IMP

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Homo sapiens

42 genes annotated in human

extrinsic apoptotic signaling pathway via death domain receptors

A series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with a ligand binding to a death domain receptor on the cell surface, and ends when the execution phase of apoptosis is triggered.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "extrinsic apoptotic signaling pathway via death domain receptors"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "extrinsic apoptotic signaling pathway via death domain receptors" (in gray)

Name	Description	Probability	Func Analog Organism
CASP8	caspase 8, apoptosis-related cysteine peptidase	1.000
SQSTM1	sequestosome 1	0.980
CASP10	caspase 10, apoptosis-related cysteine peptidase	0.977	Human
CFLAR	CASP8 and FADD-like apoptosis regulator	0.977
FAS	Fas (TNF receptor superfamily, member 6)	0.949	Human Mouse Rat
FADD	Fas (TNFRSF6)-associated via death domain	0.922
CASP3	caspase 3, apoptosis-related cysteine peptidase	0.891	Human Mouse
BCL2L11	BCL2-like 11 (apoptosis facilitator)	0.778
BCL2	B-cell CLL/lymphoma 2	0.750
TNFRSF10A	tumor necrosis factor receptor superfamily, member 10a	0.740
RIPK1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.717
TNFRSF10B	tumor necrosis factor receptor superfamily, member 10b	0.653	Human
BIRC3	baculoviral IAP repeat containing 3	0.637
TNFSF10	tumor necrosis factor (ligand) superfamily, member 10	0.542	Human
XIAP	X-linked inhibitor of apoptosis	0.433
BCL2L1	BCL2-like 1	0.416	Human
FGA	fibrinogen alpha chain	0.404
FGB	fibrinogen beta chain	0.403
TNFRSF6B	tumor necrosis factor receptor superfamily, member 6b, decoy	0.376
SNAP23	synaptosomal-associated protein, 23kDa	0.328
TEK	TEK tyrosine kinase, endothelial	0.319
TNFRSF1A	tumor necrosis factor receptor superfamily, member 1A	0.307	Human
GABARAPL2	GABA(A) receptor-associated protein-like 2	0.284
SP100	SP100 nuclear antigen	0.273
APAF1	apoptotic peptidase activating factor 1	0.268
CASP4	caspase 4, apoptosis-related cysteine peptidase	0.247	Human
TRAF1	TNF receptor-associated factor 1	0.219
TRADD	TNFRSF1A-associated via death domain	0.208
TGIF1	TGFB-induced factor homeobox 1	0.177
CRADD	CASP2 and RIPK1 domain containing adaptor with death domain	0.167
CASP9	caspase 9, apoptosis-related cysteine peptidase	0.161	Human
MAP1LC3B	microtubule-associated protein 1 light chain 3 beta	0.156
TRAF6	TNF receptor-associated factor 6	0.155
CASP1	caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)	0.154	Human
MAPK1	mitogen-activated protein kinase 1	0.146
TNFRSF1B	tumor necrosis factor receptor superfamily, member 1B	0.141
CASP8AP2	caspase 8 associated protein 2	0.132
MAP3K5	mitogen-activated protein kinase kinase kinase 5	0.131
NAPA	N-ethylmaleimide-sensitive factor attachment protein, alpha	0.116
GGA1	golgi-associated, gamma adaptin ear containing, ARF binding protein 1	0.114
VAMP3	vesicle-associated membrane protein 3 (cellubrevin)	0.109
BLOC1S3	biogenesis of lysosomal organelles complex-1, subunit 3	0.101
IGF2R	insulin-like growth factor 2 receptor	0.100
FGG	fibrinogen gamma chain	0.095
RAC1	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	0.095
PMAIP1	phorbol-12-myristate-13-acetate-induced protein 1	0.093
GABARAPL1	GABA(A) receptor-associated protein like 1	0.089	Human
CALCOCO2	calcium binding and coiled-coil domain 2	0.089
PLAT	plasminogen activator, tissue	0.085
PDPK1	3-phosphoinositide dependent protein kinase-1	0.082
ITGAL	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)	0.078
GGA2	golgi-associated, gamma adaptin ear containing, ARF binding protein 2	0.076
NLRC4	NLR family, CARD domain containing 4	0.076
PPM1F	protein phosphatase, Mg2+/Mn2+ dependent, 1F	0.074
TNFAIP3	tumor necrosis factor, alpha-induced protein 3	0.073
FAM101B	family with sequence similarity 101, member B	0.069
SMAD3	SMAD family member 3	0.068
MICA	MHC class I polypeptide-related sequence A	0.067
C1orf93	chromosome 1 open reading frame 93	0.067
PPP2CA	protein phosphatase 2, catalytic subunit, alpha isozyme	0.063
IKBKG	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma	0.063
BID	BH3 interacting domain death agonist	0.061
FTL	ferritin, light polypeptide	0.052
SORT1	sortilin 1	0.052
FTH1	ferritin, heavy polypeptide 1	0.050
VIM	vimentin	0.050
MAP2K1	mitogen-activated protein kinase kinase 1	0.049
NTRK2	neurotrophic tyrosine kinase, receptor, type 2	0.049
MET	met proto-oncogene (hepatocyte growth factor receptor)	0.047
BAD	BCL2-associated agonist of cell death	0.046
ITGB1BP1	integrin beta 1 binding protein 1	0.043
IFI16	interferon, gamma-inducible protein 16	0.042
LRDD	leucine-rich repeats and death domain containing	0.042	Mouse
BAK1	BCL2-antagonist/killer 1	0.042
MUTED	muted homolog (mouse)	0.042
HSPB1	heat shock 27kDa protein 1	0.042
SYNRG	synergin, gamma	0.042
CRP	C-reactive protein, pentraxin-related	0.041
DTNBP1	dystrobrevin binding protein 1	0.040
MAP3K2	mitogen-activated protein kinase kinase kinase 2	0.039
APOA1	apolipoprotein A-I	0.039
TRAF2	TNF receptor-associated factor 2	0.038
TNF	tumor necrosis factor	0.038
PLDN	pallidin homolog (mouse)	0.038
UBE2D3	ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)	0.037
BIRC2	baculoviral IAP repeat containing 2	0.037
ULK1	unc-51-like kinase 1 (C. elegans)	0.035
RDH11	retinol dehydrogenase 11 (all-trans/9-cis/11-cis)	0.035
PLAU	plasminogen activator, urokinase	0.035
CSNK1A1	casein kinase 1, alpha 1	0.034
PLEK	pleckstrin	0.034
RRAS	related RAS viral (r-ras) oncogene homolog	0.034
RNF144B	ring finger protein 144B	0.033
RABEP1	rabaptin, RAB GTPase binding effector protein 1	0.033
NPC2	Niemann-Pick disease, type C2	0.033
RASSF5	Ras association (RalGDS/AF-6) domain family member 5	0.032
GDF5	growth differentiation factor 5	0.032
PSEN1	presenilin 1	0.031
FASLG	Fas ligand (TNF superfamily, member 6)	0.030
ORM1	orosomucoid 1	0.030
TMC8	transmembrane channel-like 8	0.030
ZC3HC1	zinc finger, C3HC-type containing 1	0.029
OAZ1	ornithine decarboxylase antizyme 1	0.028
SMPD1	sphingomyelin phosphodiesterase 1, acid lysosomal	0.028
GBP2	guanylate binding protein 2, interferon-inducible	0.028
SORL1	sortilin-related receptor, L(DLR class) A repeats containing	0.026	Human
ITGB3	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	0.026
CA12	carbonic anhydrase XII	0.026
USP15	ubiquitin specific peptidase 15	0.026
IL8	interleukin 8	0.026
UROD	uroporphyrinogen decarboxylase	0.026
MTA2	metastasis associated 1 family, member 2	0.026
STBD1	starch binding domain 1	0.025
DNAJB1	DnaJ (Hsp40) homolog, subfamily B, member 1	0.025
RIPK2	receptor-interacting serine-threonine kinase 2	0.025
TGM2	transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)	0.025
HSPB8	heat shock 22kDa protein 8	0.025
UBE2D1	ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)	0.024
SESN2	sestrin 2	0.024
PYCARD	PYD and CARD domain containing	0.024
ITGB1	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	0.024
DIABLO	diablo, IAP-binding mitochondrial protein	0.024
MAGEH1	melanoma antigen family H, 1	0.023
CIB1	calcium and integrin binding 1 (calmyrin)	0.023
MAP3K3	mitogen-activated protein kinase kinase kinase 3	0.023
IRF1	interferon regulatory factor 1	0.023
NTRK1	neurotrophic tyrosine kinase, receptor, type 1	0.023
KRAS	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	0.023
RANBP3	RAN binding protein 3	0.023
MAP1LC3A	microtubule-associated protein 1 light chain 3 alpha	0.023
MYD88	myeloid differentiation primary response gene (88)	0.023
MALT1	mucosa associated lymphoid tissue lymphoma translocation gene 1	0.022
NGFR	nerve growth factor receptor	0.022
MAPK3	mitogen-activated protein kinase 3	0.022
BACH1	BTB and CNC homology 1, basic leucine zipper transcription factor 1	0.022
TNIP1	TNFAIP3 interacting protein 1	0.022
EIF4E	eukaryotic translation initiation factor 4E	0.021
ITGB7	integrin, beta 7	0.021
DUSP3	dual specificity phosphatase 3	0.021
FN1	fibronectin 1	0.021
OSMR	oncostatin M receptor	0.021
STRN	striatin, calmodulin binding protein	0.021
EMP3	epithelial membrane protein 3	0.021
RASSF1	Ras association (RalGDS/AF-6) domain family member 1	0.020
TUBB6	tubulin, beta 6	0.020
RNF4	ring finger protein 4	0.020
TMSB10	thymosin beta 10	0.020
PTPRJ	protein tyrosine phosphatase, receptor type, J	0.020
SRI	sorcin	0.020
TNFRSF12A	tumor necrosis factor receptor superfamily, member 12A	0.020
S100A10	S100 calcium binding protein A10	0.020
SNAPIN	SNAP-associated protein	0.019
OPTN	optineurin	0.019
RASSF2	Ras association (RalGDS/AF-6) domain family member 2	0.019
CCDC85B	coiled-coil domain containing 85B	0.019
CASP7	caspase 7, apoptosis-related cysteine peptidase	0.018	Human
CRYAB	crystallin, alpha B	0.018
SH3KBP1	SH3-domain kinase binding protein 1	0.018
FLNA	filamin A, alpha	0.018
BIK	BCL2-interacting killer (apoptosis-inducing)	0.018
CD63	CD63 molecule	0.018
TMC6	transmembrane channel-like 6	0.018	Human
ETS1	v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)	0.018
SPHK1	sphingosine kinase 1	0.018
GBP1	guanylate binding protein 1, interferon-inducible	0.018
FBN1	fibrillin 1	0.018
TRIM38	tripartite motif containing 38	0.018
TRIM21	tripartite motif containing 21	0.018
BDNF	brain-derived neurotrophic factor	0.018	Human
FLNB	filamin B, beta	0.017
S100A11	S100 calcium binding protein A11	0.017
SELPLG	selectin P ligand	0.017
NUCB2	nucleobindin 2	0.017
ANGPT1	angiopoietin 1	0.017	Human
DDAH2	dimethylarginine dimethylaminohydrolase 2	0.017
SP140L	SP140 nuclear body protein-like	0.017	Human
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.017
KDM5D	lysine (K)-specific demethylase 5D	0.017
BLOC1S1	biogenesis of lysosomal organelles complex-1, subunit 1	0.016
AMBRA1	autophagy/beclin-1 regulator 1	0.016
NMI	N-myc (and STAT) interactor	0.016
UBE2V1	ubiquitin-conjugating enzyme E2 variant 1	0.016
GAB2	GRB2-associated binding protein 2	0.016
BBC3	BCL2 binding component 3	0.016
F2	coagulation factor II (thrombin)	0.016
TRMT2A	TRM2 tRNA methyltransferase 2 homolog A (S. cerevisiae)	0.016
LRP1	low density lipoprotein receptor-related protein 1	0.016
HMHA1	histocompatibility (minor) HA-1	0.016
MCL1	myeloid cell leukemia sequence 1 (BCL2-related)	0.015	Human
HSD3B7	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7	0.015
SOD1	superoxide dismutase 1, soluble	0.015
PARP10	poly (ADP-ribose) polymerase family, member 10	0.015
ISG20	interferon stimulated exonuclease gene 20kDa	0.015
PECAM1	platelet/endothelial cell adhesion molecule	0.015
AEBP1	AE binding protein 1	0.015
HECTD1	HECT domain containing 1	0.015
CRKL	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.015
RASSF3	Ras association (RalGDS/AF-6) domain family member 3	0.015
RNR2	l-rRNA	0.015
VTN	vitronectin	0.015
STRN3	striatin, calmodulin binding protein 3	0.015
TNFAIP2	tumor necrosis factor, alpha-induced protein 2	0.015
CREM	cAMP responsive element modulator	0.015
ATXN3	ataxin 3	0.015
GADD45B	growth arrest and DNA-damage-inducible, beta	0.015
ZFYVE1	zinc finger, FYVE domain containing 1	0.014
BAG1	BCL2-associated athanogene	0.014
IMMT	inner membrane protein, mitochondrial	0.014
RHEB	Ras homolog enriched in brain	0.014
LATS2	LATS, large tumor suppressor, homolog 2 (Drosophila)	0.014
PHF11	PHD finger protein 11	0.014
CCNK	cyclin K	0.014
ALB	albumin	0.014
PEBP4	phosphatidylethanolamine-binding protein 4	0.014
ITGB5	integrin, beta 5	0.014
USP38	ubiquitin specific peptidase 38	0.014
ANXA1	annexin A1	0.014
SIAH1	seven in absentia homolog 1 (Drosophila)	0.014
STX11	syntaxin 11	0.014	Human
ANXA2	annexin A2	0.014
RANBP9	RAN binding protein 9	0.013
ZFAND5	zinc finger, AN1-type domain 5	0.013
TMSB4X	thymosin beta 4, X-linked	0.013
MDM4	Mdm4 p53 binding protein homolog (mouse)	0.013
HDAC5	histone deacetylase 5	0.013
FHL2	four and a half LIM domains 2	0.013
BCL2L2	BCL2-like 2	0.013	Human
MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	0.013
EIF1AY	eukaryotic translation initiation factor 1A, Y-linked	0.013
NTF3	neurotrophin 3	0.013	Human
TIRAP	toll-interleukin 1 receptor (TIR) domain containing adaptor protein	0.013
VPS13D	vacuolar protein sorting 13 homolog D (S. cerevisiae)	0.013
PTP4A1	protein tyrosine phosphatase type IVA, member 1	0.013
GPX4	glutathione peroxidase 4 (phospholipid hydroperoxidase)	0.013
HSPA1A	heat shock 70kDa protein 1A	0.013
SART3	squamous cell carcinoma antigen recognized by T cells 3	0.013
TGFB1	transforming growth factor, beta 1	0.013
LMNA	lamin A/C	0.013
RIOK3	RIO kinase 3 (yeast)	0.013
HMGN2	high mobility group nucleosomal binding domain 2	0.013
HSPA6	heat shock 70kDa protein 6 (HSP70B')	0.013
WIPI1	WD repeat domain, phosphoinositide interacting 1	0.013
SPRED1	sprouty-related, EVH1 domain containing 1	0.013
TNFRSF14	tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)	0.013
RBBP4	retinoblastoma binding protein 4	0.013
LAPTM5	lysosomal protein transmembrane 5	0.013
OCLN	occludin	0.013
DUSP5	dual specificity phosphatase 5	0.013
TRAF3IP3	TRAF3 interacting protein 3	0.012
ITGA5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	0.012
PPP1R14A	protein phosphatase 1, regulatory (inhibitor) subunit 14A	0.012
USP4	ubiquitin specific peptidase 4 (proto-oncogene)	0.012
ZC3H12A	zinc finger CCCH-type containing 12A	0.012
PTPN6	protein tyrosine phosphatase, non-receptor type 6	0.012
VAMP8	vesicle-associated membrane protein 8 (endobrevin)	0.012
RAI1	retinoic acid induced 1	0.012
NBR1	neighbor of BRCA1 gene 1	0.012
NSF	N-ethylmaleimide-sensitive factor	0.012
IRAK2	interleukin-1 receptor-associated kinase 2	0.012
HSPB7	heat shock 27kDa protein family, member 7 (cardiovascular)	0.012
TSPO	translocator protein (18kDa)	0.012
ITGA7	integrin, alpha 7	0.012
STK10	serine/threonine kinase 10	0.012
BBS10	Bardet-Biedl syndrome 10	0.012
IL1B	interleukin 1, beta	0.012
PTPN11	protein tyrosine phosphatase, non-receptor type 11	0.012
MBD1	methyl-CpG binding domain protein 1	0.012
FADS3	fatty acid desaturase 3	0.011
WBP5	WW domain binding protein 5	0.011
PRMT2	protein arginine methyltransferase 2	0.011
NLRP1	NLR family, pyrin domain containing 1	0.011
DAB2	disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)	0.011
GAB1	GRB2-associated binding protein 1	0.011
DOCK7	dedicator of cytokinesis 7	0.011
IER3	immediate early response 3	0.011
ARHGAP4	Rho GTPase activating protein 4	0.011
AHNAK	AHNAK nucleoprotein	0.011
PIK3R3	phosphoinositide-3-kinase, regulatory subunit 3 (gamma)	0.011
RAPGEF1	Rap guanine nucleotide exchange factor (GEF) 1	0.011
GMFG	glia maturation factor, gamma	0.011
CDK17	cyclin-dependent kinase 17	0.011
AOAH	acyloxyacyl hydrolase (neutrophil)	0.011
SAV1	salvador homolog 1 (Drosophila)	0.011
CCND2	cyclin D2	0.011
LGALS3	lectin, galactoside-binding, soluble, 3	0.011
UTY	ubiquitously transcribed tetratricopeptide repeat gene, Y-linked	0.011
TUBB2B	tubulin, beta 2B	0.011
VAMP2	vesicle-associated membrane protein 2 (synaptobrevin 2)	0.011
FGF2	fibroblast growth factor 2 (basic)	0.011
NRBP1	nuclear receptor binding protein 1	0.011
SPSB1	splA/ryanodine receptor domain and SOCS box containing 1	0.011
RPS4Y1	ribosomal protein S4, Y-linked 1	0.011
IRS1	insulin receptor substrate 1	0.010
IFRD1	interferon-related developmental regulator 1	0.010
KIAA1267	KIAA1267	0.010
CD99	CD99 molecule	0.010
WDR26	WD repeat domain 26	0.010
SLC38A2	solute carrier family 38, member 2	0.010
TCEAL1	transcription elongation factor A (SII)-like 1	0.010
IL18	interleukin 18 (interferon-gamma-inducing factor)	0.010
MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	0.010
MARCO	macrophage receptor with collagenous structure	0.010
RBBP7	retinoblastoma binding protein 7	0.010
HSPA1B	heat shock 70kDa protein 1B	0.010
MAGED1	melanoma antigen family D, 1	0.010
WNT2	wingless-type MMTV integration site family member 2	0.010
TNFRSF21	tumor necrosis factor receptor superfamily, member 21	0.010
SFRP4	secreted frizzled-related protein 4	0.010
SNRNP35	small nuclear ribonucleoprotein 35kDa (U11/U12)	0.010
NOL3	nucleolar protein 3 (apoptosis repressor with CARD domain)	0.010
PIK3CD	phosphoinositide-3-kinase, catalytic, delta polypeptide	0.010
NR4A3	nuclear receptor subfamily 4, group A, member 3	0.010
CARD16	caspase recruitment domain family, member 16	0.010
SERTAD1	SERTA domain containing 1	0.010
LRP3	low density lipoprotein receptor-related protein 3	0.010
FRZB	frizzled-related protein	0.010
RGS4	regulator of G-protein signaling 4	0.010
TBC1D2B	TBC1 domain family, member 2B	0.010
UGCG	UDP-glucose ceramide glucosyltransferase	0.010
SOCS3	suppressor of cytokine signaling 3	0.010