The network for 'negative regulation of apoptotic signaling pathway' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of apoptotic signaling pathway

Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic signaling pathway.

Mus musculus
Name Description Probability Func Analog Organism
Trp53 transformation related protein 53 0.995
Ctnnb1 catenin (cadherin associated protein), beta 1 0.984
Col1a1 collagen, type I, alpha 1 0.983
Pten phosphatase and tensin homolog 0.982
Tnfaip3 tumor necrosis factor, alpha-induced protein 3 0.980
Ikzf1 IKAROS family zinc finger 1 0.968
Bcl2 B-cell leukemia/lymphoma 2 0.958
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.955
Fas Fas (TNF receptor superfamily member 6) 0.950
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.928
Lyz2 lysozyme 2 0.913
Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.909
Rybp RING1 and YY1 binding protein 0.882
Tgfb1 transforming growth factor, beta 1 0.874
Thbs1 thrombospondin 1 0.863
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.853
Psen1 presenilin 1 0.851
Tnf tumor necrosis factor 0.822
Map3k14 mitogen-activated protein kinase kinase kinase 14 0.819
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.815
Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) 0.804
Lyn Yamaguchi sarcoma viral (v-yes-1) oncogene homolog 0.804
Fgfr1 fibroblast growth factor receptor 1 0.798
Lepr leptin receptor 0.796
Nos1 nitric oxide synthase 1, neuronal 0.779
Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 0.775
Tgfbr2 transforming growth factor, beta receptor II 0.753
Cd44 CD44 antigen 0.750
Ikbkb inhibitor of kappaB kinase beta 0.748
Runx1 runt related transcription factor 1 0.748
Ptgs2 prostaglandin-endoperoxide synthase 2 0.727
Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.721
Csf1 colony stimulating factor 1 (macrophage) 0.710
Rnf2 ring finger protein 2 0.709
Pbx1 pre B-cell leukemia transcription factor 1 0.707
Relb avian reticuloendotheliosis viral (v-rel) oncogene related B 0.690
Apoe apolipoprotein E 0.683
Mmp9 matrix metallopeptidase 9 0.669
Lox lysyl oxidase 0.662
Nos3 nitric oxide synthase 3, endothelial cell 0.640
Vhl von Hippel-Lindau tumor suppressor 0.638
Rara retinoic acid receptor, alpha 0.631
Traf6 TNF receptor-associated factor 6 0.624
Lmna lamin A 0.606
Ppp2ca protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform 0.601
Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.595
Shh sonic hedgehog 0.588
Igh immunoglobulin heavy chain complex 0.585
Sfrp2 secreted frizzled-related protein 2 0.570
Ntf3 neurotrophin 3 0.567
Mmp14 matrix metallopeptidase 14 (membrane-inserted) 0.565
Pax3 paired box gene 3 0.564
Fgf8 fibroblast growth factor 8 0.563
Gja1 gap junction protein, alpha 1 0.557
Vegfa vascular endothelial growth factor A 0.556
Ifng interferon gamma 0.551
Ret ret proto-oncogene 0.538
Nphp4 nephronophthisis 4 (juvenile) homolog (human) 0.534
Col3a1 collagen, type III, alpha 1 0.532
Pax2 paired box gene 2 0.526
Tnfrsf9 tumor necrosis factor receptor superfamily, member 9 0.496
Pdgfrb platelet derived growth factor receptor, beta polypeptide 0.489
Snai1 snail homolog 1 (Drosophila) 0.488
Sqstm1 sequestosome 1 0.478
Ccr1 chemokine (C-C motif) receptor 1 0.462
Cd40 CD40 antigen 0.459
Fbn1 fibrillin 1 0.458
Efnb2 ephrin B2 0.455
Itgb3 integrin beta 3 0.455
Rarg retinoic acid receptor, gamma 0.453
Col1a2 collagen, type I, alpha 2 0.448
Fasl Fas ligand (TNF superfamily, member 6) 0.443
Dkk1 dickkopf homolog 1 (Xenopus laevis) 0.441
Tgfbr1 transforming growth factor, beta receptor I 0.430
Ctnna1 catenin (cadherin associated protein), alpha 1 0.428
Ednra endothelin receptor type A 0.422
Hic1 hypermethylated in cancer 1 0.421
Gli2 GLI-Kruppel family member GLI2 0.401
Tbx1 T-box 1 0.398
Hif1a hypoxia inducible factor 1, alpha subunit 0.396
Casp8 caspase 8 0.396
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.394
Hoxa13 homeobox A13 0.387
Bmi1 Bmi1 polycomb ring finger oncogene 0.385
Apc adenomatosis polyposis coli 0.381
Map3k7 mitogen-activated protein kinase kinase kinase 7 0.378
Aldh1a2 aldehyde dehydrogenase family 1, subfamily A2 0.370
Ncoa3 nuclear receptor coactivator 3 0.367
Cav1 caveolin 1, caveolae protein 0.366
Itgal integrin alpha L 0.366
Col5a2 collagen, type V, alpha 2 0.364
Ikbkg inhibitor of kappaB kinase gamma 0.357
Rxra retinoid X receptor alpha 0.346
Gclm glutamate-cysteine ligase, modifier subunit 0.345
Ptprc protein tyrosine phosphatase, receptor type, C 0.344
Il10 interleukin 10 0.342
Wnt4 wingless-related MMTV integration site 4 0.338
Lhx1 LIM homeobox protein 1 0.334
Erbb3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.331
Mkl2 MKL/myocardin-like 2 0.324
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
erbb2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog 0.181
lef1 lymphocyte enhancer binding factor 1 0.169
stc1l stanniocalcin 1, like 0.165
baxa bcl2-associated X protein, a 0.142
kdrl kinase insert domain receptor like 0.128
myod1 myogenic differentiation 1 0.077
vax2 ventral anterior homeobox 2 0.073
ube2g2 ubiquitin-conjugating enzyme E2G 2 0.068
efnb2a ephrin B2a 0.067
erbb3b v-erb-b2 erythroblastic leukemia viral oncogene homolog 3b 0.064
cdh5 cadherin 5 0.064
dct dopachrome tautomerase 0.064
aldh1a2 aldehyde dehydrogenase 1 family, member A2 0.063
tal1 T-cell acute lymphocytic leukemia 1 0.062
efna5a ephrin A5a 0.051
col7a1l collagen type VII alpha 1-like 0.046
slit3 slit (Drosophila) homolog 3 0.044
cmyb transcription factor cmyb 0.043
hmga1a high mobility group AT-hook 1a 0.042
mapk14a mitogen-activated protein kinase 14a 0.041
fgg fibrinogen, gamma polypeptide 0.041
hif1ab hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) b 0.040
psen1 presenilin 1 0.039
mcl1b myeloid cell leukemia sequence 1b 0.039
egr1 early growth response 1 0.038
nrp2a neuropilin 2a 0.034
pcdh18b protocadherin 18b 0.033
bida BH3 interacting domain death agonist 0.033
h2afv H2A histone family, member V 0.033
hoxa13a homeo box A13a 0.032
wnt11r wingless-type MMTV integration site family, member 11, related 0.032
runx1 runt-related transcription factor 1 0.032
bcl2l1 bcl2-like 1 0.032
lhx2b LIM homeobox 2b 0.031
ntn1b netrin 1b 0.030
acsl4a acyl-CoA synthetase long-chain family member 4a 0.030
cdkn1a cyclin-dependent kinase inhibitor 1A 0.028
rp2 retinitis pigmentosa 2 (X-linked recessive) 0.027
ptgesl prostaglandin E synthase 2-like 0.027
nrg2a neuregulin 2a 0.027
erbb3a v-erb-b2 erythroblastic leukemia viral oncogene homolog 3a 0.027
mapk6 mitogen-activated protein kinase 6 0.026
sp2 sp2 transcription factor 0.026
fgf10a fibroblast growth factor 10a 0.024
hmgb2a high-mobility group box 2a 0.024
sod1 superoxide dismutase 1, soluble 0.024
col4a2 collagen, type IV, alpha 2 0.023
gsc goosecoid 0.023
sox11b SRY-box containing gene 11b 0.023
tcf7 transcription factor 7 (T-cell specific, HMG-box) 0.023
trpm7 transient receptor potential cation channel, subfamily M, member 7 0.022
col4a6 collagen, type IV, alpha 6 0.022
osr1 odd-skipped related 1 (Drosophila) 0.022
tshb thyroid stimulating hormone, beta subunit 0.021
il17rd interleukin 17 receptor D 0.020
ntn2 netrin 2 0.020
sat1a spermidine/spermine N1-acetyltransferase 1a 0.020
mmp2 matrix metalloproteinase 2 0.020
olig4 oligodendrocyte transcription factor 4 0.020
cnn2 calponin 2 0.019
kita kit receptor a 0.019
pcdh8 protocadherin 8 0.019
cdh1 cadherin 1, epithelial 0.019
nrp1a neuropilin 1a 0.019
gadd45aa growth arrest and DNA-damage-inducible, alpha, a 0.018
zgc:112056 zgc:112056 0.017
ptgs2a prostaglandin-endoperoxide synthase 2a 0.017
rhoab ras homolog gene family, member Ab 0.017
evx1 even-skipped homeobox 1 0.017
hmx2 H6 family homeobox 2 0.017
boc brother of CDO 0.016
trpv6 transient receptor potential cation channel, subfamily V, member 6 0.016
tgif1 TGFB-induced factor homeobox 1 0.016
mitfa microphthalmia-associated transcription factor a 0.016
hsp70 heat shock cognate 70-kd protein 0.016
nrg1 neuregulin 1 0.015
fgf3 fibroblast growth factor 3 0.015
grnb granulin b 0.015
pitx3 paired-like homeodomain transcription factor 3 0.015
aox3 aldehyde oxidase 3 0.015
itgb3b integrin beta 3b 0.015
foxa3 forkhead box A3 0.015
fadd Fas (tnfrsf6)-associated via death domain 0.015
epha4a eph receptor A4a 0.014
sox2 SRY-box containing gene 2 0.014
dlg1 discs, large (Drosophila) homolog 1 0.014
park7 parkinson disease (autosomal recessive, early onset) 7 0.014
aldh2b aldehyde dehydrogenase 2b 0.014
gfer growth factor, augmenter of liver regeneration (ERV1 homolog, S. cerevisiae) 0.014
fn1 fibronectin 1 0.014
fabp11a fatty acid binding protein 11a 0.014
fgfr1a fibroblast growth factor receptor 1a 0.014
msi1 musashi homolog 1 (Drosophila) 0.013
nrarpa notch-regulated ankyrin repeat protein a 0.013
flt4 fms-related tyrosine kinase 4 0.013
il6r interleukin 6 receptor 0.013
sulf2l sulfatase 2, like 0.013
prox1 prospero-related homeobox gene 1 0.013
chuk conserved helix-loop-helix ubiquitous kinase 0.013
ranbp1 RAN binding protein 1 0.013
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Drosophila melanogaster
Name Description Probability Func Analog Organism
Ras85D Ras oncogene at 85D 0.837
Egfr Epidermal growth factor receptor 0.613
dsh dishevelled 0.406
Cdc42 CG12530 gene product from transcript CG12530-RA 0.274
aop anterior open 0.195
hep hemipterous 0.174
Akt1 CG4006 gene product from transcript CG4006-RA 0.150
rl rolled 0.133
tkv thickveins 0.132
arm armadillo 0.128
gig gigas 0.110
spi spitz 0.082
Pten CG5671 gene product from transcript CG5671-RB 0.060
ci cubitus interruptus 0.059
Pi3K92E CG4141 gene product from transcript CG4141-RB 0.052
Mad Mothers against dpp 0.046
dm diminutive 0.046
dco discs overgrown 0.045
Src42A Src oncogene at 42A 0.045
ptc patched 0.043
NetB Netrin-B 0.043
Lam Lamin 0.041
Gap1 GTPase-activating protein 1 0.039
milt milton 0.036
EcR Ecdysone receptor 0.035
p53 CG33336 gene product from transcript CG33336-RB 0.032
ena enabled 0.031
kay kayak 0.029
dpp decapentaplegic 0.028
InR Insulin-like receptor 0.028
chico CG5686 gene product from transcript CG5686-RB 0.025
Dhc64C Dynein heavy chain 64C 0.023
Jra Jun-related antigen 0.021
kibra kibra ortholog 0.019
cindr CIN85 and CD2AP orthologue 0.019
hpo hippo 0.017
Atg1 Autophagy-specific gene 1 0.017
Pp2B-14D Protein phosphatase 2B at 14D 0.015
sd scalloped 0.015
tud tudor 0.015
msn misshapen 0.015
Pink1 PTEN-induced putative kinase 1 0.015
chic chickadee 0.014
sina seven in absentia 0.014
14-3-3epsilon CG31196 gene product from transcript CG31196-RA 0.014
CadN Cadherin-N 0.014
rho rhomboid 0.013
Hsp68 Heat shock protein 68 0.013
Sos Son of sevenless 0.013
Pcaf CG4107 gene product from transcript CG4107-RA 0.013
trbl tribbles 0.012
par-1 CG8201 gene product from transcript CG8201-RA 0.012
Rho1 CG8416 gene product from transcript CG8416-RB 0.012
rpr reaper 0.011
ex expanded 0.011
ecd ecdysoneless 0.011
ago archipelago 0.011
trx trithorax 0.010
smt3 CG4494 gene product from transcript CG4494-RA 0.010
Tsc1 CG6147 gene product from transcript CG6147-RA 0.010
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Homo sapiens
Name Description Probability Func Analog Organism
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.999
BCL2L1 BCL2-like 1 0.999
UBC ubiquitin C 0.998
BIRC3 baculoviral IAP repeat containing 3 0.998
BCL2 B-cell CLL/lymphoma 2 0.997
TP53 tumor protein p53 0.994
HDAC1 histone deacetylase 1 0.994
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.988
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.986
BIRC2 baculoviral IAP repeat containing 2 0.981
FHL2 four and a half LIM domains 2 0.980
XIAP X-linked inhibitor of apoptosis 0.977
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.977
TRAF1 TNF receptor-associated factor 1 0.966
IL8 interleukin 8 0.962
PML promyelocytic leukemia 0.952
BCL2L11 BCL2-like 11 (apoptosis facilitator) 0.951
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.951
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) 0.935
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 0.934
FN1 fibronectin 1 0.922
FLNA filamin A, alpha 0.919
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.915
PSEN1 presenilin 1 0.904
BAX BCL2-associated X protein 0.889
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.888
TGIF1 TGFB-induced factor homeobox 1 0.888
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.887
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 0.885
RAF1 v-raf-1 murine leukemia viral oncogene homolog 1 0.874
AR androgen receptor 0.872
DAXX death-domain associated protein 0.840
MAP3K3 mitogen-activated protein kinase kinase kinase 3 0.827
TEK TEK tyrosine kinase, endothelial 0.816
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.816
BAD BCL2-associated agonist of cell death 0.815
BMI1 BMI1 polycomb ring finger oncogene 0.805
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 0.804
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.803
SIN3A SIN3 homolog A, transcription regulator (yeast) 0.796
TP53BP2 tumor protein p53 binding protein, 2 0.774
MYC v-myc myelocytomatosis viral oncogene homolog (avian) 0.765
GSK3B glycogen synthase kinase 3 beta 0.759
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.748
HSPA1B heat shock 70kDa protein 1B 0.742
MAPK1 mitogen-activated protein kinase 1 0.706
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.697
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.672
TRAF3 TNF receptor-associated factor 3 0.670
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.663
VCAM1 vascular cell adhesion molecule 1 0.652
TRADD TNFRSF1A-associated via death domain 0.649
CXCL2 chemokine (C-X-C motif) ligand 2 0.645
MAPK8 mitogen-activated protein kinase 8 0.642
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.635
MCL1 myeloid cell leukemia sequence 1 (BCL2-related) 0.632
ENG endoglin 0.627
CDC42 cell division cycle 42 (GTP binding protein, 25kDa) 0.620
PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta) 0.614
GRB2 growth factor receptor-bound protein 2 0.607
RIPK2 receptor-interacting serine-threonine kinase 2 0.607
RELB v-rel reticuloendotheliosis viral oncogene homolog B 0.593
BID BH3 interacting domain death agonist 0.591
SQSTM1 sequestosome 1 0.587
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.572
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.570
TAL1 T-cell acute lymphocytic leukemia 1 0.568
MAP2K1 mitogen-activated protein kinase kinase 1 0.567
SIRT1 sirtuin 1 0.557
TRAF2 TNF receptor-associated factor 2 0.551
TRAF6 TNF receptor-associated factor 6 0.546
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 0.545
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.538
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.531
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.525
MAFG v-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian) 0.520
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.510
CRK v-crk sarcoma virus CT10 oncogene homolog (avian) 0.508
RASSF1 Ras association (RalGDS/AF-6) domain family member 1 0.506
HSPA1A heat shock 70kDa protein 1A 0.503
IL1B interleukin 1, beta 0.496
CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like 0.496
FAS Fas (TNF receptor superfamily, member 6) 0.491
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.490
CXCL10 chemokine (C-X-C motif) ligand 10 0.488
PLAU plasminogen activator, urokinase 0.478
SKP1 S-phase kinase-associated protein 1 0.469
UQCRFS1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 0.469
FGA fibrinogen alpha chain 0.465
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.464
UBXN7 UBX domain protein 7 0.459
ABL1 c-abl oncogene 1, non-receptor tyrosine kinase 0.453
PLAUR plasminogen activator, urokinase receptor 0.452
BMP2 bone morphogenetic protein 2 0.450
ICAM1 intercellular adhesion molecule 1 0.449
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 0.449
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.448
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 0.445
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.439
BTRC beta-transducin repeat containing 0.432
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism