The network for 'regulation of adaptive immune response' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of adaptive immune response

Any process that modulates the frequency, rate, or extent of an adaptive immune response.

Mus musculus
Name Description Probability Func Analog Organism
Cd40 CD40 antigen 0.997
Stat3 signal transducer and activator of transcription 3 0.984
Ikzf1 IKAROS family zinc finger 1 0.983
Tnf tumor necrosis factor 0.974
Il1b interleukin 1 beta 0.965
Lyz2 lysozyme 2 0.953
Icos inducible T-cell co-stimulator 0.943
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.939
Pik3cd phosphatidylinositol 3-kinase catalytic delta polypeptide 0.935
Il1r1 interleukin 1 receptor, type I 0.930
Ccr7 chemokine (C-C motif) receptor 7 0.926
H2-Ab1 histocompatibility 2, class II antigen A, beta 1 0.920
B2m beta-2 microglobulin 0.913
Cd74 CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) 0.910
H2-K1 histocompatibility 2, K1, K region 0.905
Casp4 caspase 4, apoptosis-related cysteine peptidase 0.905
H2-Aa histocompatibility 2, class II antigen A, alpha 0.874
Lta lymphotoxin A 0.861
Ccl2 chemokine (C-C motif) ligand 2 0.841
Cd28 CD28 antigen 0.831
Il4 interleukin 4 0.830
Tnfrsf4 tumor necrosis factor receptor superfamily, member 4 0.830
Ccr1 chemokine (C-C motif) receptor 1 0.820
Prdm1 PR domain containing 1, with ZNF domain 0.817
Tnfaip3 tumor necrosis factor, alpha-induced protein 3 0.813
Il2rg interleukin 2 receptor, gamma chain 0.804
Ccl4 chemokine (C-C motif) ligand 4 0.798
Il6st interleukin 6 signal transducer 0.780
Csf2rb2 colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage) 0.774
Tbx21 T-box 21 0.773
Relb avian reticuloendotheliosis viral (v-rel) oncogene related B 0.769
Itgb2 integrin beta 2 0.768
Ciita class II transactivator 0.768
Traf6 TNF receptor-associated factor 6 0.756
Tnfrsf9 tumor necrosis factor receptor superfamily, member 9 0.754
Pdcd1 programmed cell death 1 0.753
Ccl5 chemokine (C-C motif) ligand 5 0.736
Il6 interleukin 6 0.731
Ccr5 chemokine (C-C motif) receptor 5 0.718
H2-Eb1 histocompatibility 2, class II antigen E beta 0.716
Ccl8 chemokine (C-C motif) ligand 8 0.713
Gzma granzyme A 0.687
Folr2 folate receptor 2 (fetal) 0.653
Zap70 zeta-chain (TCR) associated protein kinase 0.648
Fcer1g Fc receptor, IgE, high affinity I, gamma polypeptide 0.646
Selp selectin, platelet 0.633
Cish cytokine inducible SH2-containing protein 0.627
Stat5a signal transducer and activator of transcription 5A 0.619
Ccr2 chemokine (C-C motif) receptor 2 0.602
Itgax integrin alpha X 0.599
Batf basic leucine zipper transcription factor, ATF-like 0.596
Tapbp TAP binding protein 0.592
Lyn Yamaguchi sarcoma viral (v-yes-1) oncogene homolog 0.591
Il27ra interleukin 27 receptor, alpha 0.588
Klrd1 killer cell lectin-like receptor, subfamily D, member 1 0.588
Cxcr5 chemokine (C-X-C motif) receptor 5 0.571
Foxp3 forkhead box P3 0.567
Itgal integrin alpha L 0.564
Cd6 CD6 antigen 0.544
Clec4d C-type lectin domain family 4, member d 0.526
Jak2 Janus kinase 2 0.524
Sh2d2a SH2 domain protein 2A 0.524
Igh immunoglobulin heavy chain complex 0.516
Pitx1 paired-like homeodomain transcription factor 1 0.512
Ptprc protein tyrosine phosphatase, receptor type, C 0.499
H2-Q7 histocompatibility 2, Q region locus 7 0.497
Klrg1 killer cell lectin-like receptor subfamily G, member 1 0.493
Xcl1 chemokine (C motif) ligand 1 0.486
Hdac4 histone deacetylase 4 0.483
Itk IL2-inducible T-cell kinase 0.480
Irf1 interferon regulatory factor 1 0.478
Stat6 signal transducer and activator of transcription 6 0.476
Lag3 lymphocyte-activation gene 3 0.475
Casp8 caspase 8 0.471
Il12rb2 interleukin 12 receptor, beta 2 0.469
Ccl12 chemokine (C-C motif) ligand 12 0.460
Cd8b1 CD8 antigen, beta chain 1 0.457
Casp1 caspase 1 0.454
Fasl Fas ligand (TNF superfamily, member 6) 0.450
Ifngr1 interferon gamma receptor 1 0.446
Il10 interleukin 10 0.444
Prf1 perforin 1 (pore forming protein) 0.441
Bcl3 B-cell leukemia/lymphoma 3 0.435
H2-D1 histocompatibility 2, D region locus 1 0.430
Klrk1 killer cell lectin-like receptor subfamily K, member 1 0.429
Stat5b signal transducer and activator of transcription 5B 0.428
Rc3h1 RING CCCH (C3H) domains 1 0.425
Il2rb interleukin 2 receptor, beta chain 0.425
Nkx3-2 NK3 homeobox 2 0.422
Abca1 ATP-binding cassette, sub-family A (ABC1), member 1 0.419
Ifng interferon gamma 0.409
Socs1 suppressor of cytokine signaling 1 0.405
P2rx7 purinergic receptor P2X, ligand-gated ion channel, 7 0.399
Cd79a CD79A antigen (immunoglobulin-associated alpha) 0.397
Xcr1 chemokine (C motif) receptor 1 0.383
Il1rl1 interleukin 1 receptor-like 1 0.383
C3 complement component 3 0.380
Cd86 CD86 antigen 0.379
Cd5 CD5 antigen 0.370
Flt3 FMS-like tyrosine kinase 3 0.366
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.972
TRAF6 TNF receptor-associated factor 6 0.964
TRAF2 TNF receptor-associated factor 2 0.958
TRAF3 TNF receptor-associated factor 3 0.953
BIRC3 baculoviral IAP repeat containing 3 0.947
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.945
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 0.936
B2M beta-2-microglobulin 0.931
HLA-A major histocompatibility complex, class I, A 0.931
HLA-C major histocompatibility complex, class I, C 0.876
IL4R interleukin 4 receptor 0.868
HLA-G major histocompatibility complex, class I, G 0.844
HLA-E major histocompatibility complex, class I, E 0.768
HLA-F major histocompatibility complex, class I, F 0.755
HLA-B major histocompatibility complex, class I, B 0.744
TAPBP TAP binding protein (tapasin) 0.674
SYK spleen tyrosine kinase 0.632
CCL4 chemokine (C-C motif) ligand 4 0.629
CCL5 chemokine (C-C motif) ligand 5 0.562
FAS Fas (TNF receptor superfamily, member 6) 0.557
LCK lymphocyte-specific protein tyrosine kinase 0.521
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 0.502
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.497
TRAF1 TNF receptor-associated factor 1 0.470
IL2RG interleukin 2 receptor, gamma 0.459
CD40 CD40 molecule, TNF receptor superfamily member 5 0.429
TNF tumor necrosis factor 0.417
CASP1 caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) 0.396
HLA-DRA major histocompatibility complex, class II, DR alpha 0.380
CCR5 chemokine (C-C motif) receptor 5 0.337
STAT2 signal transducer and activator of transcription 2, 113kDa 0.328
MAP3K7 mitogen-activated protein kinase kinase kinase 7 0.302
BIRC2 baculoviral IAP repeat containing 2 0.281
TANK TRAF family member-associated NFKB activator 0.272
IRF9 interferon regulatory factor 9 0.258
GRAP2 GRB2-related adaptor protein 2 0.252
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B 0.246
IL12B interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) 0.240
LTA lymphotoxin alpha (TNF superfamily, member 1) 0.216
CXCL9 chemokine (C-X-C motif) ligand 9 0.214
TRIM21 tripartite motif containing 21 0.212
PTPN6 protein tyrosine phosphatase, non-receptor type 6 0.194
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 0.184
TNFRSF14 tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) 0.182
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.178
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 0.174
CD80 CD80 molecule 0.173
HLA-DMB major histocompatibility complex, class II, DM beta 0.166
CCL22 chemokine (C-C motif) ligand 22 0.159
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced 0.151
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 1 0.147
CCR7 chemokine (C-C motif) receptor 7 0.146
IRF1 interferon regulatory factor 1 0.138
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 0.136
CD163 CD163 molecule 0.134
ZMYND11 zinc finger, MYND-type containing 11 0.130
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.125
CCL8 chemokine (C-C motif) ligand 8 0.123
IRF2 interferon regulatory factor 2 0.113
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 0.112
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 0.108
HDAC9 histone deacetylase 9 0.107
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 0.106
NLRC4 NLR family, CARD domain containing 4 0.104
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 0.094
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain 0.091
THOC5 THO complex 5 0.087
CD48 CD48 molecule 0.085
IL23A interleukin 23, alpha subunit p19 0.083
MALT1 mucosa associated lymphoid tissue lymphoma translocation gene 1 0.081
CCR1 chemokine (C-C motif) receptor 1 0.081
IL10RA interleukin 10 receptor, alpha 0.079
IFITM1 interferon induced transmembrane protein 1 (9-27) 0.078
MED15 mediator complex subunit 15 0.075
MX2 myxovirus (influenza virus) resistance 2 (mouse) 0.070
CXCL10 chemokine (C-X-C motif) ligand 10 0.069
MAVS mitochondrial antiviral signaling protein 0.069
IRF8 interferon regulatory factor 8 0.068
PVRL3 poliovirus receptor-related 3 0.067
HLA-DPB1 major histocompatibility complex, class II, DP beta 1 0.066
CD1C CD1c molecule 0.064
HDAC4 histone deacetylase 4 0.060
CCL19 chemokine (C-C motif) ligand 19 0.060
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7) 0.059
MAP3K14 mitogen-activated protein kinase kinase kinase 14 0.059
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 0.058
IL2RB interleukin 2 receptor, beta 0.057
CXCL11 chemokine (C-X-C motif) ligand 11 0.056
CD3E CD3e molecule, epsilon (CD3-TCR complex) 0.056
TGIF1 TGFB-induced factor homeobox 1 0.056
RIPK2 receptor-interacting serine-threonine kinase 2 0.054
CCL13 chemokine (C-C motif) ligand 13 0.053
SQSTM1 sequestosome 1 0.053
IRAK1 interleukin-1 receptor-associated kinase 1 0.052
NLRP3 NLR family, pyrin domain containing 3 0.051
CD2 CD2 molecule 0.051
HK3 hexokinase 3 (white cell) 0.050
PRKD2 protein kinase D2 0.050
TYROBP TYRO protein tyrosine kinase binding protein 0.050
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 0.050
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Rattus norvegicus
Name Description Probability Func Analog Organism
RT1-EC2 RT1 class Ib, locus EC2 0.739
RT1-Da RT1 class II, locus Da 0.654
RT1-Ba RT1 class II, locus Ba 0.442
Hsp90aa1 heat shock protein 90, alpha (cytosolic), class A member 1 0.395
Hsph1 heat shock 105/110 protein 1 0.388
RT1-S3 RT1 class Ib, locus S3 0.382
Hsp90ab1 heat shock protein 90 alpha (cytosolic), class B member 1 0.328
RT1-Db1 RT1 class II, locus Db1 0.194
Casp1 caspase 1 0.146
Cd74 Cd74 molecule, major histocompatibility complex, class II invariant chain 0.140
Aif1 allograft inflammatory factor 1 0.109
Gbp2 guanylate binding protein 2 0.088
Dnajb1 DnaJ (Hsp40) homolog, subfamily B, member 1 0.084
Hspb1 heat shock protein 1 0.083
Fgg fibrinogen gamma chain 0.077
Cd37 CD37 molecule 0.077
Psmb9 proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2) 0.063
Anpep alanyl (membrane) aminopeptidase 0.062
RT1-DMb RT1 class II, locus DMb 0.056
Kmo kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) 0.052
Slfn2 schlafen 2 0.051
Stip1 stress-induced phosphoprotein 1 0.048
Atf3 activating transcription factor 3 0.047
Cxcl10 chemokine (C-X-C motif) ligand 10 0.044
Cd53 Cd53 molecule 0.042
Il1b interleukin 1 beta 0.040
Fth1 ferritin, heavy polypeptide 1 0.038
Il2rb interleukin 2 receptor, beta 0.036
Ccl5 chemokine (C-C motif) ligand 5 0.035
Apol3 apolipoprotein L, 3 0.033
Tap2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) 0.033
Hck hemopoietic cell kinase 0.033
Fga fibrinogen alpha chain 0.029
Cxcr4 chemokine (C-X-C motif) receptor 4 0.027
Lyn v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.026
Dnaja4 DnaJ (Hsp40) homolog, subfamily A, member 4 0.025
Plaur plasminogen activator, urokinase receptor 0.024
Psmb8 proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7) 0.024
Ripk3 receptor-interacting serine-threonine kinase 3 0.024
Hspd1 heat shock protein 1 (chaperonin) 0.022
Tnfrsf14 tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) 0.021
Hspa8 heat shock protein 8 0.021
RT1-N3 RT1 class Ib, locus N3 0.020
Lyz2 lysozyme 2 0.019
Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 0.019
Hspa5 heat shock protein 5 0.016
Dnaja1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.015
Il2rg interleukin 2 receptor, gamma 0.015
Mx1 myxovirus (influenza virus) resistance 1 0.015
Acp5 acid phosphatase 5, tartrate resistant 0.014
Tfec transcription factor EC 0.014
Oas1a 2'-5' oligoadenylate synthetase 1A 0.013
Tnf tumor necrosis factor (TNF superfamily, member 2) 0.013
Ctsh cathepsin H 0.013
Irf1 interferon regulatory factor 1 0.012
RT1-CE12 RT1 class I, locus CE12 0.012
LOC681996 similar to AHA1, activator of heat shock 90kDa protein ATPase homolog 1 0.012
Sqstm1 sequestosome 1 0.012
Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 0.011
Gzmb granzyme B 0.011
Ctss cathepsin S 0.011
Apob apolipoprotein B 0.011
P2ry14 purinergic receptor P2Y, G-protein coupled, 14 0.011
Icam1 intercellular adhesion molecule 1 0.010
Tap1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism