The network for 'regulation of t cell activation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of t cell activation

Any process that modulates the frequency, rate or extent of T cell activation.

Mus musculus
Name Description Probability Func Analog Organism
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.995
Cd40 CD40 antigen 0.994
Tnf tumor necrosis factor 0.992
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.989
Cd28 CD28 antigen 0.987
Fas Fas (TNF receptor superfamily member 6) 0.984
Icos inducible T-cell co-stimulator 0.979
Stat3 signal transducer and activator of transcription 3 0.968
Lta lymphotoxin A 0.965
Jak2 Janus kinase 2 0.959
Ifng interferon gamma 0.951
Egfr epidermal growth factor receptor 0.950
Rarg retinoic acid receptor, gamma 0.938
Batf basic leucine zipper transcription factor, ATF-like 0.937
Casp4 caspase 4, apoptosis-related cysteine peptidase 0.933
Tnfaip3 tumor necrosis factor, alpha-induced protein 3 0.929
Stat5a signal transducer and activator of transcription 5A 0.920
Lyz2 lysozyme 2 0.911
Cbl Casitas B-lineage lymphoma 0.900
Foxp3 forkhead box P3 0.893
Tnfrsf4 tumor necrosis factor receptor superfamily, member 4 0.885
Ikzf1 IKAROS family zinc finger 1 0.881
Rnf2 ring finger protein 2 0.874
Il2rb interleukin 2 receptor, beta chain 0.871
H2-Aa histocompatibility 2, class II antigen A, alpha 0.864
Pik3cd phosphatidylinositol 3-kinase catalytic delta polypeptide 0.856
Stat1 signal transducer and activator of transcription 1 0.851
Stat5b signal transducer and activator of transcription 5B 0.848
Adam19 a disintegrin and metallopeptidase domain 19 (meltrin beta) 0.846
Il1b interleukin 1 beta 0.844
Map3k14 mitogen-activated protein kinase kinase kinase 14 0.844
Il6st interleukin 6 signal transducer 0.829
Cish cytokine inducible SH2-containing protein 0.828
H2-Ab1 histocompatibility 2, class II antigen A, beta 1 0.826
Lyn Yamaguchi sarcoma viral (v-yes-1) oncogene homolog 0.821
Il1r1 interleukin 1 receptor, type I 0.819
Traf6 TNF receptor-associated factor 6 0.818
Csf2rb2 colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage) 0.816
Grb2 growth factor receptor bound protein 2 0.815
Rxra retinoid X receptor alpha 0.812
Itk IL2-inducible T-cell kinase 0.791
Smad4 MAD homolog 4 (Drosophila) 0.786
Rybp RING1 and YY1 binding protein 0.784
Socs1 suppressor of cytokine signaling 1 0.783
Csf1 colony stimulating factor 1 (macrophage) 0.782
Jak1 Janus kinase 1 0.780
Sfpi1 SFFV proviral integration 1 0.770
Tnfrsf18 tumor necrosis factor receptor superfamily, member 18 0.762
Ltb lymphotoxin B 0.758
Btk Bruton agammaglobulinemia tyrosine kinase 0.758
Ubd ubiquitin D 0.753
Igh immunoglobulin heavy chain complex 0.752
Bcl3 B-cell leukemia/lymphoma 3 0.750
Relb avian reticuloendotheliosis viral (v-rel) oncogene related B 0.749
Cd80 CD80 antigen 0.747
Cd86 CD86 antigen 0.744
Tbx21 T-box 21 0.732
Tnfrsf9 tumor necrosis factor receptor superfamily, member 9 0.719
Lck lymphocyte protein tyrosine kinase 0.713
Ccr7 chemokine (C-C motif) receptor 7 0.709
Ciita class II transactivator 0.702
Itgax integrin alpha X 0.699
Il27ra interleukin 27 receptor, alpha 0.699
Ntf3 neurotrophin 3 0.693
Igf1r insulin-like growth factor I receptor 0.681
Nlrp3 NLR family, pyrin domain containing 3 0.679
Nf1 neurofibromatosis 1 0.674
Prf1 perforin 1 (pore forming protein) 0.672
Erbb2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.665
Inpp5d inositol polyphosphate-5-phosphatase D 0.657
Cd4 CD4 antigen 0.655
Ccr6 chemokine (C-C motif) receptor 6 0.655
Zap70 zeta-chain (TCR) associated protein kinase 0.654
Pdcd1 programmed cell death 1 0.638
Fyn Fyn proto-oncogene 0.633
Itgb2 integrin beta 2 0.625
Klrg1 killer cell lectin-like receptor subfamily G, member 1 0.624
Ctnnb1 catenin (cadherin associated protein), beta 1 0.614
Runx1 runt related transcription factor 1 0.610
Sox2 SRY-box containing gene 2 0.607
Klrd1 killer cell lectin-like receptor, subfamily D, member 1 0.607
Myd88 myeloid differentiation primary response gene 88 0.604
Cxcr5 chemokine (C-X-C motif) receptor 5 0.604
H2-DMb2 histocompatibility 2, class II, locus Mb2 0.603
Adam17 a disintegrin and metallopeptidase domain 17 0.602
Cxcl13 chemokine (C-X-C motif) ligand 13 0.593
Dok1 docking protein 1 0.592
Hhex hematopoietically expressed homeobox 0.592
Ccl2 chemokine (C-C motif) ligand 2 0.591
Ccr2 chemokine (C-C motif) receptor 2 0.587
Cd44 CD44 antigen 0.587
Ifnb1 interferon beta 1, fibroblast 0.586
Zeb1 zinc finger E-box binding homeobox 1 0.581
Ccr5 chemokine (C-C motif) receptor 5 0.578
Pou2af1 POU domain, class 2, associating factor 1 0.573
Ccr1 chemokine (C-C motif) receptor 1 0.567
Il7 interleukin 7 0.564
Birc3 baculoviral IAP repeat-containing 3 0.563
Hspa9 heat shock protein 9 0.547
Rac1 RAS-related C3 botulinum substrate 1 0.547
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
LCK lymphocyte-specific protein tyrosine kinase 0.996
WAS Wiskott-Aldrich syndrome (eczema-thrombocytopenia) 0.995
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1 0.952
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.922
HLA-B major histocompatibility complex, class I, B 0.917
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.914
HLA-C major histocompatibility complex, class I, C 0.904
B2M beta-2-microglobulin 0.885
CD3E CD3e molecule, epsilon (CD3-TCR complex) 0.883
SYK spleen tyrosine kinase 0.877
HLA-F major histocompatibility complex, class I, F 0.867
HLA-A major histocompatibility complex, class I, A 0.864
CD2 CD2 molecule 0.852
CD247 CD247 molecule 0.847
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.846
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa 0.830
HLA-G major histocompatibility complex, class I, G 0.800
CD6 CD6 molecule 0.797
IL12B interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) 0.795
CD86 CD86 molecule 0.779
CCR7 chemokine (C-C motif) receptor 7 0.776
HLA-DRA major histocompatibility complex, class II, DR alpha 0.776
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.723
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 0.715
EGFR epidermal growth factor receptor 0.707
BTN3A1 butyrophilin, subfamily 3, member A1 0.702
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 1 0.689
HLA-DMA major histocompatibility complex, class II, DM alpha 0.687
HLA-E major histocompatibility complex, class I, E 0.685
CCL22 chemokine (C-C motif) ligand 22 0.642
BTN3A3 butyrophilin, subfamily 3, member A3 0.636
HLA-DMB major histocompatibility complex, class II, DM beta 0.635
CCR5 chemokine (C-C motif) receptor 5 0.633
CD80 CD80 molecule 0.630
TRAF1 TNF receptor-associated factor 1 0.629
BTN3A2 butyrophilin, subfamily 3, member A2 0.622
CXCL10 chemokine (C-X-C motif) ligand 10 0.619
IL2RB interleukin 2 receptor, beta 0.599
BCL10 B-cell CLL/lymphoma 10 0.597
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.589
IL1R1 interleukin 1 receptor, type I 0.585
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain 0.558
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 0.557
LTA lymphotoxin alpha (TNF superfamily, member 1) 0.540
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.528
CASP1 caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) 0.507
LILRA1 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1 0.502
MALT1 mucosa associated lymphoid tissue lymphoma translocation gene 1 0.494
SIGLEC7 sialic acid binding Ig-like lectin 7 0.490
JAK2 Janus kinase 2 0.468
LAT linker for activation of T cells 0.447
ICAM1 intercellular adhesion molecule 1 0.406
HLA-DRB5 major histocompatibility complex, class II, DR beta 5 0.388
CXCL9 chemokine (C-X-C motif) ligand 9 0.388
CTLA4 cytotoxic T-lymphocyte-associated protein 4 0.386
SH2D1A SH2 domain containing 1A 0.371
IL16 interleukin 16 (lymphocyte chemoattractant factor) 0.370
HK3 hexokinase 3 (white cell) 0.360
FCN1 ficolin (collagen/fibrinogen domain containing) 1 0.356
NCOR2 nuclear receptor corepressor 2 0.353
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.352
BMPR1A bone morphogenetic protein receptor, type IA 0.347
PTPRC protein tyrosine phosphatase, receptor type, C 0.343
SLAMF1 signaling lymphocytic activation molecule family member 1 0.342
CSK c-src tyrosine kinase 0.338
CCL4 chemokine (C-C motif) ligand 4 0.334
CAV1 caveolin 1, caveolae protein, 22kDa 0.326
TFF1 trefoil factor 1 0.325
CCL5 chemokine (C-C motif) ligand 5 0.324
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 0.319
NLRC4 NLR family, CARD domain containing 4 0.300
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 0.299
BIRC3 baculoviral IAP repeat containing 3 0.293
PRKCQ protein kinase C, theta 0.289
CD52 CD52 molecule 0.285
LILRA2 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2 0.277
ITCH itchy E3 ubiquitin protein ligase homolog (mouse) 0.274
SOCS3 suppressor of cytokine signaling 3 0.273
CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.272
IL10RA interleukin 10 receptor, alpha 0.270
HCK hemopoietic cell kinase 0.270
IL2RG interleukin 2 receptor, gamma 0.261
CLEC10A C-type lectin domain family 10, member A 0.259
CASP9 caspase 9, apoptosis-related cysteine peptidase 0.250
NLRP3 NLR family, pyrin domain containing 3 0.250
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 0.249
MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1 0.245
BBS10 Bardet-Biedl syndrome 10 0.245
FGR Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog 0.242
LAIR1 leukocyte-associated immunoglobulin-like receptor 1 0.235
SASH3 SAM and SH3 domain containing 3 0.234
MEFV Mediterranean fever 0.230
TRAF3IP3 TRAF3 interacting protein 3 0.229
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 0.224
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 0.223
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.222
CCL2 chemokine (C-C motif) ligand 2 0.222
FSTL1 follistatin-like 1 0.219
GHR growth hormone receptor 0.215
IRF4 interferon regulatory factor 4 0.214
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Rattus norvegicus
Name Description Probability Func Analog Organism
RT1-Da RT1 class II, locus Da 0.910
Cd74 Cd74 molecule, major histocompatibility complex, class II invariant chain 0.873
RT1-Bb RT1 class II, locus Bb 0.846
RT1-Ba RT1 class II, locus Ba 0.743
RT1-DMb RT1 class II, locus DMb 0.709
Cd37 CD37 molecule 0.486
RT1-Db1 RT1 class II, locus Db1 0.431
Cd247 Cd247 molecule 0.226
Spn sialophorin 0.168
Cd5 Cd5 molecule 0.117
Il2rb interleukin 2 receptor, beta 0.106
Anxa2 annexin A2 0.088
Cd2 Cd2 molecule 0.069
Ptprc protein tyrosine phosphatase, receptor type, C 0.067
RT1-DMa RT1 class II, locus DMa 0.066
Il1b interleukin 1 beta 0.064
Cd53 Cd53 molecule 0.062
Laptm5 lysosomal protein transmembrane 5 0.061
Lyz2 lysozyme 2 0.056
Lyn v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.055
Tcrb T-cell receptor beta chain 0.054
Gzmk granzyme K 0.051
LOC100364854 similar to RIKEN cDNA A430107P09 gene-like 0.047
Ciita class II, major histocompatibility complex, transactivator 0.046
Casp1 caspase 1 0.045
Aif1 allograft inflammatory factor 1 0.042
Cd3g CD3 molecule, gamma 0.040
Ctss cathepsin S 0.037
Sell selectin L 0.034
Igh-6 immunoglobulin heavy chain 6 0.031
Nrarp Notch-regulated ankyrin repeat protein 0.030
Il17ra interleukin 17 receptor A 0.030
Cd44 Cd44 molecule 0.029
Fgfr2 fibroblast growth factor receptor 2 0.028
Nkg7 natural killer cell group 7 sequence 0.028
Slfn2 schlafen 2 0.027
Iapp islet amyloid polypeptide 0.027
C1qb complement component 1, q subcomponent, B chain 0.026
Itgb7 integrin, beta 7 0.026
Cxcr4 chemokine (C-X-C motif) receptor 4 0.024
Bmp7 bone morphogenetic protein 7 0.024
Il6 interleukin 6 0.024
Hck hemopoietic cell kinase 0.024
Efhd2 EF-hand domain family, member D2 0.022
Cd83 CD83 molecule 0.021
Arhgap4 Rho GTPase activating protein 4 0.021
Vom2r31 vomeronasal 2 receptor, 31 0.021
RT1-A3 RT1 class I, locus A3 0.020
Ptprq protein tyrosine phosphatase, receptor type, Q 0.020
Fcgr2a Fc fragment of IgG, low affinity IIa, receptor (CD32) 0.019
Icos inducible T-cell co-stimulator 0.019
MGC112715 hypothetical protein LOC690899 0.019
Arrb2 arrestin, beta 2 0.019
Laptm4a lysosomal protein transmembrane 4 alpha 0.019
Ece1 endothelin converting enzyme 1 0.019
Stat6 signal transducer and activator of transcription 6 0.018
Bin2 bridging integrator 2 0.018
Icam1 intercellular adhesion molecule 1 0.018
Clec10a C-type lectin domain family 10, member A 0.018
Mylk2 myosin light chain kinase 2 0.018
Dhrs7c dehydrogenase/reductase (SDR family) member 7C 0.017
Ctla4 cytotoxic T-lymphocyte-associated protein 4 0.017
Calcrl calcitonin receptor-like 0.017
Hcst hematopoietic cell signal transducer 0.017
Fgb fibrinogen beta chain 0.017
Socs3 suppressor of cytokine signaling 3 0.017
Cd38 CD38 molecule 0.017
Lat linker for activation of T cells 0.016
Map3k3 mitogen activated protein kinase kinase kinase 3 0.016
St8sia4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 0.016
Klra22 killer cell lectin-like receptor subfamily A, member 22 0.016
Ccr5 chemokine (C-C motif) receptor 5 0.016
Hbp1 HMG-box transcription factor 1 0.016
Sqstm1 sequestosome 1 0.016
Il7r interleukin 7 receptor 0.015
Tnfrsf14 tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) 0.015
Xcl1 chemokine (C motif) ligand 1 0.015
Ccl5 chemokine (C-C motif) ligand 5 0.015
Kmo kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) 0.015
Alox5ap arachidonate 5-lipoxygenase activating protein 0.015
Ptger4 prostaglandin E receptor 4 (subtype EP4) 0.015
Jak1 Janus kinase 1 0.015
Cd3d CD3 molecule, delta 0.014
Fmnl1 formin-like 1 0.014
Zap70 zeta-chain (TCR) associated protein kinase 0.014
Lepr leptin receptor 0.014
Gimap4 GTPase, IMAP family member 4 0.014
Nek9 NIMA (never in mitosis gene a)- related kinase 9 0.014
Cd200r1 CD200 receptor 1 0.014
Jak2 Janus kinase 2 0.013
Cd8a CD8a molecule 0.013
Ncr1 natural cytotoxicity triggering receptor 1 0.013
Gpr176 G protein-coupled receptor 176 0.013
Cd3e CD3 molecule, epsilon 0.013
Add2 adducin 2 (beta) 0.013
Prrx1 paired related homeobox 1 0.013
Cxcl3 chemokine (C-X-C motif) ligand 3 0.012
Fgfr1 Fibroblast growth factor receptor 1 0.012
Klrk1 killer cell lectin-like receptor subfamily K, member 1 0.012
Dnase1l3 deoxyribonuclease 1-like 3 0.012
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism