IMP

Process View

Mus musculus

1 genes annotated in mouse

mitotic sister chromatid cohesion

The cell cycle process in which the sister chromatids of a replicated chromosome are joined along the entire length of the chromosome, from their formation in S phase through metaphase during a mitotic cell cycle. This cohesion cycle is critical for high fidelity chromosome transmission.

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "mitotic sister chromatid cohesion"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "mitotic sister chromatid cohesion" (in gray)

Name	Description	Probability	Func Analog Organism
Smc1a	structural maintenance of chromosomes 1A	0.998	Yeast
Pten	phosphatase and tensin homolog	0.924
Mecp2	methyl CpG binding protein 2	0.889
Brca1	breast cancer 1	0.872
Atrx	alpha thalassemia/mental retardation syndrome X-linked homolog (human)	0.862
Pds5a	PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae)	0.749	Human Worm
Smc3	structural maintenace of chromosomes 3	0.713	Yeast Zebrafish
Rb1	retinoblastoma 1	0.698	Human
Mcm3	minichromosome maintenance deficient 3 (S. cerevisiae)	0.590
Brca2	breast cancer 2	0.545
Cenpf	centromere protein F	0.524
Ctnnb1	catenin (cadherin associated protein), beta 1	0.493
Zfp871	zinc finger protein 871	0.489
Pold1	polymerase (DNA directed), delta 1, catalytic subunit	0.487
Sgol1	shugoshin-like 1 (S. pombe)	0.486
Rad51ap1	RAD51 associated protein 1	0.479
Stag2	stromal antigen 2	0.440
Atm	ataxia telangiectasia mutated homolog (human)	0.402
Rbl2	retinoblastoma-like 2	0.377	Fly
E2f1	E2F transcription factor 1	0.325
Chek1	checkpoint kinase 1 homolog (S. pombe)	0.313
Cdkn1b	cyclin-dependent kinase inhibitor 1B	0.313
Mms22l	MMS22-like, DNA repair protein	0.308
Trp53	transformation related protein 53	0.287
Wdhd1	WD repeat and HMG-box DNA binding protein 1	0.278
Plk1	polo-like kinase 1 (Drosophila)	0.272
Timeless	timeless homolog (Drosophila)	0.266	Worm
Dlgap5	discs, large (Drosophila) homolog-associated protein 5	0.244
Cdkn1a	cyclin-dependent kinase inhibitor 1A (P21)	0.240
Dtl	denticleless homolog (Drosophila)	0.239
Tpx2	TPX2, microtubule-associated protein homolog (Xenopus laevis)	0.237
Msh2	mutS homolog 2 (E. coli)	0.216
Clspn	claspin homolog (Xenopus laevis)	0.204
Ccnf	cyclin F	0.203
Pik3ca	phosphatidylinositol 3-kinase, catalytic, alpha polypeptide	0.190
Aspm	asp (abnormal spindle)-like, microcephaly associated (Drosophila)	0.185
Stag1	stromal antigen 1	0.174
Ttk	Ttk protein kinase	0.170
Ndc80	NDC80 homolog, kinetochore complex component (S. cerevisiae)	0.170
Kif2c	kinesin family member 2C	0.169
Kif22	kinesin family member 22	0.163
Ncaph	non-SMC condensin I complex, subunit H	0.146
Aurkb	aurora kinase B	0.146
Mybl2	myeloblastosis oncogene-like 2	0.139
Lig1	ligase I, DNA, ATP-dependent	0.139
Mycbp2	MYC binding protein 2	0.138
Exo1	exonuclease 1	0.132
Kif11	kinesin family member 11	0.131
Atf2	activating transcription factor 2	0.129
Cenpn	centromere protein N	0.128
Cdc6	cell division cycle 6 homolog (S. cerevisiae)	0.127
Kif4	kinesin family member 4	0.123
Cdt1	chromatin licensing and DNA replication factor 1	0.110
Hmmr	hyaluronan mediated motility receptor (RHAMM)	0.109
Cdc25c	cell division cycle 25 homolog C (S. pombe)	0.108
Bub1	budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae)	0.104
Ercc6l	excision repair cross-complementing rodent repair deficiency complementation group 6 - like	0.102
Uhrf1	ubiquitin-like, containing PHD and RING finger domains, 1	0.100
Melk	maternal embryonic leucine zipper kinase	0.099
Pds5b	PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)	0.098	Human Worm
Cdca2	cell division cycle associated 2	0.095
Mll3	myeloid/lymphoid or mixed-lineage leukemia 3	0.095
Scaf11	SR-related CTD-associated factor 11	0.091
Ncoa6	nuclear receptor coactivator 6	0.090
Kif20a	kinesin family member 20A	0.090
Pole	polymerase (DNA directed), epsilon	0.088	Yeast
Cenpe	centromere protein E	0.086
Apc	adenomatosis polyposis coli	0.084
Ckap2	cytoskeleton associated protein 2	0.080
Mcm5	minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)	0.079
Eme1	essential meiotic endonuclease 1 homolog 1 (S. pombe)	0.079
Rad51	RAD51 homolog (S. cerevisiae)	0.079
Rsf1	remodeling and spacing factor 1	0.078
Mis18bp1	MIS18 binding protein 1	0.077
Ncapg	non-SMC condensin I complex, subunit G	0.075
Bub1b	budding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae)	0.075
Dlg1	discs, large homolog 1 (Drosophila)	0.074
Mcm2	minichromosome maintenance deficient 2 mitotin (S. cerevisiae)	0.070
Mll5	myeloid/lymphoid or mixed-lineage leukemia 5	0.068
Suz12	suppressor of zeste 12 homolog (Drosophila)	0.066
Asf1b	ASF1 anti-silencing function 1 homolog B (S. cerevisiae)	0.065
Racgap1	Rac GTPase-activating protein 1	0.065
Crebbp	CREB binding protein	0.065
Txndc16	thioredoxin domain containing 16	0.064
Blm	Bloom syndrome, RecQ helicase-like	0.064
Usp9x	ubiquitin specific peptidase 9, X chromosome	0.063
Incenp	inner centromere protein	0.063
Kras	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	0.063
Ccna2	cyclin A2	0.061
E2f8	E2F transcription factor 8	0.058
Cnot6l	CCR4-NOT transcription complex, subunit 6-like	0.057
Ube2c	ubiquitin-conjugating enzyme E2C	0.057
Bod1l	biorientation of chromosomes in cell division 1-like	0.055
Kif23	kinesin family member 23	0.055
Twsg1	twisted gastrulation homolog 1 (Drosophila)	0.054
Ncor1	nuclear receptor co-repressor 1	0.054
Kntc1	kinetochore associated 1	0.054
Mdm2	transformed mouse 3T3 cell double minute 2	0.051
Cdc20	cell division cycle 20 homolog (S. cerevisiae)	0.049
Stil	Scl/Tal1 interrupting locus	0.049
Zranb2	zinc finger, RAN-binding domain containing 2	0.047
Ptch1	patched homolog 1	0.046
Rmnd5a	required for meiotic nuclear division 5 homolog A (S. cerevisiae)	0.045
Cep55	centrosomal protein 55	0.045
Cbx5	chromobox homolog 5 (Drosophila HP1a)	0.044
Bmpr1a	bone morphogenetic protein receptor, type 1A	0.043
Rad54l	RAD54 like (S. cerevisiae)	0.041
Foxo3	forkhead box O3	0.041
Thoc2	THO complex 2	0.040
Fbxo5	F-box protein 5	0.039
Vezf1	vascular endothelial zinc finger 1	0.039
Chtf18	CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae)	0.039
Lrr1	leucine rich repeat protein 1	0.038
Kit	kit oncogene	0.036
Xpo1	exportin 1, CRM1 homolog (yeast)	0.036
Lmnb1	lamin B1	0.034
Smarca2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	0.034
Apaf1	apoptotic peptidase activating factor 1	0.034
Ash1l	ash1 (absent, small, or homeotic)-like (Drosophila)	0.033
Prc1	protein regulator of cytokinesis 1	0.033
Pcmtd2	protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2	0.032
Brd8	bromodomain containing 8	0.032
Gtse1	G two S phase expressed protein 1	0.032
Arid2	AT rich interactive domain 2 (ARID, RFX-like)	0.032
Ncapd2	non-SMC condensin I complex, subunit D2	0.031
Nr3c1	nuclear receptor subfamily 3, group C, member 1	0.031
Xpa	xeroderma pigmentosum, complementation group A	0.031
Ep300	E1A binding protein p300	0.031
Kitl	kit ligand	0.030
Smad4	MAD homolog 4 (Drosophila)	0.030
Ckap2l	cytoskeleton associated protein 2-like	0.030
Pole2	polymerase (DNA directed), epsilon 2 (p59 subunit)	0.029
Notch1	Notch gene homolog 1 (Drosophila)	0.028
Nek2	NIMA (never in mitosis gene a)-related expressed kinase 2	0.028
Tk1	thymidine kinase 1	0.028
Ccdc99	coiled-coil domain containing 99	0.027
Zfp280d	zinc finger protein 280D	0.027
Nfatc3	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3	0.027
Hif1a	hypoxia inducible factor 1, alpha subunit	0.027
Ctcf	CCCTC-binding factor	0.027
Aurka	aurora kinase A	0.027
Cenpm	centromere protein M	0.026
Rbl1	retinoblastoma-like 1 (p107)	0.026	Fly
Trip13	thyroid hormone receptor interactor 13	0.026
Zeb1	zinc finger E-box binding homeobox 1	0.026
Top2b	topoisomerase (DNA) II beta	0.025
Spag5	sperm associated antigen 5	0.025
Dna2	DNA replication helicase 2 homolog (yeast)	0.024
Mbtd1	mbt domain containing 1	0.023
Pdpk1	3-phosphoinositide dependent protein kinase 1	0.023
Spnb2	spectrin beta 2	0.023
Cdca7l	cell division cycle associated 7 like	0.022
Prkdc	protein kinase, DNA activated, catalytic polypeptide	0.022
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.022
Cenpi	centromere protein I	0.022
Diap3	diaphanous homolog 3 (Drosophila)	0.022
Bptf	bromodomain PHD finger transcription factor	0.021
Nfyb	nuclear transcription factor-Y beta	0.021
Mll1	myeloid/lymphoid or mixed-lineage leukemia 1	0.021
Prpf4b	PRP4 pre-mRNA processing factor 4 homolog B (yeast)	0.021
Cenpk	centromere protein K	0.021
D2Ertd750e	DNA segment, Chr 2, ERATO Doi 750, expressed	0.021
Cdca8	cell division cycle associated 8	0.020
Ccnb1	cyclin B1	0.020
Chd7	chromodomain helicase DNA binding protein 7	0.020
Ndufaf4	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 4	0.020
Mcm10	minichromosome maintenance deficient 10 (S. cerevisiae)	0.019
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.019
Kdm6a	4lysine (K)-specific demethylase 6A	0.019
Zcchc11	zinc finger, CCHC domain containing 11	0.019
Psen1	presenilin 1	0.019
Tcf19	transcription factor 19	0.019
Chek2	CHK2 checkpoint homolog (S. pombe)	0.018
Orc1	origin recognition complex, subunit 1	0.018
Macf1	microtubule-actin crosslinking factor 1	0.018
Pum1	pumilio 1 (Drosophila)	0.018
Mastl	microtubule associated serine/threonine kinase-like	0.018
2610101N10Rik	RIKEN cDNA 2610101N10 gene	0.017
Gins1	GINS complex subunit 1 (Psf1 homolog)	0.017
Cdkn2d	cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)	0.017
Zmym5	zinc finger, MYM-type 5	0.017
Espl1	extra spindle poles-like 1 (S. cerevisiae)	0.017
Ncapd3	non-SMC condensin II complex, subunit D3	0.016
Ncoa1	nuclear receptor coactivator 1	0.016
Sltm	SAFB-like, transcription modulator	0.016
Krit1	KRIT1, ankyrin repeat containing	0.016
Trip12	thyroid hormone receptor interactor 12	0.016
Akap9	A kinase (PRKA) anchor protein (yotiao) 9	0.016
Rif1	Rap1 interacting factor 1 homolog (yeast)	0.016
Senp6	SUMO/sentrin specific peptidase 6	0.015
Rfx7	regulatory factor X, 7	0.015
Rfc5	replication factor C (activator 1) 5	0.015
Pias1	protein inhibitor of activated STAT 1	0.015
Cenpa	centromere protein A	0.015
E2f7	E2F transcription factor 7	0.015
Ruvbl2	RuvB-like protein 2	0.015
Kif20b	kinesin family member 20B	0.015
Pkdcc	protein kinase domain containing, cytoplasmic	0.015
Tmpo	thymopoietin	0.015
Ylpm1	YLP motif containing 1	0.014
Ung	uracil DNA glycosylase	0.014
Mns1	meiosis-specific nuclear structural protein 1	0.014
Iqgap3	IQ motif containing GTPase activating protein 3	0.014
Eri2	exoribonuclease 2	0.014
Wrn	Werner syndrome homolog (human)	0.014
Mysm1	myb-like, SWIRM and MPN domains 1	0.014
Smc2	structural maintenance of chromosomes 2	0.014
Casp3	caspase 3	0.014
Atad2	ATPase family, AAA domain containing 2	0.014
Birc5	baculoviral IAP repeat-containing 5	0.014
Nipbl	Nipped-B homolog (Drosophila)	0.014	Human
Wapal	wings apart-like homolog (Drosophila)	0.014
AW549877	expressed sequence AW549877	0.014
Anp32e	acidic (leucine-rich) nuclear phosphoprotein 32 family, member E	0.014
Rad51c	RAD51 homolog c (S. cerevisiae)	0.014
Wnk1	WNK lysine deficient protein kinase 1	0.013
Pum2	pumilio 2 (Drosophila)	0.013
Usp33	ubiquitin specific peptidase 33	0.013
Hook3	hook homolog 3 (Drosophila)	0.013
Ola1	Obg-like ATPase 1	0.013
Hnrnpul2	heterogeneous nuclear ribonucleoprotein U-like 2	0.013
A930001N09Rik	RIKEN cDNA A930001N09 gene	0.013
Pold2	polymerase (DNA directed), delta 2, regulatory subunit	0.013
Sesn1	sestrin 1	0.013
Arid4a	AT rich interactive domain 4A (RBP1-like)	0.013
Smc6	structural maintenance of chromosomes 6	0.013
Sirt1	sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae)	0.013
Phip	pleckstrin homology domain interacting protein	0.013
Wdr26	WD repeat domain 26	0.013
Tacc3	transforming, acidic coiled-coil containing protein 3	0.012
Hells	helicase, lymphoid specific	0.012
2810417H13Rik	RIKEN cDNA 2810417H13 gene	0.012
Jarid2	jumonji, AT rich interactive domain 2	0.012
Rad21	RAD21 homolog (S. pombe)	0.012
G2e3	G2/M-phase specific E3 ubiquitin ligase	0.012
Cenpt	centromere protein T	0.012
Atad1	ATPase family, AAA domain containing 1	0.012
Spc24	SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae)	0.012
Cdc7	cell division cycle 7 (S. cerevisiae)	0.012
Zfp292	zinc finger protein 292	0.012
Cenph	centromere protein H	0.012
Dram2	VDNA-damage regulated autophagy modulator 2	0.012
Ddx6	DEAD (Asp-Glu-Ala-Asp) box polypeptide 6	0.012
Ulk2	Unc-51 like kinase 2 (C. elegans)	0.012
Trim33	tripartite motif-containing 33	0.012
Gen1	Gen homolog 1, endonuclease (Drosophila)	0.011
Taf6	TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor	0.011
2700049A03Rik	RIKEN cDNA 2700049A03 gene	0.011
Sp1	trans-acting transcription factor 1	0.011
Fanca	Fanconi anemia, complementation group A	0.011
Zmym2	zinc finger, MYM-type 2	0.011
Myo6	myosin VI	0.011
4921513D23Rik	RIKEN cDNA 4921513D23 gene	0.011
Suv420h1	suppressor of variegation 4-20 homolog 1 (Drosophila)	0.011
Ckap5	cytoskeleton associated protein 5	0.011
Cdc25a	cell division cycle 25 homolog A (S. pombe)	0.011
Nktr	natural killer tumor recognition sequence	0.011
Prkd3	protein kinase D3	0.011
Hp1bp3	heterochromatin protein 1, binding protein 3	0.011
Braf	Braf transforming gene	0.011
F630043A04Rik	RIKEN cDNA F630043A04 gene	0.011
Ccne1	cyclin E1	0.010
Lcorl	ligand dependent nuclear receptor corepressor-like	0.010
Mphosph9	M-phase phosphoprotein 9	0.010
Rfc1	replication factor C (activator 1) 1	0.010
Rapgef6	Rap guanine nucleotide exchange factor (GEF) 6	0.010
Foxm1	forkhead box M1	0.010
Igh	immunoglobulin heavy chain complex	0.010
Tnks2	tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2	0.010