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Homo sapiens

29 genes annotated in human

cell death in response to oxidative stress

Any biological process that results in permanent cessation of all vital functions of a cell upon exposure to an oxidative stress stimulus.

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "cell death in response to oxidative stress"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "cell death in response to oxidative stress" (in gray)

Name	Description	Probability	Func Analog Organism
STRN3	striatin, calmodulin binding protein 3	0.901
SERPINE1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	0.900
MAFG	v-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian)	0.882
MOBKL3	MOB1, Mps One Binder kinase activator-like 3 (yeast)	0.853
TRIB3	tribbles homolog 3 (Drosophila)	0.798
GAS6	growth arrest-specific 6	0.756
AKT1	v-akt murine thymoma viral oncogene homolog 1	0.751
HIF1A	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	0.726
PRDX1	peroxiredoxin 1	0.707
BCL2L1	BCL2-like 1	0.574	Human
MCL1	myeloid cell leukemia sequence 1 (BCL2-related)	0.510
SLMAP	sarcolemma associated protein	0.509
BCL2L11	BCL2-like 11 (apoptosis facilitator)	0.506
STRN4	striatin, calmodulin binding protein 4	0.447
CASP9	caspase 9, apoptosis-related cysteine peptidase	0.447
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.390
XIAP	X-linked inhibitor of apoptosis	0.317
SOD1	superoxide dismutase 1, soluble	0.288
STRN	striatin, calmodulin binding protein	0.288
APAF1	apoptotic peptidase activating factor 1	0.247
ZNF746	zinc finger protein 746	0.245
WBP4	WW domain binding protein 4 (formin binding protein 21)	0.242
ASB2	ankyrin repeat and SOCS box containing 2	0.239
IFNGR1	interferon gamma receptor 1	0.222
FGFR1OP2	FGFR1 oncogene partner 2	0.217
UBE3A	ubiquitin protein ligase E3A	0.215
FBXO7	F-box protein 7	0.207
BAX	BCL2-associated X protein	0.200	Human
BID	BH3 interacting domain death agonist	0.197
MET	met proto-oncogene (hepatocyte growth factor receptor)	0.195
PPP2R1A	protein phosphatase 2, regulatory subunit A, alpha	0.194
LAT	linker for activation of T cells	0.190
MAP2K5	mitogen-activated protein kinase kinase 5	0.152
SKP1	S-phase kinase-associated protein 1	0.148
PINK1	PTEN induced putative kinase 1	0.147
NONO	non-POU domain containing, octamer-binding	0.144
CTTNBP2NL	CTTNBP2 N-terminal like	0.140
RPS6KB1	ribosomal protein S6 kinase, 70kDa, polypeptide 1	0.137
STK24	serine/threonine kinase 24	0.128
EPS15	epidermal growth factor receptor pathway substrate 15	0.126
CALR	calreticulin	0.124
FTL	ferritin, light polypeptide	0.122
GSK3B	glycogen synthase kinase 3 beta	0.119
BAD	BCL2-associated agonist of cell death	0.118
TGIF1	TGFB-induced factor homeobox 1	0.106
SQSTM1	sequestosome 1	0.100
FAM40A	family with sequence similarity 40, member A	0.095
EGLN1	egl nine homolog 1 (C. elegans)	0.093
VDAC1	voltage-dependent anion channel 1	0.092
PARK2	parkinson protein 2, E3 ubiquitin protein ligase (parkin)	0.091
PLAT	plasminogen activator, tissue	0.090	Human
DCTN1	dynactin 1	0.087
UBE2D1	ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)	0.082
SNCA	synuclein, alpha (non A4 component of amyloid precursor)	0.081
TOP1	topoisomerase (DNA) I	0.079
HSPB8	heat shock 22kDa protein 8	0.078
ARNT	aryl hydrocarbon receptor nuclear translocator	0.076
RNF144B	ring finger protein 144B	0.074
PDCD10	programmed cell death 10	0.069
FAM40B	family with sequence similarity 40, member B	0.068
DAXX	death-domain associated protein	0.064
CUL1	cullin 1	0.063
KAT2B	K(lysine) acetyltransferase 2B	0.063
IL8	interleukin 8	0.060
AHR	aryl hydrocarbon receptor	0.056
COX7A2	cytochrome c oxidase subunit VIIa polypeptide 2 (liver)	0.055
MAP1LC3B	microtubule-associated protein 1 light chain 3 beta	0.054
BCL2	B-cell CLL/lymphoma 2	0.054	Human Mouse
EGLN3	egl nine homolog 3 (C. elegans)	0.053
RANBP9	RAN binding protein 9	0.053
CSNK1A1	casein kinase 1, alpha 1	0.052
PLXNB1	plexin B1	0.052
CDK2AP2	cyclin-dependent kinase 2 associated protein 2	0.052
PPP2CB	protein phosphatase 2, catalytic subunit, beta isozyme	0.052
BAG3	BCL2-associated athanogene 3	0.051
FAS	Fas (TNF receptor superfamily, member 6)	0.050
PLAU	plasminogen activator, urokinase	0.050	Human
CCDC6	coiled-coil domain containing 6	0.050
HMGB1	high mobility group box 1	0.049
PPP2CA	protein phosphatase 2, catalytic subunit, alpha isozyme	0.049
CRYAB	crystallin, alpha B	0.047
TUBA1A	tubulin, alpha 1a	0.047
CTTN	cortactin	0.047
RNR2	l-rRNA	0.047
ADRBK1	adrenergic, beta, receptor kinase 1	0.046
VHL	von Hippel-Lindau tumor suppressor	0.045
SIKE1	suppressor of IKBKE 1	0.044
SLC1A2	solute carrier family 1 (glial high affinity glutamate transporter), member 2	0.044
GCH1	GTP cyclohydrolase 1	0.043
SFPQ	splicing factor proline/glutamine-rich	0.043
HGF	hepatocyte growth factor (hepapoietin A; scatter factor)	0.041
SRC	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	0.040
LRP6	low density lipoprotein receptor-related protein 6	0.040
CTSL1	cathepsin L1	0.040
DYNLL1	dynein, light chain, LC8-type 1	0.039
CTSD	cathepsin D	0.038
GAB1	GRB2-associated binding protein 1	0.037
BAK1	BCL2-antagonist/killer 1	0.037	Human
PPP2R2A	protein phosphatase 2, regulatory subunit B, alpha	0.036
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.036
RIPK2	receptor-interacting serine-threonine kinase 2	0.036
PARK7	Parkinson disease (autosomal recessive, early onset) 7	0.035
SOCS1	suppressor of cytokine signaling 1	0.035
DAB2IP	DAB2 interacting protein	0.035
CDKN1B	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	0.034
BANP	BTG3 associated nuclear protein	0.034
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.034
HNRNPC	heterogeneous nuclear ribonucleoprotein C (C1/C2)	0.033
PRDX2	peroxiredoxin 2	0.033
DBN1	drebrin 1	0.032
NAMPT	nicotinamide phosphoribosyltransferase	0.032
PPP2R1B	protein phosphatase 2, regulatory subunit A, beta	0.031
EGFR	epidermal growth factor receptor	0.030
PGK1	phosphoglycerate kinase 1	0.030
STK4	serine/threonine kinase 4	0.030
ZBED1	zinc finger, BED-type containing 1	0.030
DAPK1	death-associated protein kinase 1	0.029
LAMP1	lysosomal-associated membrane protein 1	0.028
ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.028
SRP14	signal recognition particle 14kDa (homologous Alu RNA binding protein)	0.028
MAP2K6	mitogen-activated protein kinase kinase 6	0.028
RAB5B	RAB5B, member RAS oncogene family	0.027
CREBBP	CREB binding protein	0.027
DAD1	defender against cell death 1	0.027
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.027
PLAUR	plasminogen activator, urokinase receptor	0.027
ENO1	enolase 1, (alpha)	0.027
MAP1B	microtubule-associated protein 1B	0.027
HNRNPK	heterogeneous nuclear ribonucleoprotein K	0.026
ATF4	activating transcription factor 4 (tax-responsive enhancer element B67)	0.024
NDUFC1	NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa	0.024
SDCBP	syndecan binding protein (syntenin)	0.024
TXN	thioredoxin	0.024
USP7	ubiquitin specific peptidase 7 (herpes virus-associated)	0.024
TCEB1	transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)	0.023
HIPK2	homeodomain interacting protein kinase 2	0.023
EFTUD2	elongation factor Tu GTP binding domain containing 2	0.022
CCNE1	cyclin E1	0.022
MEF2C	myocyte enhancer factor 2C	0.022
GNS	glucosamine (N-acetyl)-6-sulfatase	0.021
SRGN	serglycin	0.021
DDX3X	DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked	0.021
MAP3K5	mitogen-activated protein kinase kinase kinase 5	0.021
LRRK2	leucine-rich repeat kinase 2	0.021
RUNX1	runt-related transcription factor 1	0.021
SNIP1	Smad nuclear interacting protein 1	0.021
NCOR2	nuclear receptor corepressor 2	0.021
MMP1	matrix metallopeptidase 1 (interstitial collagenase)	0.021
MTOR	mechanistic target of rapamycin (serine/threonine kinase)	0.021
MARK1	MAP/microtubule affinity-regulating kinase 1	0.021
PLD3	phospholipase D family, member 3	0.020
DYNLT1	dynein, light chain, Tctex-type 1	0.020
NCL	nucleolin	0.020
POLR2C	polymerase (RNA) II (DNA directed) polypeptide C, 33kDa	0.020
PPP1CC	protein phosphatase 1, catalytic subunit, gamma isozyme	0.019
CDC42	cell division cycle 42 (GTP binding protein, 25kDa)	0.019
GGH	gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)	0.019
PRPF6	PRP6 pre-mRNA processing factor 6 homolog (S. cerevisiae)	0.019
VCP	valosin containing protein	0.019
STK25	serine/threonine kinase 25	0.019	Human
YBX1	Y box binding protein 1	0.019
OS9	osteosarcoma amplified 9, endoplasmic reticulum lectin	0.019
GAPDH	glyceraldehyde-3-phosphate dehydrogenase	0.019
HSF1	heat shock transcription factor 1	0.018
IL6ST	interleukin 6 signal transducer (gp130, oncostatin M receptor)	0.018
APOH	apolipoprotein H (beta-2-glycoprotein I)	0.018
RNF11	ring finger protein 11	0.018
RGS2	regulator of G-protein signaling 2, 24kDa	0.018
SLC1A5	solute carrier family 1 (neutral amino acid transporter), member 5	0.017
ASB6	ankyrin repeat and SOCS box containing 6	0.017
CTTNBP2	cortactin binding protein 2	0.017
HNRNPU	heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)	0.017
DDIT3	DNA-damage-inducible transcript 3	0.017
SOCS3	suppressor of cytokine signaling 3	0.017
GHR	growth hormone receptor	0.017
SGK3	serum/glucocorticoid regulated kinase family, member 3	0.017
ASB7	ankyrin repeat and SOCS box containing 7	0.017
ZFYVE9	zinc finger, FYVE domain containing 9	0.017
B2M	beta-2-microglobulin	0.016
RAC1	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	0.016
PLOD1	procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1	0.016
PPIB	peptidylprolyl isomerase B (cyclophilin B)	0.016
ATF5	activating transcription factor 5	0.016	Human
ATM	ataxia telangiectasia mutated	0.016
PACRG	PARK2 co-regulated	0.016
UVRAG	UV radiation resistance associated gene	0.016
ACSL1	acyl-CoA synthetase long-chain family member 1	0.016
TGM2	transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)	0.016
HM13	histocompatibility (minor) 13	0.015
ZBTB16	zinc finger and BTB domain containing 16	0.015
MAFK	v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian)	0.015
PPP2R5A	protein phosphatase 2, regulatory subunit B', alpha	0.015
ARRB1	arrestin, beta 1	0.015
MAPK6	mitogen-activated protein kinase 6	0.015
EZR	ezrin	0.015
HUWE1	HECT, UBA and WWE domain containing 1	0.015
ARNTL	aryl hydrocarbon receptor nuclear translocator-like	0.015
OSMR	oncostatin M receptor	0.015
LAMP2	lysosomal-associated membrane protein 2	0.014
INSR	insulin receptor	0.014
CRKL	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.014
RICTOR	RPTOR independent companion of MTOR, complex 2	0.014
EID1	EP300 interacting inhibitor of differentiation 1	0.014
LBX1	ladybird homeobox 1	0.014
OTUD4	OTU domain containing 4	0.014
PHF17	PHD finger protein 17	0.014
HSPA1A	heat shock 70kDa protein 1A	0.014
MAPKAPK2	mitogen-activated protein kinase-activated protein kinase 2	0.014
G3BP2	GTPase activating protein (SH3 domain) binding protein 2	0.014
TERT	telomerase reverse transcriptase	0.014
MAPT	microtubule-associated protein tau	0.014	Rat
BTRC	beta-transducin repeat containing	0.014
EIF2S3	eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa	0.013
HSP90AB1	heat shock protein 90kDa alpha (cytosolic), class B member 1	0.013
UQCRH	ubiquinol-cytochrome c reductase hinge protein	0.013
SIAH1	seven in absentia homolog 1 (Drosophila)	0.013
CDC34	cell division cycle 34 homolog (S. cerevisiae)	0.013
CRYBB2	crystallin, beta B2	0.013
FGFR1	fibroblast growth factor receptor 1	0.013
CTSB	cathepsin B	0.013
ORM1	orosomucoid 1	0.013
IRF3	interferon regulatory factor 3	0.013
WTAP	Wilms tumor 1 associated protein	0.013
CREBZF	CREB/ATF bZIP transcription factor	0.013
PPP2R5D	protein phosphatase 2, regulatory subunit B', delta	0.013
PAX3	paired box 3	0.013
UBE2Q1	ubiquitin-conjugating enzyme E2Q family member 1	0.012
ATG4B	ATG4 autophagy related 4 homolog B (S. cerevisiae)	0.012
IL1R1	interleukin 1 receptor, type I	0.012
HNRNPA1	heterogeneous nuclear ribonucleoprotein A1	0.012
GLRX	glutaredoxin (thioltransferase)	0.012
FUS	fused in sarcoma	0.012
RBCK1	RanBP-type and C3HC4-type zinc finger containing 1	0.012
HSPB7	heat shock 27kDa protein family, member 7 (cardiovascular)	0.012
APLP2	amyloid beta (A4) precursor-like protein 2	0.012
UBQLN2	ubiquilin 2	0.012	Human
FTH1	ferritin, heavy polypeptide 1	0.012
WBP2	WW domain binding protein 2	0.012
CSNK1D	casein kinase 1, delta	0.012
MAPK1IP1L	mitogen-activated protein kinase 1 interacting protein 1-like	0.012
MYC	v-myc myelocytomatosis viral oncogene homolog (avian)	0.012
FOXO3	forkhead box O3	0.012
ASB1	ankyrin repeat and SOCS box containing 1	0.012
MAP3K3	mitogen-activated protein kinase kinase kinase 3	0.012
ASB12	ankyrin repeat and SOCS box containing 12	0.012
MMS22L	MMS22-like, DNA repair protein	0.012
STC1	stanniocalcin 1	0.012
NDUFA4	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4, 9kDa	0.012
CEBPD	CCAAT/enhancer binding protein (C/EBP), delta	0.012
TBC1D14	TBC1 domain family, member 14	0.011
MAFF	v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)	0.011
EPAS1	endothelial PAS domain protein 1	0.011	Human
NBN	nibrin	0.011
PRDX4	peroxiredoxin 4	0.011
ERO1L	ERO1-like (S. cerevisiae)	0.011
PABPC4	poly(A) binding protein, cytoplasmic 4 (inducible form)	0.011
ARL6IP1	ADP-ribosylation factor-like 6 interacting protein 1	0.011
PRKCA	protein kinase C, alpha	0.011
PRDX6	peroxiredoxin 6	0.011
STX12	syntaxin 12	0.011
CASP7	caspase 7, apoptosis-related cysteine peptidase	0.011
UBQLN1	ubiquilin 1	0.011
SH3BGRL	SH3 domain binding glutamic acid-rich protein like	0.011
CELSR1	cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila)	0.011
EED	embryonic ectoderm development	0.011
TP63	tumor protein p63	0.011
CRY1	cryptochrome 1 (photolyase-like)	0.011
MAX	MYC associated factor X	0.011
AFTPH	aftiphilin	0.011
PCK2	phosphoenolpyruvate carboxykinase 2 (mitochondrial)	0.011
BIRC3	baculoviral IAP repeat containing 3	0.011
CARS	cysteinyl-tRNA synthetase	0.011
CRYAA	crystallin, alpha A	0.011
CYLD	cylindromatosis (turban tumor syndrome)	0.011
SMAD2	SMAD family member 2	0.011
CLIP1	CAP-GLY domain containing linker protein 1	0.011
RAD52	RAD52 homolog (S. cerevisiae)	0.011
TNFAIP6	tumor necrosis factor, alpha-induced protein 6	0.011
RHOA	ras homolog gene family, member A	0.011
ABI2	abl-interactor 2	0.011
STC2	stanniocalcin 2	0.011
ETS2	v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)	0.010
HK2	hexokinase 2	0.010
PRAF2	PRA1 domain family, member 2	0.010
EP300	E1A binding protein p300	0.010
MIF	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	0.010
RARA	retinoic acid receptor, alpha	0.010
BAZ1A	bromodomain adjacent to zinc finger domain, 1A	0.010
SIRT2	sirtuin 2	0.010
TFR2	transferrin receptor 2	0.010
SERPINF2	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2	0.010
EIF2AK3	eukaryotic translation initiation factor 2-alpha kinase 3	0.010
BIRC2	baculoviral IAP repeat containing 2	0.010
HNRNPH2	heterogeneous nuclear ribonucleoprotein H2 (H')	0.010
NME2	non-metastatic cells 2, protein (NM23B) expressed in	0.010
SKI	v-ski sarcoma viral oncogene homolog (avian)	0.010
TNFAIP3	tumor necrosis factor, alpha-induced protein 3	0.010