IMP

Process View

Homo sapiens

32 genes annotated in human

integrin mediated signaling pathway

A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "integrin mediated signaling pathway"

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Name	Description	Probability	Func Analog Organism
ITGB1	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	1.000
FN1	fibronectin 1	1.000
FLNA	filamin A, alpha	0.998
FYN	FYN oncogene related to SRC, FGR, YES	0.996	Human
FHL2	four and a half LIM domains 2	0.985
ITGB3	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	0.980
ITGA5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	0.978	Human Rat
NME2	non-metastatic cells 2, protein (NM23B) expressed in	0.976
LCK	lymphocyte-specific protein tyrosine kinase	0.964	Human
HCK	hemopoietic cell kinase	0.875	Human
TLN1	talin 1	0.870	Human
SRC	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	0.857
CD63	CD63 molecule	0.817
VCL	vinculin	0.809
PXN	paxillin	0.801	Mouse
COL1A1	collagen, type I, alpha 1	0.776	Human
ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.742
COL4A1	collagen, type IV, alpha 1	0.715
LGALS1	lectin, galactoside-binding, soluble, 1	0.709
ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.700
COL1A2	collagen, type I, alpha 2	0.676	Human
SPARC	secreted protein, acidic, cysteine-rich (osteonectin)	0.657
ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	0.653
PTK2	PTK2 protein tyrosine kinase 2	0.649
THBS1	thrombospondin 1	0.614
CDC42	cell division cycle 42 (GTP binding protein, 25kDa)	0.571
LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	0.539
FLNB	filamin B, beta	0.533
ILK	integrin-linked kinase	0.528
PDIA3	protein disulfide isomerase family A, member 3	0.519
COL3A1	collagen, type III, alpha 1	0.491
MMP14	matrix metallopeptidase 14 (membrane-inserted)	0.476
SYK	spleen tyrosine kinase	0.417	Mouse
WAS	Wiskott-Aldrich syndrome (eczema-thrombocytopenia)	0.409
GRB2	growth factor receptor-bound protein 2	0.407
BCAR1	breast cancer anti-estrogen resistance 1	0.403
IGFBP3	insulin-like growth factor binding protein 3	0.372
BLNK	B-cell linker	0.361
COL5A2	collagen, type V, alpha 2	0.351	Human
SHC1	SHC (Src homology 2 domain containing) transforming protein 1	0.351
EGFR	epidermal growth factor receptor	0.323
SPRR2A	small proline-rich protein 2A	0.320
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.317
ITGAV	integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)	0.303	Human
ITGB4	integrin, beta 4	0.299	Human
DDR2	discoidin domain receptor tyrosine kinase 2	0.290
ABI2	abl-interactor 2	0.262
LYN	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	0.256
ACTN1	actinin, alpha 1	0.248
TIMP1	TIMP metallopeptidase inhibitor 1	0.237
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.233
ITGB2	integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)	0.227	Human Mouse
PDGFB	platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)	0.222
PLEC	plectin	0.205
DLG1	discs, large homolog 1 (Drosophila)	0.200
COL4A2	collagen, type IV, alpha 2	0.194
PIK3R2	phosphoinositide-3-kinase, regulatory subunit 2 (beta)	0.193
LAMC1	laminin, gamma 1 (formerly LAMB2)	0.181
VAV1	vav 1 guanine nucleotide exchange factor	0.179	Mouse
GAB1	GRB2-associated binding protein 1	0.176
PTPRC	protein tyrosine phosphatase, receptor type, C	0.173
LATS2	LATS, large tumor suppressor, homolog 2 (Drosophila)	0.172
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.163
SNX33	sorting nexin 33	0.156
ZNF746	zinc finger protein 746	0.154
VCAM1	vascular cell adhesion molecule 1	0.141
SNX9	sorting nexin 9	0.136
HP	haptoglobin	0.135
FYB	FYN binding protein	0.131
ITGA2B	integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)	0.125
ITGA2	integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)	0.123
HSPG2	heparan sulfate proteoglycan 2	0.122
CDH1	cadherin 1, type 1, E-cadherin (epithelial)	0.122
TGM2	transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)	0.112
FBN1	fibrillin 1	0.112
PARVA	parvin, alpha	0.103
COL6A1	collagen, type VI, alpha 1	0.101
NME1	non-metastatic cells 1, protein (NM23A) expressed in	0.101
PDGFRB	platelet-derived growth factor receptor, beta polypeptide	0.097
ANXA5	annexin A5	0.092
COL6A2	collagen, type VI, alpha 2	0.091
PLCG1	phospholipase C, gamma 1	0.091
ALB	albumin	0.090
FCGR2A	Fc fragment of IgG, low affinity IIa, receptor (CD32)	0.088
PDLIM5	PDZ and LIM domain 5	0.088
TCF4	transcription factor 4	0.085
TGFBI	transforming growth factor, beta-induced, 68kDa	0.082
ENG	endoglin	0.082
ITGA6	integrin, alpha 6	0.082	Human
ITGB5	integrin, beta 5	0.079
FCER1G	Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide	0.072	Mouse
LAMB1	laminin, beta 1	0.072
APOC1	apolipoprotein C-I	0.069
MED28	mediator complex subunit 28	0.068
UBASH3B	ubiquitin associated and SH3 domain containing B	0.064
PTN	pleiotrophin	0.064
PTPN6	protein tyrosine phosphatase, non-receptor type 6	0.063
TNS3	tensin 3	0.061
CALD1	caldesmon 1	0.060
FERMT2	fermitin family member 2	0.060
IBTK	inhibitor of Bruton agammaglobulinemia tyrosine kinase	0.057
TENC1	tensin like C1 domain containing phosphatase (tensin 2)	0.056
CSF1R	colony stimulating factor 1 receptor	0.055
CD9	CD9 molecule	0.055
MSN	moesin	0.052
GRAP2	GRB2-related adaptor protein 2	0.051
TGFB1I1	transforming growth factor beta 1 induced transcript 1	0.051
COL6A3	collagen, type VI, alpha 3	0.051
COL7A1	collagen, type VII, alpha 1	0.048
TNC	tenascin C	0.047
LST1	leukocyte specific transcript 1	0.047
AXL	AXL receptor tyrosine kinase	0.047
CYR61	cysteine-rich, angiogenic inducer, 61	0.047
TYROBP	TYRO protein tyrosine kinase binding protein	0.043	Mouse
LOX	lysyl oxidase	0.043
GSK3B	glycogen synthase kinase 3 beta	0.041
NCK2	NCK adaptor protein 2	0.041
FASLG	Fas ligand (TNF superfamily, member 6)	0.040
LPXN	leupaxin	0.039
APOC3	apolipoprotein C-III	0.038
VAV3	vav 3 guanine nucleotide exchange factor	0.037	Mouse
FGR	Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog	0.035
PALLD	palladin, cytoskeletal associated protein	0.034
ZYX	zyxin	0.034
SH3D19	SH3 domain containing 19	0.033
POSTN	periostin, osteoblast specific factor	0.033
FBLN2	fibulin 2	0.033
LRP1	low density lipoprotein receptor-related protein 1	0.033
LCAT	lecithin-cholesterol acyltransferase	0.033
SH3PXD2A	SH3 and PX domains 2A	0.032
ITK	IL2-inducible T-cell kinase	0.032	Human
PACSIN3	protein kinase C and casein kinase substrate in neurons 3	0.032
COL16A1	collagen, type XVI, alpha 1	0.031
COL5A1	collagen, type V, alpha 1	0.031	Human
MET	met proto-oncogene (hepatocyte growth factor receptor)	0.031
AIF1	allograft inflammatory factor 1	0.031
COL18A1	collagen, type XVIII, alpha 1	0.031
CTNND1	catenin (cadherin-associated protein), delta 1	0.030
AGTR2	angiotensin II receptor, type 2	0.030
PXDN	peroxidasin homolog (Drosophila)	0.030
BMP1	bone morphogenetic protein 1	0.029
S100A6	S100 calcium binding protein A6	0.029
ZAP70	zeta-chain (TCR) associated protein kinase 70kDa	0.029
SFN	stratifin	0.028
CD151	CD151 molecule (Raph blood group)	0.028
LTBP2	latent transforming growth factor beta binding protein 2	0.027
JUP	junction plakoglobin	0.027
ITCH	itchy E3 ubiquitin protein ligase homolog (mouse)	0.027
CTGF	connective tissue growth factor	0.026	Mouse
PTRF	polymerase I and transcript release factor	0.026
GAS7	growth arrest-specific 7	0.026
PLP2	proteolipid protein 2 (colonic epithelium-enriched)	0.025
MYO10	myosin X	0.025
TNS4	tensin 4	0.025
GRB7	growth factor receptor-bound protein 7	0.025
NME3	non-metastatic cells 3, protein expressed in	0.025	Human
ITGA3	integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)	0.025	Human
MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	0.024
AHNAK	AHNAK nucleoprotein	0.024
S100A4	S100 calcium binding protein A4	0.024
DOCK1	dedicator of cytokinesis 1	0.023
ITGA4	integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)	0.023	Human
GSN	gelsolin	0.023
SH2D3C	SH2 domain containing 3C	0.022
FCGR3B	Fc fragment of IgG, low affinity IIIb, receptor (CD16b)	0.022
NME4	non-metastatic cells 4, protein expressed in	0.022
IGFBP5	insulin-like growth factor binding protein 5	0.021
LTBP1	latent transforming growth factor beta binding protein 1	0.021
PTPN22	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	0.021
EPS8	epidermal growth factor receptor pathway substrate 8	0.021
IRS1	insulin receptor substrate 1	0.021
RHOU	ras homolog gene family, member U	0.020
HOXA9	homeobox A9	0.020
F13A1	coagulation factor XIII, A1 polypeptide	0.020
FSTL3	follistatin-like 3 (secreted glycoprotein)	0.019
SPI1	spleen focus forming virus (SFFV) proviral integration oncogene spi1	0.019
ZNF775	zinc finger protein 775	0.019
SIRPB1	signal-regulatory protein beta 1	0.019
TNK2	tyrosine kinase, non-receptor, 2	0.019	Human
MYH9	myosin, heavy chain 9, non-muscle	0.019
DAG1	dystroglycan 1 (dystrophin-associated glycoprotein 1)	0.018
APC	adenomatous polyposis coli	0.018
PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	0.018
SERPINE1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	0.018
MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	0.018
C3AR1	complement component 3a receptor 1	0.017
TPM1	tropomyosin 1 (alpha)	0.017
SGK3	serum/glucocorticoid regulated kinase family, member 3	0.017
LMNA	lamin A/C	0.017
CYTH1	cytohesin 1	0.017
CSF2RB	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	0.017
WDYHV1	WDYHV motif containing 1	0.017
JAK3	Janus kinase 3	0.017
DLC1	deleted in liver cancer 1	0.017
AMOTL2	angiomotin like 2	0.017
MATK	megakaryocyte-associated tyrosine kinase	0.017
NPC2	Niemann-Pick disease, type C2	0.017
JAG2	jagged 2	0.017
SELPLG	selectin P ligand	0.017
MDFI	MyoD family inhibitor	0.017
NID2	nidogen 2 (osteonidogen)	0.017
NRP1	neuropilin 1	0.016
MFAP2	microfibrillar-associated protein 2	0.016
LUM	lumican	0.016
CD79A	CD79a molecule, immunoglobulin-associated alpha	0.016
NID1	nidogen 1	0.016
FXYD5	FXYD domain containing ion transport regulator 5	0.016
NPHP1	nephronophthisis 1 (juvenile)	0.016
COL17A1	collagen, type XVII, alpha 1	0.016
SDC2	syndecan 2	0.016
SNRPD2	small nuclear ribonucleoprotein D2 polypeptide 16.5kDa	0.016
CRKL	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.016
COL11A1	collagen, type XI, alpha 1	0.015	Human
SLA	Src-like-adaptor	0.015
MAP4K4	mitogen-activated protein kinase kinase kinase kinase 4	0.015
HCLS1	hematopoietic cell-specific Lyn substrate 1	0.015
PIK3R3	phosphoinositide-3-kinase, regulatory subunit 3 (gamma)	0.015
CLEC4M	C-type lectin domain family 4, member M	0.015
RAB31	RAB31, member RAS oncogene family	0.015
SH2D1A	SH2 domain containing 1A	0.015
FGA	fibrinogen alpha chain	0.015
PLAT	plasminogen activator, tissue	0.015
ITGB7	integrin, beta 7	0.015
PECAM1	platelet/endothelial cell adhesion molecule	0.015
PSTPIP1	proline-serine-threonine phosphatase interacting protein 1	0.015
PDLIM7	PDZ and LIM domain 7 (enigma)	0.014
DNAJB11	DnaJ (Hsp40) homolog, subfamily B, member 11	0.014
LY6G6F	lymphocyte antigen 6 complex, locus G6F	0.014
ITGAL	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)	0.014	Human
SNAI1	snail homolog 1 (Drosophila)	0.014
FGL2	fibrinogen-like 2	0.014
WISP1	WNT1 inducible signaling pathway protein 1	0.014
BGN	biglycan	0.014
ITGB1BP1	integrin beta 1 binding protein 1	0.014
APOA2	apolipoprotein A-II	0.014
MCAM	melanoma cell adhesion molecule	0.014
TNFRSF10C	tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain	0.014
PIK3AP1	phosphoinositide-3-kinase adaptor protein 1	0.014
LYZ	lysozyme	0.014
RAC2	ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)	0.014
SRCIN1	SRC kinase signaling inhibitor 1	0.014
MYO6	myosin VI	0.014
LAMC2	laminin, gamma 2	0.014
CDH11	cadherin 11, type 2, OB-cadherin (osteoblast)	0.014
MAP2	microtubule-associated protein 2	0.013
WIPF1	WAS/WASL interacting protein family, member 1	0.013
MMP1	matrix metallopeptidase 1 (interstitial collagenase)	0.013
LASP1	LIM and SH3 protein 1	0.013
SRPX	sushi-repeat containing protein, X-linked	0.013
FBLIM1	filamin binding LIM protein 1	0.013	Human
CDH3	cadherin 3, type 1, P-cadherin (placental)	0.013
PARD3	par-3 partitioning defective 3 homolog (C. elegans)	0.012
HIPK3	homeodomain interacting protein kinase 3	0.012
MAPT	microtubule-associated protein tau	0.012
IGSF6	immunoglobulin superfamily, member 6	0.012
PRKCQ	protein kinase C, theta	0.012
FRS2	fibroblast growth factor receptor substrate 2	0.012
PMEPA1	prostate transmembrane protein, androgen induced 1	0.012
CFP	complement factor properdin	0.012
FNDC1	fibronectin type III domain containing 1	0.012
LCP1	lymphocyte cytosolic protein 1 (L-plastin)	0.012
PTPRJ	protein tyrosine phosphatase, receptor type, J	0.012
TRIO	triple functional domain (PTPRF interacting)	0.012
CYBB	cytochrome b-245, beta polypeptide	0.012
SLAMF1	signaling lymphocytic activation molecule family member 1	0.012
PRKCB	protein kinase C, beta	0.012
RIN1	Ras and Rab interactor 1	0.012
LAMB3	laminin, beta 3	0.012
ANGPTL4	angiopoietin-like 4	0.012
PTPRA	protein tyrosine phosphatase, receptor type, A	0.012
PLXND1	plexin D1	0.012
STC2	stanniocalcin 2	0.012
FAF1	Fas (TNFRSF6) associated factor 1	0.012
BTK	Bruton agammaglobulinemia tyrosine kinase	0.012	Human
DOK1	docking protein 1, 62kDa (downstream of tyrosine kinase 1)	0.012
PPP1R16A	protein phosphatase 1, regulatory (inhibitor) subunit 16A	0.011
HTRA1	HtrA serine peptidase 1	0.011
MIF	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	0.011
MPEG1	macrophage expressed 1	0.011
SERPINH1	serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)	0.011
LOXL2	lysyl oxidase-like 2	0.011
LATS1	LATS, large tumor suppressor, homolog 1 (Drosophila)	0.011
CD99	CD99 molecule	0.011
RRAS	related RAS viral (r-ras) oncogene homolog	0.011
PLTP	phospholipid transfer protein	0.011
CRIM1	cysteine rich transmembrane BMP regulator 1 (chordin-like)	0.011
COL10A1	collagen, type X, alpha 1	0.011
FBLN1	fibulin 1	0.011
NRP2	neuropilin 2	0.011
ANGPTL2	angiopoietin-like 2	0.011
CAPG	capping protein (actin filament), gelsolin-like	0.011
COL15A1	collagen, type XV, alpha 1	0.011
AGRN	agrin	0.011
COL12A1	collagen, type XII, alpha 1	0.011
TMSB10	thymosin beta 10	0.011
EPPK1	epiplakin 1	0.010
LDLR	low density lipoprotein receptor	0.010
PPIC	peptidylprolyl isomerase C (cyclophilin C)	0.010
PTK6	PTK6 protein tyrosine kinase 6	0.010	Human
CD28	CD28 molecule	0.010
PTK2B	PTK2B protein tyrosine kinase 2 beta	0.010
EMP3	epithelial membrane protein 3	0.010	Human
APOC2	apolipoprotein C-II	0.010
HOXA1	homeobox A1	0.010
MAD1L1	MAD1 mitotic arrest deficient-like 1 (yeast)	0.010
CSPG4	chondroitin sulfate proteoglycan 4	0.010
TGFB3	transforming growth factor, beta 3	0.010
TXNDC2	thioredoxin domain containing 2 (spermatozoa)	0.010