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Mus musculus

1 genes annotated in mouse

microglial cell activation involved in immune response

The change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.

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Gene Predictions

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Name	Description	Probability	Func Analog Organism
Ccr2	chemokine (C-C motif) receptor 2	0.999	Mouse
Ccl2	chemokine (C-C motif) ligand 2	0.958
Cd44	CD44 antigen	0.889
Ccl3	chemokine (C-C motif) ligand 3	0.712
Tnfrsf4	tumor necrosis factor receptor superfamily, member 4	0.658
Ccr6	chemokine (C-C motif) receptor 6	0.638	Mouse
Tlr4	toll-like receptor 4	0.636
Ifng	interferon gamma	0.583
Klrk1	killer cell lectin-like receptor subfamily K, member 1	0.540
Nos2	nitric oxide synthase 2, inducible	0.537
Ccr5	chemokine (C-C motif) receptor 5	0.510	Mouse
Tlr2	toll-like receptor 2	0.480
Fcrla	Fc receptor-like A	0.463
Cd6	CD6 antigen	0.461
Mmp9	matrix metallopeptidase 9	0.435
Blk	B lymphoid kinase	0.433
Gzmb	granzyme B	0.430
Cd7	CD7 antigen	0.419
Klrd1	killer cell lectin-like receptor, subfamily D, member 1	0.399
Cd96	CD96 antigen	0.380
Selp	selectin, platelet	0.368
Spib	Spi-B transcription factor (Spi-1/PU.1 related)	0.352
Prdm1	PR domain containing 1, with ZNF domain	0.320
Xcr1	chemokine (C motif) receptor 1	0.303	Mouse
Cd180	CD180 antigen	0.252
Fcer2a	Fc receptor, IgE, low affinity II, alpha polypeptide	0.230
Ccl4	chemokine (C-C motif) ligand 4	0.229
Klrg1	killer cell lectin-like receptor subfamily G, member 1	0.223
Batf	basic leucine zipper transcription factor, ATF-like	0.210
Cxcl13	chemokine (C-X-C motif) ligand 13	0.199
P2rx7	purinergic receptor P2X, ligand-gated ion channel, 7	0.196
Apoe	apolipoprotein E	0.192
Tnfsf14	tumor necrosis factor (ligand) superfamily, member 14	0.191
Itk	IL2-inducible T-cell kinase	0.188
Xcl1	chemokine (C motif) ligand 1	0.186
Icos	inducible T-cell co-stimulator	0.179
Ciita	class II transactivator	0.177
Il18rap	interleukin 18 receptor accessory protein	0.176
H2-Ob	histocompatibility 2, O region beta locus	0.174
Itgax	integrin alpha X	0.172
Map3k14	mitogen-activated protein kinase kinase kinase 14	0.170
Fasl	Fas ligand (TNF superfamily, member 6)	0.162
S1pr4	sphingosine-1-phosphate receptor 4	0.157
Lta	lymphotoxin A	0.153
Gzmk	granzyme K	0.137
Il12rb2	interleukin 12 receptor, beta 2	0.129
Il18r1	interleukin 18 receptor 1	0.121
Lyz2	lysozyme 2	0.120
Klrb1b	killer cell lectin-like receptor subfamily B member 1B	0.119
Sfpi1	SFFV proviral integration 1	0.119
Pik3cg	phosphoinositide-3-kinase, catalytic, gamma polypeptide	0.119
Itgal	integrin alpha L	0.114
Ccr1	chemokine (C-C motif) receptor 1	0.114	Mouse
Ncr1	natural cytotoxicity triggering receptor 1	0.113
Sh2d2a	SH2 domain protein 2A	0.112
Il1r1	interleukin 1 receptor, type I	0.109
Igj	immunoglobulin joining chain	0.108
Spn	sialophorin	0.107
Cd2	CD2 antigen	0.103
Spp1	secreted phosphoprotein 1	0.102
Cd1d2	CD1d2 antigen	0.099
Rac2	RAS-related C3 botulinum substrate 2	0.096
Il2rb	interleukin 2 receptor, beta chain	0.095
Ifngr1	interferon gamma receptor 1	0.093
Klra5	killer cell lectin-like receptor, subfamily A, member 5	0.093
Klra9	killer cell lectin-like receptor subfamily A, member 9	0.093
Ccr3	chemokine (C-C motif) receptor 3	0.089	Mouse
Art2a-ps	ADP-ribosyltransferase 2a, pseudogene	0.088
Fgd3	FYVE, RhoGEF and PH domain containing 3	0.083
Elf4	E74-like factor 4 (ets domain transcription factor)	0.082
Il1b	interleukin 1 beta	0.081
Ctsw	cathepsin W	0.081
Ms4a1	membrane-spanning 4-domains, subfamily A, member 1	0.080
Ear2	eosinophil-associated, ribonuclease A family, member 2	0.077
Csf3r	colony stimulating factor 3 receptor (granulocyte)	0.074
Krtap3-1	keratin associated protein 3-1	0.071
Cd22	CD22 antigen	0.071
Cd4	CD4 antigen	0.069
Ltb	lymphotoxin B	0.067
Tnfrsf17	tumor necrosis factor receptor superfamily, member 17	0.066
Ctla4	cytotoxic T-lymphocyte-associated protein 4	0.064
Pla2g2d	phospholipase A2, group IID	0.063
Cd3e	CD3 antigen, epsilon polypeptide	0.062
Oosp1	oocyte secreted protein 1	0.060
C3ar1	complement component 3a receptor 1	0.060
Cxcr3	chemokine (C-X-C motif) receptor 3	0.060	Mouse
Sell	selectin, lymphocyte	0.058
Csf1	colony stimulating factor 1 (macrophage)	0.058
Slamf6	SLAM family member 6	0.058
Il10	interleukin 10	0.058
Gimap7	GTPase, IMAP family member 7	0.057
Tnfrsf9	tumor necrosis factor receptor superfamily, member 9	0.053
Olfr140	olfactory receptor 140	0.053
Cd19	CD19 antigen	0.052
Cxcr5	chemokine (C-X-C motif) receptor 5	0.051	Mouse
Aire	autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy)	0.050
Flt3	FMS-like tyrosine kinase 3	0.049
Cybb	cytochrome b-245, beta polypeptide	0.049
Ccr9	chemokine (C-C motif) receptor 9	0.047	Mouse
Klrc1	killer cell lectin-like receptor subfamily C, member 1	0.047
Itgam	integrin alpha M	0.046
Cd5	CD5 antigen	0.045
Efnb2	ephrin B2	0.045
Pyhin1	pyrin and HIN domain family, member 1	0.045
Bex6	brain expressed gene 6	0.044
Mmp8	matrix metallopeptidase 8	0.043
Fcrl1	Fc receptor-like 1	0.042
Slamf1	signaling lymphocytic activation molecule family member 1	0.042
Icam1	intercellular adhesion molecule 1	0.042
H2-Eb2	histocompatibility 2, class II antigen E beta2	0.042
Acap1	ArfGAP with coiled-coil, ankyrin repeat and PH domains 1	0.041
Gzma	granzyme A	0.041
Gpr132	G protein-coupled receptor 132	0.040
Tlr7	toll-like receptor 7	0.040
Lepr	leptin receptor	0.040
Sit1	suppression inducing transmembrane adaptor 1	0.040
Rhag	Rhesus blood group-associated A glycoprotein	0.039
Cd8b1	CD8 antigen, beta chain 1	0.038
F2rl2	coagulation factor II (thrombin) receptor-like 2	0.038
Il1r2	interleukin 1 receptor, type II	0.038
Il2ra	interleukin 2 receptor, alpha chain	0.037
Cd8a	CD8 antigen, alpha chain	0.037
Clec2i	C-type lectin domain family 2, member i	0.037
Slfn4	schlafen 4	0.036
H2-Oa	histocompatibility 2, O region alpha locus	0.036
Tnfsf8	tumor necrosis factor (ligand) superfamily, member 8	0.034
Slc30a3	solute carrier family 30 (zinc transporter), member 3	0.034
Il15ra	interleukin 15 receptor, alpha chain	0.034
Nfatc2	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2	0.034
Txk	TXK tyrosine kinase	0.033
Prg3	proteoglycan 3	0.033
Tnf	tumor necrosis factor	0.033
Gcet2	germinal center expressed transcript 2	0.032
Rhoh	ras homolog gene family, member H	0.032
Il27ra	interleukin 27 receptor, alpha	0.032
Dnase1l3	deoxyribonuclease 1-like 3	0.032
Nckap1l	NCK associated protein 1 like	0.031
Gdf9	growth differentiation factor 9	0.031
Cma1	chymase 1, mast cell	0.031
Rfpl4	ret finger protein-like 4	0.029
Abcg3	ATP-binding cassette, sub-family G (WHITE), member 3	0.029
Cd86	CD86 antigen	0.029
Il7	interleukin 7	0.029
H2-Eb1	histocompatibility 2, class II antigen E beta	0.029
Wisp2	WNT1 inducible signaling pathway protein 2	0.029
Dock1	dedicator of cytokinesis 1	0.029
Itgae	integrin alpha E, epithelial-associated	0.029
Cnr2	cannabinoid receptor 2 (macrophage)	0.029
H2-DMb2	histocompatibility 2, class II, locus Mb2	0.028
Fgr	Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog	0.028
Ccr8	chemokine (C-C motif) receptor 8	0.028	Mouse
Cxcr2	chemokine (C-X-C motif) receptor 2	0.028	Mouse
Oxt	oxytocin	0.028
Serpinb7	serine (or cysteine) peptidase inhibitor, clade B, member 7	0.028
Pdcd1lg2	programmed cell death 1 ligand 2	0.028
Fcgr1	Fc receptor, IgG, high affinity I	0.028
Snx20	sorting nexin 20	0.028
Art2b	ADP-ribosyltransferase 2b	0.028
C5ar1	complement component 5a receptor 1	0.028
Nfe2	nuclear factor, erythroid derived 2	0.027
Efna1	ephrin A1	0.027
Il1rl1	interleukin 1 receptor-like 1	0.027
Pdcd1	programmed cell death 1	0.027
Tnfrsf1a	tumor necrosis factor receptor superfamily, member 1a	0.027
Havcr2	hepatitis A virus cellular receptor 2	0.026
Myo1f	myosin IF	0.026
Tspo2	translocator protein 2	0.026
Lcn4	lipocalin 4	0.026
Klra2	killer cell lectin-like receptor, subfamily A, member 2	0.025
Il1rn	interleukin 1 receptor antagonist	0.025
Vpreb3	pre-B lymphocyte gene 3	0.025
Kcna3	potassium voltage-gated channel, shaker-related subfamily, member 3	0.025
LOC100502924	hypothetical protein LOC100502924	0.025
Fgf7	fibroblast growth factor 7	0.025
Retnlb	resistin like beta	0.025
Amelx	amelogenin X chromosome	0.024
Prss2	protease, serine, 2	0.024
Uts2r	urotensin 2 receptor	0.024
Npy1r	neuropeptide Y receptor Y1	0.024
Asprv1	aspartic peptidase, retroviral-like 1	0.024
H2-Ab1	histocompatibility 2, class II antigen A, beta 1	0.024
Cysltr1	cysteinyl leukotriene receptor 1	0.023
Tff1	trefoil factor 1	0.023
Elane	elastase, neutrophil expressed	0.023
Folr2	folate receptor 2 (fetal)	0.023
S100a9	S100 calcium binding protein A9 (calgranulin B)	0.023
Ms4a6c	membrane-spanning 4-domains, subfamily A, member 6C	0.022
Ltb4r1	leukotriene B4 receptor 1	0.022
Tnfsf10	tumor necrosis factor (ligand) superfamily, member 10	0.022
Il4	interleukin 4	0.022
Ly9	lymphocyte antigen 9	0.022
Myd88	myeloid differentiation primary response gene 88	0.022
Elk4	ELK4, member of ETS oncogene family	0.022
Il7r	interleukin 7 receptor	0.022
Reg2	regenerating islet-derived 2	0.022
Ins1	insulin I	0.022
Mpo	myeloperoxidase	0.022
Ptger2	prostaglandin E receptor 2 (subtype EP2)	0.022
Gpr182	G protein-coupled receptor 182	0.022
Pparg	peroxisome proliferator activated receptor gamma	0.021
Tlr8	toll-like receptor 8	0.021
Cr2	complement receptor 2	0.021
Cd300ld	CD300 molecule-like family member d	0.021
Gimap3	GTPase, IMAP family member 3	0.021
Tssk1	testis-specific serine kinase 1	0.021
Il6	interleukin 6	0.021
Retn	resistin	0.020
Prg2	proteoglycan 2, bone marrow	0.020
Pabpc2	poly(A) binding protein, cytoplasmic 2	0.020
Mmp12	matrix metallopeptidase 12	0.020
Cd3d	CD3 antigen, delta polypeptide	0.020
Ngp	neutrophilic granule protein	0.020
Ccl22	chemokine (C-C motif) ligand 22	0.019
Kynu	kynureninase (L-kynurenine hydrolase)	0.019
Fpr3	formyl peptide receptor 3	0.019
Mmp3	matrix metallopeptidase 3	0.019
Gbp1	guanylate binding protein 1	0.019
Slamf9	SLAM family member 9	0.019
Il12a	interleukin 12a	0.019
Cd209a	CD209a antigen	0.019
Kmo	kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)	0.018
Star	steroidogenic acute regulatory protein	0.018
St6galnac3	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3	0.018
Olfr1509	olfactory receptor 1509	0.018
Zan	zonadhesin	0.018
Crtam	cytotoxic and regulatory T cell molecule	0.018
Mc2r	melanocortin 2 receptor	0.018
Sele	selectin, endothelial cell	0.018
Gzmc	granzyme C	0.018
Tnfsf11	tumor necrosis factor (ligand) superfamily, member 11	0.018
Tbx21	T-box 21	0.018
Il10ra	interleukin 10 receptor, alpha	0.018
Gabrr1	gamma-aminobutyric acid (GABA) C receptor, subunit rho 1	0.018
Fpr1	formyl peptide receptor 1	0.018
Chi3l3	chitinase 3-like 3	0.018
Slfn1	schlafen 1	0.018
Il15	interleukin 15	0.017
Cd207	CD207 antigen	0.017
Ubd	ubiquitin D	0.017
Ccl20	chemokine (C-C motif) ligand 20	0.017
Ms4a4c	membrane-spanning 4-domains, subfamily A, member 4C	0.017
Slfn3	schlafen 3	0.017
Slamf7	SLAM family member 7	0.017
Cnga1	cyclic nucleotide gated channel alpha 1	0.017
Adig	adipogenin	0.017
Id2	inhibitor of DNA binding 2	0.017
Ccl17	chemokine (C-C motif) ligand 17	0.017
Entpd1	ectonucleoside triphosphate diphosphohydrolase 1	0.017
Psp	parotid secretory protein	0.016
Gp9	glycoprotein 9 (platelet)	0.016
Ccr1l1	chemokine (C-C motif) receptor 1-like 1	0.016	Mouse
Htr2b	5-hydroxytryptamine (serotonin) receptor 2B	0.016
Abp1	amiloride binding protein 1 (amine oxidase, copper-containing)	0.016
AF251705	cDNA sequence AF251705	0.016
Il9r	interleukin 9 receptor	0.015
Edaradd	EDAR (ectodysplasin-A receptor)-associated death domain	0.015
Fli1	Friend leukemia integration 1	0.015
H2-M9	histocompatibility 2, M region locus 9	0.015
Itgb7	integrin beta 7	0.015
LOC677008	natural killer cell receptor 2B4-like	0.015
Cd160	CD160 antigen	0.015
Lair1	leukocyte-associated Ig-like receptor 1	0.015
Opn1sw	opsin 1 (cone pigments), short-wave-sensitive (color blindness, tritan)	0.015
Reg3g	regenerating islet-derived 3 gamma	0.015
Irf4	interferon regulatory factor 4	0.015
Cst7	cystatin F (leukocystatin)	0.015
Foxp3	forkhead box P3	0.015
Lat2	linker for activation of T cells family, member 2	0.014
Hprt	hypoxanthine guanine phosphoribosyl transferase	0.014
Slamf8	SLAM family member 8	0.014
Sla	src-like adaptor	0.014
Clec5a	C-type lectin domain family 5, member a	0.014
Cysltr2	cysteinyl leukotriene receptor 2	0.014
Ccl8	chemokine (C-C motif) ligand 8	0.014
Emr1	EGF-like module containing, mucin-like, hormone receptor-like sequence 1	0.014
Cd209e	CD209e antigen	0.014
Rapsn	receptor-associated protein of the synapse	0.014
Ly6d	lymphocyte antigen 6 complex, locus D	0.014
Isg20	interferon-stimulated protein	0.014
Il1a	interleukin 1 alpha	0.014
Ifitm6	interferon induced transmembrane protein 6	0.014
Ppef2	protein phosphatase, EF hand calcium-binding domain 2	0.014
Gna15	guanine nucleotide binding protein, alpha 15	0.014
Ccl5	chemokine (C-C motif) ligand 5	0.014
Cd33	CD33 antigen	0.013
Fas	Fas (TNF receptor superfamily member 6)	0.013
Klra17	killer cell lectin-like receptor, subfamily A, member 17	0.013
Soat2	sterol O-acyltransferase 2	0.013
Cd209b	CD209b antigen	0.013
Gpr34	G protein-coupled receptor 34	0.013
Vnn3	vanin 3	0.013
Cd14	CD14 antigen	0.013
Cd244	CD244 natural killer cell receptor 2B4	0.013
Clec4d	C-type lectin domain family 4, member d	0.013
Spo11	sporulation protein, meiosis-specific, SPO11 homolog (S. cerevisiae)	0.013
Gcnt1	glucosaminyl (N-acetyl) transferase 1, core 2	0.013
Cd28	CD28 antigen	0.013
Nkg7	natural killer cell group 7 sequence	0.013
Ldlr	low density lipoprotein receptor	0.013
Ntf3	neurotrophin 3	0.013
Ccr4	chemokine (C-C motif) receptor 4	0.013	Mouse
Ptgir	prostaglandin I receptor (IP)	0.013
Cd5l	CD5 antigen-like	0.013
Olfr90	olfactory receptor 90	0.013
Cxcl10	chemokine (C-X-C motif) ligand 10	0.013
Fpr2	formyl peptide receptor 2	0.012
Lep	leptin	0.012
Siglec1	sialic acid binding Ig-like lectin 1, sialoadhesin	0.012
Faim3	Fas apoptotic inhibitory molecule 3	0.012
Car1	carbonic anhydrase 1	0.012
Mef2c	myocyte enhancer factor 2C	0.012
Tbxas1	thromboxane A synthase 1, platelet	0.012
Klrb1c	killer cell lectin-like receptor subfamily B member 1C	0.012
Hpgds	hematopoietic prostaglandin D synthase	0.012
Rgs14	regulator of G-protein signaling 14	0.012
Plau	plasminogen activator, urokinase	0.012
Lbr	lamin B receptor	0.012
C3	complement component 3	0.012
Ighg	Immunoglobulin heavy chain (gamma polypeptide)	0.012
Emr4	EGF-like module containing, mucin-like, hormone receptor-like sequence 4	0.012
Igk	immunoglobulin kappa chain complex	0.012
Pou2af1	POU domain, class 2, associating factor 1	0.012
Anxa1	annexin A1	0.012
Trim10	tripartite motif-containing 10	0.012
Prl4a1	prolactin family 4, subfamily a, member 1	0.012
Tcstv3	2-cell-stage, variable group, member 3	0.011
Mgl2	macrophage galactose N-acetyl-galactosamine specific lectin 2	0.011
Fcer1a	Fc receptor, IgE, high affinity I, alpha polypeptide	0.011
Rltpr	RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing	0.011
Ucp3	uncoupling protein 3 (mitochondrial, proton carrier)	0.011
Tex19.1	testis expressed gene 19.1	0.011
Cpa3	carboxypeptidase A3, mast cell	0.011
Niacr1	niacin receptor 1	0.011
Gpr18	G protein-coupled receptor 18	0.011
Reg1	regenerating islet-derived 1	0.011
Fmo3	flavin containing monooxygenase 3	0.011
Ms4a7	membrane-spanning 4-domains, subfamily A, member 7	0.011
Ncf1	neutrophil cytosolic factor 1	0.011
Stab2	stabilin 2	0.011
Trem3	triggering receptor expressed on myeloid cells 3	0.011
St6galnac1	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1	0.011
Ggt5	gamma-glutamyltransferase 5	0.011
Rab8b	RAB8B, member RAS oncogene family	0.011
Fpr-rs3	formyl peptide receptor, related sequence 3	0.011
Fut7	fucosyltransferase 7	0.011
Cxcr6	chemokine (C-X-C motif) receptor 6	0.011	Mouse
Lce1i	late cornified envelope 1I	0.011
Cd46	CD46 antigen, complement regulatory protein	0.011
Gpr174	G protein-coupled receptor 174	0.011
Ccr7	chemokine (C-C motif) receptor 7	0.011	Mouse
Dock2	dedicator of cyto-kinesis 2	0.011
Opn1mw	opsin 1 (cone pigments), medium-wave-sensitive (color blindness, deutan)	0.011
Cox8c	cytochrome c oxidase, subunit VIIIc	0.011
2210010C04Rik	RIKEN cDNA 2210010C04 gene	0.011
Cxcl9	chemokine (C-X-C motif) ligand 9	0.011
Sag	retinal S-antigen	0.011
Sytl3	synaptotagmin-like 3	0.010
Tktl1	transketolase-like 1	0.010
Tnfrsf1b	tumor necrosis factor receptor superfamily, member 1b	0.010
Cdkn1a	cyclin-dependent kinase inhibitor 1A (P21)	0.010
Dmbt1	deleted in malignant brain tumors 1	0.010
Epsti1	epithelial stromal interaction 1 (breast)	0.010
Hey2	hairy/enhancer-of-split related with YRPW motif 2	0.010
Gadd45a	growth arrest and DNA-damage-inducible 45 alpha	0.010
Ms4a4b	membrane-spanning 4-domains, subfamily A, member 4B	0.010
Pkib	protein kinase inhibitor beta, cAMP dependent, testis specific	0.010
Hbb-y	hemoglobin Y, beta-like embryonic chain	0.010
Mcpt8	mast cell protease 8	0.010
Bdkrb1	bradykinin receptor, beta 1	0.010
Lilrb3	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3	0.010
S100a8	S100 calcium binding protein A8 (calgranulin A)	0.010
H2-T24	histocompatibility 2, T region locus 24	0.010
Ltk	leukocyte tyrosine kinase	0.010