The network for 'regulation of protein catabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of protein catabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.

Mus musculus
Name Description Probability Func Analog Organism
Ctnnb1 catenin (cadherin associated protein), beta 1 0.998
Trp53 transformation related protein 53 0.995
Axin1 axin 1 0.939
Per1 period homolog 1 (Drosophila) 0.836
Mdm2 transformed mouse 3T3 cell double minute 2 0.762
Gsk3b glycogen synthase kinase 3 beta 0.667
Ptgs2 prostaglandin-endoperoxide synthase 2 0.645
Pten phosphatase and tensin homolog 0.613
Cyld cylindromatosis (turban tumor syndrome) 0.589
Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) 0.566
Hif1a hypoxia inducible factor 1, alpha subunit 0.544
Hprt hypoxanthine guanine phosphoribosyl transferase 0.540
Vcp valosin containing protein 0.516
Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.475
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.466
Nos3 nitric oxide synthase 3, endothelial cell 0.439
Apoe apolipoprotein E 0.439
Rac1 RAS-related C3 botulinum substrate 1 0.391
Traf6 TNF receptor-associated factor 6 0.389
Tgfb2 transforming growth factor, beta 2 0.384
Smad6 MAD homolog 6 (Drosophila) 0.346
Skil SKI-like 0.336
Nf1 neurofibromatosis 1 0.331
Cbl Casitas B-lineage lymphoma 0.329
Ube2d3 ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast) 0.323
Cry2 cryptochrome 2 (photolyase-like) 0.319
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.304
Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 0.302
Grb2 growth factor receptor bound protein 2 0.294
Tgfbr2 transforming growth factor, beta receptor II 0.293
Notch2 Notch gene homolog 2 (Drosophila) 0.289
Mdm4 transformed mouse 3T3 cell double minute 4 0.284
Stat3 signal transducer and activator of transcription 3 0.274
Pkd1 polycystic kidney disease 1 homolog 0.265
Prkcd protein kinase C, delta 0.263
Ncoa3 nuclear receptor coactivator 3 0.260
Cdc42 cell division cycle 42 homolog (S. cerevisiae) 0.250
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.248
Ap2a1 adaptor protein complex AP-2, alpha 1 subunit 0.247
Plcg2 phospholipase C, gamma 2 0.241
Smurf2 SMAD specific E3 ubiquitin protein ligase 2 0.237
Dvl1 dishevelled, dsh homolog 1 (Drosophila) 0.235
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.234
Prkce protein kinase C, epsilon 0.230
Adam17 a disintegrin and metallopeptidase domain 17 0.215
Fbn1 fibrillin 1 0.205
Egfr epidermal growth factor receptor 0.203
Cdc20 cell division cycle 20 homolog (S. cerevisiae) 0.200
Ppp2r1a protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform 0.198
Igh immunoglobulin heavy chain complex 0.197
Igf1r insulin-like growth factor I receptor 0.190
Cebpa CCAAT/enhancer binding protein (C/EBP), alpha 0.186
T brachyury 0.184
Efnb2 ephrin B2 0.184
Bub1b budding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae) 0.178
Smad7 MAD homolog 7 (Drosophila) 0.176
Csf1 colony stimulating factor 1 (macrophage) 0.176
Stk11 serine/threonine kinase 11 0.175
Htt huntingtin 0.171
Trim30a tripartite motif-containing 30A 0.164
Adam15 a disintegrin and metallopeptidase domain 15 (metargidin) 0.162
Rbpj recombination signal binding protein for immunoglobulin kappa J region 0.161
Kpna3 karyopherin (importin) alpha 3 0.152
Nr6a1 nuclear receptor subfamily 6, group A, member 1 0.149
Socs1 suppressor of cytokine signaling 1 0.147
Rnf111 ring finger 111 0.147
Akt1 thymoma viral proto-oncogene 1 0.146
Prnp prion protein 0.146
Mbd3 methyl-CpG binding domain protein 3 0.144
Wnt7b wingless-related MMTV integration site 7B 0.143
Fgfr2 fibroblast growth factor receptor 2 0.143
Atf4 activating transcription factor 4 0.141
Prlr prolactin receptor 0.141
Snai1 snail homolog 1 (Drosophila) 0.140
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.134
Fgf8 fibroblast growth factor 8 0.134
Blnk B-cell linker 0.134
Setdb1 SET domain, bifurcated 1 0.133
Nbn nibrin 0.132
Ppp1cc protein phosphatase 1, catalytic subunit, gamma isoform 0.132
Erbb3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.132
Dab1 disabled homolog 1 (Drosophila) 0.132
Gfra1 glial cell line derived neurotrophic factor family receptor alpha 1 0.131
Ywhag tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 0.128
Ube2n ubiquitin-conjugating enzyme E2N 0.127
Eif2s1 eukaryotic translation initiation factor 2, subunit 1 alpha 0.126
Hes1 hairy and enhancer of split 1 (Drosophila) 0.125
Pik3ca phosphatidylinositol 3-kinase, catalytic, alpha polypeptide 0.125
Ooep oocyte expressed protein homolog (dog) 0.125
Map3k7 mitogen-activated protein kinase kinase kinase 7 0.125
Apc adenomatosis polyposis coli 0.124
Rarg retinoic acid receptor, gamma 0.123
Cops2 COP9 (constitutive photomorphogenic) homolog, subunit 2 (Arabidopsis thaliana) 0.121
Col1a1 collagen, type I, alpha 1 0.120
Glrx3 glutaredoxin 3 0.119
2310014H01Rik RIKEN cDNA 2310014H01 gene 0.118
Il1a interleukin 1 alpha 0.118
Dok1 docking protein 1 0.117
Mapk8ip1 mitogen-activated protein kinase 8 interacting protein 1 0.116
Ywhaq tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide 0.116
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
hgrs-1 Protein HGRS-1 0.257
egl-18 Protein EGL-18 0.223
R11A8.7 Protein R11A8.7 0.158
uaf-1 Protein UAF-1 0.151
lag-1 Protein LAG-1 0.147
daf-4 Protein DAF-4 0.135
bar-1 Protein BAR-1 0.118
sli-1 Protein SLI-1 0.093
daf-14 Protein DAF-14 0.091
skr-1 Protein SKR-1 0.088
imb-2 Protein IMB-2 0.084
madf-5 Protein MADF-5 0.083
spk-1 Protein SPK-1 0.082
daf-1 Protein DAF-1 0.075
cul-1 Protein CUL-1 0.068
rpn-7 Protein RPN-7 0.062
pcn-1 Protein PCN-1 0.060
ubq-1 Protein UBQ-1 0.055
let-502 Protein LET-502 0.053
ubc-3 Protein UBC-3 0.053
cam-1 Protein CAM-1 0.051
zyg-9 Protein ZYG-9 0.050
sel-12 Protein SEL-12 0.050
stam-1 Protein STAM-1 0.049
eif-3.B Protein EIF-3.B 0.049
klp-16 Protein KLP-16 0.048
his-6 Protein HIS-6 0.047
pap-1 Protein PAP-1 0.046
ima-3 Protein IMA-3 0.044
T22F3.2 Protein T22F3.2 0.044
pry-1 Protein PRY-1 0.042
rnr-1 Protein RNR-1 0.038
mex-5 Protein MEX-5 0.037
pqn-87 Protein PQN-87 0.035
dpy-31 Protein DPY-31 0.035
F25B3.6 Protein F25B3.6 0.034
htz-1 Protein HTZ-1 0.033
mex-3 Protein MEX-3 0.033
his-42 Protein HIS-42 0.033
T08A11.2 Protein T08A11.2 0.033
rpt-2 Protein RPT-2 0.033
vab-1 Protein VAB-1 0.032
CELE_C25A1.4 Protein C25A1.4 0.032
mom-2 Protein MOM-2 0.032
pup-2 Protein PUP-2 0.032
hpo-10 Protein HPO-10 0.031
eor-2 Protein EOR-2 0.030
F07A11.2 Protein F07A11.2 0.030
sel-2 Protein SEL-2 0.029
ect-2 Protein ECT-2 0.026
cdc-48.2 Protein CDC-48.2 0.025
taf-5 Protein TAF-5 0.025
pkc-3 Protein PKC-3 0.024
air-1 Protein AIR-1 0.024
cul-3 Protein CUL-3 0.023
eef-1A.1 Protein EEF-1A.1 0.023
gly-20 Protein GLY-20 0.023
cyb-1 Protein CYB-1 0.023
rbg-1 Protein RBG-1 0.022
hcp-2 Protein HCP-2 0.022
cki-2 Protein CKI-2 0.022
K10D6.4 Protein K10D6.4 0.022
lin-25 Protein LIN-25 0.021
itr-1 Protein ITR-1 0.021
C05C10.5 Protein C05C10.5 0.020
cnt-2 Protein CNT-2 0.020
par-5 Protein PAR-5 0.020
rga-1 Protein RGA-1 0.019
W09D10.1 Protein W09D10.1 0.019
dsh-2 Protein DSH-2 0.019
csnk-1 Protein CSNK-1 0.019
Y54E5A.7 Protein Y54E5A.7 0.018
trcs-2 Protein TRCS-2 0.018
tdc-1 Protein TDC-1 0.018
chd-7 Protein CHD-7 0.018
ceh-44 Protein CEH-44 0.017
csn-3 Protein CSN-3 0.017
tba-2 Protein TBA-2 0.017
pac-1 Protein PAC-1 0.016
egl-8 Protein EGL-8 0.016
kin-10 Protein KIN-10 0.016
his-45 Protein HIS-45 0.016
alx-1 Protein ALX-1 0.016
T12B3.4 Protein T12B3.4 0.016
mrg-1 Protein MRG-1 0.016
CELE_Y69A2AR.16 Protein Y69A2AR.16 0.015
hcp-6 Protein HCP-6 0.015
C09F5.1 Protein C09F5.1 0.015
sma-6 Protein SMA-6 0.015
bmk-1 Protein BMK-1 0.015
zfp-1 Protein ZFP-1 0.015
cyk-4 Protein CYK-4 0.015
rab-5 Protein RAB-5 0.015
ceh-39 Protein CEH-39 0.015
mbk-2 Protein MBK-2 0.015
rpn-2 Protein RPN-2 0.014
C49H3.9 Protein C49H3.9 0.014
T22C1.1 Protein T22C1.1 0.014
daf-3 Protein DAF-3 0.014
math-33 Protein MATH-33 0.014
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Danio rerio
Name Description Probability Func Analog Organism
gsc goosecoid 0.744
epha4a eph receptor A4a 0.643
sox32 SRY-box containing gene 32 0.542
usp5 ubiquitin specific protease 5 0.486
chd chordin 0.471
kif23 kinesin family member 23 0.435
ccnb1 cyclin B1 0.403
bmp2b bone morphogenetic protein 2b 0.378
smad5 MAD homolog 5 (Drosophila) 0.345
tp53 tumor protein p53 0.331
ahr2 aryl hydrocarbon receptor 2 0.328
pcdh8 protocadherin 8 0.290
gro2 groucho 2 0.278
psmd6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 0.278
sox9a SRY-box containing gene 9a 0.275
acvr1b activin A receptor, type IB 0.270
melk maternal embryonic leucine zipper kinase 0.239
polr2b polymerase (RNA) II (DNA directed) polypeptide B 0.223
zgc:64114 zgc:64114 0.220
szl sizzled 0.209
orc1 origin recognition complex, subunit 1 0.208
gna13b guanine nucleotide binding protein (G protein), alpha 13b 0.206
barx1 BarH-like homeobox 1 0.203
tp53bp2 tumor protein p53 binding protein, 2 0.202
wnt11 wingless-type MMTV integration site family, member 11 0.198
hspa4b heat shock protein 4b 0.198
bon bonnie and clyde 0.194
dlgap5 discs, large (Drosophila) homolog-associated protein 5 0.192
tacc3 transforming, acidic coiled-coil containing protein 3 0.192
arhgdia Rho GDP dissociation inhibitor (GDI) alpha 0.191
sox9b SRY-box containing gene 9b 0.188
mapk3 mitogen-activated protein kinase 3 0.180
eif3s10 eukaryotic translation initiation factor 3, subunit 10 (theta) 0.179
crabp2a cellular retinoic acid binding protein 2, a 0.175
rxrba retinoid x receptor, beta a 0.171
bmp1a bone morphogenetic protein 1a 0.164
fstl1b follistatin-like 1b 0.164
aurka aurora kinase A 0.161
cyp26c1 cytochrome P450, family 26, subfamily C, polypeptide 1 0.161
plk1 polo-like kinase 1 (Drosophila) 0.160
zgc:92661 zgc:92661 0.158
ptch2 patched 2 0.157
chd7 chromodomain helicase DNA binding protein 7 0.157
sp2 sp2 transcription factor 0.155
cdh1 cadherin 1, epithelial 0.150
dnaja2l DnaJ (Hsp40) homolog, subfamily A, member 2, like 0.149
s1pr2 sphingosine-1-phosphate receptor 2 0.148
brd3a bromodomain containing 3a 0.147
usp4 ubiquitin specific protease 4 (proto-oncogene) 0.147
ggnbp2 gametogenetin binding protein 2 0.146
si:ch211-69g19.2 si:ch211-69g19.2 0.146
extl3 exostoses (multiple)-like 3 0.145
bactin2 bactin2 0.142
dact2 dapper homolog 2, antagonist of beta-catenin (xenopus) 0.142
zgc:158603 zgc:158603 0.141
ihha Indian hedgehog homolog a 0.141
gstp1 glutathione S-transferase pi 0.140
mcl1b myeloid cell leukemia sequence 1b 0.140
pold1 polymerase (DNA directed), delta 1, catalytic subunit 0.139
foxo3b forkhead box O3b 0.139
pxn paxillin 0.136
ccnb2 cyclin B2 0.136
ywhabb tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide b 0.136
oprm1 opioid receptor, mu 1 0.133
capn2b calpain 2, (m/II) large subunit b 0.133
fras1 Fraser syndrome 1 0.133
csnk1g2a casein kinase 1, gamma 2a 0.131
elovl2 elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 2 0.130
pfn2l profilin 2 like 0.126
ncaph non-SMC condensin I complex, subunit H 0.125
LOC799612 prolactin 2 0.124
rqcd1 RCD1 required for cell differentiation1 homolog (S. pombe) 0.124
aurkb aurora kinase B 0.121
uxs1 UDP-glucuronic acid decarboxylase 1 0.119
tollip toll interacting protein 0.117
mdm2 transformed 3T3 cell double minute 2 homolog (mouse) 0.117
col2a1a collagen type II, alpha-1a 0.117
ck2b casein kinase 2 beta 0.117
wu:fv91b12 wu:fv91b12 0.117
mapk7 mitogen-activated protein kinase 7 0.117
zgc:136773 zgc:136773 0.116
arf2 ADP-ribosylation factor 2 0.116
bmpr1aa bone morphogenetic protein receptor, type 1aa 0.115
ctnnb1 catenin (cadherin-associated protein), beta 1 0.115
psmd12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 0.115
capns1b calpain, small subunit 1 b 0.114
igf1rb insulin-like growth factor 1b receptor 0.113
hmcn1 hemicentin 1 0.113
hspg2 heparan sulfate proteoglycan 2 0.112
kpna2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) 0.112
mmp2 matrix metalloproteinase 2 0.112
cdc20 cell division cycle 20 homolog 0.111
zgc:55813 zgc:55813 0.111
gro1 groucho 1 0.109
psmd11b proteasome (prosome, macropain) 216S subunit, non-ATPase, 11b 0.109
rbb4l retinoblastoma binding protein 4, like 0.108
pbrm1l polybromo 1, like 0.108
wnt4a wingless-type MMTV integration site family, member 4a 0.107
ntla no tail a 0.105
nrg2a neuregulin 2a 0.105
Loading network...
Drosophila melanogaster
Name Description Probability Func Analog Organism
Ras85D Ras oncogene at 85D 0.943
Mad Mothers against dpp 0.497
smo smoothened 0.446
CycB Cyclin B 0.421
N Notch 0.358
Vap-33-1 CG5014 gene product from transcript CG5014-RB 0.355
Akt1 CG4006 gene product from transcript CG4006-RA 0.261
brm brahma 0.239
sax saxophone 0.238
shg shotgun 0.221
Su(var)205 Suppressor of variegation 205 0.220
Iswi Imitation SWI 0.202
CycB3 Cyclin B3 0.202
UbcD2 Ubiquitin conjugating enzyme 2 0.198
SF2 CG6987 gene product from transcript CG6987-RA 0.176
Stam Signal transducing adaptor molecule 0.155
brat brain tumor 0.142
Cul-4 Cullin-4 0.140
gwl greatwall 0.138
CSN5 COP9 complex homolog subunit 5 0.135
tefu telomere fusion 0.135
ci cubitus interruptus 0.131
Cul-5 Cullin-5 0.122
fzy fizzy 0.120
Stat92E Signal-transducer and activator of transcription protein at 92E 0.118
asl asterless 0.113
Pten CG5671 gene product from transcript CG5671-RB 0.112
arm armadillo 0.106
Pi3K92E CG4141 gene product from transcript CG4141-RB 0.101
cdc2 CG5363 gene product from transcript CG5363-RA 0.099
gbb glass bottom boat 0.096
mts microtubule star 0.096
hpo hippo 0.095
ncd non-claret disjunctional 0.095
Doa Darkener of apricot 0.089
CG11347 CG11347 gene product from transcript CG11347-RE 0.089
Fcp1 CG12252 gene product from transcript CG12252-RA 0.085
Pka-C1 cAMP-dependent protein kinase 1 0.079
Rpt3 CG16916 gene product from transcript CG16916-RA 0.079
polo CG12306 gene product from transcript CG12306-RA 0.078
tsr twinstar 0.076
Pp2A-29B Protein phosphatase 2A at 29B 0.076
CycE Cyclin E 0.073
CycA Cyclin A 0.073
Clk Clock 0.073
CG9986 CG9986 gene product from transcript CG9986-RA 0.073
morgue modifier of rpr and grim, ubiquitously expressed 0.072
CSN3 COP9 complex homolog subunit 3 0.071
Taz Tafazzin 0.065
Myb Myb oncogene-like 0.064
ptc patched 0.063
Cap-G CG34438 gene product from transcript CG34438-RF 0.063
fwd four wheel drive 0.062
Ras64B Ras oncogene at 64B 0.062
dpp decapentaplegic 0.061
EcR Ecdysone receptor 0.061
borr borealin-related 0.061
ovo CG6824 gene product from transcript CG6824-RE 0.061
cdc2c CG10498 gene product from transcript CG10498-RC 0.061
rl rolled 0.060
CG30382 CG30382 gene product from transcript CG30382-RB 0.058
Bap55 Brahma associated protein 55kD 0.057
nej nejire 0.057
Dref DNA replication-related element factor 0.056
twin CG31137 gene product from transcript CG31137-RB 0.056
Ube3a Ubiquitin protein ligase E3A 0.055
zfh2 Zn finger homeodomain 2 0.054
Cul-2 Cullin-2 0.054
baz bazooka 0.053
dco discs overgrown 0.053
prod proliferation disrupter 0.052
Mcm10 Sensitized chromosome inheritance modifier 19 0.051
vg vestigial 0.050
p53 CG33336 gene product from transcript CG33336-RB 0.049
Rpn6 Proteasome p44.5 subunit 0.049
CG2924 CG2924 gene product from transcript CG2924-RA 0.049
CycK Cyclin K 0.049
Smox Smad on X 0.048
stan starry night 0.048
Egfr Epidermal growth factor receptor 0.047
cdc23 CG2508 gene product from transcript CG2508-RA 0.047
flfl falafel 0.046
cal1 chromosome alignment defect 1 0.045
Smg6 CG6369 gene product from transcript CG6369-RA 0.045
Rpn3 Regulatory particle non-ATPase 3 0.045
Rpn9 CG10230 gene product from transcript CG10230-RB 0.045
Nup153 Nucleoporin 153 0.044
tws twins 0.044
lds lodestar 0.044
dap dacapo 0.043
cdc16 CG6759 gene product from transcript CG6759-RA 0.042
CG17912 CG17912 gene product from transcript CG17912-RB 0.042
alphaTub67C alpha-Tubulin at 67C 0.041
RYBP Ring and YY1 Binding Protein 0.041
Dl Delta 0.039
fs(1)Ya female sterile (1) Young arrest 0.039
CG5555 CG5555 gene product from transcript CG5555-RA 0.039
NiPp1 Nuclear inhibitor of Protein phosphatase 1 0.038
plu plutonium 0.038
p47 CG11139 gene product from transcript CG11139-RA 0.038
Loading network...
Homo sapiens
Name Description Probability Func Analog Organism
UBC ubiquitin C 0.999
SMAD3 SMAD family member 3 0.980
CREBBP CREB binding protein 0.979
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.947
NCF1 neutrophil cytosolic factor 1 0.922
RB1 retinoblastoma 1 0.918
SMAD7 SMAD family member 7 0.909
UBQLN1 ubiquilin 1 0.902
CUL2 cullin 2 0.901
RNF11 ring finger protein 11 0.888
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.885
BUB1B budding uninhibited by benzimidazoles 1 homolog beta (yeast) 0.883
TP53 tumor protein p53 0.871
TRADD TNFRSF1A-associated via death domain 0.870
GGA1 golgi-associated, gamma adaptin ear containing, ARF binding protein 1 0.866
ADAM15 ADAM metallopeptidase domain 15 0.862
FASLG Fas ligand (TNF superfamily, member 6) 0.849
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.770
TCEB1 transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C) 0.767
CDK2 cyclin-dependent kinase 2 0.757
SOCS1 suppressor of cytokine signaling 1 0.706
DLG4 discs, large homolog 4 (Drosophila) 0.699
VHL von Hippel-Lindau tumor suppressor 0.698
DAXX death-domain associated protein 0.685
TRAF6 TNF receptor-associated factor 6 0.685
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.661
PSEN1 presenilin 1 0.654
PML promyelocytic leukemia 0.653
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 0.638
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.602
CDC27 cell division cycle 27 homolog (S. cerevisiae) 0.595
RBX1 ring-box 1, E3 ubiquitin protein ligase 0.590
IL1R1 interleukin 1 receptor, type I 0.590
ITCH itchy E3 ubiquitin protein ligase homolog (mouse) 0.585
SMAD1 SMAD family member 1 0.583
PIAS4 protein inhibitor of activated STAT, 4 0.575
FYN FYN oncogene related to SRC, FGR, YES 0.565
TRAF5 TNF receptor-associated factor 5 0.563
IGF2R insulin-like growth factor 2 receptor 0.553
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 0.549
GSK3B glycogen synthase kinase 3 beta 0.544
SMAD2 SMAD family member 2 0.534
CCNA2 cyclin A2 0.532
SKP2 S-phase kinase-associated protein 2 (p45) 0.522
PXN paxillin 0.520
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.514
TCEB2 transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B) 0.485
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 0.484
PSEN2 presenilin 2 (Alzheimer disease 4) 0.479
AXIN1 axin 1 0.478
COPS5 COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis) 0.471
SMAD4 SMAD family member 4 0.462
DVL3 dishevelled, dsh homolog 3 (Drosophila) 0.458
SNX9 sorting nexin 9 0.450
DCUN1D1 DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae) 0.446
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme 0.445
SQSTM1 sequestosome 1 0.437
MYC v-myc myelocytomatosis viral oncogene homolog (avian) 0.430
SUMO3 SMT3 suppressor of mif two 3 homolog 3 (S. cerevisiae) 0.426
MYD88 myeloid differentiation primary response gene (88) 0.424
DNM1 dynamin 1 0.420
NCF2 neutrophil cytosolic factor 2 0.412
ARIH2 ariadne homolog 2 (Drosophila) 0.411
SMAD5 SMAD family member 5 0.409
HIF1AN hypoxia inducible factor 1, alpha subunit inhibitor 0.408
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.396
DVL1 dishevelled, dsh homolog 1 (Drosophila) 0.394
CSNK1E casein kinase 1, epsilon 0.392
APC adenomatous polyposis coli 0.387
CENPJ centromere protein J 0.378
APP amyloid beta (A4) precursor protein 0.375
SKP1 S-phase kinase-associated protein 1 0.371
BRCA1 breast cancer 1, early onset 0.370
EPAS1 endothelial PAS domain protein 1 0.368
GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2 0.365
RAD23A RAD23 homolog A (S. cerevisiae) 0.353
CCNB1 cyclin B1 0.346
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.345
TADA3 transcriptional adaptor 3 0.335
TRAF3 TNF receptor-associated factor 3 0.323
CUL5 cullin 5 0.323
BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast) 0.318
OTUB1 OTU domain, ubiquitin aldehyde binding 1 0.315
CDC42 cell division cycle 42 (GTP binding protein, 25kDa) 0.311
CUL1 cullin 1 0.310
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) 0.306
E2F1 E2F transcription factor 1 0.297
RAD23B RAD23 homolog B (S. cerevisiae) 0.295
PPP2R5B protein phosphatase 2, regulatory subunit B', beta 0.294
UBE2A ubiquitin-conjugating enzyme E2A (RAD6 homolog) 0.289
MAPT microtubule-associated protein tau 0.286
CHEK1 CHK1 checkpoint homolog (S. pombe) 0.279
UBE2N ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast) 0.274
PSMC6 proteasome (prosome, macropain) 26S subunit, ATPase, 6 0.271
ANAPC7 anaphase promoting complex subunit 7 0.271
EP300 E1A binding protein p300 0.268
ANAPC11 anaphase promoting complex subunit 11 0.266
BRAF v-raf murine sarcoma viral oncogene homolog B1 0.266
MED15 mediator complex subunit 15 0.264
CBX5 chromobox homolog 5 0.264
Loading network...
Rattus norvegicus
Name Description Probability Func Analog Organism
Dnaja2 DnaJ (Hsp40) homolog, subfamily A, member 2 0.414
Ube2g1 ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast) 0.324
Phkg1 phosphorylase kinase, gamma 1 0.128
Eef2 eukaryotic translation elongation factor 2 0.125
Gja1 gap junction protein, alpha 1 0.118
Magi2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.114
Hprt1 hypoxanthine phosphoribosyltransferase 1 0.083
Nudt3 nudix (nucleoside diphosphate linked moiety X)-type motif 3 0.072
Mapre1 microtubule-associated protein, RP/EB family, member 1 0.067
Cd14 CD14 molecule 0.060
Ccnb1 cyclin B1 0.052
Cnbp CCHC-type zinc finger, nucleic acid binding protein 0.044
Ppm1b protein phosphatase 1B, magnesium dependent, beta isoform 0.035
Eif4a2 eukaryotic translation initiation factor 4A, isoform 2 0.035
Mmp14 matrix metallopeptidase 14 (membrane-inserted) 0.032
Ppp2ca protein phosphatase 2, catalytic subunit, alpha isoform 0.030
Vapa VAMP (vesicle-associated membrane protein)-associated protein A 0.030
Psmc5 proteasome (prosome, macropain) 26S subunit, ATPase, 5 0.029
Vcp valosin-containing protein 0.029
Sstr3 somatostatin receptor 3 0.026
Psmd2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 0.026
Rap1b RAP1B, member of RAS oncogene family 0.025
Prkca protein kinase C, alpha 0.025
LOC100310874 antisense RNA overlapping MCH 0.025
Cops2 COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis) 0.025
Psmc1 proteasome (prosome, macropain) 26S subunit, ATPase, 1 0.024
Psmd7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 0.023
Nploc4 nuclear protein localization 4 homolog (S. cerevisiae) 0.023
Dlg4 discs, large homolog 4 (Drosophila) 0.021
Grasp GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein 0.021
Sumo1 SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae) 0.021
Smad7 SMAD family member 7 0.021
Ppp1cb protein phosphatase 1, catalytic subunit, beta isoform 0.021
Usf2 upstream transcription factor 2, c-fos interacting 0.021
Ptges3 prostaglandin E synthase 3 (cytosolic) 0.020
Ntrk1 neurotrophic tyrosine kinase, receptor, type 1 0.020
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.020
Usp47 ubiquitin specific peptidase 47 0.020
Cdh22 cadherin 22 0.019
Eif2c2 eukaryotic translation initiation factor 2C, 2 0.019
Rpn2 ribophorin II 0.018
Shank3 SH3 and multiple ankyrin repeat domains 3 0.018
Gfi1 growth factor independent 1 transcription repressor 0.018
Pfkfb3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.018
Psmc2 proteasome (prosome, macropain) 26S subunit, ATPase 2 0.018
Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 0.017
Psmc3 proteasome (prosome, macropain) 26S subunit, ATPase 3 0.017
Plk1 polo-like kinase 1 (Drosophila) 0.017
Ipo5 importin 5 0.016
Cx3cl1 chemokine (C-X3-C motif) ligand 1 0.016
Camk2a calcium/calmodulin-dependent protein kinase II alpha 0.016
Taok1 TAO kinase 1 0.016
Nsfl1c NSFL1 (p97) cofactor (p47) 0.016
Tpm4 tropomyosin 4 0.016
Rasgrp1 RAS guanyl releasing protein 1 (calcium and DAG-regulated) 0.016
Ppp1r12a protein phosphatase 1, regulatory (inhibitor) subunit 12A 0.016
Sgta small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha 0.015
Fdxr ferredoxin reductase 0.015
Prp15 proline-rich protein 15 0.015
Jak1 Janus kinase 1 0.015
Pgr progesterone receptor 0.015
Pink1 PTEN induced putative kinase 1 0.015
Rpl28 ribosomal protein L28 0.015
Dpp9 dipeptidyl peptidase 9 0.015
March8 membrane-associated ring finger (C3HC4) 8 0.015
Ppp2r1a protein phosphatase 2 (formerly 2A), regulatory subunit A, alpha isoform 0.015
Pde3a phosphodiesterase 3A, cGMP inhibited 0.015
Ywhaq tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide 0.015
Snap29 synaptosomal-associated protein 29 0.014
Il1a interleukin 1 alpha 0.014
App amyloid beta (A4) precursor protein 0.014
Hoxb7 homeo box B7 0.014
St3gal3 ST3 beta-galactoside alpha-2,3-sialyltransferase 3 0.014
Il1r2 interleukin 1 receptor, type II 0.014
Ppp1r2 protein phosphatase 1, regulatory (inhibitor) subunit 2 0.014
Pdcd10 programmed cell death 10 0.014
Cxcl6 chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2) 0.014
Psmd3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 0.014
Rbbp7 retinoblastoma binding protein 7 0.014
Tomm20 translocase of outer mitochondrial membrane 20 homolog (yeast) 0.013
Cenpn centromere protein N 0.013
Top2a topoisomerase (DNA) II alpha 0.013
Adrbk1 adrenergic, beta, receptor kinase 1 0.013
Myo1b myosin Ib 0.013
Il6 interleukin 6 0.013
Snx6 sorting nexin 6 0.013
Prc1 protein regulator of cytokinesis 1 0.013
Dlgap5 discs, large (Drosophila) homolog-associated protein 5 0.012
Elavl1 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R) 0.012
Vcan versican 0.012
Zfp37 zinc finger protein 37 0.012
Ccl2 chemokine (C-C motif) ligand 2 0.012
Anxa1 annexin A1 0.012
Birc5 baculoviral IAP repeat-containing 5 0.012
S100a8 S100 calcium binding protein A8 0.012
Rbm8a RNA binding motif protein 8A 0.012
Epb4.1l2 erythrocyte membrane protein band 4.1-like 2 0.012
Ccr1 chemokine (C-C motif) receptor 1 0.012
Gja5 gap junction protein, alpha 5 0.012
Ndst1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 0.012
Loading network...
Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
CDC55 Cdc55p 0.851
PPH21 Pph21p 0.660
MAD2 Mad2p 0.637
YBP2 Ybp2p 0.538
CKA1 Cka1p 0.454
RPT6 Rpt6p 0.425
CDC26 Cdc26p 0.419
CSE4 Cse4p 0.387
CDC16 Cdc16p 0.363
APP1 App1p 0.321
CDC20 Cdc20p 0.312
GIP2 Gip2p 0.278
CTF13 Ctf13p 0.246
MLC1 Mlc1p 0.241
UBR1 Ubr1p 0.234
KSP1 Ksp1p 0.228
BUB1 Bub1p 0.226
RHO1 Rho1p 0.222
RPN11 Rpn11p 0.198
CDC23 Cdc23p 0.193
PSH1 Psh1p 0.187
PPZ1 Ppz1p 0.177
BMH1 Bmh1p 0.173
CHL4 Chl4p 0.171
AFT1 Aft1p 0.170
DAM1 Dam1p 0.169
SLK19 Slk19p 0.154
MND2 Mnd2p 0.151
HHF2 Hhf2p 0.138
CLA4 Cla4p 0.137
CMK1 Cmk1p 0.136
SDS22 Sds22p 0.133
CDC27 Cdc27p 0.132
HTA1 Hta1p 0.131
CTF3 Ctf3p 0.123
HHO1 Hho1p 0.123
RPN3 Rpn3p 0.121
APC2 Apc2p 0.118
YJL163C hypothetical protein 0.111
DCC1 Dcc1p 0.105
YPI1 Ypi1p 0.104
RPN7 Rpn7p 0.103
MTW1 Mtw1p 0.102
KIP1 Kip1p 0.099
DOC1 Doc1p 0.096
HHT1 Hht1p 0.095
UBC13 Ubc13p 0.094
KIN1 Kin1p 0.094
TIP41 Tip41p 0.088
YAP1 Yap1p 0.086
GIC1 Gic1p 0.085
MAD3 Mad3p 0.084
ECO1 Eco1p 0.084
PPH22 Pph22p 0.084
CIN8 Cin8p 0.083
ATG20 Atg20p 0.083
RTS1 Rts1p 0.082
TOM1 Tom1p 0.081
IRC15 Irc15p 0.081
MET4 Met4p 0.079
ECM29 Ecm29p 0.078
RPN1 Rpn1p 0.077
CKB1 Ckb1p 0.077
IML3 Iml3p 0.075
CLB6 Clb6p 0.074
RPN9 Rpn9p 0.073
ZDS2 Zds2p 0.071
ASE1 Ase1p 0.070
VPS60 Vps60p 0.070
TAF10 Taf10p 0.068
PIG2 Pig2p 0.067
TID3 Tid3p 0.066
SLI15 Sli15p 0.065
MAD1 Mad1p 0.065
PDS1 Pds1p 0.064
BUB3 Bub3p 0.064
CDC28 Cdc28p 0.064
SIN3 Sin3p 0.064
MBR1 Mbr1p 0.062
RFA1 Rfa1p 0.061
HSF1 Hsf1p 0.060
NBL1 Nbl1p 0.060
RAD23 Rad23p 0.060
ZAP1 Zap1p 0.059
THI21 Thi21p 0.059
APC4 Apc4p 0.058
KIN3 Kin3p 0.058
KAP95 Kap95p 0.057
IRA1 Ira1p 0.057
CIN1 Cin1p 0.055
MPH1 Mph1p 0.054
MCM21 Mcm21p 0.054
SEC4 Sec4p 0.053
PIG1 Pig1p 0.053
CBF1 Cbf1p 0.053
SMC4 Smc4p 0.052
FPK1 Fpk1p 0.052
RAD59 Rad59p 0.051
STE4 Ste4p 0.050
IRC23 Irc23p 0.050