The network for 'negative regulation of cell activation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of cell activation

Any process that stops, prevents, or reduces the frequency, rate or extent of cell activation.

Mus musculus
Name Description Probability Func Analog Organism
Lyz2 lysozyme 2 0.992
Lyn Yamaguchi sarcoma viral (v-yes-1) oncogene homolog 0.986
Stat3 signal transducer and activator of transcription 3 0.963
Cd19 CD19 antigen 0.961
Fcgr2b Fc receptor, IgG, low affinity IIb 0.958
Nlrp3 NLR family, pyrin domain containing 3 0.950
Fas Fas (TNF receptor superfamily member 6) 0.949
Zeb1 zinc finger E-box binding homeobox 1 0.926
Cbl Casitas B-lineage lymphoma 0.919
Grb2 growth factor receptor bound protein 2 0.913
Foxc1 forkhead box C1 0.911
Fcer1g Fc receptor, IgE, high affinity I, gamma polypeptide 0.907
Igh immunoglobulin heavy chain complex 0.900
Rc3h1 RING CCCH (C3H) domains 1 0.898
Vegfa vascular endothelial growth factor A 0.891
Plcg1 phospholipase C, gamma 1 0.878
Jak2 Janus kinase 2 0.864
Cd40 CD40 antigen 0.863
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.832
Pten phosphatase and tensin homolog 0.825
Ptprc protein tyrosine phosphatase, receptor type, C 0.820
Tnf tumor necrosis factor 0.754
Il27ra interleukin 27 receptor, alpha 0.745
Inpp5d inositol polyphosphate-5-phosphatase D 0.742
Rb1 retinoblastoma 1 0.726
Foxp3 forkhead box P3 0.726
Gli2 GLI-Kruppel family member GLI2 0.723
Cd22 CD22 antigen 0.705
Axl AXL receptor tyrosine kinase 0.705
Ifng interferon gamma 0.704
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.687
Shc1 src homology 2 domain-containing transforming protein C1 0.681
Csf2rb2 colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage) 0.669
Pik3cd phosphatidylinositol 3-kinase catalytic delta polypeptide 0.660
Bcl3 B-cell leukemia/lymphoma 3 0.659
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.657
S100a9 S100 calcium binding protein A9 (calgranulin B) 0.653
Prkcd protein kinase C, delta 0.652
Ccr6 chemokine (C-C motif) receptor 6 0.649
Il10ra interleukin 10 receptor, alpha 0.643
Il2rb interleukin 2 receptor, beta chain 0.642
Stat6 signal transducer and activator of transcription 6 0.640
Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 0.639
Id3 inhibitor of DNA binding 3 0.633
Fasl Fas ligand (TNF superfamily, member 6) 0.608
Gab1 growth factor receptor bound protein 2-associated protein 1 0.607
Stat1 signal transducer and activator of transcription 1 0.599
Tlr4 toll-like receptor 4 0.585
Ripk1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.583
Tcra T-cell receptor alpha chain 0.570
Irf1 interferon regulatory factor 1 0.569
Ciita class II transactivator 0.563
Id1 inhibitor of DNA binding 1 0.550
Spib Spi-B transcription factor (Spi-1/PU.1 related) 0.546
Cyld cylindromatosis (turban tumor syndrome) 0.540
Hhex hematopoietically expressed homeobox 0.535
Il4 interleukin 4 0.532
Il1b interleukin 1 beta 0.525
Nf1 neurofibromatosis 1 0.524
Irf4 interferon regulatory factor 4 0.512
Cd14 CD14 antigen 0.511
Sfpi1 SFFV proviral integration 1 0.511
Tnip1 TNFAIP3 interacting protein 1 0.504
Prf1 perforin 1 (pore forming protein) 0.503
Ccr7 chemokine (C-C motif) receptor 7 0.486
Pstpip2 proline-serine-threonine phosphatase-interacting protein 2 0.482
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.477
Ltb lymphotoxin B 0.475
Prdm1 PR domain containing 1, with ZNF domain 0.469
Il4ra interleukin 4 receptor, alpha 0.467
Meox2 mesenchyme homeobox 2 0.460
Selp selectin, platelet 0.449
Il6 interleukin 6 0.431
Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) 0.430
Casp4 caspase 4, apoptosis-related cysteine peptidase 0.427
Ccr2 chemokine (C-C motif) receptor 2 0.425
Csf2rb colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 0.410
Nos3 nitric oxide synthase 3, endothelial cell 0.409
Csf1r colony stimulating factor 1 receptor 0.408
Socs1 suppressor of cytokine signaling 1 0.408
Src Rous sarcoma oncogene 0.407
Gdnf glial cell line derived neurotrophic factor 0.401
H2-Ab1 histocompatibility 2, class II antigen A, beta 1 0.399
Mefv Mediterranean fever 0.399
Was Wiskott-Aldrich syndrome homolog (human) 0.394
Cd180 CD180 antigen 0.392
Erbb2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.391
Rag1 recombination activating gene 1 0.387
Irf5 interferon regulatory factor 5 0.379
Tnfaip8l2 tumor necrosis factor, alpha-induced protein 8-like 2 0.375
Gnrh1 gonadotropin releasing hormone 1 0.368
Ikzf1 IKAROS family zinc finger 1 0.366
Lama5 laminin, alpha 5 0.362
Fgfr2 fibroblast growth factor receptor 2 0.361
Ifnb1 interferon beta 1, fibroblast 0.357
Ptch1 patched homolog 1 0.351
Tnfrsf4 tumor necrosis factor receptor superfamily, member 4 0.350
Abca1 ATP-binding cassette, sub-family A (ABC1), member 1 0.348
H2-Eb1 histocompatibility 2, class II antigen E beta 0.344
Stat2 signal transducer and activator of transcription 2 0.337
Loading network...
Caenorhabditis elegans
Name Description Probability Func Analog Organism
Loading network...
Danio rerio
Name Description Probability Func Analog Organism
Loading network...
Drosophila melanogaster
Name Description Probability Func Analog Organism
Loading network...
Homo sapiens
Name Description Probability Func Analog Organism
C1QA complement component 1, q subcomponent, A chain 0.792
SYK spleen tyrosine kinase 0.775
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 0.690
PTPN6 protein tyrosine phosphatase, non-receptor type 6 0.648
HLA-B major histocompatibility complex, class I, B 0.551
CD80 CD80 molecule 0.533
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.509
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.474
B2M beta-2-microglobulin 0.466
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain 0.411
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.408
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.334
HLA-G major histocompatibility complex, class I, G 0.319
HLA-DRA major histocompatibility complex, class II, DR alpha 0.314
HLA-A major histocompatibility complex, class I, A 0.286
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1 0.260
FASLG Fas ligand (TNF superfamily, member 6) 0.241
CD86 CD86 molecule 0.220
CXCL9 chemokine (C-X-C motif) ligand 9 0.220
HLA-C major histocompatibility complex, class I, C 0.203
HLA-E major histocompatibility complex, class I, E 0.202
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.190
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin 0.187
HLA-DMA major histocompatibility complex, class II, DM alpha 0.181
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 0.177
IL4R interleukin 4 receptor 0.165
IL2RG interleukin 2 receptor, gamma 0.164
CCR5 chemokine (C-C motif) receptor 5 0.159
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 0.157
HLA-F major histocompatibility complex, class I, F 0.150
IL10RA interleukin 10 receptor, alpha 0.147
FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.122
LAIR1 leukocyte-associated immunoglobulin-like receptor 1 0.122
XIAP X-linked inhibitor of apoptosis 0.119
ICAM1 intercellular adhesion molecule 1 0.117
PILRA paired immunoglobin-like type 2 receptor alpha 0.115
EPOR erythropoietin receptor 0.115
PAX3 paired box 3 0.107
BMPR1A bone morphogenetic protein receptor, type IA 0.106
HLA-DMB major histocompatibility complex, class II, DM beta 0.096
CASP9 caspase 9, apoptosis-related cysteine peptidase 0.090
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.086
IL10 interleukin 10 0.085
NRP1 neuropilin 1 0.084
DRD2 dopamine receptor D2 0.079
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A 0.074
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 0.072
FSTL1 follistatin-like 1 0.071
A2M alpha-2-macroglobulin 0.068
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 0.067
POU3F2 POU class 3 homeobox 2 0.063
GHR growth hormone receptor 0.059
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.058
TFF1 trefoil factor 1 0.056
HLA-DPB1 major histocompatibility complex, class II, DP beta 1 0.055
CCL2 chemokine (C-C motif) ligand 2 0.053
HK3 hexokinase 3 (white cell) 0.052
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 1 0.051
SIGLEC7 sialic acid binding Ig-like lectin 7 0.051
SLC9A3R1 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 0.049
ADAM17 ADAM metallopeptidase domain 17 0.049
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32) 0.049
PTPRB protein tyrosine phosphatase, receptor type, B 0.048
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide 0.048
BIRC3 baculoviral IAP repeat containing 3 0.046
CCR1 chemokine (C-C motif) receptor 1 0.044
PCYT2 phosphate cytidylyltransferase 2, ethanolamine 0.044
CD14 CD14 molecule 0.044
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 0.044
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.043
CCL4 chemokine (C-C motif) ligand 4 0.042
LYN v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.041
C1QC complement component 1, q subcomponent, C chain 0.041
CCL8 chemokine (C-C motif) ligand 8 0.041
SLA Src-like-adaptor 0.040
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 0.040
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.040
IL22RA1 interleukin 22 receptor, alpha 1 0.040
CSK c-src tyrosine kinase 0.040
CD163 CD163 molecule 0.039
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced 0.038
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 0.038
APOC1 apolipoprotein C-I 0.038
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) 0.038
CD33 CD33 molecule 0.036
PTK2B PTK2B protein tyrosine kinase 2 beta 0.036
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.036
HP haptoglobin 0.035
LAT linker for activation of T cells 0.035
ECSIT ECSIT homolog (Drosophila) 0.034
APAF1 apoptotic peptidase activating factor 1 0.034
CXCL10 chemokine (C-X-C motif) ligand 10 0.033
GAB2 GRB2-associated binding protein 2 0.033
LILRA2 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2 0.033
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 0.032
NCF4 neutrophil cytosolic factor 4, 40kDa 0.032
C19orf50 chromosome 19 open reading frame 50 0.032
PGF placental growth factor 0.032
BTN3A1 butyrophilin, subfamily 3, member A1 0.032
BTN3A3 butyrophilin, subfamily 3, member A3 0.032
Loading network...
Rattus norvegicus
Name Description Probability Func Analog Organism
RT1-Ba RT1 class II, locus Ba 0.704
RT1-DMb RT1 class II, locus DMb 0.287
RT1-Da RT1 class II, locus Da 0.200
Ddr2 discoidin domain receptor tyrosine kinase 2 0.020
Fgfr2 fibroblast growth factor receptor 2 0.019
MGC112715 hypothetical protein LOC690899 0.018
Cd2 Cd2 molecule 0.018
Bgn biglycan 0.016
Lyz2 lysozyme 2 0.016
Gna15 guanine nucleotide binding protein, alpha 15 0.016
RT1-DMa RT1 class II, locus DMa 0.015
Cd5 Cd5 molecule 0.013
Cd74 Cd74 molecule, major histocompatibility complex, class II invariant chain 0.012
Ms4a2 membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide) 0.012
Alox5ap arachidonate 5-lipoxygenase activating protein 0.012
Aif1 allograft inflammatory factor 1 0.012
Plau plasminogen activator, urokinase 0.012
Icam1 intercellular adhesion molecule 1 0.012
Hrh1 histamine receptor H 1 0.011
Hck hemopoietic cell kinase 0.011
Aebp1 AE binding protein 1 0.010
Nos3 nitric oxide synthase 3, endothelial cell 0.010
Cxcr5 chemokine (C-X-C motif) receptor 5 0.010
Cd4 Cd4 molecule 0.010
Loading network...
Saccharomyces cerevisiae
Name Description Probability Func Analog Organism