The network for 'b cell differentiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

b cell differentiation

The process in which a precursor cell type acquires the specialized features of a B cell. A B cell is a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity.

Mus musculus
Name Description Probability Func Analog Organism
Pten phosphatase and tensin homolog 1.000
Ikzf1 IKAROS family zinc finger 1 1.000
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 1.000
Igh immunoglobulin heavy chain complex 0.991
Fyn Fyn proto-oncogene 0.981
Trp53 transformation related protein 53 0.979
Prkdc protein kinase, DNA activated, catalytic polypeptide 0.976
Tcf3 transcription factor 3 0.963
Rag2 recombination activating gene 2 0.963
Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.962
Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 0.957
Csf1 colony stimulating factor 1 (macrophage) 0.949
Map3k14 mitogen-activated protein kinase kinase kinase 14 0.940
Bcl2 B-cell leukemia/lymphoma 2 0.933
Foxp3 forkhead box P3 0.924
Onecut1 one cut domain, family member 1 0.907
Sox2 SRY-box containing gene 2 0.906
Lyn Yamaguchi sarcoma viral (v-yes-1) oncogene homolog 0.902
Grb2 growth factor receptor bound protein 2 0.901
H2-Aa histocompatibility 2, class II antigen A, alpha 0.893
Neurod1 neurogenic differentiation 1 0.879
Tnf tumor necrosis factor 0.878
Shh sonic hedgehog 0.875
Emx1 empty spiracles homolog 1 (Drosophila) 0.863
Ltb lymphotoxin B 0.860
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.852
Pik3cd phosphatidylinositol 3-kinase catalytic delta polypeptide 0.850
Inpp5d inositol polyphosphate-5-phosphatase D 0.849
Cbl Casitas B-lineage lymphoma 0.846
Gli2 GLI-Kruppel family member GLI2 0.835
Otx2 orthodenticle homolog 2 (Drosophila) 0.818
Pax6 paired box gene 6 0.791
Mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.790
Lyz2 lysozyme 2 0.755
Neurog2 neurogenin 2 0.736
Il2rg interleukin 2 receptor, gamma chain 0.710
Lat linker for activation of T cells 0.706
Id1 inhibitor of DNA binding 1 0.701
Relb avian reticuloendotheliosis viral (v-rel) oncogene related B 0.667
Bax BCL2-associated X protein 0.665
Hand2 heart and neural crest derivatives expressed transcript 2 0.655
Abl1 c-abl oncogene 1, non-receptor tyrosine kinase 0.651
Zeb1 zinc finger E-box binding homeobox 1 0.650
Kiss1 KiSS-1 metastasis-suppressor 0.613
Hif1a hypoxia inducible factor 1, alpha subunit 0.613
Pik3r1 phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha) 0.579
Esr1 estrogen receptor 1 (alpha) 0.565
Cxcr5 chemokine (C-X-C motif) receptor 5 0.564
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.563
Hes1 hairy and enhancer of split 1 (Drosophila) 0.562
Cd19 CD19 antigen 0.558
Ntf3 neurotrophin 3 0.546
Id3 inhibitor of DNA binding 3 0.541
Kdr kinase insert domain protein receptor 0.533
Lta lymphotoxin A 0.527
Socs1 suppressor of cytokine signaling 1 0.520
Lhx3 LIM homeobox protein 3 0.519
Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.514
Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.513
Sfpi1 SFFV proviral integration 1 0.505
Dok1 docking protein 1 0.503
Insm1 insulinoma-associated 1 0.495
Tgfb2 transforming growth factor, beta 2 0.491
Pax5 paired box gene 5 0.490
Epor erythropoietin receptor 0.480
Cd22 CD22 antigen 0.473
Fzd7 frizzled homolog 7 (Drosophila) 0.471
Ptpn6 protein tyrosine phosphatase, non-receptor type 6 0.463
Tlx3 T-cell leukemia, homeobox 3 0.445
Pik3ca phosphatidylinositol 3-kinase, catalytic, alpha polypeptide 0.440
Hoxd13 homeobox D13 0.440
Egfr epidermal growth factor receptor 0.432
Cyld cylindromatosis (turban tumor syndrome) 0.428
Cxcr4 chemokine (C-X-C motif) receptor 4 0.423
Ets1 E26 avian leukemia oncogene 1, 5' domain 0.418
2010106G01Rik RIKEN cDNA 2010106G01 gene 0.414
Trp73 transformation related protein 73 0.412
Pnp2 purine-nucleoside phosphorylase 2 0.407
Ptf1a pancreas specific transcription factor, 1a 0.390
Shc1 src homology 2 domain-containing transforming protein C1 0.389
Sox18 SRY-box containing gene 18 0.380
Adam19 a disintegrin and metallopeptidase domain 19 (meltrin beta) 0.377
Irf8 interferon regulatory factor 8 0.377
Tnfrsf13c tumor necrosis factor receptor superfamily, member 13c 0.369
Tnfsf14 tumor necrosis factor (ligand) superfamily, member 14 0.364
Six3 sine oculis-related homeobox 3 homolog (Drosophila) 0.364
Tgfb1 transforming growth factor, beta 1 0.360
Igdcc3 immunoglobulin superfamily, DCC subclass, member 3 0.357
Gab2 growth factor receptor bound protein 2-associated protein 2 0.354
Notch2 Notch gene homolog 2 (Drosophila) 0.354
Sykb spleen tyrosine kinase 0.352
Id2 inhibitor of DNA binding 2 0.344
Stat5b signal transducer and activator of transcription 5B 0.339
Il4 interleukin 4 0.334
Bcl6 B-cell leukemia/lymphoma 6 0.333
Kit kit oncogene 0.323
Ngfr nerve growth factor receptor (TNFR superfamily, member 16) 0.322
Hand1 heart and neural crest derivatives expressed transcript 1 0.320
Rspo2 R-spondin 2 homolog (Xenopus laevis) 0.317
Spna1 spectrin alpha 1 0.316
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
cmyb transcription factor cmyb 0.726
kita kit receptor a 0.364
hmgb1b high-mobility group box 1b 0.357
hbae1 hemoglobin alpha embryonic-1 0.220
tbx1 T-box 1 0.189
mcm5 MCM5 minichromosome maintenance deficient 5 (S. cerevisiae) 0.168
il7r interleukin 7 receptor 0.166
gata1a GATA binding protein 1a 0.164
lcp1 lymphocyte cytosolic plastin 1 0.150
pdcd2 programmed cell death 2 0.138
fancd2 Fanconi anemia, complementation group D2 0.123
lyz lysozyme 0.122
rest RE1-silencing transcription factor 0.120
mitfa microphthalmia-associated transcription factor a 0.117
mmp9 matrix metalloproteinase 9 0.116
npnt nephronectin 0.105
ighz immunoglobulin heavy constant zeta 0.103
cdkn1a cyclin-dependent kinase inhibitor 1A 0.095
gch2 GTP cyclohydrolase 2 0.093
bcl2l10 BCL2-like 10 (apoptosis facilitator) 0.092
pdap1 pdgfa associated protein 1 0.090
cobl cordon-bleu homolog (mouse) 0.090
rspo3 R-spondin 3 homolog (Xenopus laevis) 0.085
hmgb2a high-mobility group box 2a 0.083
tfec transcription factor EC 0.082
zfp36l1a zinc finger protein 36, C3H type-like 1a 0.079
edn1 endothelin 1 0.079
cxcr4b chemokine (C-X-C motif), receptor 4b 0.078
ltk leukocyte tyrosine kinase 0.075
runx3 runt-related transcription factor 3 0.075
foxe3 forkhead box E3 0.073
wls wntless homolog (Drosophila) 0.068
pdcd6 programmed cell death 6 0.067
zbtb4 zinc finger and BTB domain containing 4 0.066
shmt2 serine hydroxymethyltransferase 2 (mitochondrial) 0.065
ryk receptor-like tyrosine kinase 0.062
jak1 Janus kinase 1 0.056
tshb thyroid stimulating hormone, beta subunit 0.056
traf4a tnf receptor-associated factor 4a 0.055
cldn15la claudin 15-like a 0.055
zgc:172101 zgc:172101 0.054
tsc22d3 TSC22 domain family, member 3 0.054
m6pr mannose-6-phosphate receptor (cation dependent) 0.052
bcl2l1 bcl2-like 1 0.051
aox3 aldehyde oxidase 3 0.050
f2r coagulation factor II (thrombin) receptor 0.050
prim1 primase polypeptide 1 0.049
isl2b islet2b 0.049
lef1 lymphocyte enhancer binding factor 1 0.049
tgfb2 transforming growth factor, beta 2 0.048
zgc:56136 zgc:56136 0.047
zgc:162329 zgc:162329 0.047
lmx1b.1 LIM homeobox transcription factor 1, beta 1 0.047
cfl2l cofilin 2, like 0.047
cd74 CD74 molecule, major histocompatibility complex, class II invariant chain 0.047
LOC100148845 neurogenin-1-like 0.046
dkk3l dickkopf homolog 3 like (Xenopus laevis) 0.046
abl1 c-abl oncogene 1, non-receptor tyrosine kinase 0.046
pcdh18b protocadherin 18b 0.046
runx1 runt-related transcription factor 1 0.045
LOC100151531 zinc finger protein Gfi-1b-like 0.044
LOC554173 abnormal spindles 0.044
gro2 groucho 2 0.044
mpx myeloid-specific peroxidase 0.044
taf3 TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated facto 0.044
zgc:110784 zgc:110784 0.043
atic 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase 0.042
fbxo32 F-box protein 32 0.042
cga glycoprotein hormones, alpha polypeptide 0.041
ildr1b immunoglobulin-like domain containing receptor 1b 0.041
coro1a coronin, actin binding protein, 1A 0.040
ddr2b discoidin domain receptor family, member 2b 0.040
men1 multiple endocrine neoplasia type 1 and multiple endocrine neoplasia I 0.040
impdh1b inosine 5'-phosphate dehydrogenase 1b 0.039
tp53 tumor protein p53 0.039
eif4e eukaryotic translation initiation factor 4e 0.039
wu:fb80a07 wu:fb80a07 0.039
zeb2b zinc finger E-box binding homeobox 2b 0.038
cldn15a claudin 15a 0.038
fzd8a frizzled homolog 8a 0.038
myh11a myosin, heavy polypeptide 11, smooth muscle a 0.038
mst1rb macrophage stimulating 1 receptor (c-met-related tyrosine kinase), b 0.037
foxi3a forkhead box I3a 0.037
slc30a7 solute carrier family 30 (zinc transporter), member 7 0.037
ntrk3b neurotrophic tyrosine kinase, receptor, type 3b 0.037
dyrk1b dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B 0.036
syk spleen tyrosine kinase 0.036
tnfsf18 tumor necrosis factor (ligand) superfamily, member 18 0.036
pacsin3 protein kinase C and casein kinase substrate in neurons 3 0.036
lmx1b.2 LIM homeobox transcription factor 1, beta 2 0.036
ccnd1 cyclin D1 0.036
gro1 groucho 1 0.036
fshb follicle stimulating hormone, beta polypeptide 0.036
fzd5 frizzled homolog 5 0.035
utrn utrophin 0.035
irx5a iroquois homeobox protein 5a 0.035
itga2b integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41B) 0.035
ptenb phosphatase and tensin homolog B (mutated in multiple advanced cancers 1) 0.035
pax5 paired box gene 5 0.035
cbfb core-binding factor, beta subunit 0.034
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.334
IL4R interleukin 4 receptor 0.311
PTPN6 protein tyrosine phosphatase, non-receptor type 6 0.273
GHR growth hormone receptor 0.203
INSR insulin receptor 0.193
PLCG1 phospholipase C, gamma 1 0.191
DDIT3 DNA-damage-inducible transcript 3 0.158
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.122
BCL10 B-cell CLL/lymphoma 10 0.105
SOCS3 suppressor of cytokine signaling 3 0.095
TAL1 T-cell acute lymphocytic leukemia 1 0.093
JAK2 Janus kinase 2 0.087
TGIF1 TGFB-induced factor homeobox 1 0.086
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.085
CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.075
DLG1 discs, large homolog 1 (Drosophila) 0.073
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 0.068
UBE2I ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) 0.066
BCL2L1 BCL2-like 1 0.065
RUNX1 runt-related transcription factor 1 0.058
EPOR erythropoietin receptor 0.052
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 0.048
CTBP1 C-terminal binding protein 1 0.046
HIPK2 homeodomain interacting protein kinase 2 0.041
SIN3A SIN3 homolog A, transcription regulator (yeast) 0.038
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 0.037
BRCA1 breast cancer 1, early onset 0.036
PTPRC protein tyrosine phosphatase, receptor type, C 0.034
NCOR2 nuclear receptor corepressor 2 0.034
WAS Wiskott-Aldrich syndrome (eczema-thrombocytopenia) 0.030
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.028
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.026
STAT5A signal transducer and activator of transcription 5A 0.026
EGFR epidermal growth factor receptor 0.025
ESR1 estrogen receptor 1 0.025
ABL1 c-abl oncogene 1, non-receptor tyrosine kinase 0.023
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.023
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein 0.022
LAT linker for activation of T cells 0.021
CALCOCO2 calcium binding and coiled-coil domain 2 0.019
NOTCH1 notch 1 0.019
TCF12 transcription factor 12 0.019
FANCD2 Fanconi anemia, complementation group D2 0.019
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced 0.018
CD22 CD22 molecule 0.018
BCAR1 breast cancer anti-estrogen resistance 1 0.017
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.017
CARD11 caspase recruitment domain family, member 11 0.016
EP300 E1A binding protein p300 0.014
BLNK B-cell linker 0.013
NGF nerve growth factor (beta polypeptide) 0.013
CD79B CD79b molecule, immunoglobulin-associated beta 0.012
CLTC clathrin, heavy chain (Hc) 0.011
TRIM33 tripartite motif containing 33 0.011
PRKCQ protein kinase C, theta 0.011
SH3BP2 SH3-domain binding protein 2 0.011
KPNA1 karyopherin alpha 1 (importin alpha 5) 0.010
PIAS1 protein inhibitor of activated STAT, 1 0.010
SOS1 son of sevenless homolog 1 (Drosophila) 0.010
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Rattus norvegicus
Name Description Probability Func Analog Organism
Cd37 CD37 molecule 0.639
RT1-Ba RT1 class II, locus Ba 0.323
Gpsm3 G-protein signaling modulator 3 (AGS3-like, C. elegans) 0.323
Fgr Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog 0.211
Cfp complement factor properdin 0.205
Plcg2 phospholipase C, gamma 2 0.190
RT1-Db1 RT1 class II, locus Db1 0.188
Cd74 Cd74 molecule, major histocompatibility complex, class II invariant chain 0.171
Wipf1 WAS/WASL interacting protein family, member 1 0.162
Lcp2 lymphocyte cytosolic protein 2 0.159
Bin2 bridging integrator 2 0.149
Igh-6 immunoglobulin heavy chain 6 0.146
Cd4 Cd4 molecule 0.141
Hck hemopoietic cell kinase 0.140
Ptpn18 protein tyrosine phosphatase, non-receptor type 18 0.139
Pld4 phospholipase D family, member 4 0.137
Stk10 serine/threonine kinase 10 0.132
Pdzd2 PDZ domain containing 2 0.124
Arhgap4 Rho GTPase activating protein 4 0.120
Rac2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) 0.114
Rap2b RAP2B, member of RAS oncogene family 0.107
Cyp4a2 cytochrome P450, family 4, subfamily a, polypeptide 2 0.104
Prrx1 paired related homeobox 1 0.104
Ehf ets homologous factor 0.103
Map4k1 mitogen activated protein kinase kinase kinase kinase 1 0.097
Runx1 runt-related transcription factor 1 0.090
Apbb1ip amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein 0.089
Pecam1 platelet/endothelial cell adhesion molecule 1 0.089
Acacb acetyl-Coenzyme A carboxylase beta 0.088
Acap1 ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 0.087
Ly86 lymphocyte antigen 86 0.085
Dock8 dedicator of cytokinesis 8 0.082
Met met proto-oncogene 0.079
Ctse cathepsin E 0.079
Pik3cd phosphoinositide-3-kinase, catalytic, delta polypeptide 0.079
Utrn utrophin 0.074
Irs3 insulin receptor substrate 3 0.072
Laptm5 lysosomal protein transmembrane 5 0.071
Arhgef11 Rho guanine nucleotide exchange factor (GEF) 11 0.070
Klhl6 kelch-like 6 (Drosophila) 0.069
Lyn v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.066
Inpp5d inositol polyphosphate-5-phosphatase D 0.065
Rps6ka1 ribosomal protein S6 kinase polypeptide 1 0.065
P2rx1 purinergic receptor P2X, ligand-gated ion channel, 1 0.065
Vegfa vascular endothelial growth factor A 0.065
Ngfr nerve growth factor receptor (TNFR superfamily, member 16) 0.064
Lamc1 laminin, gamma 1 0.061
Kcnn4 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4 0.060
Nos3 nitric oxide synthase 3, endothelial cell 0.058
Vav1 vav 1 guanine nucleotide exchange factor 0.057
Fmnl1 formin-like 1 0.056
Lphn3 latrophilin 3 0.056
Lcp1 lymphocyte cytosolic protein 1 0.055
Cdcp1 CUB domain containing protein 1 0.053
Clcn7 chloride channel 7 0.053
Hmha1 histocompatibility (minor) HA-1 0.052
Tap2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) 0.052
Rassf5 Ras association (RalGDS/AF-6) domain family member 5 0.051
Nup205 nucleoporin 205 0.051
Adcy4 adenylate cyclase 4 0.050
Irs1 insulin receptor substrate 1 0.050
Podxl podocalyxin-like 0.050
Alox5 arachidonate 5-lipoxygenase 0.049
Tgfb1 transforming growth factor, beta 1 0.049
Nek9 NIMA (never in mitosis gene a)- related kinase 9 0.049
Ddr2 discoidin domain receptor tyrosine kinase 2 0.049
Cxcr4 chemokine (C-X-C motif) receptor 4 0.049
Testin testin gene 0.048
Gabrr2 gamma-aminobutyric acid (GABA) receptor, rho 2 0.048
Gmip Gem-interacting protein 0.046
Snap29 synaptosomal-associated protein 29 0.046
Il1r1 interleukin 1 receptor, type I 0.046
Sla src-like adaptor 0.046
Arhgap25 Rho GTPase activating protein 25 0.045
Foxs1 forkhead box S1 0.045
Egfl7 EGF-like-domain, multiple 7 0.045
Slit3 slit homolog 3 (Drosophila) 0.045
Twist1 twist homolog 1 (Drosophila) 0.045
Il6st interleukin 6 signal transducer 0.045
Abcb4 ATP-binding cassette, subfamily B (MDR/TAP), member 4 0.044
Nacc1 nucleus accumbens associated 1, BEN and BTB (POZ) domain containing 0.044
Tcrb T-cell receptor beta chain 0.044
Itgb4 integrin, beta 4 0.044
Muc1 mucin 1, cell surface associated 0.043
Tgfbr2 transforming growth factor, beta receptor II 0.042
Ptpre protein tyrosine phosphatase, receptor type, E 0.042
Casp3 caspase 3 0.042
Prdm4 PR domain containing 4 0.041
Igfbp5 insulin-like growth factor binding protein 5 0.041
Cd97 CD97 molecule 0.041
Nras neuroblastoma ras oncogene 0.041
Pstpip1 proline-serine-threonine phosphatase-interacting protein 1 0.041
Plxnd1 plexin D1 0.040
Creb1 cAMP responsive element binding protein 1 0.039
Hsd17b1 hydroxysteroid (17-beta) dehydrogenase 1 0.039
Slco2b1 solute carrier organic anion transporter family, member 2b1 0.038
Hspb2 heat shock protein beta 2 0.037
Prss2 protease, serine, 2 0.037
Prkcd protein kinase C, delta 0.037
LOC100362331 rCG59612-like 0.037
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism