IMP

Process View

Homo sapiens

37 genes annotated in human

intrinsic apoptotic signaling pathway by p53 class mediator

A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, and ends when the execution phase of apoptosis is triggered.

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "intrinsic apoptotic signaling pathway by p53 class mediator"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "intrinsic apoptotic signaling pathway by p53 class mediator" (in gray)

Name	Description	Probability	Func Analog Organism
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.999
RB1	retinoblastoma 1	0.964
NFKB1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	0.952
EP300	E1A binding protein p300	0.949
NFKB2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)	0.940
BRCA1	breast cancer 1, early onset	0.932
REL	v-rel reticuloendotheliosis viral oncogene homolog (avian)	0.909
ESR1	estrogen receptor 1	0.894
HDAC1	histone deacetylase 1	0.841
BCL2	B-cell CLL/lymphoma 2	0.806
BTRC	beta-transducin repeat containing	0.736
CHEK2	CHK2 checkpoint homolog (S. pombe)	0.674	Fly
HIPK2	homeodomain interacting protein kinase 2	0.647	Mouse
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.594
BCL2L1	BCL2-like 1	0.575
RELB	v-rel reticuloendotheliosis viral oncogene homolog B	0.523
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.508
NBN	nibrin	0.456
MCL1	myeloid cell leukemia sequence 1 (BCL2-related)	0.436
PPP2R5C	protein phosphatase 2, regulatory subunit B', gamma	0.401
STAT3	signal transducer and activator of transcription 3 (acute-phase response factor)	0.386
NFKBIE	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon	0.367	Human
USP7	ubiquitin specific peptidase 7 (herpes virus-associated)	0.360
SIRT1	sirtuin 1	0.334
BID	BH3 interacting domain death agonist	0.325
TNIP2	TNFAIP3 interacting protein 2	0.278
BCL3	B-cell CLL/lymphoma 3	0.270
IER3	immediate early response 3	0.270
MAP3K8	mitogen-activated protein kinase kinase kinase 8	0.260
RAD51	RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)	0.259	Worm
RASSF5	Ras association (RalGDS/AF-6) domain family member 5	0.258
BCL2L11	BCL2-like 11 (apoptosis facilitator)	0.239
TP53BP2	tumor protein p53 binding protein, 2	0.238
TP53	tumor protein p53	0.238
NFKBIA	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.217	Human
PPP1CC	protein phosphatase 1, catalytic subunit, gamma isozyme	0.195
MDM4	Mdm4 p53 binding protein homolog (mouse)	0.194
PML	promyelocytic leukemia	0.183	Mouse
TNFAIP3	tumor necrosis factor, alpha-induced protein 3	0.181
BAX	BCL2-associated X protein	0.178	Human Mouse
PPP2R5A	protein phosphatase 2, regulatory subunit B', alpha	0.166	Human
DYRK1A	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A	0.164	Human
KAT2B	K(lysine) acetyltransferase 2B	0.158
FANCD2	Fanconi anemia, complementation group D2	0.155
SETD7	SET domain containing (lysine methyltransferase) 7	0.146
IKBKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	0.146
NCOA3	nuclear receptor coactivator 3	0.144
XRCC6	X-ray repair complementing defective repair in Chinese hamster cells 6	0.141
HIF1A	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	0.129
BAK1	BCL2-antagonist/killer 1	0.113	Human
DDX5	DEAD (Asp-Glu-Ala-Asp) box polypeptide 5	0.112
RPS14	ribosomal protein S14	0.111
PPP2CA	protein phosphatase 2, catalytic subunit, alpha isozyme	0.106
PPP2R1B	protein phosphatase 2, regulatory subunit A, beta	0.105
ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	0.087
PARP1	poly (ADP-ribose) polymerase 1	0.086
LATS2	LATS, large tumor suppressor, homolog 2 (Drosophila)	0.085	Fly
YAP1	Yes-associated protein 1	0.077
ICAM1	intercellular adhesion molecule 1	0.075
MOBKL1B	MOB1, Mps One Binder kinase activator-like 1B (yeast)	0.073
IL8	interleukin 8	0.073
CDK2	cyclin-dependent kinase 2	0.073
HDAC2	histone deacetylase 2	0.072
HLA-DRB1	major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 1	0.072
IKBKG	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma	0.072
SNIP1	Smad nuclear interacting protein 1	0.071
NCOR2	nuclear receptor corepressor 2	0.068
PPP1CA	protein phosphatase 1, catalytic subunit, alpha isozyme	0.062
UHRF2	ubiquitin-like with PHD and ring finger domains 2	0.062
WWOX	WW domain containing oxidoreductase	0.061
RBBP8	retinoblastoma binding protein 8	0.061
AHR	aryl hydrocarbon receptor	0.061
RPS27	ribosomal protein S27	0.060	Human
MEFV	Mediterranean fever	0.059
SNAI1	snail homolog 1 (Drosophila)	0.058
PPP2R2A	protein phosphatase 2, regulatory subunit B, alpha	0.057
MSN	moesin	0.057
DYRK2	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2	0.056
DAXX	death-domain associated protein	0.055
RAD18	RAD18 homolog (S. cerevisiae)	0.053
DYRK1B	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B	0.053	Human
UBE2I	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	0.051
CREB1	cAMP responsive element binding protein 1	0.051
PPFIA1	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1	0.050
CXCR4	chemokine (C-X-C motif) receptor 4	0.050
DYRK4	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4	0.049	Human
UBR1	ubiquitin protein ligase E3 component n-recognin 1	0.048
HLA-DPA1	major histocompatibility complex, class II, DP alpha 1	0.047
RYBP	RING1 and YY1 binding protein	0.046
STRADA	STE20-related kinase adaptor alpha	0.046
UBR3	ubiquitin protein ligase E3 component n-recognin 3 (putative)	0.046
PLK1	polo-like kinase 1	0.043
HNRNPK	heterogeneous nuclear ribonucleoprotein K	0.043	Mouse
H2AFX	H2A histone family, member X	0.041
ATM	ataxia telangiectasia mutated	0.041
MOBKL1A	MOB1, Mps One Binder kinase activator-like 1A (yeast)	0.040
PPP6C	protein phosphatase 6, catalytic subunit	0.040
HUWE1	HECT, UBA and WWE domain containing 1	0.040
DDX17	DEAD (Asp-Glu-Ala-Asp) box polypeptide 17	0.039	Human
RBL1	retinoblastoma-like 1 (p107)	0.038
LATS1	LATS, large tumor suppressor, homolog 1 (Drosophila)	0.038	Fly
AMOTL1	angiomotin like 1	0.036
STK3	serine/threonine kinase 3	0.036
MED1	mediator complex subunit 1	0.036
STK38L	serine/threonine kinase 38 like	0.036
LZTS2	leucine zipper, putative tumor suppressor 2	0.035
STX5	syntaxin 5	0.035
NCOA2	nuclear receptor coactivator 2	0.034
CREBBP	CREB binding protein	0.033	Human
NFKBIZ	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta	0.033
RPA1	replication protein A1, 70kDa	0.033
WRN	Werner syndrome, RecQ helicase-like	0.033
PPM1D	protein phosphatase, Mg2+/Mn2+ dependent, 1D	0.032
STK4	serine/threonine kinase 4	0.032
RBBP4	retinoblastoma binding protein 4	0.032
SP1	Sp1 transcription factor	0.032
OTUB1	OTU domain, ubiquitin aldehyde binding 1	0.031
CEBPD	CCAAT/enhancer binding protein (C/EBP), delta	0.031
RPS27L	ribosomal protein S27-like	0.031
DHX30	DEAH (Asp-Glu-Ala-His) box polypeptide 30	0.031
IK	IK cytokine, down-regulator of HLA II	0.030
HLA-DRA	major histocompatibility complex, class II, DR alpha	0.030
CUX1	cut-like homeobox 1	0.030
CHEK1	CHK1 checkpoint homolog (S. pombe)	0.029
NCOA6	nuclear receptor coactivator 6	0.029
MYST1	MYST histone acetyltransferase 1	0.029
E2F3	E2F transcription factor 3	0.029
PCNA	proliferating cell nuclear antigen	0.028
RB1CC1	RB1-inducible coiled-coil 1	0.028
PCDH9	protocadherin 9	0.028
CCND1	cyclin D1	0.028
SAV1	salvador homolog 1 (Drosophila)	0.028
CDKN2A	cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)	0.027
HNRNPH1	heterogeneous nuclear ribonucleoprotein H1 (H)	0.027
NR4A1	nuclear receptor subfamily 4, group A, member 1	0.026
KRT5	keratin 5	0.026
NFKBIB	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta	0.026	Human
SYVN1	synovial apoptosis inhibitor 1, synoviolin	0.025
RNF144B	ring finger protein 144B	0.025
BBC3	BCL2 binding component 3	0.025
MSH6	mutS homolog 6 (E. coli)	0.025
PIAS4	protein inhibitor of activated STAT, 4	0.025
UBE3A	ubiquitin protein ligase E3A	0.025
STAT6	signal transducer and activator of transcription 6, interleukin-4 induced	0.025
PTPN14	protein tyrosine phosphatase, non-receptor type 14	0.025
RPA3	replication protein A3, 14kDa	0.024
CHUK	conserved helix-loop-helix ubiquitous kinase	0.024
ISOC2	isochorismatase domain containing 2	0.024
RBBP7	retinoblastoma binding protein 7	0.024
NCOR1	nuclear receptor corepressor 1	0.023
POLH	polymerase (DNA directed), eta	0.023
MRE11A	MRE11 meiotic recombination 11 homolog A (S. cerevisiae)	0.023
PRKDC	protein kinase, DNA-activated, catalytic polypeptide	0.023
CABLES1	Cdk5 and Abl enzyme substrate 1	0.023
TP53BP1	tumor protein p53 binding protein 1	0.023
RPLP2	ribosomal protein, large, P2	0.022
AMOTL2	angiomotin like 2	0.022
C11orf10	chromosome 11 open reading frame 10	0.022
LYN	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	0.022
SUV39H1	suppressor of variegation 3-9 homolog 1 (Drosophila)	0.021
SOD2	superoxide dismutase 2, mitochondrial	0.021
DVL2	dishevelled, dsh homolog 2 (Drosophila)	0.021
HNRNPUL1	heterogeneous nuclear ribonucleoprotein U-like 1	0.021
BMI1	BMI1 polycomb ring finger oncogene	0.021
STRADB	STE20-related kinase adaptor beta	0.021
PCGF2	polycomb group ring finger 2	0.021
PPP2R1A	protein phosphatase 2, regulatory subunit A, alpha	0.021
HNRNPH2	heterogeneous nuclear ribonucleoprotein H2 (H')	0.021
RBM4	RNA binding motif protein 4	0.020
BIK	BCL2-interacting killer (apoptosis-inducing)	0.020
EFTUD2	elongation factor Tu GTP binding domain containing 2	0.020
RPS29	ribosomal protein S29	0.020	Zebrafish
UXT	ubiquitously-expressed transcript	0.020
SATB2	SATB homeobox 2	0.020
TDGF1	teratocarcinoma-derived growth factor 1	0.020
BHLHE40	basic helix-loop-helix family, member e40	0.019
NOTCH1	notch 1	0.019
HNRNPA0	heterogeneous nuclear ribonucleoprotein A0	0.019
CEBPB	CCAAT/enhancer binding protein (C/EBP), beta	0.019
PIM1	pim-1 oncogene	0.019
GSK3B	glycogen synthase kinase 3 beta	0.019
AR	androgen receptor	0.019
S100A4	S100 calcium binding protein A4	0.019
DMC1	DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination (yeast)	0.019
PURA	purine-rich element binding protein A	0.018
TOP1	topoisomerase (DNA) I	0.018
AKT1	v-akt murine thymoma viral oncogene homolog 1	0.018
FAM117B	family with sequence similarity 117, member B	0.018
E2F4	E2F transcription factor 4, p107/p130-binding	0.018
SRGN	serglycin	0.018
UBR5	ubiquitin protein ligase E3 component n-recognin 5	0.018
SKIL	SKI-like oncogene	0.018
IRF1	interferon regulatory factor 1	0.018
MSX2	msh homeobox 2	0.018	Human
SESN2	sestrin 2	0.018
YY1	YY1 transcription factor	0.017
PCGF6	polycomb group ring finger 6	0.017
USP28	ubiquitin specific peptidase 28	0.017
C2orf79	chromosome 2 open reading frame 79	0.017
SMARCA5	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5	0.017
RNF20	ring finger protein 20	0.017
FAU	Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed	0.016
PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	0.016
ANXA1	annexin A1	0.016
SUMO1	SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)	0.016
RNF11	ring finger protein 11	0.016
JUB	jub, ajuba homolog (Xenopus laevis)	0.016
APLF	aprataxin and PNKP like factor	0.016
TNFRSF10B	tumor necrosis factor receptor superfamily, member 10b	0.015
BCOR	BCL6 corepressor	0.015
GLUL	glutamate-ammonia ligase	0.015
DZIP1	DAZ interacting protein 1	0.015
SIAH1	seven in absentia homolog 1 (Drosophila)	0.015
CNOT4	CCR4-NOT transcription complex, subunit 4	0.015
RPL39	ribosomal protein L39	0.015
C5orf41	chromosome 5 open reading frame 41	0.015
EZR	ezrin	0.015
RHOG	ras homolog gene family, member G (rho G)	0.015
BRCA2	breast cancer 2, early onset	0.015	Mouse
NR2E3	nuclear receptor subfamily 2, group E, member 3	0.015
NFIL3	nuclear factor, interleukin 3 regulated	0.015
COX7C	cytochrome c oxidase subunit VIIc	0.015
ING2	inhibitor of growth family, member 2	0.015
VDR	vitamin D (1,25- dihydroxyvitamin D3) receptor	0.014
PLAUR	plasminogen activator, urokinase receptor	0.014
CDKN1B	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	0.014
XRCC1	X-ray repair complementing defective repair in Chinese hamster cells 1	0.014
SRP14	signal recognition particle 14kDa (homologous Alu RNA binding protein)	0.014
USP42	ubiquitin specific peptidase 42	0.014
TOPORS	topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase	0.014	Mouse
MARK4	MAP/microtubule affinity-regulating kinase 4	0.014
SF1	splicing factor 1	0.014
MYC	v-myc myelocytomatosis viral oncogene homolog (avian)	0.014
RASSF1	Ras association (RalGDS/AF-6) domain family member 1	0.014
RAD52	RAD52 homolog (S. cerevisiae)	0.014
AMOT	angiomotin	0.014
TERF2	telomeric repeat binding factor 2	0.014
NAMPT	nicotinamide phosphoribosyltransferase	0.014
MAPK14	mitogen-activated protein kinase 14	0.014
KRT6C	keratin 6C	0.014
FAS	Fas (TNF receptor superfamily, member 6)	0.014
NINJ1	ninjurin 1	0.014
DOCK8	dedicator of cytokinesis 8	0.014
COX7A2	cytochrome c oxidase subunit VIIa polypeptide 2 (liver)	0.014
CTSS	cathepsin S	0.014
SSR4	signal sequence receptor, delta (translocon-associated protein delta)	0.014
TNFAIP2	tumor necrosis factor, alpha-induced protein 2	0.014
MBNL1	muscleblind-like (Drosophila)	0.014
GSTM4	glutathione S-transferase mu 4	0.013
SPRR2A	small proline-rich protein 2A	0.013
STRAP	serine/threonine kinase receptor associated protein	0.013
GORAB	golgin, RAB6-interacting	0.013
RAD54B	RAD54 homolog B (S. cerevisiae)	0.013
NCOA1	nuclear receptor coactivator 1	0.013
RAD50	RAD50 homolog (S. cerevisiae)	0.013
UBXN7	UBX domain protein 7	0.013
RUNX1	runt-related transcription factor 1	0.013
MZT2A	mitotic spindle organizing protein 2A	0.013
IRF2	interferon regulatory factor 2	0.013
RNF19B	ring finger protein 19B	0.013
FAM162A	family with sequence similarity 162, member A	0.013
PPME1	protein phosphatase methylesterase 1	0.013
RNR2	l-rRNA	0.013
SMAD7	SMAD family member 7	0.013
UBE2D1	ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)	0.013
PRKACA	protein kinase, cAMP-dependent, catalytic, alpha	0.013
TSG101	tumor susceptibility gene 101	0.012
ELF1	E74-like factor 1 (ets domain transcription factor)	0.012
HTT	huntingtin	0.012
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.012
FRK	fyn-related kinase	0.012
CCL20	chemokine (C-C motif) ligand 20	0.012
SLC7A11	solute carrier family 7, (cationic amino acid transporter, y+ system) member 11	0.012
KPNA3	karyopherin alpha 3 (importin alpha 4)	0.012
IL6	interleukin 6 (interferon, beta 2)	0.012
XRCC3	X-ray repair complementing defective repair in Chinese hamster cells 3	0.012
CBX8	chromobox homolog 8	0.012
SLC3A2	solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2	0.012
RNF40	ring finger protein 40	0.012
MTCP1NB	mature T-cell proliferation 1 neighbor	0.012
MAPK8	mitogen-activated protein kinase 8	0.012
PPP2R5D	protein phosphatase 2, regulatory subunit B', delta	0.012	Human
CD44	CD44 molecule (Indian blood group)	0.012
TCAP	titin-cap (telethonin)	0.012
SFN	stratifin	0.012
HDAC3	histone deacetylase 3	0.012
CUL7	cullin 7	0.012
GNL3L	guanine nucleotide binding protein-like 3 (nucleolar)-like	0.012
RNF38	ring finger protein 38	0.012
MAX	MYC associated factor X	0.012
E2F2	E2F transcription factor 2	0.012	Mouse
RPS10	ribosomal protein S10	0.012
CCDC72	coiled-coil domain containing 72	0.012
PPP2R5E	protein phosphatase 2, regulatory subunit B', epsilon isoform	0.012	Human
UBQLN2	ubiquilin 2	0.011
MAVS	mitochondrial antiviral signaling protein	0.011
HLA-DPB1	major histocompatibility complex, class II, DP beta 1	0.011
TNIP1	TNFAIP3 interacting protein 1	0.011
ANKRD28	ankyrin repeat domain 28	0.011
RRM2B	ribonucleotide reductase M2 B (TP53 inducible)	0.011	Mouse
BTG1	B-cell translocation gene 1, anti-proliferative	0.011
MSX1	msh homeobox 1	0.011
FOXO3	forkhead box O3	0.011
CITED2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	0.011
FKBP8	FK506 binding protein 8, 38kDa	0.011
SOD1	superoxide dismutase 1, soluble	0.011
CXCL3	chemokine (C-X-C motif) ligand 3	0.011
PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	0.011
TAGLN2	transgelin 2	0.011
IQGAP1	IQ motif containing GTPase activating protein 1	0.011
PCGF5	polycomb group ring finger 5	0.011
UQCRQ	ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa	0.011
CCDC106	coiled-coil domain containing 106	0.011
ARL15	ADP-ribosylation factor-like 15	0.011
FBXL5	F-box and leucine-rich repeat protein 5	0.011
PPP1R2	protein phosphatase 1, regulatory (inhibitor) subunit 2	0.011
HBP1	HMG-box transcription factor 1	0.011
PTPN21	protein tyrosine phosphatase, non-receptor type 21	0.011
S100A2	S100 calcium binding protein A2	0.011
DDB2	damage-specific DNA binding protein 2, 48kDa	0.011
XIAP	X-linked inhibitor of apoptosis	0.011
C12orf5	chromosome 12 open reading frame 5	0.011
EID1	EP300 interacting inhibitor of differentiation 1	0.011
SP3	Sp3 transcription factor	0.011
UBTF	upstream binding transcription factor, RNA polymerase I	0.011
NCL	nucleolin	0.011
PELP1	proline, glutamate and leucine rich protein 1	0.011
ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.011
CASP4	caspase 4, apoptosis-related cysteine peptidase	0.011
RTF1	Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)	0.011
PPP2R5B	protein phosphatase 2, regulatory subunit B', beta	0.011	Human
PPAP2B	phosphatidic acid phosphatase type 2B	0.011
TP73	tumor protein p73	0.011
ZMAT3	zinc finger, matrin-type 3	0.011
RIN1	Ras and Rab interactor 1	0.011
DDX56	DEAD (Asp-Glu-Ala-Asp) box polypeptide 56	0.010
FOSL2	FOS-like antigen 2	0.010
TSC22D3	TSC22 domain family, member 3	0.010
MT1A	metallothionein 1A	0.010
BLM	Bloom syndrome, RecQ helicase-like	0.010
ZC3H12A	zinc finger CCCH-type containing 12A	0.010
LY96	lymphocyte antigen 96	0.010
SLC29A1	solute carrier family 29 (nucleoside transporters), member 1	0.010
CDK6	cyclin-dependent kinase 6	0.010
TEAD1	TEA domain family member 1 (SV40 transcriptional enhancer factor)	0.010
GSTP1	glutathione S-transferase pi 1	0.010
PPP1R3F	protein phosphatase 1, regulatory (inhibitor) subunit 3F	0.010
RCOR1	REST corepressor 1	0.010
DLX5	distal-less homeobox 5	0.010
PALB2	partner and localizer of BRCA2	0.010
HLA-DQA1	major histocompatibility complex, class II, DQ alpha 1	0.010
ITCH	itchy E3 ubiquitin protein ligase homolog (mouse)	0.010
PIK3R2	phosphoinositide-3-kinase, regulatory subunit 2 (beta)	0.010