The network for 'regulation of insulin receptor signaling pathway' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of insulin receptor signaling pathway

Any process that modulates the frequency, rate or extent of insulin receptor signaling.

Mus musculus
Name Description Probability Func Analog Organism
Lepr leptin receptor 1.000
Insr insulin receptor 1.000
Jak2 Janus kinase 2 0.999
Irs2 insulin receptor substrate 2 0.998
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.997
Lep leptin 0.996
Fyn Fyn proto-oncogene 0.996
Stat3 signal transducer and activator of transcription 3 0.990
Ldb3 LIM domain binding 3 0.990
Pparg peroxisome proliferator activated receptor gamma 0.987
Grb2 growth factor receptor bound protein 2 0.972
Igf1r insulin-like growth factor I receptor 0.972
Ghr growth hormone receptor 0.970
Nos3 nitric oxide synthase 3, endothelial cell 0.964
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.962
Gnas GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus 0.955
Cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.955
Cebpa CCAAT/enhancer binding protein (C/EBP), alpha 0.954
Pik3r1 phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha) 0.954
Apc adenomatosis polyposis coli 0.951
Nos1 nitric oxide synthase 1, neuronal 0.923
Tsc1 tuberous sclerosis 1 0.914
Egfr epidermal growth factor receptor 0.893
Tgfb1 transforming growth factor, beta 1 0.893
Cish cytokine inducible SH2-containing protein 0.861
Irs1 insulin receptor substrate 1 0.850
Cbl Casitas B-lineage lymphoma 0.813
Tsc2 tuberous sclerosis 2 0.786
Csf1 colony stimulating factor 1 (macrophage) 0.765
Agtr1a angiotensin II receptor, type 1a 0.752
Stat5b signal transducer and activator of transcription 5B 0.736
Fas Fas (TNF receptor superfamily member 6) 0.735
Ctnnb1 catenin (cadherin associated protein), beta 1 0.732
Nf1 neurofibromatosis 1 0.728
Clock circadian locomotor output cycles kaput 0.728
Plcg1 phospholipase C, gamma 1 0.725
Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) 0.723
Npc1 Niemann Pick type C1 0.716
Tnf tumor necrosis factor 0.704
Ptk2 PTK2 protein tyrosine kinase 2 0.686
Nck2 non-catalytic region of tyrosine kinase adaptor protein 2 0.683
Il1r1 interleukin 1 receptor, type I 0.675
Lipe lipase, hormone sensitive 0.660
Dok2 docking protein 2 0.618
Cav1 caveolin 1, caveolae protein 0.614
Stat5a signal transducer and activator of transcription 5A 0.607
Grb10 growth factor receptor bound protein 10 0.607
Ren1 renin 1 structural 0.581
Ccl2 chemokine (C-C motif) ligand 2 0.581
Akt1 thymoma viral proto-oncogene 1 0.575
Ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 0.519
Pten phosphatase and tensin homolog 0.502
Socs2 suppressor of cytokine signaling 2 0.487
Apoe apolipoprotein E 0.484
Il6st interleukin 6 signal transducer 0.459
Serpina1c serine (or cysteine) peptidase inhibitor, clade A, member 1C 0.459
Kit kit oncogene 0.458
Efnb2 ephrin B2 0.448
Vhl von Hippel-Lindau tumor suppressor 0.446
Kiss1 KiSS-1 metastasis-suppressor 0.415
Tek endothelial-specific receptor tyrosine kinase 0.408
Il6 interleukin 6 0.385
Vav2 vav 2 oncogene 0.382
Socs3 suppressor of cytokine signaling 3 0.378
Pnpla2 patatin-like phospholipase domain containing 2 0.351
Jak1 Janus kinase 1 0.328
Actn2 actinin alpha 2 0.322
Dok1 docking protein 1 0.318
Esr1 estrogen receptor 1 (alpha) 0.311
Shc1 src homology 2 domain-containing transforming protein C1 0.305
Jak3 Janus kinase 3 0.304
Prkce protein kinase C, epsilon 0.297
Ptpn12 protein tyrosine phosphatase, non-receptor type 12 0.296
Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.293
Elavl1 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R) 0.292
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.282
Npy1r neuropeptide Y receptor Y1 0.281
Il1b interleukin 1 beta 0.280
Vdr vitamin D receptor 0.280
Ptpn22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 0.277
Nsf N-ethylmaleimide sensitive fusion protein 0.273
Ptk2b PTK2 protein tyrosine kinase 2 beta 0.271
Ar androgen receptor 0.268
Itga1 integrin alpha 1 0.267
Abl1 c-abl oncogene 1, non-receptor tyrosine kinase 0.253
Smad3 MAD homolog 3 (Drosophila) 0.247
Nf2 neurofibromatosis 2 0.247
Efnb1 ephrin B1 0.240
Blnk B-cell linker 0.227
Relb avian reticuloendotheliosis viral (v-rel) oncogene related B 0.218
Ptgs2 prostaglandin-endoperoxide synthase 2 0.218
Vav3 vav 3 oncogene 0.215
Pim1 proviral integration site 1 0.213
Nr1h4 nuclear receptor subfamily 1, group H, member 4 0.206
Crim1 cysteine rich transmembrane BMP regulator 1 (chordin like) 0.205
Il1a interleukin 1 alpha 0.202
Fmr1 fragile X mental retardation syndrome 1 homolog 0.195
Fxr1 fragile X mental retardation gene 1, autosomal homolog 0.193
Cxcl2 chemokine (C-X-C motif) ligand 2 0.191
Serpina1b serine (or cysteine) preptidase inhibitor, clade A, member 1B 0.189
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
ptr-11 Protein PTR-11 0.483
acs-20 Protein ACS-20 0.421
T19A5.3 Protein T19A5.3 0.116
ptr-6 Protein PTR-6 0.070
oac-46 Protein OAC-46 0.046
ifg-1 Protein IFG-1 0.042
CELE_ZK1025.2 Protein ZK1025.2 0.037
daf-6 Protein DAF-6 0.033
unc-104 Protein UNC-104 0.032
che-2 Protein CHE-2 0.031
pry-1 Protein PRY-1 0.025
skn-1 Protein SKN-1 0.023
K02A6.2 Protein K02A6.2 0.022
nhx-9 Protein NHX-9 0.022
nas-38 Protein NAS-38 0.020
qua-1 Protein QUA-1 0.020
Y38F1A.8 Protein Y38F1A.8 0.017
pde-2 Protein PDE-2 0.017
F28H7.8 Protein F28H7.8 0.016
ptr-23 Protein PTR-23 0.015
che-1 Protein CHE-1 0.015
F32D8.1 Protein F32D8.1 0.014
che-3 Protein CHE-3 0.013
ccch-1 Protein CCCH-1 0.013
rbg-2 Protein RBG-2 0.013
osm-6 Protein OSM-6 0.013
T05A8.3 Protein T05A8.3 0.013
ZK909.3 Protein ZK909.3 0.013
R13H4.5 Protein R13H4.5 0.012
wrt-6 Protein WRT-6 0.012
ptr-10 Protein PTR-10 0.012
CELE_ZK337.2 Protein ZK337.2 0.012
Y12A6A.2 Protein Y12A6A.2 0.012
pqn-44 Protein PQN-44 0.012
kcc-3 Protein KCC-3 0.011
T17H7.7 Protein T17H7.7 0.011
mam-2 Protein MAM-2 0.011
daf-7 Protein DAF-7 0.010
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
foxo forkhead box, sub-group O 0.547
Pi3K92E CG4141 gene product from transcript CG4141-RB 0.459
chico CG5686 gene product from transcript CG5686-RB 0.390
InR Insulin-like receptor 0.277
Ide Insulin degrading metalloproteinase 0.249
Akt1 CG4006 gene product from transcript CG4006-RA 0.234
dm diminutive 0.203
path pathetic 0.197
Pten CG5671 gene product from transcript CG5671-RB 0.189
Thor CG8846 gene product from transcript CG8846-RA 0.183
sNPF-R short neuropeptide F receptor 0.151
Ilp2 Insulin-like peptide 2 0.108
Pk61C Protein kinase 61C 0.097
babo baboon 0.096
Ilp6 Insulin-like peptide 6 0.094
Lnk CG17367 gene product from transcript CG17367-RC 0.089
CG14815 CG14815 gene product from transcript CG14815-RA 0.088
S6k RPS6-p70-protein kinase 0.088
rictor rapamycin-insensitive companion of Tor 0.063
Kap3 Kinesin associated protein 3 0.062
ttm50 tiny tim 50 0.055
ttv tout-velu 0.052
kis kismet 0.050
p38b CG7393 gene product from transcript CG7393-RA 0.048
CG3837 CG3837 gene product from transcript CG3837-RA 0.046
MTF-1 Metal response element-binding Transcription Factor-1 0.044
Nop60B Nucleolar protein at 60B 0.044
Coq2 Coenzyme Q biosynthesis protein 2 0.043
ninaC neither inactivation nor afterpotential C 0.039
Lk6 CG17342 gene product from transcript CG17342-RA 0.036
CG9316 CG9316 gene product from transcript CG9316-RA 0.036
enok enoki mushroom 0.035
CG4221 CG4221 gene product from transcript CG4221-RA 0.035
Rheb CG1081 gene product from transcript CG1081-RA 0.034
chrb charybde 0.033
Smox Smad on X 0.031
ClC-c Chloride channel-c 0.029
bun bunched 0.028
CG8451 CG8451 gene product from transcript CG8451-RA 0.026
CG8443 CG8443 gene product from transcript CG8443-RA 0.025
Cdk4 Cyclin-dependent kinase 4 0.025
Met Methoprene-tolerant 0.024
Fatp Fatty acid (long chain) transport protein 0.023
CG11255 CG11255 gene product from transcript CG11255-RA 0.023
hpo hippo 0.022
mtt mangetout 0.022
inaD inactivation no afterpotential D 0.022
Tsc1 CG6147 gene product from transcript CG6147-RA 0.021
npf neuropeptide F 0.021
ras raspberry 0.021
bwa brain washing 0.021
RanBPM Ran-binding protein M 0.021
dnr1 defense repressor 1 0.020
t tan 0.019
hppy happyhour 0.019
magu CG2264 gene product from transcript CG2264-RD 0.019
cher cheerio 0.019
Tsp42Ef Tetraspanin 42Ef 0.019
CG13890 CG13890 gene product from transcript CG13890-RA 0.018
pico CG11940 gene product from transcript CG11940-RA 0.018
pzg putzig 0.018
klg klingon 0.018
CG14937 CG14937 gene product from transcript CG14937-RA 0.017
Ptp10D Protein tyrosine phosphatase 10D 0.017
Gef64C Guanine nucleotide exchange factor GEF64C 0.017
Gclc Glutamate-cysteine ligase catalytic subunit 0.017
NLaz Neural Lazarillo 0.017
Pcmt Protein-L-isoaspartate (D-aspartate) O-methyltransferase 0.017
B4 CG9239 gene product from transcript CG9239-RA 0.016
sav salvador 0.016
raptor CG4320 gene product from transcript CG4320-RA 0.015
Irk3 Inwardly rectifying potassium channel 3 0.015
capt capulet 0.015
CG14317 CG14317 gene product from transcript CG14317-RA 0.014
Gbeta76C G protein beta-subunit 76C 0.014
ort ora transientless 0.014
Unc-76 CG3981 gene product from transcript CG3981-RB 0.014
ph-p polyhomeotic proximal 0.014
park parkin 0.014
Dad Daughters against dpp 0.014
Gadd45 CG11086 gene product from transcript CG11086-RA 0.014
nct nicastrin 0.013
CG6623 CG6623 gene product from transcript CG6623-RA 0.013
caz cabeza 0.013
Nf1 Neurofibromin 1 0.013
MP1 Melanization Protease 1 0.013
ntc nutcracker 0.013
CG10990 CG10990 gene product from transcript CG10990-RB 0.013
pasha partner of drosha 0.013
Ork1 Open rectifier K[+] channel 1 0.013
cln3 CG5582 gene product from transcript CG5582-RA 0.013
Sin3A CG8815 gene product from transcript CG8815-RC 0.013
Hsp68 Heat shock protein 68 0.013
ImpL2 Ecdysone-inducible gene L2 0.012
boss bride of sevenless 0.012
Uba1 Ubiquitin activating enzyme 1 0.012
slmb supernumerary limbs 0.012
Hsp22 Heat shock protein 22 0.012
asf1 anti-silencing factor 1 0.012
Atg8a Autophagy-specific gene 8a 0.012
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Homo sapiens
Name Description Probability Func Analog Organism
INSR insulin receptor 0.995
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.991
CREBBP CREB binding protein 0.941
NCOA1 nuclear receptor coactivator 1 0.910
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.880
EGFR epidermal growth factor receptor 0.811
FBXW11 F-box and WD repeat domain containing 11 0.683
CUL1 cullin 1 0.674
GRB10 growth factor receptor-bound protein 10 0.662
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.585
FYN FYN oncogene related to SRC, FGR, YES 0.579
TSC2 tuberous sclerosis 2 0.523
IRS2 insulin receptor substrate 2 0.442
MAP3K11 mitogen-activated protein kinase kinase kinase 11 0.405
SH2B1 SH2B adaptor protein 1 0.321
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.297
JAK2 Janus kinase 2 0.295
BTRC beta-transducin repeat containing 0.234
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.216
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.207
IRS1 insulin receptor substrate 1 0.191
NOXA1 NADPH oxidase activator 1 0.190
IL1R1 interleukin 1 receptor, type I 0.159
KAT2B K(lysine) acetyltransferase 2B 0.154
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.148
CREB1 cAMP responsive element binding protein 1 0.134
CRK v-crk sarcoma virus CT10 oncogene homolog (avian) 0.133
IGF1R insulin-like growth factor 1 receptor 0.115
BCAR1 breast cancer anti-estrogen resistance 1 0.108
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.104
ABL1 c-abl oncogene 1, non-receptor tyrosine kinase 0.102
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.085
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.084
SH3RF1 SH3 domain containing ring finger 1 0.084
SOS1 son of sevenless homolog 1 (Drosophila) 0.082
RASA1 RAS p21 protein activator (GTPase activating protein) 1 0.081
PLCG1 phospholipase C, gamma 1 0.081
SMAD3 SMAD family member 3 0.080
CAV1 caveolin 1, caveolae protein, 22kDa 0.079
AR androgen receptor 0.077
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.071
RXRA retinoid X receptor, alpha 0.069
GSK3B glycogen synthase kinase 3 beta 0.066
NCF1 neutrophil cytosolic factor 1 0.066
TSC1 tuberous sclerosis 1 0.063
STAT5B signal transducer and activator of transcription 5B 0.057
CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.056
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.055
GHR growth hormone receptor 0.055
NCOA3 nuclear receptor coactivator 3 0.052
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 0.051
NCK1 NCK adaptor protein 1 0.051
SKP1 S-phase kinase-associated protein 1 0.050
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 0.047
PRKCA protein kinase C, alpha 0.045
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2 0.043
EP300 E1A binding protein p300 0.043
RAB6A RAB6A, member RAS oncogene family 0.040
IL1RAP interleukin 1 receptor accessory protein 0.040
SORBS1 sorbin and SH3 domain containing 1 0.040
ABI1 abl-interactor 1 0.039
SIRT1 sirtuin 1 0.039
PRKCB protein kinase C, beta 0.037
MAPT microtubule-associated protein tau 0.035
MAPK3 mitogen-activated protein kinase 3 0.032
MAPK14 mitogen-activated protein kinase 14 0.032
CEP250 centrosomal protein 250kDa 0.032
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 0.031
MAPK8IP2 mitogen-activated protein kinase 8 interacting protein 2 0.031
DOCK1 dedicator of cytokinesis 1 0.029
NCOA2 nuclear receptor coactivator 2 0.028
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 0.027
ITGB1BP3 integrin beta 1 binding protein 3 0.026
FOXO1 forkhead box O1 0.026
CDC42 cell division cycle 42 (GTP binding protein, 25kDa) 0.026
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.025
EEF2K eukaryotic elongation factor-2 kinase 0.025
RHOU ras homolog gene family, member U 0.025
CBLB Cas-Br-M (murine) ecotropic retroviral transforming sequence b 0.024
CYFIP2 cytoplasmic FMR1 interacting protein 2 0.023
EPOR erythropoietin receptor 0.023
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.022
GRB2 growth factor receptor-bound protein 2 0.022
YES1 v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 0.021
PRKCZ protein kinase C, zeta 0.021
PRKACA protein kinase, cAMP-dependent, catalytic, alpha 0.021
ITSN1 intersectin 1 (SH3 domain protein) 0.020
ESR1 estrogen receptor 1 0.020
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.020
PARD6A par-6 partitioning defective 6 homolog alpha (C. elegans) 0.019
PDPK1 3-phosphoinositide dependent protein kinase-1 0.019
KIAA1217 KIAA1217 0.019
CDC34 cell division cycle 34 homolog (S. cerevisiae) 0.019
COASY CoA synthase 0.018
STAT5A signal transducer and activator of transcription 5A 0.018
MAPK1 mitogen-activated protein kinase 1 0.018
SOCS3 suppressor of cytokine signaling 3 0.017
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.017
SFN stratifin 0.017
YAP1 Yes-associated protein 1 0.016
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism