IMP

Process View

Mus musculus

21 genes annotated in mouse

cellular response to tumor necrosis factor

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "cellular response to tumor necrosis factor"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "cellular response to tumor necrosis factor" (in gray)

Name	Description	Probability	Func Analog Organism
Tnf	tumor necrosis factor	0.998
Nfkb2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100	0.966
Tnfrsf1a	tumor necrosis factor receptor superfamily, member 1a	0.963
Apoe	apolipoprotein E	0.872
Relb	avian reticuloendotheliosis viral (v-rel) oncogene related B	0.800
Lyz2	lysozyme 2	0.770
Map3k14	mitogen-activated protein kinase kinase kinase 14	0.732
Lta	lymphotoxin A	0.724	Mouse
Ccl2	chemokine (C-C motif) ligand 2	0.673
Ikbkg	inhibitor of kappaB kinase gamma	0.649
Csf1	colony stimulating factor 1 (macrophage)	0.636
Traf6	TNF receptor-associated factor 6	0.583	Mouse
Ccr2	chemokine (C-C motif) receptor 2	0.550
Nfkb1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105	0.529
Ifng	interferon gamma	0.520
Mdm2	transformed mouse 3T3 cell double minute 2	0.514
Tlr4	toll-like receptor 4	0.478
Nos2	nitric oxide synthase 2, inducible	0.477	Rat
Tnfsf11	tumor necrosis factor (ligand) superfamily, member 11	0.423
Cd44	CD44 antigen	0.374
Igh	immunoglobulin heavy chain complex	0.352
Tgfb1	transforming growth factor, beta 1	0.330
Rela	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.325	Human
Tnfaip3	tumor necrosis factor, alpha-induced protein 3	0.312
Map3k7	mitogen-activated protein kinase kinase kinase 7	0.298
Krt17	keratin 17	0.293	Mouse
Socs1	suppressor of cytokine signaling 1	0.284
Icam1	intercellular adhesion molecule 1	0.282	Rat
Irf1	interferon regulatory factor 1	0.234
Stat3	signal transducer and activator of transcription 3	0.210
Krt33b	keratin 33B	0.193	Mouse
Ccl4	chemokine (C-C motif) ligand 4	0.186
Casp4	caspase 4, apoptosis-related cysteine peptidase	0.185
Ltb	lymphotoxin B	0.181
Traf2	TNF receptor-associated factor 2	0.180	Human Mouse
Krt19	keratin 19	0.180	Mouse
Lepr	leptin receptor	0.179
Il6	interleukin 6	0.175
Il10	interleukin 10	0.169
Tlr2	toll-like receptor 2	0.164
Selp	selectin, platelet	0.155
Krtap8-1	keratin associated protein 8-1	0.153
Pik3cd	phosphatidylinositol 3-kinase catalytic delta polypeptide	0.153
Ikbkb	inhibitor of kappaB kinase beta	0.144	Human
Pkp1	plakophilin 1	0.132
Cxcl13	chemokine (C-X-C motif) ligand 13	0.130
Vdr	vitamin D receptor	0.114
Tnfrsf9	tumor necrosis factor receptor superfamily, member 9	0.113
Sprr1a	small proline-rich protein 1A	0.113
Cd40	CD40 antigen	0.110	Mouse
Sharpin	SHANK-associated RH domain interacting protein	0.105
Krt6a	keratin 6A	0.105	Mouse
Krt5	keratin 5	0.100	Mouse
Fas	Fas (TNF receptor superfamily member 6)	0.099	Mouse Rat
Nos1	nitric oxide synthase 1, neuronal	0.097
Myd88	myeloid differentiation primary response gene 88	0.095
Krt86	keratin 86	0.094	Mouse
Ccr1	chemokine (C-C motif) receptor 1	0.084
Nlrp3	NLR family, pyrin domain containing 3	0.080
Rnf31	ring finger protein 31	0.076
Il7	interleukin 7	0.075
Runx1	runt related transcription factor 1	0.074
Casp1	caspase 1	0.072
Tnfrsf18	tumor necrosis factor receptor superfamily, member 18	0.071
Krt27	keratin 27	0.071	Mouse
Pdcd1	programmed cell death 1	0.069
Pparg	peroxisome proliferator activated receptor gamma	0.067
Cdkn1a	cyclin-dependent kinase inhibitor 1A (P21)	0.067
Krt35	keratin 35	0.064	Mouse
Mmp14	matrix metallopeptidase 14 (membrane-inserted)	0.064
Ncoa3	nuclear receptor coactivator 3	0.063
Bcl3	B-cell leukemia/lymphoma 3	0.063
Egfr	epidermal growth factor receptor	0.063
Krt14	keratin 14	0.058	Mouse
Slc6a3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	0.058
Grin1	glutamate receptor, ionotropic, NMDA1 (zeta 1)	0.056
Ifngr1	interferon gamma receptor 1	0.054
Traf1	TNF receptor-associated factor 1	0.053	Mouse
Il1r1	interleukin 1 receptor, type I	0.053
Tnfsf14	tumor necrosis factor (ligand) superfamily, member 14	0.052	Mouse
Tnfrsf1b	tumor necrosis factor receptor superfamily, member 1b	0.051
Foxn1	forkhead box N1	0.050
Krt7	keratin 7	0.050	Mouse
Krtap3-1	keratin associated protein 3-1	0.049
Mmp9	matrix metallopeptidase 9	0.049	Rat
Hr	hairless	0.048
Mef2d	myocyte enhancer factor 2D	0.047
Krt77	keratin 77	0.045	Mouse
Krt1	keratin 1	0.044	Mouse
Krt71	keratin 71	0.044	Mouse
Klk6	kallikrein related-peptidase 6	0.044
Trp63	transformation related protein 63	0.043
Nfkbia	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.043
Krt15	keratin 15	0.043	Mouse
Asprv1	aspartic peptidase, retroviral-like 1	0.042
Lgals7	lectin, galactose binding, soluble 7	0.041
Hif1a	hypoxia inducible factor 1, alpha subunit	0.041
Wnt10a	wingless related MMTV integration site 10a	0.039
Psapl1	prosaposin-like 1	0.038
Ccr5	chemokine (C-C motif) receptor 5	0.036
Cxcr5	chemokine (C-X-C motif) receptor 5	0.036
S100a3	S100 calcium binding protein A3	0.036
Krt85	keratin 85	0.035
Thbs1	thrombospondin 1	0.035
Eda	ectodysplasin-A	0.034
Runx2	runt related transcription factor 2	0.033
Il12rb2	interleukin 12 receptor, beta 2	0.032
Krt8	keratin 8	0.032
Ripk1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.032	Human
Cd19	CD19 antigen	0.032
Krt72-ps	keratin 72, pseudogene	0.032	Mouse
Foxp3	forkhead box P3	0.031
Birc3	baculoviral IAP repeat-containing 3	0.030
Gbp5	guanylate binding protein 5	0.030
Krt33a	keratin 33A	0.029	Mouse
5430421N21Rik	RIKEN cDNA 5430421N21 gene	0.029
Nsf	N-ethylmaleimide sensitive fusion protein	0.029
Drd2	dopamine receptor D2	0.029
Cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.029
Trp53	transformation related protein 53	0.028
Msx2	homeobox, msh-like 2	0.028
Agtr2	angiotensin II receptor, type 2	0.028
Ttn	titin	0.027
Stat6	signal transducer and activator of transcription 6	0.027
Spp1	secreted phosphoprotein 1	0.027
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.026
Nr3c1	nuclear receptor subfamily 3, group C, member 1	0.026
Alox12e	arachidonate lipoxygenase, epidermal	0.026
Serpinb5	serine (or cysteine) peptidase inhibitor, clade B, member 5	0.025
Fasl	Fas ligand (TNF superfamily, member 6)	0.025	Mouse
Slc25a48	solute carrier family 25, member 48	0.025
Il4	interleukin 4	0.025
Ctsk	cathepsin K	0.025
Fgf3	fibroblast growth factor 3	0.025
Cxcl2	chemokine (C-X-C motif) ligand 2	0.025
Rb1	retinoblastoma 1	0.025
Spna1	spectrin alpha 1	0.024
Hoxa10	homeobox A10	0.024
Krt31	keratin 31	0.024	Mouse
Dlx3	distal-less homeobox 3	0.024
C3	complement component 3	0.024
Notch2	Notch gene homolog 2 (Drosophila)	0.023
Alox8	arachidonate 8-lipoxygenase	0.023
Tox	thymocyte selection-associated high mobility group box	0.023
Brca2	breast cancer 2	0.023
Asap1	ArfGAP with SH# domain, ankyrin repeat and PH domain1	0.023
Lypd3	Ly6/Plaur domain containing 3	0.023
Il22	interleukin 22	0.022
Elovl3	elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 3	0.022
Calm4	calmodulin 4	0.022
Pthlh	parathyroid hormone-like peptide	0.022
Sypl2	synaptophysin-like 2	0.021
Mavs	mitochondrial antiviral signaling protein	0.021
Ivl	involucrin	0.021
Cryaa	crystallin, alpha A	0.021
Esr1	estrogen receptor 1 (alpha)	0.021
S100a14	S100 calcium binding protein A14	0.021
Rab25	RAB25, member RAS oncogene family	0.021
Ptgs2	prostaglandin-endoperoxide synthase 2	0.021
Krt2	keratin 2	0.021	Mouse
Ate1	arginyltransferase 1	0.020
Krt13	keratin 13	0.020
Grid2ip	glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein 1	0.020
Cdsn	corneodesmosin	0.020
Tg	thyroglobulin	0.020
Nfe2l3	nuclear factor, erythroid derived 2, like 3	0.020
Cxcl10	chemokine (C-X-C motif) ligand 10	0.019
Fcgr2b	Fc receptor, IgG, low affinity IIb	0.019
Krtap16-8	keratin associated protein 16-8	0.019
Esr2	estrogen receptor 2 (beta)	0.019
Ubd	ubiquitin D	0.019
Ldlr	low density lipoprotein receptor	0.019
Gm10229	predicted gene 10229	0.019
Ccl7	chemokine (C-C motif) ligand 7	0.019
Lif	leukemia inhibitory factor	0.019
Traf3ip2	TRAF3 interacting protein 2	0.019
Socs3	suppressor of cytokine signaling 3	0.019
Gpr143	G protein-coupled receptor 143	0.019
Syt8	synaptotagmin VIII	0.019
Barx1	BarH-like homeobox 1	0.019
Lyn	Yamaguchi sarcoma viral (v-yes-1) oncogene homolog	0.018
Itgb2	integrin beta 2	0.018
Id2	inhibitor of DNA binding 2	0.018
Krtap5-1	keratin associated protein 5-1	0.018
Fam83f	family with sequence similarity 83, member F	0.017
Eya2	eyes absent 2 homolog (Drosophila)	0.017
Col1a1	collagen, type I, alpha 1	0.017	Rat
Mb	myoglobin	0.017
Sfrp2	secreted frizzled-related protein 2	0.017
Sfn	stratifin	0.017
Ch25h	cholesterol 25-hydroxylase	0.016
Tax1bp1	Tax1 (human T-cell leukemia virus type I) binding protein 1	0.016
Il2ra	interleukin 2 receptor, alpha chain	0.016
Mefv	Mediterranean fever	0.016
Aldh1a3	aldehyde dehydrogenase family 1, subfamily A3	0.016
Sult2b1	sulfotransferase family, cytosolic, 2B, member 1	0.016
Il4ra	interleukin 4 receptor, alpha	0.016
Pten	phosphatase and tensin homolog	0.016
Mfn2	mitofusin 2	0.016
Cdkn1b	cyclin-dependent kinase inhibitor 1B	0.016
Mybph	myosin binding protein H	0.016
Lag3	lymphocyte-activation gene 3	0.016
Map3k8	mitogen-activated protein kinase kinase kinase 8	0.016
Il6st	interleukin 6 signal transducer	0.016
Ctsl	cathepsin L	0.016
Myo1c	myosin IC	0.015
Pou3f4	POU domain, class 3, transcription factor 4	0.015
Gp5	glycoprotein 5 (platelet)	0.015
Itgal	integrin alpha L	0.015
Krt82	keratin 82	0.015
Krtdap	keratinocyte differentiation associated protein	0.015
Pitx1	paired-like homeodomain transcription factor 1	0.015
Krt36	keratin 36	0.015	Mouse
Chuk	conserved helix-loop-helix ubiquitous kinase	0.015	Human
Vhl	von Hippel-Lindau tumor suppressor	0.015
Ikbke	inhibitor of kappaB kinase epsilon	0.015
Aim2	absent in melanoma 2	0.015
Fgf5	fibroblast growth factor 5	0.015
Inhba	inhibin beta-A	0.015
Ccl8	chemokine (C-C motif) ligand 8	0.015
Grin2b	glutamate receptor, ionotropic, NMDA2B (epsilon 2)	0.015
Gm10228	predicted gene 10228	0.015
Plg	plasminogen	0.015
Trim29	tripartite motif-containing 29	0.015
Nphp4	nephronophthisis 4 (juvenile) homolog (human)	0.015
Cav1	caveolin 1, caveolae protein	0.015
Tnip1	TNFAIP3 interacting protein 1	0.015
Zfp185	zinc finger protein 185	0.014
Gzmb	granzyme B	0.014
Cacng1	calcium channel, voltage-dependent, gamma subunit 1	0.014
Il1b	interleukin 1 beta	0.014
Olfr159	olfactory receptor 159	0.014
Col17a1	collagen, type XVII, alpha 1	0.014
Wfdc2	WAP four-disulfide core domain 2	0.014
Wfdc12	WAP four-disulfide core domain 12	0.014
Cyp19a1	cytochrome P450, family 19, subfamily a, polypeptide 1	0.014
Lrp10	low-density lipoprotein receptor-related protein 10	0.014
Chrna1	cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle)	0.014
Ccl22	chemokine (C-C motif) ligand 22	0.014
Sh2d2a	SH2 domain protein 2A	0.014
Ciita	class II transactivator	0.014
Abcb1a	ATP-binding cassette, sub-family B (MDR/TAP), member 1A	0.014
Krt18	keratin 18	0.013
Il12b	interleukin 12b	0.013
Klk7	kallikrein related-peptidase 7 (chymotryptic, stratum corneum)	0.013
Lamc2	laminin, gamma 2	0.013
Ccl3	chemokine (C-C motif) ligand 3	0.013	Human
Tcf3	transcription factor 3	0.013
Nod2	nucleotide-binding oligomerization domain containing 2	0.013
Rassf5	Ras association (RalGDS/AF-6) domain family member 5	0.013
Slurp1	secreted Ly6/Plaur domain containing 1	0.013
Myl2	myosin, light polypeptide 2, regulatory, cardiac, slow	0.013
Krt34	keratin 34	0.013
Ccndbp1	cyclin D-type binding-protein 1	0.013
Clock	circadian locomotor output cycles kaput	0.013
Cstb	cystatin B	0.013
Mt4	metallothionein 4	0.013
Cdcp1	CUB domain containing protein 1	0.013
Tnfrsf11a	tumor necrosis factor receptor superfamily, member 11a	0.013
Sprr1b	small proline-rich protein 1B	0.012
S1pr2	sphingosine-1-phosphate receptor 2	0.012
Stx11	syntaxin 11	0.012
Fxyd3	FXYD domain-containing ion transport regulator 3	0.012
Krtap13-1	keratin associated protein 13-1	0.012
Cldn4	claudin 4	0.012
Cd40lg	CD40 ligand	0.012	Mouse
Ccl12	chemokine (C-C motif) ligand 12	0.012
Casp8	caspase 8	0.012
Tnnt3	troponin T3, skeletal, fast	0.012
Aire	autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy)	0.012
Il2rg	interleukin 2 receptor, gamma chain	0.012
Krt20	keratin 20	0.012
Pkp3	plakophilin 3	0.012
Tnni2	troponin I, skeletal, fast 2	0.012
Krt6b	keratin 6B	0.012	Mouse
Mpl	myeloproliferative leukemia virus oncogene	0.012
Krt16	keratin 16	0.012	Mouse
Has1	hyaluronan synthase1	0.012
Jak2	Janus kinase 2	0.012	Human
Muc13	mucin 13, epithelial transmembrane	0.012
Lgr5	leucine rich repeat containing G protein coupled receptor 5	0.012
Defb1	defensin beta 1	0.012
Il2	interleukin 2	0.011
Xcl1	chemokine (C motif) ligand 1	0.011
Fgf10	fibroblast growth factor 10	0.011
Dsc3	desmocollin 3	0.011
Krtap1-5	keratin associated protein 1-5	0.011
Tnfrsf14	tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)	0.011	Mouse
Prkcd	protein kinase C, delta	0.011
Ptpn5	protein tyrosine phosphatase, non-receptor type 5	0.011
Edn2	endothelin 2	0.011
Casp14	caspase 14	0.011
Lad1	ladinin	0.011
Jak1	Janus kinase 1	0.011
Wnt5a	wingless-related MMTV integration site 5A	0.011
Ltbr	lymphotoxin B receptor	0.011	Mouse
Lce1a1	late cornified envelope 1A1	0.011
Msln	mesothelin	0.011
Dab1	disabled homolog 1 (Drosophila)	0.011
Osmr	oncostatin M receptor	0.011
Hdac5	histone deacetylase 5	0.011
Ephb4	Eph receptor B4	0.011
Krtap11-1	keratin associated protein 11-1	0.011
Cldn7	claudin 7	0.011
Guca2b	guanylate cyclase activator 2b (retina)	0.011
Lce1i	late cornified envelope 1I	0.011
Ly6g6c	lymphocyte antigen 6 complex, locus G6C	0.011
Pax8	paired box gene 8	0.011
Epx	eosinophil peroxidase	0.011
Ccl17	chemokine (C-C motif) ligand 17	0.011
Hrc	histidine rich calcium binding protein	0.011
1600029D21Rik	RIKEN cDNA 1600029D21 gene	0.011
Lce1b	late cornified envelope 1B	0.010
Col10a1	collagen, type X, alpha 1	0.010
Rag1	recombination activating gene 1	0.010
Sult5a1	sulfotransferase family 5A, member 1	0.010
Dsc1	desmocollin 1	0.010
Tacstd2	tumor-associated calcium signal transducer 2	0.010
Ikzf1	IKAROS family zinc finger 1	0.010
Mvp	major vault protein	0.010
Gpr84	G protein-coupled receptor 84	0.010
Oprd1	opioid receptor, delta 1	0.010
Il1rn	interleukin 1 receptor antagonist	0.010
Tgm2	transglutaminase 2, C polypeptide	0.010
Gpr87	G protein-coupled receptor 87	0.010
Oxt	oxytocin	0.010
Il10ra	interleukin 10 receptor, alpha	0.010
Tyr	tyrosinase	0.010