth factor receptor 2	0.055	Human
KRT8	keratin 8	0.052
CXCL6	chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)	0.046
SOS1	son of sevenless homolog 1 (Drosophila)	0.045
PDGFRB	platelet-derived growth factor receptor, beta polypeptide	0.044	Human
STAT1	signal transducer and activator of transcription 1, 91kDa	0.043
IL1R1	interleukin 1 receptor, type I	0.043
KITLG	KIT ligand	0.043
FGR	Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog	0.043
FGF10	fibroblast growth factor 10	0.042
IFNG	interferon, gamma	0.041
LIFR	leukemia inhibitory factor receptor alpha	0.040	Human
FGF7	fibroblast growth factor 7	0.040
FRS2	fibroblast growth factor receptor substrate 2	0.040
CSF3	colony stimulating factor 3 (granulocyte)	0.039
SNAP23	synaptosomal-associated protein, 23kDa	0.038
IL1A	interleukin 1, alpha	0.038
CCL20	chemokine (C-C motif) ligand 20	0.038	Human
NTRK1	neurotrophic tyrosine kinase, receptor, type 1	0.037
CMIP	c-Maf-inducing protein	0.037
CD28	CD28 molecule	0.036
IL13	interleukin 13	0.035
OSM	oncostatin M	0.035
SHC2	SHC (Src homology 2 domain containing) transforming protein 2	0.035
BCL2A1	BCL2-related protein A1	0.035
CH25H	cholesterol 25-hydroxylase	0.034
CD14	CD14 molecule	0.033
MET	met proto-oncogene (hepatocyte growth factor receptor)	0.032
FGF2	fibroblast growth factor 2 (basic)	0.032
ARRB1	arrestin, beta 1	0.032
DARC	Duffy blood group, chemokine receptor	0.031
BCL2	B-cell CLL/lymphoma 2	0.031
PIK3R2	phosphoinositide-3-kinase, regulatory subunit 2 (beta)	0.031
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.031
MMP12	matrix metallopeptidase 12 (macrophage elastase)	0.030
HCK	hemopoietic cell kinase	0.030
JAK3	Janus kinase 3	0.030
MAP3K5	mitogen-activated protein kinase kinase kinase 5	0.030
TNFRSF1A	tumor necrosis factor receptor superfamily, member 1A	0.030
TNFAIP2	tumor necrosis factor, alpha-induced protein 2	0.030
PTPRB	protein tyrosine phosphatase, receptor type, B	0.030
ANKS1B	ankyrin repeat and sterile alpha motif domain containing 1B	0.029
CNTF	ciliary neurotrophic factor	0.029
UBD	ubiquitin D	0.028
IL9	interleukin 9	0.027
SIGLEC1	sialic acid binding Ig-like lectin 1, sialoadhesin	0.026
LDLR	low density lipoprotein receptor	0.026
PDGFB	platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)	0.025
HLA-DOA	major histocompatibility complex, class II, DO alpha	0.025
ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	0.025
IL7R	interleukin 7 receptor	0.025
TNFRSF13B	tumor necrosis factor receptor superfamily, member 13B	0.025
FCER1G	Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide	0.025
CXCR6	chemokine (C-X-C motif) receptor 6	0.025
CD83	CD83 molecule	0.024
PTPN6	protein tyrosine phosphatase, non-receptor type 6	0.023
EXT1	exostosin 1	0.023
PLAUR	plasminogen activator, urokinase receptor	0.023
CCR4	chemokine (C-C motif) receptor 4	0.022
IL2RB	interleukin 2 receptor, beta	0.022
DLG4	discs, large homolog 4 (Drosophila)	0.022
CD2	CD2 molecule	0.022
AKT2	v-akt murine thymoma viral oncogene homolog 2	0.021
ICA1	islet cell autoantigen 1, 69kDa	0.021
TNFSF14	tumor necrosis factor (ligand) superfamily, member 14	0.021
STC1	stanniocalcin 1	0.021
PECAM1	platelet/endothelial cell adhesion molecule	0.021
BBS10	Bardet-Biedl syndrome 10	0.021
BCL3	B-cell CLL/lymphoma 3	0.021
TIRAP	toll-interleukin 1 receptor (TIR) domain containing adaptor protein	0.021
IFNB1	interferon, beta 1, fibroblast	0.020	Human
APOE	apolipoprotein E	0.020
LTA	lymphotoxin alpha (TNF superfamily, member 1)	0.020
INHBA	inhibin, beta A	0.020
PLEK	pleckstrin	0.019
RGS1	regulator of G-protein signaling 1	0.019
GFPT2	glutamine-fructose-6-phosphate transaminase 2	0.019
PIK3CA	phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.019
VAV1	vav 1 guanine nucleotide exchange factor	0.019
IL1RN	interleukin 1 receptor antagonist	0.019
BCAR1	breast cancer anti-estrogen resistance 1	0.019
VEGFC	vascular endothelial growth factor C	0.019
IDO1	indoleamine 2,3-dioxygenase 1	0.019
ITGB1BP1	integrin beta 1 binding protein 1	0.019
FCGR2A	Fc fragment of IgG, low affinity IIa, receptor (CD32)	0.019
TIFA	TRAF-interacting protein with forkhead-associated domain	0.019
KYNU	kynureninase	0.018
IRF4	interferon regulatory factor 4	0.018
AXL	AXL receptor tyrosine kinase	0.018
NNMT	nicotinamide N-methyltransferase	0.018
C3	complement component 3	0.017
CD7	CD7 molecule	0.017
TLR3	toll-like receptor 3	0.017
GGA2	golgi-associated, gamma adaptin ear containing, ARF binding protein 2	0.017
STAB1	stabilin 1	0.017
PTGIS	prostaglandin I2 (prostacyclin) synthase	0.017
FAF1	Fas (TNFRSF6) associated factor 1	0.017
IL2	interleukin 2	0.017
TRAF3IP2	TRAF3 interacting protein 2	0.017
GRB7	growth factor receptor-bound protein 7	0.016
EBI3	Epstein-Barr virus induced 3	0.016	Human
FYN	FYN oncogene related to SRC, FGR, YES	0.016
ARL2	ADP-ribosylation factor-like 2	0.016
IL1R2	interleukin 1 receptor, type II	0.016
IL21R	interleukin 21 receptor	0.016
CCL1	chemokine (C-C motif) ligand 1	0.016
IL11	interleukin 11	0.016
GGA1	golgi-associated, gamma adaptin ear containing, ARF binding protein 1	0.016
NR4A3	nuclear receptor subfamily 4, group A, member 3	0.016
VHL	von Hippel-Lindau tumor suppressor	0.016
PHLDA1	pleckstrin homology-like domain, family A, member 1	0.016
FOSL1	FOS-like antigen 1	0.016
C1R	complement component 1, r subcomponent	0.016
IL5	interleukin 5 (colony-stimulating factor, eosinophil)	0.016
C2	complement component 2	0.016
CXCR3	chemokine (C-X-C motif) receptor 3	0.015
MSC	musculin	0.015
EPHA2	EPH receptor A2	0.015
PTPRJ	protein tyrosine phosphatase, receptor type, J	0.015
IL2RA	interleukin 2 receptor, alpha	0.015
FGFR3	fibroblast growth factor receptor 3	0.015
ADAMDEC1	ADAM-like, decysin 1	0.014
CHI3L1	chitinase 3-like 1 (cartilage glycoprotein-39)	0.014
RGS16	regulator of G-protein signaling 16	0.014
IFNA16	interferon, alpha 16	0.014	Human
HSD11B1	hydroxysteroid (11-beta) dehydrogenase 1	0.014
DCN	decorin	0.014
CSNK1E	casein kinase 1, epsilon	0.014
PIK3CB	phosphoinositide-3-kinase, catalytic, beta polypeptide	0.014
FASLG	Fas ligand (TNF superfamily, member 6)	0.014
IL18R1	interleukin 18 receptor 1	0.014
PTEN	phosphatase and tensin homolog	0.014
XCL2	chemokine (C motif) ligand 2	0.013
IL12RB1	interleukin 12 receptor, beta 1	0.013
CCR3	chemokine (C-C motif) receptor 3	0.013
HAS2	hyaluronan synthase 2	0.013
PDGFA	platelet-derived growth factor alpha polypeptide	0.013
PIK3CD	phosphoinositide-3-kinase, catalytic, delta polypeptide	0.013
ZMYND11	zinc finger, MYND-type containing 11	0.013
ZBTB48	zinc finger and BTB domain containing 48	0.013
SLAMF7	SLAM family member 7	0.013
HLA-DRB4	major histocompatibility complex, class II, DR beta 4	0.013
GZMB	granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)	0.013
CTLA4	cytotoxic T-lymphocyte-associated protein 4	0.012
IL12RB2	interleukin 12 receptor, beta 2	0.012	Human
BID	BH3 interacting domain death agonist	0.012
IFNA4	interferon, alpha 4	0.012
CCL3L3	chemokine (C-C motif) ligand 3-like 3	0.012
TRO	trophinin	0.012
NKG7	natural killer cell group 7 sequence	0.012
FPR3	formyl peptide receptor 3	0.012
C3AR1	complement component 3a receptor 1	0.012
ABL2	v-abl Abelson murine leukemia viral oncogene homolog 2	0.012
KHDRBS1	KH domain containing, RNA binding, signal transduction associated 1	0.012
C1QA	complement component 1, q subcomponent, A chain	0.012
RUNX3	runt-related transcription factor 3	0.012
TGFB3	transforming growth factor, beta 3	0.012
FAS	Fas (TNF receptor superfamily, member 6)	0.012	Human
PTX3	pentraxin 3, long	0.011
TGFB1	transforming growth factor, beta 1	0.011
CCL17	chemokine (C-C motif) ligand 17	0.011
ITGB2	integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)	0.011
DAXX	death-domain associated protein	0.011
CELA3B	chymotrypsin-like elastase family, member 3B	0.011
ROBO4	roundabout homolog 4, magic roundabout (Drosophila)	0.011
C1QB	complement component 1, q subcomponent, B chain	0.011
TRAF6	TNF receptor-associated factor 6	0.011
EDN1	endothelin 1	0.011
SERPINE1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	0.011
DDR2	discoidin domain receptor tyrosine kinase 2	0.011
CD22	CD22 molecule	0.011
TFPI	tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)	0.011
MPEG1	macrophage expressed 1	0.011
FANCD2	Fanconi anemia, complementation group D2	0.011
CCL23	chemokine (C-C motif) ligand 23	0.011	Human
TNC	tenascin C	0.011
HSPA6	heat shock 70kDa protein 6 (HSP70B')	0.011
CXCL12	chemokine (C-X-C motif) ligand 12	0.011
XCL1	chemokine (C motif) ligand 1	0.010	Human
IL32	interleukin 32	0.010
RAPGEF1	Rap guanine nucleotide exchange factor (GEF) 1	0.010
TLR2	toll-like receptor 2	0.010
MMP1	matrix metallopeptidase 1 (interstitial collagenase)	0.010
RELB	v-rel reticuloendotheliosis viral oncogene homolog B	0.010
SPSB1	splA/ryanodine receptor domain and SOCS box containing 1	0.010
GCG	glucagon	0.010
CD40LG	CD40 ligand	0.010
MMP10	matrix metallopeptidase 10 (stromelysin 2)	0.010
NUDT3	nudix (nucleoside diphosphate linked moiety X)-type motif 3	0.010