IMP

Process View

Homo sapiens

20 genes annotated in human

lymphocyte apoptotic process

Any apoptotic process in a lymphocyte, a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "lymphocyte apoptotic process"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "lymphocyte apoptotic process" (in gray)

Name	Description	Probability	Func Analog Organism
CASP8	caspase 8, apoptosis-related cysteine peptidase	1.000	Mouse
TRAF1	TNF receptor-associated factor 1	0.995
RIPK1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.992	Mouse
BCL2	B-cell CLL/lymphoma 2	0.986	Human
CFLAR	CASP8 and FADD-like apoptosis regulator	0.984
BAX	BCL2-associated X protein	0.935
BCL2L1	BCL2-like 1	0.926	Human
FAS	Fas (TNF receptor superfamily, member 6)	0.925	Mouse
FADD	Fas (TNFRSF6)-associated via death domain	0.917	Mouse
CASP10	caspase 10, apoptosis-related cysteine peptidase	0.916
TNFRSF10A	tumor necrosis factor receptor superfamily, member 10a	0.906
BIRC3	baculoviral IAP repeat containing 3	0.854	Human
BID	BH3 interacting domain death agonist	0.839
TNFRSF10B	tumor necrosis factor receptor superfamily, member 10b	0.823
MCL1	myeloid cell leukemia sequence 1 (BCL2-related)	0.801	Human
IKBKG	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma	0.766
CCR5	chemokine (C-C motif) receptor 5	0.742
CD2	CD2 molecule	0.685
ZAP70	zeta-chain (TCR) associated protein kinase 70kDa	0.665
BCL2L11	BCL2-like 11 (apoptosis facilitator)	0.646	Mouse
TRAF2	TNF receptor-associated factor 2	0.598
CASP3	caspase 3, apoptosis-related cysteine peptidase	0.546
IL10RA	interleukin 10 receptor, alpha	0.523
CCL4	chemokine (C-C motif) ligand 4	0.468	Human
TNFRSF6B	tumor necrosis factor receptor superfamily, member 6b, decoy	0.466
BMPR1A	bone morphogenetic protein receptor, type IA	0.450
FASLG	Fas ligand (TNF superfamily, member 6)	0.437
CCR7	chemokine (C-C motif) receptor 7	0.415
INSR	insulin receptor	0.408
CD3E	CD3e molecule, epsilon (CD3-TCR complex)	0.390	Human
LCK	lymphocyte-specific protein tyrosine kinase	0.337
TP53	tumor protein p53	0.335	Mouse
LTA	lymphotoxin alpha (TNF superfamily, member 1)	0.333
TRADD	TNFRSF1A-associated via death domain	0.251
DFFB	DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)	0.224
CASP9	caspase 9, apoptosis-related cysteine peptidase	0.198
BAD	BCL2-associated agonist of cell death	0.196
FYN	FYN oncogene related to SRC, FGR, YES	0.191
NOXA1	NADPH oxidase activator 1	0.190
IL22RA1	interleukin 22 receptor, alpha 1	0.181
TRAF3	TNF receptor-associated factor 3	0.177
SQSTM1	sequestosome 1	0.175
MALT1	mucosa associated lymphoid tissue lymphoma translocation gene 1	0.170
S100A6	S100 calcium binding protein A6	0.167
TNFRSF9	tumor necrosis factor receptor superfamily, member 9	0.167
CCL5	chemokine (C-C motif) ligand 5	0.158
CXCR4	chemokine (C-X-C motif) receptor 4	0.156
CCL13	chemokine (C-C motif) ligand 13	0.150	Human
TGIF1	TGFB-induced factor homeobox 1	0.139
CARD11	caspase recruitment domain family, member 11	0.126
BAK1	BCL2-antagonist/killer 1	0.124	Human
RIPK2	receptor-interacting serine-threonine kinase 2	0.123
TNFRSF1A	tumor necrosis factor receptor superfamily, member 1A	0.117
CDC37	cell division cycle 37 homolog (S. cerevisiae)	0.113
MSN	moesin	0.108
CXCL9	chemokine (C-X-C motif) ligand 9	0.104
AKT1	v-akt murine thymoma viral oncogene homolog 1	0.102
MAGI3	membrane associated guanylate kinase, WW and PDZ domain containing 3	0.091
CCL8	chemokine (C-C motif) ligand 8	0.090	Human
PMAIP1	phorbol-12-myristate-13-acetate-induced protein 1	0.088
S100A4	S100 calcium binding protein A4	0.087
IL2RB	interleukin 2 receptor, beta	0.085
CD28	CD28 molecule	0.082
TNF	tumor necrosis factor	0.081
CD80	CD80 molecule	0.080
CD3G	CD3g molecule, gamma (CD3-TCR complex)	0.078
VIM	vimentin	0.072
CCL18	chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)	0.072	Human
BIRC2	baculoviral IAP repeat containing 2	0.070	Human
PARD6A	par-6 partitioning defective 6 homolog alpha (C. elegans)	0.068
IL2RG	interleukin 2 receptor, gamma	0.067
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.066
IL32	interleukin 32	0.066
INCENP	inner centromere protein antigens 135/155kDa	0.066
CD40	CD40 molecule, TNF receptor superfamily member 5	0.065
PXMP2	peroxisomal membrane protein 2, 22kDa	0.064
IL10	interleukin 10	0.062
CTLA4	cytotoxic T-lymphocyte-associated protein 4	0.062
CD48	CD48 molecule	0.059
PRKCZ	protein kinase C, zeta	0.058	Human
PDPK1	3-phosphoinositide dependent protein kinase-1	0.057
PTPRC	protein tyrosine phosphatase, receptor type, C	0.055
TNFRSF1B	tumor necrosis factor receptor superfamily, member 1B	0.055
IL2RA	interleukin 2 receptor, alpha	0.054	Mouse
TP53BP2	tumor protein p53 binding protein, 2	0.054
IL22RA2	interleukin 22 receptor, alpha 2	0.052
SOCS3	suppressor of cytokine signaling 3	0.051
CD5	CD5 molecule	0.050
ANXA2	annexin A2	0.049
TNFAIP3	tumor necrosis factor, alpha-induced protein 3	0.049
IFNG	interferon, gamma	0.049
HLA-DQB1	major histocompatibility complex, class II, DQ beta 1	0.048
GRB10	growth factor receptor-bound protein 10	0.047
SH2D1A	SH2 domain containing 1A	0.046
IDE	insulin-degrading enzyme	0.044
C9orf89	chromosome 9 open reading frame 89	0.044
PARD6G	par-6 partitioning defective 6 homolog gamma (C. elegans)	0.043
APAF1	apoptotic peptidase activating factor 1	0.043
CAV1	caveolin 1, caveolae protein, 22kDa	0.043
IKBKE	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon	0.043
MAP3K3	mitogen-activated protein kinase kinase kinase 3	0.042
S100A10	S100 calcium binding protein A10	0.042
CCL3	chemokine (C-C motif) ligand 3	0.042	Human
KPNA1	karyopherin alpha 1 (importin alpha 5)	0.042
CD3D	CD3d molecule, delta (CD3-TCR complex)	0.042	Human
HLA-DPA1	major histocompatibility complex, class II, DP alpha 1	0.041
GABARAPL1	GABA(A) receptor-associated protein like 1	0.041
CD6	CD6 molecule	0.041
CCL2	chemokine (C-C motif) ligand 2	0.041	Human
GZMB	granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)	0.040
MICA	MHC class I polypeptide-related sequence A	0.039
CASP7	caspase 7, apoptosis-related cysteine peptidase	0.038
BIRC5	baculoviral IAP repeat containing 5	0.038
VCAM1	vascular cell adhesion molecule 1	0.036
ATM	ataxia telangiectasia mutated	0.036
TRAT1	T cell receptor associated transmembrane adaptor 1	0.036
CCR4	chemokine (C-C motif) receptor 4	0.035
IL18RAP	interleukin 18 receptor accessory protein	0.035
HPCAL4	hippocalcin like 4	0.035
USP15	ubiquitin specific peptidase 15	0.034
TRAF6	TNF receptor-associated factor 6	0.034
SH3RF1	SH3 domain containing ring finger 1	0.034
FSTL1	follistatin-like 1	0.034
PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	0.033
IL7R	interleukin 7 receptor	0.033
MAP3K14	mitogen-activated protein kinase kinase kinase 14	0.033
BCL10	B-cell CLL/lymphoma 10	0.033
KIAA1377	KIAA1377	0.032
GNLY	granulysin	0.032
GZMK	granzyme K (granzyme 3; tryptase II)	0.032
CD247	CD247 molecule	0.032
VHL	von Hippel-Lindau tumor suppressor	0.032	Mouse
CALCOCO2	calcium binding and coiled-coil domain 2	0.032
CRLF3	cytokine receptor-like factor 3	0.031
CREBBP	CREB binding protein	0.031
CD86	CD86 molecule	0.031
IKBKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	0.030
CXCL10	chemokine (C-X-C motif) ligand 10	0.030
RGS1	regulator of G-protein signaling 1	0.029
TNFRSF14	tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)	0.029
CD83	CD83 molecule	0.028
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.026
CCL22	chemokine (C-C motif) ligand 22	0.026
NR4A1	nuclear receptor subfamily 4, group A, member 1	0.025
C4orf14	chromosome 4 open reading frame 14	0.025
CDCP1	CUB domain containing protein 1	0.025
BCL2A1	BCL2-related protein A1	0.025	Mouse
PARD6B	par-6 partitioning defective 6 homolog beta (C. elegans)	0.025
SRGN	serglycin	0.023
CA12	carbonic anhydrase XII	0.023
SIGLEC1	sialic acid binding Ig-like lectin 1, sialoadhesin	0.022	Mouse
TARP	TCR gamma alternate reading frame protein	0.022
BBS10	Bardet-Biedl syndrome 10	0.021
ZHX1	zinc fingers and homeoboxes 1	0.021
KLRK1	killer cell lectin-like receptor subfamily K, member 1	0.021
KLRD1	killer cell lectin-like receptor subfamily D, member 1	0.021
IRF4	interferon regulatory factor 4	0.021
HIF1A	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	0.021	Mouse
SLAMF1	signaling lymphocytic activation molecule family member 1	0.021
FLNA	filamin A, alpha	0.021
PRF1	perforin 1 (pore forming protein)	0.020
ICAM1	intercellular adhesion molecule 1	0.020
CCL11	chemokine (C-C motif) ligand 11	0.020	Human
IL1B	interleukin 1, beta	0.020
EGLN1	egl nine homolog 1 (C. elegans)	0.020
TMSB10	thymosin beta 10	0.020
CCL7	chemokine (C-C motif) ligand 7	0.019	Human
C1orf93	chromosome 1 open reading frame 93	0.019
MAPK12	mitogen-activated protein kinase 12	0.019
CCL14	chemokine (C-C motif) ligand 14	0.018	Human
HUWE1	HECT, UBA and WWE domain containing 1	0.018
GPR171	G protein-coupled receptor 171	0.018
SLAMF7	SLAM family member 7	0.018
PRKCB	protein kinase C, beta	0.018
CCL19	chemokine (C-C motif) ligand 19	0.018	Human
ZNF282	zinc finger protein 282	0.018
CXCL13	chemokine (C-X-C motif) ligand 13	0.018
CD40LG	CD40 ligand	0.018
ICOS	inducible T-cell co-stimulator	0.017
SYK	spleen tyrosine kinase	0.017
ANXA1	annexin A1	0.017
SPRR2D	small proline-rich protein 2D	0.017
LTB	lymphotoxin beta (TNF superfamily, member 3)	0.017
HLA-DMA	major histocompatibility complex, class II, DM alpha	0.017
CXCR6	chemokine (C-X-C motif) receptor 6	0.017
CCR1	chemokine (C-C motif) receptor 1	0.016
PARD3	par-3 partitioning defective 3 homolog (C. elegans)	0.016
BIK	BCL2-interacting killer (apoptosis-inducing)	0.016
YWHAZ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.016
EZR	ezrin	0.016
PPP1CA	protein phosphatase 1, catalytic subunit, alpha isozyme	0.016
SGOL1	shugoshin-like 1 (S. pombe)	0.016
IL21R	interleukin 21 receptor	0.016
CD27	CD27 molecule	0.015	Mouse
CD7	CD7 molecule	0.015
EGLN3	egl nine homolog 3 (C. elegans)	0.015
CD8A	CD8a molecule	0.015
BBC3	BCL2 binding component 3	0.014
RIPK3	receptor-interacting serine-threonine kinase 3	0.014	Mouse
ITK	IL2-inducible T-cell kinase	0.014
PML	promyelocytic leukemia	0.014
MMP12	matrix metallopeptidase 12 (macrophage elastase)	0.014
FPR3	formyl peptide receptor 3	0.014
CTSW	cathepsin W	0.014
KLRB1	killer cell lectin-like receptor subfamily B, member 1	0.014
ADAMDEC1	ADAM-like, decysin 1	0.013
AKT2	v-akt murine thymoma viral oncogene homolog 2	0.013	Human
MTOR	mechanistic target of rapamycin (serine/threonine kinase)	0.013
IL12B	interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)	0.013
DIABLO	diablo, IAP-binding mitochondrial protein	0.013
TCEB2	transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B)	0.013
STAT4	signal transducer and activator of transcription 4	0.013
TSC22D1	TSC22 domain family, member 1	0.013
NAA10	N(alpha)-acetyltransferase 10, NatA catalytic subunit	0.013
DBNDD2	dysbindin (dystrobrevin binding protein 1) domain containing 2	0.013
MAPK1	mitogen-activated protein kinase 1	0.013
RNR2	l-rRNA	0.012
PICK1	protein interacting with PRKCA 1	0.012
DCTN1	dynactin 1	0.012
PLP2	proteolipid protein 2 (colonic epithelium-enriched)	0.012
EIF4A1	eukaryotic translation initiation factor 4A1	0.012
MS4A1	membrane-spanning 4-domains, subfamily A, member 1	0.012
ACP5	acid phosphatase 5, tartrate resistant	0.012
ZFYVE9	zinc finger, FYVE domain containing 9	0.012
RNF144B	ring finger protein 144B	0.012
TNFSF10	tumor necrosis factor (ligand) superfamily, member 10	0.012	Human
RPS14	ribosomal protein S14	0.012
NKG7	natural killer cell group 7 sequence	0.012
LMO4	LIM domain only 4	0.012
CD69	CD69 molecule	0.012
RAF1	v-raf-1 murine leukemia viral oncogene homolog 1	0.012
SAMD4B	sterile alpha motif domain containing 4B	0.012
DPP4	dipeptidyl-peptidase 4	0.011
IGL@	immunoglobulin lambda locus	0.011
GAS2L3	growth arrest-specific 2 like 3	0.011
BECN1	beclin 1, autophagy related	0.011
GZMH	granzyme H (cathepsin G-like 2, protein h-CCPX)	0.011
TNFSF8	tumor necrosis factor (ligand) superfamily, member 8	0.011
ANXA5	annexin A5	0.011
FKBP8	FK506 binding protein 8, 38kDa	0.011
LAG3	lymphocyte-activation gene 3	0.011
PSEN1	presenilin 1	0.011
HSPA1L	heat shock 70kDa protein 1-like	0.011
BMP2	bone morphogenetic protein 2	0.011	Human
IL6	interleukin 6 (interferon, beta 2)	0.011
SBF1	SET binding factor 1	0.011
CFTR	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	0.011
BCL3	B-cell CLL/lymphoma 3	0.011
SH2D2A	SH2 domain containing 2A	0.011
IL1A	interleukin 1, alpha	0.010
SPRR2A	small proline-rich protein 2A	0.010
EMP3	epithelial membrane protein 3	0.010
CAPG	capping protein (actin filament), gelsolin-like	0.010
GLA	galactosidase, alpha	0.010
PPP1CC	protein phosphatase 1, catalytic subunit, gamma isozyme	0.010
SELE	selectin E	0.010
WRN	Werner syndrome, RecQ helicase-like	0.010
AIP	aryl hydrocarbon receptor interacting protein	0.010
LAMP3	lysosomal-associated membrane protein 3	0.010
SMAD3	SMAD family member 3	0.010
TXK	TXK tyrosine kinase	0.010
PYCARD	PYD and CARD domain containing	0.010